{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_cryoEM = 1, has_known_aptamer = 0 and in_cev_map = 0 sorted by priority_score descending", "rows": [["P12263", null, null, "Tier 1", 0.9, 7, 63.59, 1, 0, null, null, null, 0, 0, null, 0, null, null], ["Q12879", "GRIN2A", "Glutamate receptor ionotropic, NMDA 2A", "Tier 1", 0.88, 37, 60.84, 1, 0, null, null, null, 0, 0, null, 0, "Landau-Kleffner syndrome", 0.8407159711916629], ["P35346", "SSTR5", "Somatostatin receptor type 5", "Tier 1.5", 0.841, 7, 81.25, 1, 0, null, null, null, 0, 0, null, 0, "acromegaly", 0.6094707180356006], ["Q5T848", "GPR158", "Metabotropic glycine receptor", "Tier 1", 0.839, 6, 58.03, 1, 0, null, null, null, 0, 0, null, 0, "diverticular disease", 0.4384404783771627], ["P21439", "ABCB4", "Phosphatidylcholine translocator ABCB4", "Tier 1.5", 0.835, 4, 83.25, 1, 0, null, null, null, 0, 0, null, 0, "progressive familial intrahepatic cholestasis type 3", 0.851728159166962], ["P0DSE2", "TRB", "M1-specific T cell receptor beta chain", "Tier 1", 0.83, 5, 90.12, 1, 0, null, null, null, 0, 0, null, 0, null, null], ["O75899", "GABBR2", "Gamma-aminobutyric acid type B receptor subunit 2", "Tier 1.5", 0.824, 26, 77.75, 1, 0, null, null, null, 0, 0, null, 0, "developmental and epileptic encephalopathy, 59", 0.7356789732167734], ["Q9NS82", "SLC7A10", "Asc-type amino acid transporter 1", "Tier 1", 0.803, 4, 83.38, 1, 0, null, null, null, 0, 0, null, 0, "asthma", 0.5295411410172121], ["O60895", "RAMP2", "Receptor activity-modifying protein 2", "Tier 1", 0.802, 10, 80.94, 1, 0, null, null, null, 0, 0, null, 0, "diabetes mellitus", 0.4219370007650345], ["Q04844", "CHRNE", "Acetylcholine receptor subunit epsilon", "Tier 1.5", 0.802, 13, 80.69, 1, 0, null, null, null, 0, 0, null, 0, "Congenital myasthenic syndromes", 0.8223287249629152], ["P29275", "ADORA2B", "Adenosine receptor A2b", "Tier 1.5", 0.801, 4, 88.12, 1, 0, null, null, null, 0, 0, null, 0, "migraine disorder", 0.6060142180667235], ["Q9H2X9", "SLC12A5", "Solute carrier family 12 member 5", "Tier 1.5", 0.8, 2, 78.44, 1, 0, null, null, null, 0, 0, null, 0, "genetic developmental and epileptic encephalopathy", 0.6993945840545625], ["P01909", "HLA-DQA1", "HLA class II histocompatibility antigen, DQ alpha 1 chain", "Tier 1", 0.792, 27, 87.94, 1, 0, null, null, null, 0, 0, null, 0, "Pleural Mesothelioma", 0.1228600330569846], ["Q13705", "ACVR2B", "Activin receptor type-2B", "Tier 1.5", 0.791, 9, 83.31, 1, 0, null, null, null, 0, 0, null, 0, "Heterotaxia", 0.7109733260300651], ["Q96CS2", "HAUS1", "HAUS augmin-like complex subunit 1", "Tier 1.5", 0.79, 1, 88.62, 1, 0, null, null, null, 0, 0, null, 0, "device complication", 0.27547205131467467], ["Q5JUK3", "KCNT1", "Potassium channel subfamily T member 1", "Tier 1.5", 0.782, 6, 73.88, 1, 0, null, null, null, 0, 0, null, 0, "developmental and epileptic encephalopathy, 14", 0.8165232785825526], ["Q13639", null, null, "Tier 1", 0.781, 3, 80.88, 1, 0, null, null, null, 0, 0, null, 0, "schizophrenia", 0.6060830827022777], ["P13866", "SLC5A1", "Sodium/glucose cotransporter 1", "Tier 1.5", 0.777, 4, 84.38, 1, 0, null, null, null, 0, 0, null, 0, "glucose-galactose malabsorption", 0.8220991027793896], ["P30542", "ADORA1", "Adenosine receptor A1", "Tier 1.5", 0.777, 5, 92.44, 1, 0, null, null, null, 0, 0, null, 0, "asthma", 0.7232344154541454], ["O15393", null, null, "Tier 1", 0.775, 31, 79.38, 1, 0, null, null, null, 0, 0, null, 0, "COVID-19", 