{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_cryoEM = 0, surface_class = \"B_cargo\" and tier = \"Tier 1\" sorted by evidence_priority descending", "rows": [["P06280", "GLA", "Alpha-galactosidase A", "Tier 1", 0.768, 1, "B_cargo", 31, 94.31, 0, 0, null, null, 1, 15, "41930712,41508958,41143454,38347795,38230795,37459647,37423441,37288783,36593537,36197710,35362383,31433757,31112933,29793133,17461758", 1, "Fabry disease", 0.8939694636235022], ["P01112", "HRAS", "GTPase HRas", "Tier 1", 0.765, 1, "B_cargo", 100, 91.94, 0, 1, "5P21", "4Q21", 0, 0, null, 1, "Costello syndrome", 0.8839339324666988], ["P51608", "MECP2", "Methyl-CpG-binding protein 2", "Tier 1", 0.765, 1, "B_cargo", 9, 56.59, 0, 0, null, null, 1, 4, "40894892,25934574", 1, "Rett syndrome", 0.8836154777062162], ["P15289", "ARSA", "Arylsulfatase A", "Tier 1", 0.763, 1, "B_cargo", 10, 96.12, 0, 0, null, null, 0, 0, null, 1, "metachromatic leukodystrophy", 0.8781786404283894], ["P10253", "GAA", "Lysosomal alpha-glucosidase", "Tier 1", 0.763, 1, "B_cargo", 19, 91.88, 0, 0, null, null, 1, 9, "41639270,38804293,36935137,36290911,33674421,34122904,31657561,28477231,8756406", 1, "Glycogen storage disease due to acid maltase deficiency", 0.8766674295528372], ["P01130", "LDLR", "Low-density lipoprotein receptor", "Tier 1", 0.763, 1, "B_cargo", 36, 75.44, 0, 0, null, null, 1, 18, "41707385,38796450,37351166,37175248,33177004,32415571,31841991,31493779,42031715,41599761,41276911,38996211,30269613,25855589", 1, "hypercholesterolemia, familial, 1", 0.8776305284554387], ["P04637", "TP53", "Cellular tumor antigen p53", "Tier 1", 0.763, 1, "B_cargo", 100, 75.06, 0, 0, null, null, 1, 13, "38811338,36591491,36364157,34375633,32370304,32161460,29737162,29610332,29323871,26413153,26406332,21324664,19734942", 1, "Li-Fraumeni syndrome", 0.876069213988417], ["Q06124", "PTPN11", "Tyrosine-protein phosphatase non-receptor type 11", "Tier 1", 0.762, 1, "B_cargo", 100, 85.94, 0, 0, null, null, 1, 1, "35821507", 1, "Noonan syndrome", 0.8741645623918622], ["P00441", "SOD1", "Superoxide dismutase [Cu-Zn]", "Tier 1", 0.761, 1, "B_cargo", 100, 97.94, 0, 0, null, null, 1, 7, "37671010,35052634,34208092,32592467,28771197,41325160", 1, "amyotrophic lateral sclerosis", 0.8701480663155676], ["O15305", "PMM2", "Phosphomannomutase 2", "Tier 1", 0.761, 1, "B_cargo", 7, 96.44, 0, 0, null, null, 0, 0, null, 1, "PMM2-congenital disorder of glycosylation", 0.8687293837006977], ["P04424", "ASL", "Argininosuccinate lyase", "Tier 1", 0.76, 1, "B_cargo", 2, 96.31, 0, 0, null, null, 1, 7, "41897330,36768220,35926421,35123334,32157125,31942851,25825978", 1, "argininosuccinic aciduria", 0.8658097399401212], ["P08559", "PDHA1", "Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial", "Tier 1", 0.758, 1, "B_cargo", 9, 94.5, 0, 0, null, null, 0, 0, null, 1, "pyruvate dehydrogenase E1-alpha deficiency", 0.8590861671403908], ["P07902", "GALT", "Galactose-1-phosphate uridylyltransferase", "Tier 1", 0.758, 1, "B_cargo", 2, 91.69, 0, 0, null, null, 1, 1, "25483705", 1, "classic galactosemia", 0.8596600028722636], ["P36507", "MAP2K2", "Dual specificity mitogen-activated protein kinase kinase 2", "Tier 1", 0.757, 1, "B_cargo", 3, 81.62, 0, 0, null, null, 0, 0, null, 1, "cardiofaciocutaneous syndrome", 0.8571797350022399], ["Q04656", "ATP7A", "Copper-transporting ATPase 1", "Tier 1", 0.757, 1, "B_cargo", 22, 73.38, 0, 