{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_cryoEM = 1, has_known_aptamer = 1 and in_cev_map = 0 sorted by priority_score descending", "rows": [["P21583", "KITLG", "Kit ligand", "Tier 1.5", 0.848, 6, 71.88, 1, 0, null, null, null, 1, 2, "36579647,23967247", 0, "hyperpigmentation with or without hypopigmentation, familial progressive", 0.6756727302967072], ["A0A0E3EAY4", "env", "Envelope glycoprotein gp160", "Tier 1", 0.82, 2, null, 1, 0, null, null, null, 1, 12, "36576612,29464116,29217761,22379083,18776229,18569791,16146716,16043495,16013840,12498773,11024283,9713975", 0, null, null], ["Q00975", "CACNA1B", "Voltage-dependent N-type calcium channel subunit alpha-1B", "Tier 1.5", 0.807, 7, 59.91, 1, 0, null, null, null, 1, 2, "31118475,25782368", 0, "Seizure", 0.7217241968702018], ["P35414", "APLNR", "Apelin receptor", "Tier 1", 0.8, 37, 81.69, 1, 0, null, null, null, 1, 1, "36126144", 0, "essential hypertension", 0.2159614840844307], ["P03971", "AMH", "Anti-Muellerian hormone", "Tier 1.5", 0.783, 3, 68.62, 1, 0, null, null, null, 1, 2, "41101154,27364573", 0, "persistent Mullerian duct syndrome", 0.7847328444470535], ["P07911", "UMOD", "Uromodulin", "Tier 1", 0.774, 10, 82.94, 1, 0, null, null, null, 1, 4, "37533140,35446786", 0, "familial juvenile hyperuricemic nephropathy type 1", 0.8446536377993564], ["P40225", "THPO", "Thrombopoietin", "Tier 1", 0.76, 3, 61.44, 1, 0, null, null, null, 1, 2, "38928037,30312735", 0, "thrombocythemia 1", 0.7027329039559379], ["Q9ULV1", "FZD4", "Frizzled-4", "Tier 1", 0.745, 11, 84.31, 1, 0, null, null, null, 1, 1, "18673242", 0, "Familial exudative vitreoretinopathy", 0.8152111103672746], ["P21730", "C5AR1", "C5a anaphylatoxin chemotactic receptor 1", "Tier 1", 0.741, 19, 85.75, 1, 0, null, null, null, 1, 5, "33495506,29981048,29327939,28288993,25901944", 0, "anti-neutrophil cytoplasmic antibody-associated vasculitis", 0.5076734733894334], ["Q00604", "NDP", "Norrin", "Tier 1.5", 0.716, 11, 83.56, 1, 0, null, null, null, 1, 2, "39057719,11352723", 0, "Norrie disease", 0.8566451682188412], ["P46094", "XCR1", "Chemokine XC receptor 1", "Tier 1.5", 0.715, 1, 84.94, 1, 0, null, null, null, 1, 1, "35212764", 0, "COVID-19", 0.459103766220463], ["P32239", "CCKBR", "Gastrin/cholecystokinin type B receptor", "Tier 1.5", 0.713, 5, 75.75, 1, 0, null, null, null, 1, 2, "33776434,27754762", 0, "gastroesophageal reflux disease", 0.4256110167566802], ["P20809", "IL11", "Interleukin-11", "Tier 1", 0.712, 8, 82.62, 1, 0, null, null, null, 1, 8, "39408993,39263947,28791655,27878687,25696907,24629635", 0, "osteoarthritis, hip", 0.31754029889853136], ["P25106", "ACKR3", "Atypical chemokine receptor 3", "Tier 1.5", 0.71, 14, 82.44, 1, 0, null, null, null, 1, 2, "40401615,28670693", 0, "oculomotor-abducens synkinesis", 0.49893280382434735], ["P15309", "ACP3", "Prostatic acid phosphatase", "Tier 1", 0.695, 17, 92.25, 1, 0, null, null, null, 1, 3, "41890985,25591398", 0, "prostate cancer", 0.5521391557206573], ["P48061", "CXCL12", "Stromal cell-derived factor 1", "Tier 1", 0.685, 34, 83.25, 1, 0, null, null, null, 1, 36, "41951573,41931849,41907643,41527798,40401615,40008515,39865939,39263947,38806504,38477735,32784904,31267721,31097627,30465210,30385042,29111236,28963140,28670693,27940247,27924617,27392463,26265085,25560701,25236655,24526776,24277076,23615526,22376154,21147843,41963275", 0, "HIV-1 infection", 0.3675509850165065], ["Q6NW40", "RGMB", "Repulsive guidance molecule B", "Tier 1", 0.683, 11, 79.44, 