{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_cryoEM = 0, surface_class = \"A_surface\" and tier = \"Tier 1\" sorted by evidence_priority descending", "rows": [["P21802", "FGFR2", "Fibroblast growth factor receptor 2", "Tier 1", 0.959, 1, "A_surface", 62, 73.94, 0, 0, null, null, 1, 5, "41786503,39759879,31357131,24242861,19212647", 1, "Crouzon syndrome", 0.8637438969881663], ["P78504", "JAG1", "Protein jagged-1", "Tier 1", 0.958, 1, "A_surface", 7, 73.12, 0, 0, null, null, 1, 4, "37338014,37052638,23341879,18673242", 1, "Alagille syndrome due to a JAG1 point mutation", 0.8586542923232751], ["P11166", "SLC2A1", "Solute carrier family 2, facilitated glucose transporter member 1", "Tier 1", 0.956, 1, "A_surface", 5, 90.25, 0, 0, null, null, 1, 2, "39627234,33184583", 1, "encephalopathy due to GLUT1 deficiency", 0.8521823225896756], ["P11362", "FGFR1", "Fibroblast growth factor receptor 1", "Tier 1", 0.954, 1, "A_surface", 82, 73.88, 0, 0, null, null, 1, 13, "41873087,41820318,40092750,39759879,39249203,37336759,33536494,31583159,31357131,30297602,28442904", 1, "hypogonadotropic hypogonadism 2 with or without anosmia", 0.8472925100660907], ["P08581", "MET", "Hepatocyte growth factor receptor", "Tier 1", 0.953, 1, "A_surface", 100, 79.25, 0, 0, null, null, 1, 149, "42012469,41992303,41973478,41873087,41861669,41858296,41848278,41601428,41462891,41391726,41234744,41123956,41084363,41065179,41024479,40954195,40938088,40923343,40840349,40740738,40728393,40640119,40388621,40189053,40116812,40041032,39930702,39853766,39852082,39744222,39735310,39674868,39631842,39586988,39527480,39513807,39355222,39348183,39288204,39087949,38925633,38923378,38876234,38829176,38697444,38515622,38298092,38277932,38230289,38225704,30237882,29416033,26131766", 1, "papillary renal cell carcinoma", 0.84195976263742], ["P06213", "INSR", "Insulin receptor", "Tier 1", 0.953, 1, "A_surface", 87, 77.62, 0, 0, null, null, 1, 14, "33410883,24768638,40603733,37779149,36310231,35478209,29262294,27648925,26387957,26245346,19396447,17167487", 1, "Leprechaunism", 0.8448849372402896], ["Q8WZ42", "TTN", "Titin", "Tier 1", 0.953, 1, "A_surface", 64, null, 0, 0, null, null, 1, 1, "29952259", 1, "dilated cardiomyopathy", 0.8419847660466327], ["O00571", "DDX3X", "ATP-dependent RNA helicase DDX3X", "Tier 1", 0.951, 1, "A_surface", 17, 72.19, 0, 0, null, null, 0, 0, null, 1, "X-linked non-syndromic intellectual disability", 0.8362533125067105], ["P54760", "EPHB4", "Ephrin type-B receptor 4", "Tier 1", 0.95, 1, "A_surface", 23, 82.0, 0, 0, null, null, 0, 0, null, 1, "Capillary malformation - arteriovenous malformation", 0.8317426466005666], ["Q8WZA1", "POMGNT1", "Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1", "Tier 1", 0.948, 1, "A_surface", 10, 89.88, 0, 0, null, null, 0, 0, null, 1, "muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A3", 0.826104223872448], ["P36894", "BMPR1A", "Bone morphogenetic protein receptor type-1A", "Tier 1", 0.948, 1, "A_surface", 11, 82.62, 0, 0, null, null, 1, 1, "30537181", 1, "juvenile polyposis syndrome", 0.8278395086688584], ["O75844", "ZMPSTE24", "CAAX prenyl protease 1 homolog", "Tier 1", 0.942, 1, "A_surface", 4, 89.44, 0, 0, null, null, 1, 1, "37565451", 1, "mandibuloacral dysplasia with type B lipodystrophy", 0.8071967390737101], ["P25942", "CD40", "Tumor