{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_cryoEM = 1, has_known_aptamer = 0 and surface_class = \"B_cargo\" sorted by evidence_priority descending", "rows": [["P43246", "MSH2", "DNA mismatch repair protein Msh2", "Tier 1", 0.766, 1, "B_cargo", 30, 85.31, 1, 0, null, null, 0, 0, null, 1, "Lynch syndrome", 0.8882239051809577], ["P68133", "ACTA1", "Actin, alpha skeletal muscle", "Tier 1.5", 0.758, 1, "B_cargo", 5, 95.12, 1, 0, null, null, 0, 0, null, 1, "congenital myopathy 2a, typical, autosomal dominant", 0.8588441418736817], ["Q96RQ3", "MCCC1", "Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial", "Tier 1", 0.757, 1, "B_cargo", 14, 87.62, 1, 0, null, null, 0, 0, null, 1, "Isolated 3-methylcrotonyl-CoA carboxylase deficiency", 0.8573370131864518], ["Q16595", "FXN", "Frataxin, mitochondrial", "Tier 1", 0.757, 1, "B_cargo", 20, 75.5, 1, 0, null, null, 0, 0, null, 1, "Friedreich ataxia", 0.8550760415889643], ["P11310", "ACADM", "Medium-chain specific acyl-CoA dehydrogenase, mitochondrial", "Tier 1", 0.756, 1, "B_cargo", 7, 93.38, 1, 0, null, null, 0, 0, null, 1, "medium chain acyl-CoA dehydrogenase deficiency", 0.8542618568274527], ["Q14896", "MYBPC3", "Myosin-binding protein C, cardiac-type", "Tier 1.5", 0.755, 1, "B_cargo", 17, 78.81, 1, 0, null, null, 0, 0, null, 1, "hypertrophic cardiomyopathy", 0.8502637105703099], ["P30084", "ECHS1", "Enoyl-CoA hydratase, mitochondrial", "Tier 1.5", 0.755, 1, "B_cargo", 6, 91.69, 1, 0, null, null, 0, 0, null, 1, "mitochondrial short-chain Enoyl-Coa hydratase 1 deficiency", 0.8483381531913922], ["Q12756", "KIF1A", "Kinesin-like protein KIF1A", "Tier 1", 0.754, 1, "B_cargo", 21, 70.5, 1, 0, null, null, 0, 0, null, 1, "intellectual disability, autosomal dominant 9", 0.8481151412193974], ["Q9HCC0", "MCCC2", "Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial", "Tier 1", 0.753, 1, "B_cargo", 14, 94.69, 1, 0, null, null, 0, 0, null, 1, "3-methylcrotonyl-CoA carboxylase 2 deficiency", 0.8437575319886195], ["Q13144", "EIF2B5", "Translation initiation factor eIF2B subunit epsilon", "Tier 1", 0.752, 1, "B_cargo", 25, 78.75, 1, 0, null, null, 0, 0, null, 1, "CACH syndrome", 0.8411470079917355], ["P46777", "RPL5", "Large ribosomal subunit protein uL18", "Tier 1", 0.751, 1, "B_cargo", 30, 94.5, 1, 0, null, null, 0, 0, null, 1, "Blackfan-Diamond anemia", 0.8352702821155725], ["P16219", "ACADS", "Short-chain specific acyl-CoA dehydrogenase, mitochondrial", "Tier 1", 0.751, 1, "B_cargo", 4, 93.62, 1, 0, null, null, 0, 0, null, 1, "short chain acyl-CoA dehydrogenase deficiency", 0.8352413435265167], ["P00367", "GLUD1", "Glutamate dehydrogenase 1, mitochondrial", "Tier 1", 0.751, 1, "B_cargo", 7, 90.25, 1, 0, null, null, 0, 0, null, 1, "hyperinsulinism-hyperammonemia syndrome", 0.8355052949188112], ["P49768", "PSEN1", "Presenilin-1", "Tier 1", 0.751, 1, "B_cargo", 27, 72.12, 1, 0, null, null, 0, 0, null, 1, "Alzheimer disease 3", 0.8373536811398027], ["P63261", "ACTG1", "Actin, cytoplasmic 2", "Tier 1", 0.75, 1, "B_cargo", 10, 95.38, 1, 0, null, null, 0, 0, null, 1, "Baraitser-Winter