{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_cryoEM = 0, surface_class = \"B_cargo\" and tier = \"Tier 1.5\" sorted by evidence_priority descending", "rows": [["P14136", "GFAP", "Glial fibrillary acidic protein", "Tier 1.5", 0.761, 1, "B_cargo", 1, 80.0, 0, 0, null, null, 1, 4, "42022738,40983220,27924617,27399849", 1, "Alexander disease", 0.8713727112153956], ["P15848", "ARSB", "Arylsulfatase B", "Tier 1.5", 0.761, 1, "B_cargo", 1, 93.12, 0, 0, null, null, 0, 0, null, 1, "mucopolysaccharidosis type 6", 0.8708405439406184], ["P54802", "NAGLU", "Alpha-N-acetylglucosaminidase", "Tier 1.5", 0.761, 1, "B_cargo", 1, 96.75, 0, 0, null, null, 0, 0, null, 1, "mucopolysaccharidosis type 3B", 0.8688752515463204], ["P00480", "OTC", "Ornithine transcarbamylase, mitochondrial", "Tier 1.5", 0.76, 1, "B_cargo", 4, 92.19, 0, 0, null, null, 1, 71, "42031033,41819402,41207276,41033028,40970979,40801924,40719766,40644866,40602786,40187287,40064103,40015047,39904249,39644528,39571486,39275399,39030014,38504447,38193253,37459789,37364386,37103619,36891736,36618689,36454704,36403375,35884270,35672499,35006795,34973550,34821674,34684942,34152736,33812186,33035887,32862845,32768827,32674777,31673790,31580049,31325751,31016392,30837641,30778448,30594079,30426224,30202432,30128033,29937498,28578167", 1, "ornithine carbamoyltransferase deficiency", 0.8675763935672858], ["P49748", "ACADVL", "Very long-chain acyl-CoA dehydrogenase, mitochondrial", "Tier 1.5", 0.76, 1, "B_cargo", 3, 90.25, 0, 0, null, null, 0, 0, null, 1, "very long chain acyl-CoA dehydrogenase deficiency", 0.8655785842544526], ["P11532", "DMD", "Dystrophin", "Tier 1.5", 0.76, 1, "B_cargo", 6, 76.38, 0, 0, null, null, 1, 32, "41983899,41503480,41083485,40396427,39910928,39469668,38050701,37765072,37261868,34876524,34693888,34440571,34075115,33617542,32592467,28315675,28252048,27530235,27173731,26594036,26163061,26039989,21838691,20962041,17011811,38448545", 1, "Duchenne muscular dystrophy", 0.865885140119287], ["Q01968", "OCRL", "Inositol polyphosphate 5-phosphatase OCRL", "Tier 1.5", 0.759, 1, "B_cargo", 5, 82.56, 0, 0, null, null, 0, 0, null, 1, "oculocerebrorenal syndrome", 0.8639646099557533], ["P30566", "ADSL", "Adenylosuccinate lyase", "Tier 1.5", 0.756, 1, "B_cargo", 4, 96.56, 0, 0, null, null, 0, 0, null, 1, "adenylosuccinate lyase deficiency", 0.8537075354730899], ["P35914", "HMGCL", "Hydroxymethylglutaryl-CoA lyase, mitochondrial", "Tier 1.5", 0.755, 1, "B_cargo", 4, 92.0, 0, 0, null, null, 0, 0, null, 1, "3-hydroxy-3-methylglutaric aciduria", 0.84972741897364], ["P51648", "ALDH3A2", "Aldehyde dehydrogenase family 3 member A2", "Tier 1.5", 0.755, 1, "B_cargo", 1, 96.62, 0, 0, null, null, 0, 0, null, 1, "Sj\u00f6gren-Larsson syndrome", 0.8498976178886021], ["P35475", "IDUA", "Alpha-L-iduronidase", "Tier 1.5", 0.755, 1, "B_cargo", 11, 94.75, 0, 0, null, null, 1, 1, "18838694", 1, "Scheie syndrome", 0.8500187612858606], ["P50336", "PPOX", "Protoporphyrinogen oxidase", "Tier 1.5", 0.755, 1, "B_cargo", 3, 95.31, 0, 0, null, null, 0, 0, null, 1, "variegate porphyria", 0.8511493920751063], ["P48637", "GSS", "Glutathione synthetase", "Tier 1.5", 0.754, 1, "B_cargo", 2, 94.94, 0, 0, null, null, 1, 1, "24296062", 1, "Glutathione synthetase deficiency", 0.8480115629745476], ["P36871", "PGM1", "Phosphoglucomutase-1", "Tier 1.5", 0.753, 1, "B_cargo", 16, 97.12, 0, 0, null, null, 