necrosis factor receptor superfamily member 5", "Tier 1", 0.941, 1, "A_surface", 14, 81.19, 0, 0, null, null, 1, 8, "41982466,37331977,36203210,33335251,26504624,26231918,23460531,12828856", 1, "hyper-IgM syndrome type 3", 0.8038021669520221], ["O94766", "B3GAT3", "Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3", "Tier 1", 0.94, 1, "A_surface", 3, 92.56, 0, 0, null, null, 0, 0, null, 1, "Larsen-like syndrome, B3GAT3 type", 0.7995331164339264], ["Q14118", "DAG1", "Dystroglycan 1", "Tier 1", 0.938, 1, "A_surface", 8, 68.19, 0, 0, null, null, 0, 0, null, 1, "autosomal recessive limb-girdle muscular dystrophy type 2P", 0.7935290060634741], ["Q9UPN3", "MACF1", "Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5", "Tier 1", 0.938, 1, "A_surface", 3, null, 0, 0, null, null, 0, 0, null, 1, "lissencephaly 9 with complex brainstem malformation", 0.7945569032416216], ["P08473", "MME", "Neprilysin", "Tier 1", 0.937, 1, "A_surface", 16, 96.19, 0, 0, null, null, 0, 0, null, 1, "Charcot-Marie-Tooth disease axonal type 2T", 0.7912653398252156], ["P35916", "FLT4", "Vascular endothelial growth factor receptor 3", "Tier 1", 0.937, 1, "A_surface", 2, 72.44, 0, 0, null, null, 0, 0, null, 1, "lymphatic malformation 1", 0.7904355931811005], ["Q16832", "DDR2", "Discoidin domain-containing receptor 2", "Tier 1", 0.936, 1, "A_surface", 5, 75.81, 0, 0, null, null, 1, 1, "26067556", 1, "spondyloepimetaphyseal dysplasia-short limb-abnormal calcification syndrome", 0.7854778386444168], ["O75880", "SCO1", "Cytochrome c oxidase assembly factor SCO1", "Tier 1", 0.935, 1, "A_surface", 10, 77.75, 0, 0, null, null, 0, 0, null, 1, "mitochondrial complex IV deficiency, nuclear type 4", 0.7827872588103603], ["Q13554", "CAMK2B", "Calcium/calmodulin-dependent protein kinase type II subunit beta", "Tier 1", 0.932, 1, "A_surface", 4, 70.56, 0, 0, null, null, 1, 2, "29784938,26594036", 1, "intellectual disability, autosomal dominant 54", 0.7745713380655789], ["P29317", "EPHA2", "Ephrin type-A receptor 2", "Tier 1", 0.931, 1, "A_surface", 100, 82.25, 0, 0, null, null, 1, 16, "40563410,40408544,39259047,37251690,35700603,35397426,32169805,34541193,28235049,24586375,21902173,21793789", 1, "Total congenital cataract", 0.7690993612962792], ["P12821", "ACE", "Angiotensin-converting enzyme", "Tier 1", 0.93, 1, "A_surface", 97, 90.94, 0, 0, null, null, 1, 108, "41505229,41326371,41315058,41027166,40975918,40578246,40549055,40494268,40394224,40157106,39796148,39643350,39638470,39368201,39326115,39277931,38989925,38783134,38559166,38454949,38189917,37692001,37526583,37422510,37385465,37231283,37191170,36924636,36327903,36128975,36069206,35985229,35831655,34248841,34227370,34213110,34109445,33362222,32981365,32969502,31542417,30707214,29367662,29244716,28507681,25035238,24861783,24125636,20373790,20119964,41716474,41274248,40642289,40333723,40321580,40227272,39964138,39923730,38553521,37932762,37808754,37375202,36822303,36714461,36581924,36288301,36170362,36073793,35972202,35910791,35748608,35542182,34953639,34876524,34855379,34798263,34696413,34619249,34458322,34282416,34230708,34230707,34166652,33684258,33683787,33629859,33561300,32838280,32551560,21147843,18209324,16607776", 1, "diabetic nephropathy", 0.7656590329495216], ["O95714", "HERC2", "E3 ubiquitin-protein ligase HERC2", "Tier 1", 0.925, 