syndrome", 0.834386021888207], ["P35573", "AGL", "Glycogen debranching enzyme", "Tier 1.5", 0.75, 1, "B_cargo", 1, 92.75, 1, 0, null, null, 0, 0, null, 1, "glycogen storage disease III", 0.8321686508777297], ["Q9Y4W6", "AFG3L2", "Mitochondrial inner membrane m-AAA protease component AFG3L2", "Tier 1.5", 0.75, 1, "B_cargo", 2, 76.75, 1, 0, null, null, 0, 0, null, 1, "spinocerebellar ataxia type 28", 0.8341800061294613], ["P36776", "LONP1", "Lon protease homolog, mitochondrial", "Tier 1", 0.748, 1, "B_cargo", 29, 76.69, 1, 0, null, null, 0, 0, null, 1, "CODAS syndrome", 0.8273562128539942], ["Q7Z6Z7", "HUWE1", "E3 ubiquitin-protein ligase HUWE1", "Tier 1", 0.748, 1, "B_cargo", 19, null, 1, 0, null, null, 0, 0, null, 1, "intellectual disability, X-linked syndromic, Turner type", 0.8251574698433977], ["Q71U36", "TUBA1A", "Tubulin alpha-1A chain", "Tier 1", 0.747, 1, "B_cargo", 15, 91.12, 1, 0, null, null, 0, 0, null, 1, "lissencephaly due to TUBA1A mutation", 0.8249848986700001], ["Q9UNE7", "STUB1", "E3 ubiquitin-protein ligase CHIP", "Tier 1", 0.747, 1, "B_cargo", 21, 89.31, 1, 0, null, null, 0, 0, null, 1, "autosomal recessive spinocerebellar ataxia 16", 0.8231010720948859], ["Q9Y484", "WDR45", "WD repeat domain phosphoinositide-interacting protein 4", "Tier 1.5", 0.747, 1, "B_cargo", 3, 90.5, 1, 0, null, null, 0, 0, null, 1, "neurodegeneration with brain iron accumulation 5", 0.8230559793277397], ["P09493", "TPM1", "Tropomyosin alpha-1 chain", "Tier 1", 0.746, 1, "B_cargo", 14, 91.62, 1, 0, null, null, 0, 0, null, 1, "hypertrophic cardiomyopathy", 0.8201717082603994], ["Q8IYB7", "DIS3L2", "DIS3-like exonuclease 2", "Tier 1", 0.746, 1, "B_cargo", 4, 82.69, 1, 0, null, null, 0, 0, null, 1, "Perlman syndrome", 0.8206937660793029], ["Q8TEQ6", "GEMIN5", "Gem-associated protein 5", "Tier 1", 0.746, 1, "B_cargo", 16, 78.94, 1, 0, null, null, 0, 0, null, 1, "neurodevelopmental disorder with cerebellar atrophy and motor dysfunction", 0.8184088962562686], ["O75027", "ABCB7", "Iron-sulfur clusters transporter ABCB7, mitochondrial", "Tier 1.5", 0.746, 1, "B_cargo", 1, 78.12, 1, 0, null, null, 0, 0, null, 1, "X-linked sideroblastic anemia with ataxia", 0.821045506234113], ["P63267", "ACTG2", "Actin, gamma-enteric smooth muscle", "Tier 1.5", 0.745, 1, "B_cargo", 4, 95.38, 1, 0, null, null, 0, 0, null, 1, "visceral myopathy 1", 0.8175814609874555], ["P18077", "RPL35A", "Large ribosomal subunit protein eL33", "Tier 1", 0.744, 1, "B_cargo", 30, 95.56, 1, 0, null, null, 0, 0, null, 1, "Blackfan-Diamond anemia", 0.8140112443681048], ["Q9UI10", "EIF2B4", "Translation initiation factor eIF2B subunit delta", "Tier 1", 0.744, 1, "B_cargo", 25, 76.5, 1, 0, null, null, 0, 0, null, 1, "CACH syndrome", 0.8146710778484454], ["P51159", "RAB27A", "Ras-related protein Rab-27A", "Tier 1.5", 0.744, 1, "B_cargo", 11, 83.94, 1, 0, null, null, 0, 0, null, 1, "Griscelli syndrome type 2", 0.8139882966122653], ["O95831", "AIFM1", "Apoptosis-inducing factor 1, mitochondrial", "Tier 1", 0.743, 1, "B_cargo", 26, 85.81, 1, 0, null, null, 0, 0, null, 