0, 0, null, 1, "PGM1-congenital disorder of glycosylation", 0.843931261346685], ["O95571", "ETHE1", "Persulfide dioxygenase ETHE1, mitochondrial", "Tier 1.5", 0.752, 1, "B_cargo", 1, 92.88, 0, 0, null, null, 0, 0, null, 1, "ethylmalonic encephalopathy", 0.8389957647020829], ["P50897", "PPT1", "Palmitoyl-protein thioesterase 1", "Tier 1.5", 0.752, 1, "B_cargo", 1, 91.69, 0, 0, null, null, 1, 2, "33112630", 1, "neuronal ceroid lipofuscinosis 1", 0.8400332147230634], ["P50416", "CPT1A", "Carnitine O-palmitoyltransferase 1, liver isoform", "Tier 1.5", 0.751, 1, "B_cargo", 1, 92.44, 0, 0, null, null, 1, 1, "29325019", 1, "carnitine palmitoyl transferase 1A deficiency", 0.8360102017303558], ["P54886", "ALDH18A1", "Delta-1-pyrroline-5-carboxylate synthase", "Tier 1.5", 0.75, 1, "B_cargo", 1, 84.19, 0, 0, null, null, 0, 0, null, 1, "ALDH18A1-related de Barsy syndrome", 0.8337004817329543], ["P48728", "AMT", "Aminomethyltransferase, mitochondrial", "Tier 1.5", 0.749, 1, "B_cargo", 2, 93.69, 0, 0, null, null, 1, 6, "41360349,38751431,36935143,32969502,32779681,32062632", 1, "glycine encephalopathy", 0.8307194416875259], ["Q9H0F7", "ARL6", "ADP-ribosylation factor-like protein 6", "Tier 1.5", 0.749, 1, "B_cargo", 1, 94.69, 0, 0, null, null, 0, 0, null, 1, "Bardet-Biedl syndrome", 0.831055560105815], ["P02538", "KRT6A", "Keratin, type II cytoskeletal 6A", "Tier 1.5", 0.748, 1, "B_cargo", 1, 66.31, 0, 0, null, null, 0, 0, null, 1, "pachyonychia congenita", 0.8265917804295808], ["P55809", "OXCT1", "Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial", "Tier 1.5", 0.748, 1, "B_cargo", 1, 91.94, 0, 0, null, null, 0, 0, null, 1, "succinyl-CoA:3-ketoacid CoA transferase deficiency", 0.8271377770408165], ["Q8IWV7", "UBR1", "E3 ubiquitin-protein ligase UBR1", "Tier 1.5", 0.748, 1, "B_cargo", 5, 84.69, 0, 0, null, null, 0, 0, null, 1, "Johanson-Blizzard syndrome", 0.8277473176517505], ["P12955", "PEPD", "Xaa-Pro dipeptidase", "Tier 1.5", 0.747, 1, "B_cargo", 21, 97.44, 0, 0, null, null, 0, 0, null, 1, "prolidase deficiency", 0.8227965856258603], ["Q15833", "STXBP2", "Syntaxin-binding protein 2", "Tier 1.5", 0.747, 1, "B_cargo", 1, 90.0, 0, 0, null, null, 0, 0, null, 1, "Familial hemophagocytic lymphohistiocytosis", 0.8239664182555839], ["Q14739", "LBR", "Delta(14)-sterol reductase LBR", "Tier 1.5", 0.746, 1, "B_cargo", 1, 76.62, 0, 0, null, null, 0, 0, null, 1, "Greenberg dysplasia", 0.8198252534620432], ["P08237", "PFKM", "ATP-dependent 6-phosphofructokinase, muscle type", "Tier 1.5", 0.746, 1, "B_cargo", 1, 91.69, 0, 0, null, null, 0, 0, null, 1, "glycogen storage disease VII", 0.8199812991737021], ["P38571", "LIPA", "Lysosomal acid lipase/cholesteryl ester hydrolase", "Tier 1.5", 0.745, 1, "B_cargo", 1, 91.56, 0, 0, null, null, 0, 0, null, 1, "cholesteryl ester storage disease", 0.8176913717992665], ["Q14938", "NFIX", "Nuclear factor 1 X-type", "Tier 1.5", 0.745, 1, "B_cargo", 3, 61.62, 0, 0, null, null, 0, 0, null, 1, "Malan overgrowth syndrome", 0.8156080181042044], ["P02549", "SPTA1", "Spectrin alpha chain, erythrocytic 1", "Tier 1.5", 0.745, 1, "B_cargo", 3, 76.38, 0, 0, null, null, 0, 0, null, 1, "elliptocytosis 2", 0.8153311905916062], ["P04080", "CSTB", "Cystatin-B", "Tier 1.5", 0.744, 1, "B_cargo", 3, 95.56, 0, 0, null, null, 0, 0, null, 1, "Unverricht-Lundborg disease", 