0, null, null, 0, 0, null, 1, "Menkes disease", 0.8556218833987248], ["P00966", "ASS1", "Argininosuccinate synthase", "Tier 1", 0.756, 1, "B_cargo", 1, 95.5, 0, 0, null, null, 0, 0, null, 1, "citrullinemia type I", 0.8547319473775126], ["P30613", "PKLR", "Pyruvate kinase PKLR", "Tier 1", 0.756, 1, "B_cargo", 58, 90.69, 0, 0, null, null, 0, 0, null, 1, "pyruvate kinase deficiency of red cells", 0.8545857147634045], ["P46100", "ATRX", "Transcriptional regulator ATRX", "Tier 1", 0.755, 1, "B_cargo", 12, 51.81, 0, 0, null, null, 0, 0, null, 1, "alpha thalassemia-X-linked intellectual disability syndrome", 0.8486940552679562], ["P11217", "PYGM", "Glycogen phosphorylase, muscle form", "Tier 1", 0.754, 1, "B_cargo", 1, 94.31, 0, 0, null, null, 0, 0, null, 1, "glycogen storage disease V", 0.8482737151867437], ["P04181", "OAT", "Ornithine aminotransferase, mitochondrial", "Tier 1", 0.754, 1, "B_cargo", 25, 94.06, 0, 0, null, null, 1, 5, "36610257,36010442,35744448,31883987,30847660", 1, "Gyrate atrophy of choroid and retina", 0.8467230038335781], ["P42336", "PIK3CA", "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform", "Tier 1", 0.754, 1, "B_cargo", 100, 92.38, 0, 0, null, null, 1, 2, "40560578,36801760", 1, "megalencephaly-capillary malformation-polymicrogyria syndrome", 0.846936627407075], ["P16278", "GLB1", "Beta-galactosidase", "Tier 1", 0.754, 1, "B_cargo", 8, 90.12, 0, 0, null, null, 1, 31, "41235448,40569566,40411663,37893383,36795559,36194889,34635237,34597992,34282923,29089431,28115631,27873255,25826571,25549616,24581444,24581443,24404773,23274138,21908397,21676871,21115656,18682034,17526692,17391960,17317571,17299271,23495909,12166645,11513587,11075346,11024283", 1, "mucopolysaccharidosis type 4B", 0.847874266091269], ["P51570", "GALK1", "Galactokinase", "Tier 1", 0.753, 1, "B_cargo", 20, 97.19, 0, 0, null, null, 0, 0, null, 1, "galactokinase deficiency", 0.8442002323363244], ["P10619", "CTSA", "Lysosomal protective protein", "Tier 1", 0.753, 1, "B_cargo", 12, 94.5, 0, 0, null, null, 1, 3, "41325160,10660541,41226313", 1, "galactosialidosis", 0.8421773206603207], ["Q9Y223", "GNE", "Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase", "Tier 1", 0.753, 1, "B_cargo", 5, 93.12, 0, 0, null, null, 0, 0, null, 1, "GNE myopathy", 0.8438241196803116], ["P51649", "ALDH5A1", "Succinate-semialdehyde dehydrogenase, mitochondrial", "Tier 1", 0.753, 1, "B_cargo", 5, 91.88, 0, 0, null, null, 0, 0, null, 1, "succinic semialdehyde dehydrogenase deficiency", 0.8435061416819137], ["P12694", "BCKDHA", "2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial", "Tier 1", 0.753, 1, "B_cargo", 24, 91.56, 0, 0, null, null, 0, 0, null, 1, "maple syrup urine disease type 1A", 0.8431584865455812], ["P22830", "FECH", "Ferrochelatase, mitochondrial", "Tier 1", 0.753, 1, "B_cargo", 25, 86.56, 0, 0, null, null, 1, 2, "24561613,24481979", 1, "autosomal erythropoietic protoporphyria", 0.8424032706667833], ["Q8NBK3", "SUMF1", "Formylglycine-generating enzyme", "Tier 1", 0.753, 1, "B_cargo", 18, 83.56, 0, 0, null, null, 1, 1, "38467937", 1, "Multiple sulfatase deficiency", 0.8444446120971877], ["Q14376", "GALE", "UDP-glucose 4-epimerase", "Tier 1", 0.752, 1, "B_cargo", 11, 97.06, 0, 0, null, null, 1, 1, "37486460", 1, "galactose epimerase deficiency", 0.8407417123376392], ["P35270", "SPR", "Sepiapterin reductase", "Tier 1", 0.751, 1, "B_cargo", 14, 