1, "severe X-linked mitochondrial encephalomyopathy", 0.8095652882833212], ["Q14839", "CHD4", "ATP-dependent chromatin remodeler CHD4", "Tier 1.5", 0.743, 1, "B_cargo", 12, 64.62, 1, 0, null, null, 0, 0, null, 1, "Sifrim-Hitz-Weiss syndrome", 0.8103430577478806], ["Q8TCS8", "PNPT1", "Polyribonucleotide nucleotidyltransferase 1, mitochondrial", "Tier 1.5", 0.743, 1, "B_cargo", 11, 87.44, 1, 0, null, null, 0, 0, null, 1, "combined oxidative phosphorylation defect type 13", 0.8091107966912156], ["E7ETK0", "RPS24", "40S ribosomal protein S24", "Tier 1", 0.742, 1, "B_cargo", 2, 89.44, 1, 0, null, null, 0, 0, null, 1, "Blackfan-Diamond anemia", 0.808182918000228], ["O15287", "FANCG", "Fanconi anemia group G protein", "Tier 1", 0.742, 1, "B_cargo", 6, 83.12, 1, 0, null, null, 0, 0, null, 1, "Fanconi anemia complementation group G", 0.8075342855580835], ["O43464", "HTRA2", "Serine protease HTRA2, mitochondrial", "Tier 1.5", 0.742, 1, "B_cargo", 13, 74.44, 1, 0, null, null, 0, 0, null, 1, "3-methylglutaconic aciduria type 8", 0.8079136325441377], ["Q14738", "PPP2R5D", "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform", "Tier 1.5", 0.742, 1, "B_cargo", 2, 79.94, 1, 0, null, null, 0, 0, null, 1, "Hogue-Janssens syndrome 1", 0.8058398703478188], ["Q15125", "EBP", "3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase", "Tier 1.5", 0.742, 1, "B_cargo", 4, 95.56, 1, 0, null, null, 0, 0, null, 1, "MEND syndrome", 0.8082510362309315], ["P09471", "GNAO1", "Guanine nucleotide-binding protein G(o) subunit alpha", "Tier 1", 0.741, 1, "B_cargo", 83, 94.5, 1, 0, null, null, 0, 0, null, 1, "developmental and epileptic encephalopathy, 17", 0.8046862567587088], ["Q13509", "TUBB3", "Tubulin beta-3 chain", "Tier 1", 0.741, 1, "B_cargo", 28, 91.44, 1, 0, null, null, 0, 0, null, 1, "fibrosis of extraocular muscles, congenital, 3A, with or without extraocular involvement", 0.8033756889440116], ["Q9UL18", "AGO1", "Protein argonaute-1", "Tier 1", 0.741, 1, "B_cargo", 8, 91.0, 1, 0, null, null, 0, 0, null, 1, "neurodevelopmental disorder with language delay and behavioral abnormalities, with or without seizures", 0.803337762735991], ["Q9H9Q4", "NHEJ1", "Non-homologous end-joining factor 1", "Tier 1", 0.741, 1, "B_cargo", 26, 81.75, 1, 0, null, null, 0, 0, null, 1, "Cernunnos-XLF deficiency", 0.8044005005389401], ["Q14669", "TRIP12", "E3 ubiquitin-protein ligase TRIP12", "Tier 1.5", 0.739, 1, "B_cargo", 5, 66.75, 1, 0, null, null, 0, 0, null, 1, "Clark-Baraitser syndrome", 0.795639262535032], ["Q9Y4R8", "TELO2", "Telomere length regulation protein TEL2 homolog", "Tier 1.5", 0.739, 1, "B_cargo", 3, 83.88, 1, 0, null, null, 0, 0, null, 1, "TELO2-related intellectual disability-neurodevelopmental disorder", 0.7971337980726797], ["Q14232", "EIF2B1", "Translation initiation factor eIF2B subunit alpha", "Tier 1", 0.738, 1, "B_cargo", 26, 91.81, 1, 0, null, null, 0, 0, null, 1, "leukoencephalopathy with vanishing white matter 1", 0.7919833382589645], ["P0DP24", "CALM2", "Calmodulin-2", "Tier 1", 0.738, 1, "B_cargo", 15, 85.81, 1, 0, null, null, 0, 