{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_cryoEM = 1, has_known_aptamer = 0 and tier = \"Tier 1.5\" sorted by priority_score descending", "rows": [["Q02094", "RHAG", "Ammonium transporter Rh type A", "Tier 1.5", 0.841, 8, 95.62, 1, 0, null, null, null, 0, 0, null, 1, "Rh deficiency syndrome", 0.764209214915708], ["P35346", "SSTR5", "Somatostatin receptor type 5", "Tier 1.5", 0.841, 7, 81.25, 1, 0, null, null, null, 0, 0, null, 0, "acromegaly", 0.6094707180356006], ["Q14392", "LRRC32", "Transforming growth factor beta activator LRRC32", "Tier 1.5", 0.838, 6, 86.06, 1, 0, null, null, null, 0, 0, null, 1, "cleft palate, proliferative retinopathy, and developmental delay", 0.5770707112957068], ["P21439", "ABCB4", "Phosphatidylcholine translocator ABCB4", "Tier 1.5", 0.835, 4, 83.25, 1, 0, null, null, null, 0, 0, null, 0, "progressive familial intrahepatic cholestasis type 3", 0.851728159166962], ["P12532", "CKMT1A", "Creatine kinase U-type, mitochondrial", "Tier 1.5", 0.83, 9, 89.31, 1, 0, null, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.5385822922582763], ["O75899", "GABBR2", "Gamma-aminobutyric acid type B receptor subunit 2", "Tier 1.5", 0.824, 26, 77.75, 1, 0, null, null, null, 0, 0, null, 0, "developmental and epileptic encephalopathy, 59", 0.7356789732167734], ["P54709", "ATP1B3", "Sodium/potassium-transporting ATPase subunit beta-3", "Tier 1.5", 0.81, 7, 89.69, 1, 0, null, null, null, 0, 0, null, 1, "congestive heart failure", 0.5999952111132625], ["Q04844", "CHRNE", "Acetylcholine receptor subunit epsilon", "Tier 1.5", 0.802, 13, 80.69, 1, 0, null, null, null, 0, 0, null, 0, "Congenital myasthenic syndromes", 0.8223287249629152], ["P29275", "ADORA2B", "Adenosine receptor A2b", "Tier 1.5", 0.801, 4, 88.12, 1, 0, null, null, null, 0, 0, null, 0, "migraine disorder", 0.6060142180667235], ["Q9H2X9", "SLC12A5", "Solute carrier family 12 member 5", "Tier 1.5", 0.8, 2, 78.44, 1, 0, null, null, null, 0, 0, null, 0, "genetic developmental and epileptic encephalopathy", 0.6993945840545625], ["Q13705", "ACVR2B", "Activin receptor type-2B", "Tier 1.5", 0.791, 9, 83.31, 1, 0, null, null, null, 0, 0, null, 0, "Heterotaxia", 0.7109733260300651], ["Q96CS2", "HAUS1", "HAUS augmin-like complex subunit 1", "Tier 1.5", 0.79, 1, 88.62, 1, 0, null, null, null, 0, 0, null, 0, "device complication", 0.27547205131467467], ["Q5JUK3", "KCNT1", "Potassium channel subfamily T member 1", "Tier 1.5", 0.782, 6, 73.88, 1, 0, null, null, null, 0, 0, null, 0, "developmental and epileptic encephalopathy, 14", 0.8165232785825526], ["P13866", "SLC5A1", "Sodium/glucose cotransporter 1", "Tier 1.5", 0.777, 4, 84.38, 1, 0, null, null, null, 0, 0, null, 0, "glucose-galactose malabsorption", 0.8220991027793896], ["P30542", "ADORA1", "Adenosine receptor A1", "Tier 1.5", 0.777, 5, 92.44, 1, 0, null, null, null, 0, 0, null, 0, "asthma", 0.7232344154541454], ["P43004", "SLC1A2", "Excitatory amino acid transporter 2", "Tier 1.5", 0.768, 7, 77.75, 1, 0, null, null, null, 0, 0, null, 0, "developmental and epileptic encephalopathy, 41", 0.7772658651722512], ["O60931", "CTNS", "Cystinosin", "Tier 1.5", 0.764, 6, 89.44, 1, 0, null, null, null, 0, 0, null, 0, "nephropathic cystinosis", 0.841818398377195], ["O60568", "PLOD3", "Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3", "Tier 1.5", 0.762, 18, 91.38, 1, 0, null, null, null, 0, 0, null, 1, "bone fragility with contractures, arterial rupture, and deafness", 0.7159150369336311], ["Q9Y5Y9", "SCN10A", "Sodium channel protein type 10 subunit alpha", "Tier 1.5", 0.761, 8, 67.31, 1, 0, null, null, null, 0, 0, null, 0, "atrial