1, 0, null, null, null, 1, 1, "39263947", 0, "Abnormality of the skeletal system", 0.42535629367019584], ["Q96RJ3", "TNFRSF13C", "Tumor necrosis factor receptor superfamily member 13C", "Tier 1.5", 0.681, 8, 63.03, 1, 0, null, null, null, 1, 1, "23470998", 0, "immunodeficiency, common variable, 4", 0.660711678987284], ["Q9UEF7", "KL", "Klotho", "Tier 1", 0.676, 6, 89.06, 1, 0, null, null, null, 1, 19, "41978019,41851110,41038766,40370992,39975897,39909827,38500260,38233588,37584531,36891771,36535944,35770801,35360393,34375633,33536505,31511614,25325398,18569791,40514411", 0, "type 2 diabetes mellitus", 0.5587488336100863], ["P51681", "CCR5", "C-C chemokine receptor type 5", "Tier 1", 0.674, 25, 85.38, 1, 0, null, null, null, 1, 23, "36576612,33981364,29678881,29556342,29301363,27807347,27652575,26965267,25794434,25754473,25329893,23629001,22811524,21576818,18799178,16631118,16227301,15813986,14610191,12498773", 0, "HIV infection", 0.7442590579227027], ["P56704", "WNT3A", "Protein Wnt-3a", "Tier 1", 0.665, 4, 88.31, 1, 0, null, null, null, 1, 1, "37231925", 0, "neurodegenerative disease", 0.5271953966006525], ["P05113", "IL5", "Interleukin-5", "Tier 1", 0.664, 5, 86.69, 1, 0, null, null, null, 1, 12, "40972397,35487180,35356877,34831332,32784904,32038731,29881374,28062796,26048585", 0, "asthma", 0.6399821251487101], ["Q12809", "KCNH2", "Voltage-gated inwardly rectifying potassium channel KCNH2", "Tier 1", 0.655, 23, 62.75, 1, 0, null, null, null, 1, 1, "22617876", 0, "Romano-Ward syndrome", 0.8549238933917284], ["P08100", "RHO", "Rhodopsin", "Tier 1.5", 0.645, 4, 88.75, 1, 0, null, null, null, 1, 45, "41963275,41924874,41636061,40808302,40642289,40330320,40045571,39863313,39788632,38070612,37191882,36705086,36696850,36095194,36049339,35622174,34709779,34471566,32696702,32479610,32319623,32119944,31737572,31588238,31535128,29570714,29281176,28648779,27893356,25645980,23757206,23701883,25033804,22689339,22302221,22121695,19766091,19389625,16419035,12123800,8743323,7678562,19188685,18230760", 0, "retinitis pigmentosa", 0.8481942240861982], ["P15391", "CD19", "B-lymphocyte antigen CD19", "Tier 1.5", 0.642, 4, 62.22, 1, 0, null, null, null, 1, 13, "41079126,40652441,38661725,38148412,36095289,35829681,34680368,34364920,32401486,31912987,29928472,21127492", 0, "immunodeficiency, common variable, 3", 0.6821072538733047], ["Q13651", "IL10RA", "Interleukin-10 receptor subunit alpha", "Tier 1", 0.641, 7, 62.0, 1, 0, null, null, null, 1, 2, "25870409,25558474", 0, "Autosomal recessive early-onset inflammatory bowel disease", 0.8151052076044897], ["Q8NEV9", "IL27", "Interleukin-27 subunit alpha", "Tier 1.5", 0.641, 4, 75.62, 1, 0, null, null, null, 1, 2, "35859339,32784904", 0, "Crohn's disease", 0.40963715551754365], ["P45844", "ABCG1", "ATP-binding cassette sub-family G member 1", "Tier 1.5", 0.639, 5, 81.12, 1, 0, null, null, null, 1, 1, "41854184", 0, "neurodegenerative disease", 0.3915225348167794], ["P51654", "GPC3", "Glypican-3", "Tier 1.5", 0.636, 4, 75.06, 1, 0, null, null, null, 1, 65, "42083729,41790019,41653459,41045695,40825648,40722645,39998646,39874791,39608318,39427046,38910291,38787447,38621313,38368644,37665421,36903516,36457288,36317566,36072763,35788872,35699181,35477501,35051745,34974867,34306031,33254049,33080969,32356075,30347351,30122918,29675356,29605994,29277631,27601357,28263753", 0, "Simpson-Golabi-Behmel syndrome type 1", 0.762708583613362], ["P31785", "IL2RG", "Cytokine receptor common subunit gamma", "Tier 1.5", 