{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_cryoEM = 1, has_known_aptamer = 0 and surface_class = \"A_assoc\" sorted by evidence_priority descending", "rows": [["P12883", "MYH7", "Myosin-7", "Tier 1", 0.871, 1, "A_assoc", 43, 74.25, 1, 0, null, null, 0, 0, null, 1, "hypertrophic cardiomyopathy", 0.9029865147265421], ["P04180", "LCAT", "Phosphatidylcholine-sterol acyltransferase", "Tier 1.5", 0.848, 1, "A_assoc", 7, 86.75, 1, 0, null, null, 0, 0, null, 1, "Fish-eye disease", 0.8273460309828392], ["Q15582", "TGFBI", "Transforming growth factor-beta-induced protein ig-h3", "Tier 1.5", 0.847, 1, "A_assoc", 10, 90.25, 1, 0, null, null, 0, 0, null, 1, "lattice corneal dystrophy type I", 0.8242841141270143], ["P07942", "LAMB1", "Laminin subunit beta-1", "Tier 1.5", 0.84, 1, "A_assoc", 3, 76.69, 1, 0, null, null, 0, 0, null, 1, "cobblestone lissencephaly without muscular or ocular involvement", 0.8016665947624902], ["P00488", "F13A1", "Coagulation factor XIII A chain", "Tier 1", 0.838, 1, "A_assoc", 15, 90.88, 1, 0, null, null, 0, 0, null, 1, "Factor XIII subunit A deficiency", 0.7939842013132387], ["P35858", "IGFALS", "Insulin-like growth factor-binding protein complex acid labile subunit", "Tier 1.5", 0.833, 1, "A_assoc", 1, 90.56, 1, 0, null, null, 0, 0, null, 1, "Reduced insulin like growth factor binding protein acid labile subunit concentration", 0.7760522769257892], ["O15230", "LAMA5", "Laminin subunit alpha-5", "Tier 1.5", 0.828, 1, "A_assoc", 2, 79.12, 1, 0, null, null, 0, 0, null, 1, "nephrotic syndrome, IIa 26", 0.7594872666460903], ["O60568", "PLOD3", "Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3", "Tier 1.5", 0.815, 1, "A_assoc", 18, 91.38, 1, 0, null, null, 0, 0, null, 1, "bone fragility with contractures, arterial rupture, and deafness", 0.7159150369336311], ["P48200", "IREB2", "Iron-responsive element-binding protein 2", "Tier 1", 0.799, 1, "A_assoc", 1, 86.75, 1, 0, null, null, 0, 0, null, 1, "neurodegeneration, early-onset, with choreoathetoid movements and microcytic anemia", 0.664403876125082], ["P02745", "C1QA", "Complement C1q subcomponent subunit A", "Tier 1", 0.79, 1, "A_assoc", 11, 82.62, 1, 0, null, null, 0, 0, null, 1, "C1Q deficiency 1", 0.6319053256658114], ["P02747", "C1QC", "Complement C1q subcomponent subunit C", "Tier 1", 0.787, 1, "A_assoc", 11, 80.56, 1, 0, null, null, 0, 0, null, 1, "C1Q deficiency", 0.6233532074390745], ["A8K2U0", "A2ML1", "Alpha-2-macroglobulin-like protein 1", "Tier 1", 0.764, 1, "A_assoc", 5, 80.5, 1, 0, null, null, 0, 0, null, 1, "Otitis media", 0.5479914512784171], ["Q08043", "ACTN3", "Alpha-actinin-3", "Tier 1", 0.752, 1, "A_assoc", 3, 84.19, 1, 0, null, null, 0, 0, null, 1, "Abnormality of the skeletal system", 0.5080072819822437], ["P05161", "ISG15", "Ubiquitin-like protein ISG15", "Tier 1", 0.74, 1, "A_assoc", 22, 85.88, 1, 0, null, null, 0, 0, null, 1, "COVID-19", 0.4668295741563516], ["Q9BVC4", "MLST8", "Target of rapamycin complex subunit LST8", "Tier 1", 0.733, 1, "A_assoc", 45, 91.62, 1, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.4440338170862142], ["O95970", "LGI1", "Leucine-rich glioma-inactivated protein 1", "Tier 1.5", 0.697, 1, "A_assoc", 9, 92.56, 1, 0, null, null, 0, 0, null, 0, "autosomal dominant epilepsy with auditory features", 0.8225657483127345], ["P29460", "IL12B", "Interleukin-12 subunit beta", "Tier 1", 0.687, 1, "A_assoc", 20, 91.12, 1, 0, null, null, 0, 0, null, 0, "psoriasis", 0.7914863943708039], ["P19876", "CXCL3", "C-X-C motif