{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_cryoEM = 0, surface_class = \"A_surface\" and tier = \"Tier 1.5\" sorted by evidence_priority descending", "rows": [["P00813", "ADA", "Adenosine deaminase", "Tier 1.5", 0.957, 1, "A_surface", 2, 96.56, 0, 0, null, null, 1, 72, "42012076,41877526,41762796,41635914,40403280,40189053,39856849,39847085,36796307,33998617,32043202,30876536,30060448,27589406,26606306,25597304,25521724,25360869,24976151,24893272,24682016,24035856,23462984,23202335,23037591,22944024,22613226,41910181,41791686,41267360,39673485,39396299,38583236,36855421,34241023,33147453,32546280,30926472,26605646,24624989,23373863,22543727,20345118,19381549,19378312,18293985,17440909,17000903,16856187,16619330", 1, "Severe combined immunodeficiency due to adenosine deaminase deficiency", 0.8556816060494579], ["P51795", "CLCN5", "H(+)/Cl(-) exchange transporter 5", "Tier 1.5", 0.955, 1, "A_surface", 2, 80.62, 0, 0, null, null, 0, 0, null, 1, "Dent disease type 1", 0.850724240157394], ["P25189", "MPZ", "Myelin protein P0", "Tier 1.5", 0.951, 1, "A_surface", 2, 81.69, 0, 0, null, null, 0, 0, null, 1, "Charcot-Marie-Tooth disease type 1B", 0.8377022197539885], ["P36888", "FLT3", "Receptor-type tyrosine-protein kinase FLT3", "Tier 1.5", 0.949, 1, "A_surface", 11, 75.94, 0, 0, null, null, 1, 6, "41733039,34364920,31434881,30237882,29299123,22411871", 1, "acute myeloid leukemia", 0.8313389209288576], ["P13473", "LAMP2", "Lysosome-associated membrane glycoprotein 2", "Tier 1.5", 0.948, 1, "A_surface", 2, 83.19, 0, 0, null, null, 0, 0, null, 1, "Glycogen Storage Disease Type 2b", 0.8273010649608126], ["P04626", "ERBB2", "Receptor tyrosine-protein kinase erbB-2", "Tier 1.5", 0.934, 1, "A_surface", 63, 74.0, 0, 0, null, null, 1, 119, "41836728,41744190,41540559,41494763,41413339,41321156,41297941,40851486,40761795,40494827,40403699,40382399,40223744,40220375,40120226,40080161,40056884,39873777,39809083,39756158,39748051,39643321,39609809,39539244,39263860,39233482,39177424,38901393,38813974,38789508,38693181,38679242,38604040,38409854,38066021,37729138,37659641,37591183,37522239,37392577,37038354,36272296,36255496,36001395,35504229,34952586,34476602,34236165,33876310,33627408", 1, "non-small cell lung carcinoma", 0.7789523142843545], ["O94856", "NFASC", "Neurofascin", "Tier 1.5", 0.933, 1, "A_surface", 2, 76.31, 0, 0, null, null, 0, 0, null, 1, "neurodevelopmental disorder with central and peripheral motor dysfunction", 0.7782432580663833], ["Q15746", "MYLK", "Myosin light chain kinase, smooth muscle", "Tier 1.5", 0.93, 1, "A_surface", 7, 65.88, 0, 0, null, null, 0, 0, null, 1, "aortic aneurysm, familial thoracic 7", 0.7659842793171938], ["P24394", "IL4R", "Interleukin-4 receptor subunit alpha", "Tier 1.5", 0.923, 1, "A_surface", 10, 54.75, 0, 0, null, null, 1, 3, "32751068,27819142,22282665", 1, "asthma", 0.742115080702623], ["P16671", "CD36", "Platelet glycoprotein 4", "Tier 1.5", 0.921, 1, "A_surface", 1, 93.94, 0, 0, null, null, 1, 6, "41713143,41140242,39762152,33596054,33291667,31904170", 1, "platelet-type bleeding disorder 10", 0.7360571429413174], ["Q02413", "DSG1", "Desmoglein-1", "Tier 1.5", 0.92, 1, "A_surface", 1, 62.06, 0, 0, null, null, 0, 0, null, 1, "severe dermatitis-multiple allergies-metabolic wasting syndrome", 0.7335328506238418], ["P09758", "TACSTD2", "Tumor-associated calcium signal transducer 2", "Tier 1.5", 0.919, 1, "A_surface", 7, 82.69, 0, 0, null, null, 1, 4, "41384307,41241473,40050871,39250993", 1, "gelatinous drop-like corneal dystrophy", 0.7293087728162646], ["P08637", "FCGR3A", "Low affinity immunoglobulin gamma Fc region receptor III-A", "Tier 