0.635, 14, 75.5, 1, 0, null, null, null, 1, 2, "30800133,33869115", 0, "gamma chain deficiency", 0.8469997000418428], ["O95342", "ABCB11", "Bile salt export pump", "Tier 1.5", 0.624, 8, 83.12, 1, 0, null, null, null, 1, 1, "36313979", 0, "progressive familial intrahepatic cholestasis type 2", 0.8372060401943777], ["O00206", "TLR4", "Toll-like receptor 4", "Tier 1", 0.621, 15, 89.19, 1, 0, null, null, null, 1, 32, "41864915,41444487,40521190,39897575,38931862,38742374,38280803,37360693,36916435,36908619,35410404,35402075,35189346,34831332,32784904,29910175,29250957,25483705", 0, "major depressive disorder", 0.5065500149392951], ["O14625", "CXCL11", "C-X-C motif chemokine 11", "Tier 1", 0.62, 2, 79.94, 1, 0, null, null, null, 1, 4, "36649818,32784904,30578658,23935890", 0, "neoplasm", 0.11537901464416651], ["P49238", "CX3CR1", "CX3C chemokine receptor 1", "Tier 1.5", 0.62, 2, 80.5, 1, 0, null, null, null, 1, 2, "28727998", 0, "age-related macular degeneration", 0.4006854573775187], ["Q06141", "REG3A", "Regenerating islet-derived protein 3-alpha", "Tier 1.5", 0.62, 4, 89.0, 1, 0, null, null, null, 1, 2, "39695715,24771595", 0, "alcohol drinking", 0.29724052454892086], ["Q07325", "CXCL9", "C-X-C motif chemokine 9", "Tier 1.5", 0.617, 1, 87.44, 1, 0, null, null, null, 1, 7, "42046114,37395276,35204399,35018777,33742062,27959341,27819142", 0, "neoplasm", 0.1199067650750674], ["P41146", "OPRL1", "Nociceptin receptor", "Tier 1.5", 0.61, 4, 82.31, 1, 0, null, null, null, 1, 1, "14970396", 0, "neurodegenerative disease", 0.4039002828932129], ["P15018", "LIF", "Leukemia inhibitory factor", "Tier 1", 0.605, 5, 87.12, 1, 0, null, null, null, 1, 38, "41611413,38359901,37549567,37175248,36838669,33640806,32253765,31791592,31357280,30771937,30037541,29289340,28963578,28763192,27855943,26877178,26764106,26695234,26344338,26113415,25335821,25311485,25035238,24716781,22648816,22471443,27335672,20673578,20151395,19803140,18646283,17315151,16331583,16053313,11791582,9823713,39571081,31461490", 0, "alcohol drinking", 0.24197086949132446], ["P10636", "MAPT", "Microtubule-associated protein tau", "Tier 1", 0.605, 100, 49.22, 1, 0, null, null, null, 1, 9, "40380000,39241336,38585969,38397086,37003060,31900535,30004544,29268187", 0, "Pick disease", 0.7600399335134378], ["P04201", "MAS1", "Proto-oncogene Mas", "Tier 1.5", 0.605, 3, 83.5, 1, 0, null, null, null, 1, 10, "40518278,34016094,30415442,27936442,23618401", 0, "Abnormality of the skeletal system", 0.40450059258174326], ["P41231", "P2RY2", "P2Y purinoceptor 2", "Tier 1.5", 0.605, 3, 78.88, 1, 0, null, null, null, 1, 1, "33911033", 0, "nontoxic goiter", 0.43556889579550895], ["P46059", "SLC15A1", "Solute carrier family 15 member 1", "Tier 1", 0.603, 3, 87.0, 1, 0, null, null, null, 1, 1, "26811678", 0, "cleft palate", 0.3279926002389253], ["P13500", "CCL2", "C-C motif chemokine 2", "Tier 1", 0.6, 14, 86.94, 1, 0, null, null, null, 1, 34, "42007960,41360349,41207524,39422353,39317671,38016488,34440571,32784904,31267721,31039360,30056058,29111236,28385802,28315675,28186566,27878687,27392463,26868748,25970072,25901662,25457849,25457848,25236655,24694577,24561613,24481979,21813474,21147843,19156777,18997060,18776253,18258851,11591377,36508319", 0, "Crohn's disease", 0.44619484388731423], ["Q8NER1", "TRPV1", "Transient receptor potential cation channel subfamily V member 1", "Tier 1.5", 0.6, 8, 71.94, 1, 0, null, null, null, 1, 2, "40855286,28604222", 0, "migraine disorder", 0.6269329225883602], ["P0DSE1", "TRA", "M1-specific