fibrillation", 0.7126293968222049], ["O15552", "FFAR2", "Free fatty acid receptor 2", "Tier 1.5", 0.759, 11, 88.06, 1, 0, null, null, null, 0, 0, null, 0, "type 1 diabetes mellitus", 0.09182737097469269], ["P35462", "DRD3", "D(3) dopamine receptor", "Tier 1.5", 0.757, 6, 75.38, 1, 0, null, null, null, 0, 0, null, 0, "schizophrenia", 0.6687268941647396], ["P41440", "SLC19A1", "Reduced folate transporter", "Tier 1.5", 0.755, 19, 72.06, 1, 0, null, null, null, 0, 0, null, 1, "Knobloch syndrome", 0.5526223217595396], ["O00591", "GABRP", "Gamma-aminobutyric acid receptor subunit pi", "Tier 1.5", 0.752, 2, 79.12, 1, 0, null, null, null, 0, 0, null, 0, "migraine disorder", 0.6191855696357259], ["P0DMS8", "ADORA3", "Adenosine receptor A3", "Tier 1.5", 0.751, 5, 91.31, 1, 0, null, null, null, 0, 0, null, 0, "migraine disorder", 0.6052134617149065], ["P26022", "PTX3", "Pentraxin-related protein PTX3", "Tier 1.5", 0.75, 9, 76.75, 1, 0, null, null, null, 0, 0, null, 1, "polycystic ovary syndrome", 0.12287624125782433], ["P46089", "GPR3", "G-protein coupled receptor 3", "Tier 1.5", 0.748, 8, 81.81, 1, 0, null, null, null, 0, 0, null, 0, "hypertension", 0.18488148594282316], ["Q9Y653", "ADGRG1", "Adhesion G-protein coupled receptor G1", "Tier 1.5", 0.743, 1, 77.88, 1, 0, null, null, null, 0, 0, null, 1, "bilateral frontoparietal polymicrogyria", 0.8322298896713178], ["Q86YT5", "SLC13A5", "Na(+)/citrate cotransporter", "Tier 1.5", 0.739, 4, 86.06, 1, 0, null, null, null, 0, 0, null, 0, "genetic developmental and epileptic encephalopathy", 0.6853612674939716], ["Q9H741", "SPRING1", "SREBP regulating gene protein", "Tier 1.5", 0.725, 2, 81.31, 1, 0, null, null, null, 0, 0, null, 0, "Anxiety", 0.35244791107935663], ["P48764", "SLC9A3", "Sodium/hydrogen exchanger 3", "Tier 1.5", 0.725, 1, 65.94, 1, 0, null, null, null, 0, 0, null, 0, "congenital sodium diarrhea", 0.6503153836708786], ["P41968", "MC3R", "Melanocortin receptor 3", "Tier 1.5", 0.723, 6, 83.88, 1, 0, null, null, null, 0, 0, null, 0, "alcohol drinking", 0.3298167673588826], ["P07942", "LAMB1", "Laminin subunit beta-1", "Tier 1.5", 0.72, 3, 76.69, 1, 0, null, null, null, 0, 0, null, 1, "cobblestone lissencephaly without muscular or ocular involvement", 0.8016665947624902], ["Q9NZD1", "GPRC5D", "G-protein coupled receptor family C group 5 member D", "Tier 1.5", 0.716, 2, 76.06, 1, 0, null, null, null, 0, 0, null, 0, "multiple myeloma", 0.5555243624684951], ["Q9BZV2", "SLC19A3", "Thiamine transporter 2", "Tier 1.5", 0.712, 19, 81.56, 1, 0, null, null, null, 0, 0, null, 0, "biotin-responsive basal ganglia disease", 0.8189646480334981], ["Q9NR82", "KCNQ5", "Potassium voltage-gated channel subfamily KQT member 5", "Tier 1.5", 0.711, 5, 56.41, 1, 0, null, null, null, 0, 0, null, 1, "intellectual disability, autosomal dominant 46", 0.7086662845211597], ["Q401N2", "ZACN", "Ligand-gated cation channel ZACN", "Tier 1.5", 0.711, 9, 77.56, 1, 0, null, null, null, 0, 0, null, 0, "atrial heart septal defect", 0.20510272364083965], ["Q2M385", "MPEG1", "Macrophage-expressed gene 1 protein", "Tier 1.5", 0.71, 5, 82.75, 1, 0, null, null, null, 0, 0, null, 0, "immunodeficiency 77", 0.7043238859467001], ["Q8N6U8", "GPR161", "G-protein coupled receptor 161", "Tier 1.5", 0.708, 2, 68.62, 1, 0, null, null, null, 0, 0, null, 0, "medulloblastoma", 0.583267884969527], ["P34995", "PTGER1", "Prostaglandin E2 receptor EP1 subtype", "Tier 1.5", 0.707, 1, 74.81, 1, 0, null, null, null, 0, 0, null, 0, "erectile dysfunction", 0.5684936888228123], ["Q8TDU6", "GPBAR1", "G-protein coupled bile acid receptor 1", "Tier 1.5", 0.703, 5, 80.44, 1, 0, null, null, null, 