1, "A_surface", 15, null, 0, 0, null, null, 0, 0, null, 1, "developmental delay with autism spectrum disorder and gait instability", 0.74952129063985], ["P01019", "AGT", "Angiotensinogen", "Tier 1", 0.921, 1, "A_surface", 22, 86.44, 0, 0, null, null, 1, 16, "35983901,34936368,34779902,34248841,32838280,23766021,17673982,11419945,38045440,34619249,29844151,27530235", 1, "renal tubular dysgenesis", 0.7354947364860083], ["P01730", "CD4", "T-cell surface glycoprotein CD4", "Tier 1", 0.921, 1, "A_surface", 85, 85.25, 0, 0, null, null, 1, 96, "41889731,41761629,41654945,41542672,41395530,41338305,41206244,40972397,40877519,40788329,40448637,39920212,39269432,38744189,38661725,37895096,37881079,37836456,37170724,37141264,37110712,36352911,36149728,34386332,33389440,32786336,32567629,32157125,31778957,31707227,31434881,31316164,30393236,29881374,29556342,29375127,29277631,29145483,28934318,28800954,28290464,27959341,27529508,28955932,26792955,25757623,25754473,25241192,25189099,24661998", 1, "HIV infection", 0.7364522622142639], ["P21589", "NT5E", "5'-nucleotidase", "Tier 1", 0.916, 1, "A_surface", 50, 91.88, 0, 0, null, null, 1, 3, "38689291,30472954,25720604", 1, "hereditary arterial and articular multiple calcification syndrome", 0.7199342086353593], ["P22455", "FGFR4", "Fibroblast growth factor receptor 4", "Tier 1", 0.915, 1, "A_surface", 52, 73.62, 0, 0, null, null, 1, 2, "39759879,30297602", 1, "cancer", 0.7150377661800104], ["P09601", "HMOX1", "Heme oxygenase 1", "Tier 1", 0.905, 1, "A_surface", 26, 82.88, 0, 0, null, null, 1, 6, "37533140,40526855,40509588,39812275,37457170", 1, "heme oxygenase 1 deficiency", 0.6838783130237968], ["P35968", "KDR", "Vascular endothelial growth factor receptor 2", "Tier 1", 0.904, 1, "A_surface", 54, 71.12, 0, 0, null, null, 1, 22, "29608400,27490795,26125598,10548435,9685413,41572478,41187655,39225423,33191671,32199927,30626772,21970900,21907194,20237249,19135441,18499900,17347807,16842232,16787141", 1, "neoplasm", 0.681272749535704], ["Q9NZQ7", "CD274", "Programmed cell death 1 ligand 1", "Tier 1", 0.903, 1, "A_surface", 74, 88.25, 0, 0, null, null, 1, 67, "41855853,41830812,41781380,41770936,41629133,41479885,41205458,41195987,41173800,40972397,40811947,40789156,40758411,40682599,40581004,40516668,40209314,40188671,40119836,40016918,40012368,39929085,39916963,39824759,39805944,39532409,39454136,39440615,39417693,39352679,39344385,39332044,39222892,39003918,38940673,38859589,38763821,38636085,38621341,38446717,37944524,37923412,37531891,37364303,36484532,35972912,35624582,35268583,34523014,34156677", 1, "non-small cell lung carcinoma", 0.6769230776549127], ["P17181", "IFNAR1", "Interferon alpha/beta receptor 1", "Tier 1", 0.901, 1, "A_surface", 5, 78.0, 0, 0, null, null, 1, 1, "27068091", 1, "immunodeficiency 106, susceptibility to viral infections", 0.6703994774055272], ["Q07075", "ENPEP", "Glutamyl aminopeptidase", "Tier 1", 0.9, 1, "A_surface", 7, 93.5, 0, 0, null, null, 1, 2, "38467937", 1, "hypertension", 0.6677707312760746], ["Q9Y6N7", "ROBO1", "Roundabout homolog 1", "Tier 1", 0.897, 1, "A_surface", 12, 60.0, 0, 0, null, null, 0, 0, null, 1, "neurooculorenal syndrome", 0.6567040910170603], ["P27487", "DPP4", "Dipeptidyl peptidase 4", "Tier 1", 0.893, 1, "A_surface", 100, 96.25, 0, 0, null, null, 1, 4, "30056058,26605646", 