0.6157541390484623], ["P29460", "IL12B", "Interleukin-12 subunit beta", "Tier 1", 0.769, 20, 91.12, 1, 0, null, null, null, 0, 0, null, 0, "psoriasis", 0.7914863943708039], ["P43004", "SLC1A2", "Excitatory amino acid transporter 2", "Tier 1.5", 0.768, 7, 77.75, 1, 0, null, null, null, 0, 0, null, 0, "developmental and epileptic encephalopathy, 41", 0.7772658651722512], ["O60931", "CTNS", "Cystinosin", "Tier 1.5", 0.764, 6, 89.44, 1, 0, null, null, null, 0, 0, null, 0, "nephropathic cystinosis", 0.841818398377195], ["P98073", null, null, "Tier 1", 0.761, 14, 81.5, 1, 0, null, null, null, 0, 0, null, 0, "congenital enteropathy due to enteropeptidase deficiency", 0.7102613227574134], ["Q9Y5Y9", "SCN10A", "Sodium channel protein type 10 subunit alpha", "Tier 1.5", 0.761, 8, 67.31, 1, 0, null, null, null, 0, 0, null, 0, "atrial fibrillation", 0.7126293968222049], ["O75762", "TRPA1", "Transient receptor potential cation channel subfamily A member 1", "Tier 1", 0.76, 17, 81.94, 1, 0, null, null, null, 0, 0, null, 0, "familial episodic pain syndrome with predominantly upper body involvement", 0.6615353934604322], ["O15552", "FFAR2", "Free fatty acid receptor 2", "Tier 1.5", 0.759, 11, 88.06, 1, 0, null, null, null, 0, 0, null, 0, "type 1 diabetes mellitus", 0.09182737097469269], ["P35462", "DRD3", "D(3) dopamine receptor", "Tier 1.5", 0.757, 6, 75.38, 1, 0, null, null, null, 0, 0, null, 0, "schizophrenia", 0.6687268941647396], ["O00591", "GABRP", "Gamma-aminobutyric acid receptor subunit pi", "Tier 1.5", 0.752, 2, 79.12, 1, 0, null, null, null, 0, 0, null, 0, "migraine disorder", 0.6191855696357259], ["P0DMS8", "ADORA3", "Adenosine receptor A3", "Tier 1.5", 0.751, 5, 91.31, 1, 0, null, null, null, 0, 0, null, 0, "migraine disorder", 0.6052134617149065], ["O43614", null, null, "Tier 1", 0.75, 11, 78.94, 1, 0, null, null, null, 0, 0, null, 0, "insomnia", 0.5988748728311054], ["P46089", "GPR3", "G-protein coupled receptor 3", "Tier 1.5", 0.748, 8, 81.81, 1, 0, null, null, null, 0, 0, null, 0, "hypertension", 0.18488148594282316], ["O15245", "SLC22A1", "Solute carrier family 22 member 1", "Tier 1", 0.744, 16, 84.25, 1, 0, null, null, null, 0, 0, null, 0, "coronary artery disease", 0.5384890077265535], ["Q8N158", "GPC2", "Glypican-2", "Tier 1", 0.744, 2, 79.06, 1, 0, null, null, null, 0, 0, null, 0, "COVID-19", 0.5409211817593593], ["O43526", "KCNQ2", "Potassium voltage-gated channel subfamily KQT member 2", "Tier 1", 0.744, 24, 58.19, 1, 0, null, null, null, 0, 0, null, 0, "Benign familial neonatal seizures", 0.8423358217314708], ["P40879", "SLC26A3", "Chloride anion exchanger", "Tier 1", 0.742, 13, 85.06, 1, 0, null, null, null, 0, 0, null, 0, "congenital secretory chloride diarrhea 1", 0.8189631913308207], ["D7RIG0", "HLA-DRB1", null, "Tier 1", 0.74, 10, 84.94, 1, 0, null, null, null, 0, 0, null, 0, null, null], ["Q86YT5", "SLC13A5", "Na(+)/citrate cotransporter", "Tier 1.5", 0.739, 4, 86.06, 1, 0, null, null, null, 0, 0, null, 0, "genetic developmental and epileptic encephalopathy", 0.6853612674939716], ["A0A1B0GX56", "TRDV1", "T cell receptor delta variable 1", "Tier 1", 0.737, 7, 90.69, 1, 0, null, null, null, 0, 0, null, 0, "colorectal carcinoma", 0.07391597093694036], ["Q14028", "CNGB1", "Cyclic nucleotide-gated channel beta-1", "Tier 1", 0.734, 11, 57.66, 1, 0, null, null, null, 0, 0, null, 0, "retinitis pigmentosa", 0.7931901344765326], ["P41145", "OPRK1", "Kappa-type opioid receptor", "Tier 1", 0.725, 28, 79.5, 1, 