1.5", 0.912, 1, "A_surface", 15, 85.69, 0, 0, null, null, 1, 2, "41249026,21531729", 1, "autosomal recessive primary immunodeficiency with defective spontaneous natural killer cell cytotoxicity", 0.7061437347032623], ["Q13555", "CAMK2G", "Calcium/calmodulin-dependent protein kinase type II subunit gamma", "Tier 1.5", 0.891, 1, "A_surface", 2, 78.38, 0, 0, null, null, 0, 0, null, 1, "intellectual developmental disorder 59", 0.6354497016986491], ["Q92956", "TNFRSF14", "Tumor necrosis factor receptor superfamily member 14", "Tier 1.5", 0.879, 1, "A_surface", 8, 79.94, 0, 0, null, null, 0, 0, null, 1, "diffuse large B-cell lymphoma", 0.5983171413833771], ["P01597", "IGKV1-39", "Immunoglobulin kappa variable 1-39", "Tier 1.5", 0.876, 1, "A_surface", 2, 90.5, 0, 0, null, null, 0, 0, null, 1, "cutaneous Leishmaniasis", 0.5868213846274001], ["P01764", "IGHV3-23", "Immunoglobulin heavy variable 3-23", "Tier 1.5", 0.876, 1, "A_surface", 6, 91.0, 0, 0, null, null, 0, 0, null, 1, "cutaneous Leishmaniasis", 0.5868213846274001], ["P23083", "IGHV1-2", "Immunoglobulin heavy variable 1-2", "Tier 1.5", 0.876, 1, "A_surface", 1, 91.75, 0, 0, null, null, 0, 0, null, 1, "cutaneous Leishmaniasis", 0.5868213846274001], ["P01593", "IGKV1D-33", "Immunoglobulin kappa variable 1D-33", "Tier 1.5", 0.876, 1, "A_surface", 6, 90.88, 0, 0, null, null, 0, 0, null, 1, "cutaneous Leishmaniasis", 0.5868213846274001], ["P06312", "IGKV4-1", "Immunoglobulin kappa variable 4-1", "Tier 1.5", 0.876, 1, "A_surface", 10, 90.62, 0, 0, null, null, 0, 0, null, 1, "cutaneous Leishmaniasis", 0.5868213846274001], ["Q96D96", "HVCN1", "Voltage-gated hydrogen channel 1", "Tier 1.5", 0.865, 1, "A_surface", 2, 69.75, 0, 0, null, null, 0, 0, null, 1, "Joubert syndrome", 0.5504227269701596], ["Q9P1W8", "SIRPG", "Signal-regulatory protein gamma", "Tier 1.5", 0.864, 1, "A_surface", 2, 85.5, 0, 0, null, null, 0, 0, null, 1, "type 1 diabetes mellitus", 0.5457344827318543], ["O15155", "BET1", "BET1 homolog", "Tier 1.5", 0.864, 1, "A_surface", 1, 83.06, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.5468418315282804], ["P34741", "SDC2", "Syndecan-2", "Tier 1.5", 0.863, 1, "A_surface", 1, 60.84, 0, 0, null, null, 0, 0, null, 1, "COVID-19", 0.5422254875204983], ["P15260", "IFNGR1", "Interferon gamma receptor 1", "Tier 1.5", 0.862, 1, "A_surface", 5, 66.0, 0, 0, null, null, 1, 2, "33667716", 1, "disseminated atypical mycobacterial infection", 0.5414012388034828], ["O00161", "SNAP23", "Synaptosomal-associated protein 23", "Tier 1.5", 0.859, 1, "A_surface", 2, 82.12, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.5288361677964304], ["P21926", "CD9", "CD9 antigen", "Tier 1.5", 0.858, 1, "A_surface", 5, 88.56, 0, 0, null, null, 1, 17, "41999228,41625383,40618375,39266887,38866706,38057814,37585601,37351166,37019008,36704890,34647460,34505435,33304477,32730952,32207293,28959386", 1, "diphtheria", 0.5261379875719714], ["P54756", "EPHA5", "Ephrin type-A receptor 5", "Tier 1.5", 0.858, 1, "A_surface", 2, 79.38, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.5261379875719714], ["Q9HCM2", "PLXNA4", "Plexin-A4", "Tier 1.5", 0.856, 1, "A_surface", 1, 83.06, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.518371001420808], ["P13591", "NCAM1", "Neural cell adhesion molecule 1", "Tier 1.5", 0.852, 1, "A_surface", 7, 79.5, 0, 0, null, null, 1, 1, "36649818", 1, "smoking initiation", 0.5071020926446286], ["P15814", "IGLL1", "Immunoglobulin lambda-like polypeptide 1", "Tier 1.5", 0.85, 1, "A_surface", 3, 75.06, 0, 0, null, null, 0, 0, null, 1, "isolated agammaglobulinemia", 0.4996673834185043], ["P18084", "ITGB5", "Integrin