0.8143874694671263], ["Q15738", "NSDHL", "Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating", "Tier 1.5", 0.744, 1, "B_cargo", 2, 88.62, 0, 0, null, null, 0, 0, null, 1, "CHILD syndrome", 0.81209434191833], ["O95822", "MLYCD", "Malonyl-CoA decarboxylase, mitochondrial", "Tier 1.5", 0.744, 1, "B_cargo", 2, 89.94, 0, 0, null, null, 0, 0, null, 1, "malonic aciduria", 0.8148554714603661], ["Q01433", "AMPD2", "AMP deaminase 2", "Tier 1.5", 0.744, 1, "B_cargo", 4, 80.69, 0, 0, null, null, 0, 0, null, 1, "pontocerebellar hypoplasia type 9", 0.8149450703818453], ["Q9UGM6", "WARS2", "Tryptophan--tRNA ligase, mitochondrial", "Tier 1.5", 0.743, 1, "B_cargo", 1, 89.75, 0, 0, null, null, 0, 0, null, 1, "neurodevelopmental disorder, mitochondrial, with abnormal movements and lactic acidosis, with or without seizures", 0.8094386747017313], ["P02533", "KRT14", "Keratin, type I cytoskeletal 14", "Tier 1.5", 0.743, 1, "B_cargo", 2, 73.25, 0, 0, null, null, 0, 0, null, 1, "epidermolysis bullosa simplex 1A, generalized severe", 0.8088593947918921], ["Q16836", "HADH", "Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial", "Tier 1.5", 0.742, 1, "B_cargo", 12, 96.81, 0, 0, null, null, 0, 0, null, 1, "Hyperinsulinism due to short chain 3-hydroxylacyl-CoA dehydrogenase deficiency", 0.8054501080547742], ["Q9UJS0", "SLC25A13", "Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial", "Tier 1.5", 0.742, 1, "B_cargo", 1, 82.31, 0, 0, null, null, 0, 0, null, 1, "neonatal intrahepatic cholestasis due to citrin deficiency", 0.8051027586554986], ["O95202", "LETM1", "Mitochondrial proton/calcium exchanger protein", "Tier 1.5", 0.742, 1, "B_cargo", 2, 66.56, 0, 0, null, null, 0, 0, null, 1, "neurodegeneration, childhood-onset, with multisystem involvement due to mitochondrial dysfunction", 0.8053871863850453], ["P09936", "UCHL1", "Ubiquitin carboxyl-terminal hydrolase isozyme L1", "Tier 1.5", 0.741, 1, "B_cargo", 14, 93.62, 0, 0, null, null, 1, 2, "30863411", 1, "early-onset progressive neurodegeneration-blindness-ataxia-spasticity syndrome", 0.8048623975346616], ["P51610", "HCFC1", "Host cell factor 1", "Tier 1.5", 0.741, 1, "B_cargo", 11, 46.41, 0, 0, null, null, 0, 0, null, 1, "methylmalonic acidemia with homocystinuria, type cblX", 0.8025576540875302], ["Q16854", "DGUOK", "Deoxyguanosine kinase, mitochondrial", "Tier 1.5", 0.741, 1, "B_cargo", 1, 86.06, 0, 0, null, null, 0, 0, null, 1, "mitochondrial DNA depletion syndrome 3 (hepatocerebral type)", 0.8027927477832228], ["Q6NUK1", "SLC25A24", "Mitochondrial adenyl nucleotide antiporter SLC25A24", "Tier 1.5", 0.74, 1, "B_cargo", 3, 81.31, 0, 0, null, null, 1, 1, "41871245", 1, "Fontaine progeroid syndrome", 0.7984507086824493], ["Q9BT40", "INPP5K", "Inositol polyphosphate 5-phosphatase K", "Tier 1.5", 0.738, 1, "B_cargo", 1, 88.38, 0, 0, null, null, 0, 0, null, 1, "muscular dystrophy, congenital, with cataracts and intellectual disability", 0.7921804970122728], ["O15357", "INPPL1", "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2", "Tier 1.5", 0.738, 1, "B_cargo", 11, 69.25, 0, 0, null, null, 0, 0, null, 1, "opsismodysplasia", 0.7942030158613098], ["P98175", "RBM10", "RNA-binding protein 10", "Tier 1.5", 0.738, 1, "B_cargo", 6, 59.97, 0, 0, null, null, 0, 0, null, 1, "TARP syndrome", 0.7926540744990629], ["Q5JTZ9", "AARS2", "Alanine--tRNA ligase, mitochondrial", "Tier 1.5", 0.737, 1, "B_cargo", 3, 87.88, 0, 0, null, null, 