0, null, null, null, 0, 0, null, 0, "alcohol dependence", 0.6106562988740131], ["Q9H741", "SPRING1", "SREBP regulating gene protein", "Tier 1.5", 0.725, 2, 81.31, 1, 0, null, null, null, 0, 0, null, 0, "Anxiety", 0.35244791107935663], ["P48764", "SLC9A3", "Sodium/hydrogen exchanger 3", "Tier 1.5", 0.725, 1, 65.94, 1, 0, null, null, null, 0, 0, null, 0, "congenital sodium diarrhea", 0.6503153836708786], ["P23416", "GLRA2", "Glycine receptor subunit alpha-2", "Tier 1", 0.723, 13, 83.81, 1, 0, null, null, null, 0, 0, null, 0, "intellectual developmental disorder, X-linked, syndromic, Pilorge type", 0.7805605973560554], ["P41968", "MC3R", "Melanocortin receptor 3", "Tier 1.5", 0.723, 6, 83.88, 1, 0, null, null, null, 0, 0, null, 0, "alcohol drinking", 0.3298167673588826], ["P29033", "GJB2", "Gap junction beta-2 protein", "Tier 1", 0.72, 24, 86.19, 1, 0, null, null, null, 0, 0, null, 0, "palmoplantar keratoderma-deafness syndrome", 0.8149616697051898], ["B7Z8K6", "TRDC", "T cell receptor delta constant", "Tier 1", 0.72, 12, 81.38, 1, 0, null, null, null, 0, 0, null, 0, null, null], ["Q9NZD1", "GPRC5D", "G-protein coupled receptor family C group 5 member D", "Tier 1.5", 0.716, 2, 76.06, 1, 0, null, null, null, 0, 0, null, 0, "multiple myeloma", 0.5555243624684951], ["A0A0B4J271", "TRAV12-3", "T cell receptor alpha variable 12-3", "Tier 1", 0.715, 12, 92.56, 1, 0, null, null, null, 0, 0, null, 0, "ulcerative colitis", 0.003139210371371825], ["Q695T7", "SLC6A19", "Sodium-dependent neutral amino acid transporter B(0)AT1", "Tier 1", 0.715, 19, 90.0, 1, 0, null, null, null, 0, 0, null, 0, "Hartnup disease", 0.8464240093600148]], "truncated": false, "filtered_table_rows_count": 619, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "priority_score", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "drug_count_approved", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, priority_score, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, drug_count_approved, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_cryoEM\" = :p0 and \"has_known_aptamer\" = :p1 and \"in_cev_map\" = :p2 order by priority_score desc limit 51", "params": {"p0": "1", "p1": "0", "p2": "0"}}, "facet_results": {"tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&in_cev_map=0", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 397, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&in_cev_map=0&tier=Tier+1", "selected": false}, {"value": "Tier 1.5", "label": "Tier 1.5", "count": 222, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&in_cev_map=0&tier=Tier+1.5", "selected": false}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&in_cev_map=0", "results": [{"value": 0, "label": 0, "count": 619, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&in_cev_map=0&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&in_cev_map=0", "results": [{"value": 0, "label": 0, "count": 619, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&in_cev_map=0", "results": [{"value": 0, "label": 0, "count": 619, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&in_cev_map=0", "results": [{"value": 1, "label": 1, "count": 619, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=0", "selected": true}], "truncated": false}}, "suggested_facets": [], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&in_cev_map=0&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 643.3846639993135, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}