96.69, 0, 0, null, null, 1, 368, "42010751,41791433,41759131,41646885,41572478,41547223,41524709,41522607,41330132,41294718,41248478,41231675,41185944,41035145,40897008,40839967,40821668,40801924,40558441,40516427,40331775,40277558,40251423,40207094,40191889,40174668,40163419,40130277,40113339,39954411,39927773,39894103,39852074,39808989,39742443,39644990,39584594,39206405,38934238,38870828,38829419,38742926,38732912,38682836,38645339,38613992,38606503,38552466,38444705,38342787,32456943", 1, "dopa-responsive dystonia due to sepiapterin reductase deficiency", 0.8362323603565402], ["P43235", "CTSK", "Cathepsin K", "Tier 1", 0.751, 1, "B_cargo", 70, 94.88, 0, 0, null, null, 1, 3, "32603599,32693649,29263412", 1, "pycnodysostosis", 0.8370793964210973], ["P07954", "FH", "Fumarate hydratase, mitochondrial", "Tier 1", 0.751, 1, "B_cargo", 7, 92.69, 0, 0, null, null, 1, 4, "37351166,32190730,28211680,21396765", 1, "hereditary leiomyomatosis and renal cell cancer", 0.8372834886646517], ["P07686", "HEXB", "Beta-hexosaminidase subunit beta", "Tier 1", 0.751, 1, "B_cargo", 8, 92.81, 0, 0, null, null, 0, 0, null, 1, "Sandhoff disease", 0.8358490853539441], ["P53634", "CTSC", "Dipeptidyl peptidase 1", "Tier 1", 0.751, 1, "B_cargo", 18, 90.12, 0, 0, null, null, 1, 1, "37052638", 1, "Papillon-Lef\u00e8vre syndrome", 0.8373137649306006], ["Q9BX63", "BRIP1", "Fanconi anemia group J protein", "Tier 1", 0.751, 1, "B_cargo", 3, 63.88, 0, 0, null, null, 0, 0, null, 1, "Fanconi anemia complementation group J", 0.8380329286110476], ["Q8TB36", "GDAP1", "Ganglioside-induced differentiation-associated protein 1", "Tier 1", 0.75, 1, "B_cargo", 8, 87.31, 0, 0, null, null, 0, 0, null, 1, "Autosomal recessive Charcot-Marie-Tooth disease with hoarseness", 0.8335233921018209], ["P06132", "UROD", "Uroporphyrinogen decarboxylase", "Tier 1", 0.749, 1, "B_cargo", 19, 96.75, 0, 0, null, null, 0, 0, null, 1, "Familial porphyria cutanea tarda", 0.8298171209078576], ["P38117", "ETFB", "Electron transfer flavoprotein subunit beta", "Tier 1", 0.749, 1, "B_cargo", 4, 96.12, 0, 0, null, null, 1, 4, "40102450,37599631", 1, "multiple acyl-CoA dehydrogenase deficiency", 0.8299661865891321], ["P51659", "HSD17B4", "Peroxisomal multifunctional enzyme type 2", "Tier 1", 0.749, 1, "B_cargo", 7, 89.0, 0, 0, null, null, 0, 0, null, 1, "d-bifunctional protein deficiency", 0.830341815259975], ["Q9UBK8", "MTRR", "Methionine synthase reductase", "Tier 1", 0.749, 1, "B_cargo", 2, 85.31, 0, 0, null, null, 0, 0, null, 1, "methylcobalamin deficiency type cblE", 0.8288259674381309], ["Q9Y6K9", "IKBKG", "NF-kappa-B essential modulator", "Tier 1", 0.749, 1, "B_cargo", 17, 82.0, 0, 0, null, null, 1, 2, "27802394,16891465", 1, "incontinentia pigmenti", 0.8297700299216089], ["O14936", "CASK", "Peripheral plasma membrane protein CASK", "Tier 1", 0.749, 1, "B_cargo", 22, 78.94, 0, 0, null, null, 0, 0, null, 1, "X-linked intellectual disability, Najm type", 0.8302355593197244], ["P20936", "RASA1", "Ras GTPase-activating protein 1", "Tier 1", 0.749, 1, "B_cargo", 15, 75.44, 0, 0, null, null, 1, 1, "25778421", 1, "capillary malformation-arteriovenous malformation 1", 0.8306926057172873], ["P04075", "ALDOA", "Fructose-bisphosphate aldolase A", "Tier 1", 0.748, 1, "B_cargo", 8, 96.44, 0, 0, null, null, 0, 0, null, 1, "glycogen storage disease due to aldolase A deficiency", 0.826807229393595], ["P01116", "KRAS", "GTPase