0, 0, null, 0, "cholelithiasis", 0.13532265841527905], ["Q1HG43", "DUOXA1", "Dual oxidase maturation factor 1", "Tier 1.5", 0.703, 2, 82.44, 1, 0, null, null, null, 0, 0, null, 0, "familial thyroid dyshormonogenesis", 0.33299144907091627], ["Q99705", "MCHR1", "Melanin-concentrating hormone receptor 1", "Tier 1.5", 0.702, 10, 84.44, 1, 0, null, null, null, 0, 0, null, 0, "carpal tunnel syndrome", 0.3206604001931773], ["P14770", "GP9", "Platelet glycoprotein IX", "Tier 1.5", 0.702, 2, 84.69, 1, 0, null, null, null, 0, 0, null, 1, "Bernard-Soulier syndrome", 0.8233582238860002], ["P33032", "MC5R", "Melanocortin receptor 5", "Tier 1.5", 0.693, 3, 82.62, 1, 0, null, null, null, 0, 0, null, 0, "color vision disorder", 0.32934412559476917], ["P01825", "IGHV4-59", "Immunoglobulin heavy variable 4-59", "Tier 1.5", 0.69, 3, 91.56, 1, 0, null, null, null, 0, 0, null, 1, "cutaneous Leishmaniasis", 0.5868213846274001], ["P25929", "NPY1R", "Neuropeptide Y receptor type 1", "Tier 1.5", 0.69, 6, 79.88, 1, 0, null, null, null, 0, 0, null, 0, "mathematical ability", 0.4585181664868048], ["Q16280", "CNGA2", "Cyclic nucleotide-gated channel alpha-2", "Tier 1.5", 0.689, 2, 77.75, 1, 0, null, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.3406621245682051], ["Q6NT16", "SLC18B1", "MFS-type transporter SLC18B1", "Tier 1.5", 0.688, 4, 84.62, 1, 0, null, null, null, 0, 0, null, 1, "Parkinson disease", 0.276931649354752], ["Q99250", "SCN2A", "Sodium channel protein type 2 subunit alpha", "Tier 1.5", 0.685, 5, 68.81, 1, 0, null, null, null, 0, 0, null, 1, "developmental and epileptic encephalopathy, 11", 0.8388748085806758], ["Q9UM01", "SLC7A7", "Y+L amino acid transporter 1", "Tier 1.5", 0.685, 5, 83.81, 1, 0, null, null, null, 0, 0, null, 0, "lysinuric protein intolerance", 0.8450026270275782]], "truncated": false, "filtered_table_rows_count": 409, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "priority_score", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "drug_count_approved", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, priority_score, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, drug_count_approved, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_cryoEM\" = :p0 and \"has_known_aptamer\" = :p1 and \"tier\" = :p2 order by priority_score desc limit 51", "params": {"p0": "1", "p1": "0", "p2": "Tier 1.5"}}, "facet_results": {"tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&tier=Tier+1.5", "results": [{"value": "Tier 1.5", "label": "Tier 1.5", "count": 409, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 409, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&tier=Tier+1.5&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 409, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&tier=Tier+1.5", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 222, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&tier=Tier+1.5&in_cev_map=0", "selected": false}, {"value": 1, "label": 1, "count": 187, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&tier=Tier+1.5&in_cev_map=1", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&tier=Tier+1.5", "results": [{"value": 1, "label": 1, "count": 409, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&tier=Tier+1.5", "selected": true}], "truncated": false}}, "suggested_facets": [{"name": "pdb_count_total", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&tier=Tier+1.5&_facet=pdb_count_total"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=0&tier=Tier+1.5&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 593.4347719958168, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}