chemokine 3", "Tier 1.5", 0.679, 1, "A_assoc", 2, 81.88, 1, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.26311734927710556], ["P19875", "CXCL2", "C-X-C motif chemokine 2", "Tier 1.5", 0.674, 1, "A_assoc", 4, 81.62, 1, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.24624512698601778], ["Q2MKA7", "RSPO1", "R-spondin-1", "Tier 1", 0.669, 1, "A_assoc", 12, 74.69, 1, 0, null, null, 0, 0, null, 0, "palmoplantar keratoderma-XX sex reversal-predisposition to squamous cell carcinoma syndrome", 0.7285342885472184], ["P12272", "PTHLH", "Parathyroid hormone-related protein", "Tier 1", 0.666, 1, "A_assoc", 11, 62.88, 1, 0, null, null, 0, 0, null, 0, "brachydactyly type E", 0.7203484375635054], ["Q8N300", "SVBP", "Small vasohibin-binding protein", "Tier 1", 0.649, 1, "A_assoc", 24, 85.06, 1, 0, null, null, 0, 0, null, 0, "neurodevelopmental disorder with ataxia, hypotonia, and microcephaly", 0.6640118055835142], ["O95631", "NTN1", "Netrin-1", "Tier 1.5", 0.648, 1, "A_assoc", 5, 88.5, 1, 0, null, null, 0, 0, null, 0, "mirror movements 4", 0.6611393488240481], ["Q9NWU2", "GID8", "Glucose-induced degradation protein 8 homolog", "Tier 1.5", 0.631, 1, "A_assoc", 1, 91.94, 1, 0, null, null, 0, 0, null, 1, "Abnormality of the skeletal system", 0.10187555420552867], ["Q9UHF0", "TAC3", "Tachykinin-3", "Tier 1", 0.63, 1, "A_assoc", 2, 64.88, 1, 0, null, null, 0, 0, null, 0, "hypogonadotropic hypogonadism 10 with or without anosmia", 0.5995324402695232], ["P13727", "PRG2", "Bone marrow proteoglycan", "Tier 1", 0.629, 1, "A_assoc", 9, 75.94, 1, 0, null, null, 0, 0, null, 1, "prostate cancer", 0.09730351635618993], ["Q6IBW4", "NCAPH2", "Condensin-2 complex subunit H2", "Tier 1.5", 0.62, 1, "A_assoc", 1, 62.41, 1, 0, null, null, 0, 0, null, 0, "cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 1", 0.5674645203025676], ["Q63HQ2", "EGFLAM", "Pikachurin", "Tier 1.5", 0.574, 1, "A_assoc", 3, 80.56, 1, 0, null, null, 0, 0, null, 0, "mathematical ability", 0.41387833248094535], ["P06850", "CRH", "Corticoliberin", "Tier 1", 0.562, 1, "A_assoc", 5, 61.97, 1, 0, null, null, 0, 0, null, 0, "autosomal dominant nocturnal frontal lobe epilepsy", 0.37224647599732263], ["Q7L8A9", "VASH1", "Tubulinyl-Tyr carboxypeptidase 1", "Tier 1", 0.559, 1, "A_assoc", 14, 78.25, 1, 0, null, null, 0, 0, null, 0, "Abnormality of the skeletal system", 0.36366533692746233], ["P18509", "ADCYAP1", "Pituitary adenylate cyclase-activating polypeptide", "Tier 1", 0.559, 1, "A_assoc", 12, 62.56, 1, 0, null, null, 0, 0, null, 0, "alcohol drinking", 0.36407172744864225], ["O15240", "VGF", "Neurosecretory protein VGF", "Tier 1", 0.545, 1, "A_assoc", 5, 60.44, 1, 0, null, null, 0, 0, null, 0, "Abnormality of the skeletal system", 0.3156209584671744], ["P0DMC3", "APELA", "Apelin receptor early endogenous ligand", "Tier 1", 0.544, 1, "A_assoc", 3, 72.56, 1, 0, null, null, 0, 0, null, 0, "attention deficit hyperactivity disorder", 0.3148526492327248], ["M5A8F1", "ERVH48-1", "Suppressyn", "Tier 1.5", 0.519, 1, "A_assoc", 1, 74.94, 1, 0, null, null, 0, 0, null, 0, "hypertension", 0.23115391486595976], ["Q5T4W7", "ARTN", "Artemin", "Tier 1.5", 0.512, 1, "A_assoc", 5, 75.0, 1, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.20507822956537197], ["Q99731", "CCL19", "C-C motif chemokine 19", "Tier 1", 0.485, 1, "A_assoc", 5, 83.19, 1, 0, null, null, 0, 0, null, 0, "neoplasm", 0.11672269610339286], ["Q9H293", "IL25", "Interleukin-25", "Tier 1", 0.485, 1, "A_assoc", 3, 79.0, 1, 0, null, null, 0, 