beta-5", "Tier 1.5", 0.846, 1, "A_surface", 3, 82.19, 0, 0, null, null, 0, 0, null, 1, "migraine disorder", 0.48652455084344876], ["A1L3X0", "ELOVL7", "Very long chain fatty acid elongase 7", "Tier 1.5", 0.828, 1, "A_surface", 1, 89.75, 0, 0, null, null, 0, 0, null, 1, "substance-related disorder", 0.4271436896798171], ["Q92854", "SEMA4D", "Semaphorin-4D", "Tier 1.5", 0.828, 1, "A_surface", 2, 80.81, 0, 0, null, null, 0, 0, null, 1, "skin aging", 0.4259843235238637], ["P20702", "ITGAX", "Integrin alpha-X", "Tier 1.5", 0.825, 1, "A_surface", 9, 88.0, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.41708750879240836], ["Q9P121", "NTM", "Neurotrimin", "Tier 1.5", 0.824, 1, "A_surface", 2, 82.38, 0, 0, null, null, 1, 2, "35699468,26194558", 1, "smoking initiation", 0.41382172436739945], ["Q14242", "SELPLG", "P-selectin glycoprotein ligand 1", "Tier 1.5", 0.82, 1, "A_surface", 1, 50.38, 0, 0, null, null, 1, 1, "25979951", 1, "glaucoma", 0.40058604767334977], ["P08571", "CD14", "Monocyte differentiation antigen CD14", "Tier 1.5", 0.818, 1, "A_surface", 1, 84.75, 0, 0, null, null, 1, 14, "41636061,41542672,41140242,38477735,38280803,37162508,36716100,36475636,32589412,32515246,30900705,30563044,25483705,12498773", 1, "dengue disease", 0.39219972762611355], ["P35080", "PFN2", "Profilin-2", "Tier 1.5", 0.817, 1, "A_surface", 1, 95.5, 0, 0, null, null, 0, 0, null, 1, "smoking initiation", 0.38873499449725424], ["Q08554", "DSC1", "Desmocollin-1", "Tier 1.5", 0.81, 1, "A_surface", 2, 76.75, 0, 0, null, null, 0, 0, null, 1, "atopic eczema", 0.3674657640592667], ["O95255", "ABCC6", "ATP-binding cassette sub-family C member 6", "Tier 1.5", 0.809, 1, "A_surface", 4, 80.94, 0, 0, null, null, 0, 0, null, 0, "Pseudoxanthoma elasticum", 0.864631668818611], ["O75144", "ICOSLG", "ICOS ligand", "Tier 1.5", 0.803, 1, "A_surface", 2, 82.56, 0, 0, null, null, 0, 0, null, 1, "immunodeficiency 119", 0.34184658238916177], ["P30968", "GNRHR", "Gonadotropin-releasing hormone receptor", "Tier 1.5", 0.799, 1, "A_surface", 1, 84.19, 0, 0, null, null, 0, 0, null, 0, "hypogonadotropic hypogonadism", 0.83100005285263], ["P10912", "GHR", "Growth hormone receptor", "Tier 1.5", 0.799, 1, "A_surface", 9, 58.69, 0, 0, null, null, 1, 5, "38811951,38477735,31603904", 0, "Laron syndrome", 0.8304020079647765], ["Q13308", "PTK7", "Inactive tyrosine-protein kinase 7", "Tier 1.5", 0.796, 1, "A_surface", 1, 82.69, 0, 0, null, null, 1, 110, "41949051,41786503,41782379,41780252,41473803,41172349,41097888,41065179,41047832,40987771,40652441,40618375,40556592,40488675,40479736,40415219,40388621,40274545,40033943,39933564,39583320,39468753,39405917,39315658,39226482,39211579,39161311,39127174,38985770,38922365,38889444,38773263,38708542,38695582,38642044,38466380,38359901,38148412,38064592,37974961,37480788,37473438,37458448,37247456,37105082,37003060,36765879,36722904,36722696,36471380", 1, "neurodegenerative disease", 0.3194172724024113], ["O75015", "FCGR3B", "Low affinity immunoglobulin gamma Fc region receptor III-B", "Tier 1.5", 0.795, 1, "A_surface", 6, 88.62, 0, 0, null, null, 0, 0, null, 1, "Takayasu arteritis", 0.3170299762085396], ["O43525", "KCNQ3", "Potassium voltage-gated channel subfamily KQT member 3", "Tier 1.5", 0.789, 1, "A_surface", 1, 56.72, 0, 0, null, null, 0, 0, null, 0, "Benign familial neonatal seizures", 0.7961763561533409], ["P37023", "ACVRL1", "Activin receptor type-1-like", "Tier 1.5", 0.789, 1, "A_surface", 7, 82.0, 0, 0, null, null, 0, 0, null, 0, "telangiectasia, hereditary hemorrhagic, type 2", 0.7951167515831324], ["P16410", "CTLA4", "Cytotoxic T-lymphocyte protein 4", "Tier 1.5", 0.787, 