KRas", "Tier 1", 0.748, 1, "B_cargo", 100, 91.5, 0, 1, "6GOD", "6MNX", 1, 21, "41132421,40824107,40766128,40148451,39215101,38784467,38784452,38604287,37637206,36229679,35473857,34097885,32871244,32370304,32010971,31583159,28639199,28514850,27936442,20565241,17461759", 1, "Noonan syndrome 3", 0.8263697027313498], ["P32322", "PYCR1", "Pyrroline-5-carboxylate reductase 1, mitochondrial", "Tier 1", 0.748, 1, "B_cargo", 47, 89.81, 0, 0, null, null, 0, 0, null, 1, "autosomal recessive cutis laxa type 2B", 0.826514119676127], ["P00558", "PGK1", "Phosphoglycerate kinase 1", "Tier 1", 0.747, 1, "B_cargo", 30, 96.38, 0, 0, null, null, 0, 0, null, 1, "glycogen storage disease due to phosphoglycerate kinase 1 deficiency", 0.8228898260165487], ["P27986", "PIK3R1", "Phosphatidylinositol 3-kinase regulatory subunit alpha", "Tier 1", 0.747, 1, "B_cargo", 100, 83.19, 0, 0, null, null, 1, 1, "40560578", 1, "SHORT syndrome", 0.8239278567344643], ["P00519", "ABL1", "Tyrosine-protein kinase ABL1", "Tier 1", 0.747, 1, "B_cargo", 85, 63.38, 0, 1, "2GQG", "1OPL", 1, 5, "31295447,23836560,22411871,21810089,21653319", 1, "chronic myelogenous leukemia", 0.8219762968845584]], "truncated": false, "filtered_table_rows_count": 1404, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_cryoEM\" = :p0 and \"surface_class\" = :p1 and \"tier\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "0", "p1": "B_cargo", "p2": "Tier 1"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&surface_class=B_cargo&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 1059, "toggle_url": 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"https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=B_cargo&tier=Tier+1&has_activation_state_pdb_pair=0", "selected": false}, {"value": 1, "label": 1, "count": 5, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=B_cargo&tier=Tier+1&has_activation_state_pdb_pair=1", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&surface_class=B_cargo&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 1035, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=B_cargo&tier=Tier+1&has_known_aptamer=0", "selected": false}, {"value": 1, "label": 1, "count": 369, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=B_cargo&tier=Tier+1&has_known_aptamer=1", "selected": false}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&surface_class=B_cargo&tier=Tier+1", "results": [{"value": "B_cargo", "label": "B_cargo", "count": 1404, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&tier=Tier+1", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&surface_class=B_cargo&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 831, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=B_cargo&tier=Tier+1&in_cev_map=1", "selected": false}, {"value": 0, "label": 0, "count": 573, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=B_cargo&tier=Tier+1&in_cev_map=0", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&surface_class=B_cargo&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 1404, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=B_cargo&tier=Tier+1", "selected": true}], "truncated": false}}, "suggested_facets": [], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=B_cargo&tier=Tier+1&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 1620.3210139647126, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}