1, "type 2 diabetes mellitus", 0.6432827162361505], ["P27338", "MAOB", "Amine oxidase [flavin-containing] B", "Tier 1", 0.889, 1, "A_surface", 56, 95.62, 0, 0, null, null, 1, 1, "26841904", 1, "Parkinson disease", 0.6302940908016386], ["P22303", "ACHE", "Acetylcholinesterase", "Tier 1", 0.889, 1, "A_surface", 78, 92.94, 0, 0, null, null, 1, 135, "41985393,41898380,41654945,41639270,41639254,41565777,41276911,41237904,41230502,41086326,41006757,40855286,40500390,40487355,40452137,40444021,40277325,40262341,40215752,40154972,40128122,39834132,39728786,39689579,39665919,39282962,39102642,38996565,38953438,38949022,38722683,38569854,38559166,38544485,38462144,38410271,38168820,38026177,37905115,37759795,37622311,37506391,37117194,36741760,36551106,36368824,36047811,35842727,35770801,35439419,36971430,36375221,36359944,35479481,35402070,35235478,35057959,34509014,33218485,33096123,32143069,31748191,31170561,26003847,25569873,24756130,24299064,12852840", 1, "Alzheimer disease", 0.628678841772617], ["Q13557", "CAMK2D", "Calcium/calmodulin-dependent protein kinase type II subunit delta", "Tier 1", 0.889, 1, "A_surface", 9, 83.38, 0, 0, null, null, 1, 1, "29784938", 1, "Neurodevelopmental disorder", 0.6312857608660509], ["P28907", "CD38", "ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1", "Tier 1", 0.887, 1, "A_surface", 55, 90.88, 0, 0, null, null, 1, 5, "40931580,34364920,33742062,26242462", 1, "multiple myeloma", 0.6233037747334318], ["Q07954", "LRP1", "Prolow-density lipoprotein receptor-related protein 1", "Tier 1", 0.886, 1, "A_surface", 7, 79.19, 0, 0, null, null, 1, 3, "41599761,38996211,25855589", 1, "developmental dysplasia of the hip", 0.6197148309275711], ["P31431", "SDC4", "Syndecan-4", "Tier 1", 0.885, 1, "A_surface", 5, 63.28, 0, 0, null, null, 0, 0, null, 1, "non-small cell lung carcinoma", 0.6168120240815278], ["P27448", "MARK3", "MAP/microtubule affinity-regulating kinase 3", "Tier 1", 0.879, 1, "A_surface", 14, 68.25, 0, 0, null, null, 1, 2, "33328453,32637948", 1, "cancer", 0.5979109389232433], ["P20701", "ITGAL", "Integrin alpha-L", "Tier 1", 0.877, 1, "A_surface", 41, 82.62, 0, 0, null, null, 0, 0, null, 1, "psoriasis", 0.5899795223699872], ["P0DOY3", "IGLC3", "Immunoglobulin lambda constant 3", "Tier 1", 0.876, 1, "A_surface", 4, 96.06, 0, 0, null, null, 0, 0, null, 1, "cutaneous Leishmaniasis", 0.5868213846274001], ["P01859", "IGHG2", "Immunoglobulin heavy constant gamma 2", "Tier 1", 0.876, 1, "A_surface", 5, 87.38, 0, 0, null, null, 0, 0, null, 1, "cutaneous Leishmaniasis", 0.5868213846274001], ["P01857", "IGHG1", "Immunoglobulin heavy constant gamma 1", "Tier 1", 0.876, 1, "A_surface", 100, 86.69, 0, 0, null, null, 0, 0, null, 1, "cutaneous Leishmaniasis", 0.5868213846274001], ["P30530", "AXL", "Tyrosine-protein kinase receptor UFO", "Tier 1", 0.876, 1, "A_surface", 4, 75.06, 0, 0, null, null, 1, 22, "40751315,40566927,40479828,39788632,39440615,39347825,37961806,35116429,33988982,33251048,32486489,32174798,31684958,31276956,30340138,29246304,27448441,27111415,25998051,24881764,24441398,22910292", 1, "acute myeloid leukemia", 0.5870034687571098], ["Q10588", "BST1", "ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2", "Tier 1", 0.869, 1, "A_surface", 6, 89.62, 0, 0, null, null, 0, 0, null, 1, "Parkinson disease", 