0, null, 1, "long QT syndrome 15", 0.7946166428883098], ["P46976", "GYG1", "Glycogenin-1", "Tier 1", 0.738, 1, "B_cargo", 23, 84.31, 1, 0, null, null, 0, 0, null, 1, "polyglucosan body myopathy type 2", 0.7939553356561934], ["O95163", "ELP1", "Elongator complex protein 1", "Tier 1", 0.738, 1, "B_cargo", 5, 83.94, 1, 0, null, null, 0, 0, null, 1, "Familial dysautonomia", 0.7942254141235164], ["Q4G0J3", "LARP7", "La-related protein 7", "Tier 1", 0.738, 1, "B_cargo", 5, 67.62, 1, 0, null, null, 0, 0, null, 1, "microcephalic primordial dwarfism, Alazami type", 0.7921875576744281], ["P10916", "MYL2", "Myosin regulatory light chain 2, ventricular/cardiac muscle isoform", "Tier 1.5", 0.738, 1, "B_cargo", 3, 83.5, 1, 0, null, null, 0, 0, null, 1, "hypertrophic cardiomyopathy", 0.7947577322969279]], "truncated": false, "filtered_table_rows_count": 766, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_cryoEM\" = :p0 and \"has_known_aptamer\" = :p1 and \"surface_class\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "1", "p1": "0", "p2": "B_cargo"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&surface_class=B_cargo", "results": [{"value": 1, "label": 1, "count": 766, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&surface_class=B_cargo&has_structure=1", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&surface_class=B_cargo", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 535, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&surface_class=B_cargo&tier=Tier+1", "selected": false}, {"value": "Tier 1.5", "label": "Tier 1.5", "count": 231, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&surface_class=B_cargo&tier=Tier+1.5", "selected": false}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&surface_class=B_cargo", "results": [{"value": 0, "label": 0, "count": 766, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&surface_class=B_cargo&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&surface_class=B_cargo", "results": [{"value": 0, "label": 0, "count": 766, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=B_cargo", "selected": true}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&surface_class=B_cargo", "results": [{"value": "B_cargo", "label": "B_cargo", "count": 766, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&surface_class=B_cargo", "results": [{"value": 1, "label": 1, "count": 450, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&surface_class=B_cargo&in_cev_map=1", "selected": false}, {"value": 0, "label": 0, "count": 316, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&surface_class=B_cargo&in_cev_map=0", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&surface_class=B_cargo", "results": [{"value": 1, "label": 1, "count": 766, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=B_cargo", "selected": true}], "truncated": false}}, "suggested_facets": [], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&surface_class=B_cargo&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 1629.7708828933537, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}