T cell receptor alpha chain", "Tier 1.5", 0.6, 3, 88.81, 1, 0, null, null, null, 1, 7, "41693575,41636061,39837202,37015819,28860472,25844955,19457263", 0, null, null], ["P49682", "CXCR3", "C-X-C chemokine receptor type 3", "Tier 1", 0.595, 12, 80.56, 1, 0, null, null, null, 1, 2, "27959341,15938634", 0, "neoplasm", 0.11982670035221332], ["Q9NP91", "SLC6A20", "Sodium- and chloride-dependent transporter XTRP3", "Tier 1", 0.594, 10, 93.12, 1, 0, null, null, null, 1, 1, "35212764", 0, "COVID-19", 0.5415298766216101], ["P41159", "LEP", "Leptin", "Tier 1", 0.582, 10, 81.12, 1, 0, null, null, null, 1, 14, "40330320,40008515,39263947,37331044,36508319,36173490,35884340,34016094,33650854,32527800,27530235,26529285,23232067,20594164", 0, "obesity due to congenital leptin deficiency", 0.7197450249224271], ["Q9BYF1", "ACE2", "Angiotensin-converting enzyme 2", "Tier 1", 0.58, 100, 90.69, 1, 0, null, null, null, 1, 91, "41716474,41541792,41274248,40642289,40333723,40321580,40227272,39964138,39923730,39281706,38973558,38553521,37932762,37808754,37692001,37666993,37385465,37375202,36950312,36822303,36714461,36683236,36581924,36073793,35972202,35910791,35907639,35542182,34876524,34855379,34847324,34798263,34696413,34619249,34458322,34282416,34248841,34230708,34230707,34166652,34123223,33684258,33683787,33629859,33561300,33389440,32981365,32838280,32551560,36288301,36170362,35748608,34953639", 0, "COVID-19", 0.6925739512122528], ["P55259", "GP2", "Pancreatic secretory granule membrane major glycoprotein GP2", "Tier 1.5", 0.577, 4, 78.62, 1, 0, null, null, null, 1, 3, "36902059,25483705,24334484", 0, "type 2 diabetes mellitus", 0.5235291484788168]], "truncated": false, "filtered_table_rows_count": 175, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "priority_score", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "drug_count_approved", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, priority_score, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, drug_count_approved, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_cryoEM\" = :p0 and \"has_known_aptamer\" = :p1 and \"in_cev_map\" = :p2 order by priority_score desc limit 51", "params": {"p0": "1", "p1": "1", "p2": "0"}}, "facet_results": {"tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&in_cev_map=0", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 125, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&in_cev_map=0&tier=Tier+1", "selected": false}, {"value": "Tier 1.5", "label": "Tier 1.5", "count": 50, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&in_cev_map=0&tier=Tier+1.5", "selected": false}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&in_cev_map=0", "results": [{"value": 0, "label": 0, "count": 175, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&in_cev_map=0&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&in_cev_map=0", "results": [{"value": 1, "label": 1, "count": 175, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&in_cev_map=0", "results": [{"value": 0, "label": 0, "count": 175, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&in_cev_map=0", "results": [{"value": 1, "label": 1, "count": 175, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0", "selected": true}], "truncated": false}}, "suggested_facets": [], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&in_cev_map=0&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 239.18501799926162, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}