0.5634966060310903], ["Q16513", "PKN2", "Serine/threonine-protein kinase N2", "Tier 1", 0.868, 1, "A_surface", 4, 71.44, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.5587297348479079], ["P13726", "F3", "Tissue factor", "Tier 1", 0.867, 1, "A_surface", 54, 84.81, 0, 0, null, null, 1, 36, "40611414,40001558,38811951,36291832,33892482,38776649,36203210,35036063,34386338,32224381,30302740,27563744,25953802,25521966,24998782,24880800,24319161,24263002,23876036,23528042,22951415,22658294,22632032,22116094,21696535,21389323,21144556,20139356,20135076,20004955,18826387,18235012,17272750,16676065,11127866,8578509", 1, "cervical cancer", 0.5555433402271651]], "truncated": false, "filtered_table_rows_count": 239, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_cryoEM\" = :p0 and \"surface_class\" = :p1 and \"tier\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "0", "p1": "A_surface", "p2": "Tier 1"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&surface_class=A_surface&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 231, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=A_surface&tier=Tier+1&has_structure=1", "selected": false}, {"value": 0, "label": 0, "count": 8, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=A_surface&tier=Tier+1&has_structure=0", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&surface_class=A_surface&tier=Tier+1", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 239, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=A_surface", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&surface_class=A_surface&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 239, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=A_surface&tier=Tier+1&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&surface_class=A_surface&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 143, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=A_surface&tier=Tier+1&has_known_aptamer=0", "selected": false}, {"value": 1, "label": 1, "count": 96, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=A_surface&tier=Tier+1&has_known_aptamer=1", "selected": false}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&surface_class=A_surface&tier=Tier+1", "results": [{"value": "A_surface", "label": "A_surface", "count": 239, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&tier=Tier+1", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&surface_class=A_surface&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 127, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=A_surface&tier=Tier+1&in_cev_map=0", "selected": false}, {"value": 1, "label": 1, "count": 112, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=A_surface&tier=Tier+1&in_cev_map=1", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&surface_class=A_surface&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 239, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&tier=Tier+1", "selected": true}], "truncated": false}}, "suggested_facets": [{"name": "aptamer_count_pubmed", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=A_surface&tier=Tier+1&_facet=aptamer_count_pubmed"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=A_surface&tier=Tier+1&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 648.1274589896202, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}