1, "A_surface", 22, 80.12, 0, 0, null, null, 1, 26, "41907643,40972397,40870970,40811947,40536609,39417693,38473398,38158454,36966395,36831533,36603108,36015348,33970170,32929022,32840510,32280743,32024070,31405808,28918052,28082399,26030229,25565435,24892807,23460536,23460531,14612549", 0, "autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency", 0.7906408646569979], ["Q13698", "CACNA1S", "Voltage-dependent L-type calcium channel subunit alpha-1S", "Tier 1.5", 0.786, 1, "A_surface", 2, 71.81, 0, 0, null, null, 0, 0, null, 0, "hypokalemic periodic paralysis, type 1", 0.7869997029542154]], "truncated": false, "filtered_table_rows_count": 455, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_cryoEM\" = :p0 and \"surface_class\" = :p1 and \"tier\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "0", "p1": "A_surface", "p2": "Tier 1.5"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&surface_class=A_surface&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 329, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=A_surface&tier=Tier+1.5&has_structure=0", "selected": false}, {"value": 1, "label": 1, "count": 126, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=A_surface&tier=Tier+1.5&has_structure=1", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&surface_class=A_surface&tier=Tier+1.5", "results": [{"value": "Tier 1.5", "label": "Tier 1.5", "count": 455, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=A_surface", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&surface_class=A_surface&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 454, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=A_surface&tier=Tier+1.5&has_activation_state_pdb_pair=0", "selected": false}, {"value": 1, "label": 1, "count": 1, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=A_surface&tier=Tier+1.5&has_activation_state_pdb_pair=1", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&surface_class=A_surface&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 385, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=A_surface&tier=Tier+1.5&has_known_aptamer=0", "selected": false}, {"value": 1, "label": 1, "count": 70, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=A_surface&tier=Tier+1.5&has_known_aptamer=1", "selected": false}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&surface_class=A_surface&tier=Tier+1.5", "results": [{"value": "A_surface", "label": "A_surface", "count": 455, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&tier=Tier+1.5", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&surface_class=A_surface&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 305, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=A_surface&tier=Tier+1.5&in_cev_map=0", "selected": false}, {"value": 1, "label": 1, "count": 150, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=A_surface&tier=Tier+1.5&in_cev_map=1", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&surface_class=A_surface&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 455, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&tier=Tier+1.5", "selected": true}], "truncated": false}}, "suggested_facets": [{"name": "pdb_count_total", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=A_surface&tier=Tier+1.5&_facet=pdb_count_total"}, {"name": "aptamer_count_pubmed", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=A_surface&tier=Tier+1.5&_facet=aptamer_count_pubmed"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=A_surface&tier=Tier+1.5&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 1068.2031488977373, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}