0, 0, null, 1, "combined oxidative phosphorylation defect type 8", 0.790456486417183], ["P07384", "CAPN1", "Calpain-1 catalytic subunit", "Tier 1.5", 0.735, 1, "B_cargo", 5, 89.94, 0, 0, null, null, 0, 0, null, 1, "Autosomal recessive spastic paraplegia type 76", 0.7826099721448625], ["Q13586", "STIM1", "Stromal interaction molecule 1", "Tier 1.5", 0.735, 1, "B_cargo", 6, 67.81, 0, 0, null, null, 0, 0, null, 1, "myopathy, tubular aggregate, 1", 0.7836768834970178], ["Q8TDI0", "CHD5", "ATP-dependent chromatin remodeler CHD5", "Tier 1.5", 0.735, 1, "B_cargo", 1, 62.0, 0, 0, null, null, 0, 0, null, 1, "parenti-mignot neurodevelopmental syndrome", 0.7837472852063317]], "truncated": false, "filtered_table_rows_count": 1812, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_cryoEM\" = :p0 and \"surface_class\" = :p1 and \"tier\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "0", "p1": "B_cargo", "p2": "Tier 1.5"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&surface_class=B_cargo&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 1151, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=B_cargo&tier=Tier+1.5&has_structure=0", "selected": false}, {"value": 1, "label": 1, "count": 661, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=B_cargo&tier=Tier+1.5&has_structure=1", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&surface_class=B_cargo&tier=Tier+1.5", "results": [{"value": "Tier 1.5", "label": "Tier 1.5", "count": 1812, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=B_cargo", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&surface_class=B_cargo&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 1812, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=B_cargo&tier=Tier+1.5&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&surface_class=B_cargo&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 1593, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=B_cargo&tier=Tier+1.5&has_known_aptamer=0", "selected": false}, {"value": 1, "label": 1, "count": 219, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=B_cargo&tier=Tier+1.5&has_known_aptamer=1", "selected": false}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&surface_class=B_cargo&tier=Tier+1.5", "results": [{"value": "B_cargo", "label": "B_cargo", "count": 1812, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&tier=Tier+1.5", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&surface_class=B_cargo&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 1076, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=B_cargo&tier=Tier+1.5&in_cev_map=0", "selected": false}, {"value": 1, "label": 1, "count": 736, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=B_cargo&tier=Tier+1.5&in_cev_map=1", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=0&surface_class=B_cargo&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 1812, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=B_cargo&tier=Tier+1.5", "selected": true}], "truncated": false}}, "suggested_facets": [{"name": "pdb_count_total", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=B_cargo&tier=Tier+1.5&_facet=pdb_count_total"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=0&surface_class=B_cargo&tier=Tier+1.5&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 1318.8121658749878, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}