0, null, 0, "neoplasm", 0.11536752730834607], ["Q7L2J0", "MEPCE", "7SK snRNA methylphosphate capping enzyme", "Tier 1", 0.485, 1, "A_assoc", 5, 62.66, 1, 0, null, null, 0, 0, null, 0, "Neurodevelopmental delay", 0.11826555349910459], ["Q8IZI9", "IFNL3", "Interferon lambda-3", "Tier 1.5", 0.484, 1, "A_assoc", 3, 84.81, 1, 0, null, null, 0, 0, null, 0, "hepatocellular carcinoma", 0.1145400757875244], ["O00230", "CORT", "Cortistatin", "Tier 1.5", 0.484, 1, "A_assoc", 5, 62.84, 1, 0, null, null, 0, 0, null, 0, "neoplasm", 0.11461560504839655], ["Q9Y5Q6", "INSL5", "Insulin-like peptide INSL5", "Tier 1.5", 0.477, 1, "A_assoc", 3, 64.06, 1, 0, null, null, 0, 0, null, 0, "polycystic ovary syndrome", 0.08868171274230166], ["Q7Z4H4", "ADM2", "Protein ADM2", "Tier 1", 0.469, 1, "A_assoc", 2, 58.38, 1, 0, null, null, 0, 0, null, 0, "neoplasm", 0.06251866797932627], ["P0DSE2", "TRB", "M1-specific T cell receptor beta chain", "Tier 1", 0.45, 1, "A_assoc", 5, 90.12, 1, 0, null, null, 0, 0, null, 0, null, null], ["P13848", "7", "Capsid assembly scaffolding protein", "Tier 1", 0.45, 1, "A_assoc", 15, null, 1, 0, null, null, 0, 0, null, 0, null, null]], "truncated": false, "filtered_table_rows_count": 44, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_cryoEM\" = :p0 and \"has_known_aptamer\" = :p1 and \"surface_class\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "1", "p1": "0", "p2": "A_assoc"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&surface_class=A_assoc", "results": [{"value": 1, "label": 1, "count": 44, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&surface_class=A_assoc&has_structure=1", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&surface_class=A_assoc", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 26, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&surface_class=A_assoc&tier=Tier+1", "selected": false}, {"value": "Tier 1.5", "label": "Tier 1.5", "count": 18, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&surface_class=A_assoc&tier=Tier+1.5", "selected": false}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&surface_class=A_assoc", "results": [{"value": 0, "label": 0, "count": 44, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&surface_class=A_assoc&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&surface_class=A_assoc", "results": [{"value": 0, "label": 0, "count": 44, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A_assoc", "selected": true}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&surface_class=A_assoc", "results": [{"value": "A_assoc", "label": "A_assoc", "count": 44, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&surface_class=A_assoc", "results": [{"value": 0, "label": 0, "count": 25, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&surface_class=A_assoc&in_cev_map=0", "selected": false}, {"value": 1, "label": 1, "count": 19, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&surface_class=A_assoc&in_cev_map=1", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&surface_class=A_assoc", "results": [{"value": 1, "label": 1, "count": 44, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=A_assoc", "selected": true}], "truncated": false}}, "suggested_facets": [{"name": "pdb_count_total", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&surface_class=A_assoc&_facet=pdb_count_total"}], "next": null, "next_url": null, "private": false, "allow_execute_sql": true, "query_ms": 1425.9877689182758, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}