{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_cryoEM = 1, has_known_aptamer = 1 and surface_class = \"A2_pm_peripheral\" sorted by evidence_priority descending", "rows": [["P01137", "TGFB1", "Transforming growth factor beta-1 proprotein", "Tier 1", 0.78, 1, "A2_pm_peripheral", 20, 79.56, 1, 0, null, null, 1, 4, "38132522,32370304,16775010,11856769", 1, "Camurati-Engelmann disease", 0.7995305374459716], ["Q9ULC3", "RAB23", "Ras-related protein Rab-23", "Tier 1.5", 0.776, 1, "A2_pm_peripheral", 6, 79.56, 1, 0, null, null, 1, 1, "23618401", 1, "RAB23-related Carpenter syndrome", 0.7879955689930709], ["Q92743", "HTRA1", "Serine protease HTRA1", "Tier 1", 0.768, 1, "A2_pm_peripheral", 18, 83.25, 1, 0, null, null, 1, 1, "31988066", 1, "cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2", 0.7611877816680132], ["P35221", "CTNNA1", "Catenin alpha-1", "Tier 1", 0.765, 1, "A2_pm_peripheral", 10, 82.94, 1, 0, null, null, 1, 2, "40265971", 1, "Butterfly-shaped pigment dystrophy", 0.7487735496199569], ["P84077", "ARF1", "ADP-ribosylation factor 1", "Tier 1", 0.755, 1, "A2_pm_peripheral", 36, 85.94, 1, 0, null, null, 1, 3, "30965174,11320245", 1, "periventricular nodular heterotopia 8", 0.7173626622431929], ["Q13546", "RIPK1", "Receptor-interacting serine/threonine-protein kinase 1", "Tier 1", 0.749, 1, "A2_pm_peripheral", 39, 69.75, 1, 0, null, null, 1, 2, "41290466,35919280", 1, "immunodeficiency 57", 0.698121745966467], ["P50148", "GNAQ", "Guanine nucleotide-binding protein G(q) subunit alpha", "Tier 1", 0.748, 1, "A2_pm_peripheral", 30, 93.0, 1, 0, null, null, 1, 1, "40015005", 1, "Sturge-Weber syndrome", 0.6941111530708174], ["O95786", "RIGI", "Antiviral innate immune response receptor RIG-I", "Tier 1", 0.735, 1, "A2_pm_peripheral", 44, 85.19, 1, 0, null, null, 1, 6, "34487794,33253193,32946572,31600868,26018150,22127865", 1, "Singleton-Merten dysplasia", 0.6485708110478319], ["P23921", "RRM1", "Ribonucleoside-diphosphate reductase large subunit", "Tier 1", 0.724, 1, "A2_pm_peripheral", 12, 92.25, 1, 0, null, null, 1, 1, "21955496", 1, "non-small cell lung carcinoma", 0.6122881671315019], ["P32121", "ARRB2", "Beta-arrestin-2", "Tier 1.5", 0.719, 1, "A2_pm_peripheral", 1, 83.81, 1, 0, null, null, 1, 4, "24736311,40652239,29054528", 1, "cancer", 0.5962458729823639], ["P04406", "GAPDH", "Glyceraldehyde-3-phosphate dehydrogenase", "Tier 1", 0.706, 1, "A2_pm_peripheral", 21, 98.12, 1, 0, null, null, 1, 11, "39832592,39429683,35821507,28131717,26310631,23215008,37500700,16115199", 1, "neurodegenerative disease", 0.55307368855439], ["P31948", "STIP1", "Stress-induced-phosphoprotein 1", "Tier 1.5", 0.689, 1, "A2_pm_peripheral", 8, 89.75, 1, 0, null, null, 1, 7, "41406518,38012811,34831332,32614006,27681499,24654750,24013070", 1, "neurodegenerative disease", 0.4967711525222825], ["P21980", "TGM2", "Protein-glutamine gamma-glutamyltransferase 2", "Tier 1.5", 0.688, 1, "A2_pm_peripheral", 17, 92.88, 1, 0, null, null, 1, 1, "35980938", 1, "neurodegenerative disease", 0.49455272812698803], ["P49327", "FASN", "Fatty acid synthase", "Tier 1", 0.68, 1, "A2_pm_peripheral", 34, 85.44, 1, 0, null, null, 1, 1, "41854184", 1, "dengue disease", 0.46815584653391107], ["P63098", "PPP3R1", "Calcineurin subunit B type 1", "Tier 1.5", 0.673, 1, "A2_pm_peripheral", 21, 91.12, 1, 0, null, null, 1, 2, "39263947", 1, "Abnormality of the skeletal system", 0.44389060142742937], ["P08238", "HSP90AB1", "Heat shock protein HSP 90-beta", "Tier 1", 0.661, 1, "A2_pm_peripheral", 32, 84.31, 1, 0, null, null, 1, 1, "35921069", 1, "multiple myeloma", 0.40496963397728575], ["P06702", "S100A9", "Protein S100-A9", "Tier 1", 0.651, 1, "A2_pm_peripheral", 13, 94.31, 1, 0, null, null, 1, 9, "41924874,41505229,41477217,40215752,39317671,37879125,35724603,33534888,32478041", 1, "inborn error of immunity", 0.36994943453938645], ["P15104", "GLUL", "Glutamine synthetase", "Tier 1.5", 0.622, 1, "A2_pm_peripheral", 12, 97.5, 1, 0, null, null, 1, 4, "39533430,30085248,21282981", 0, "congenital brain dysgenesis due to glutamine synthetase deficiency", 0.7733687702812198], ["P10636", "MAPT", "Microtubule-associated protein tau", "Tier 1", 0.618, 1, "A2_pm_peripheral", 100, 49.22, 1, 0, null, null, 1, 9, "40380000,39241336,38585969,38397086,37003060,31900535,30004544,29268187", 0, "Pick disease", 0.7600399335134378], ["P41159", "LEP", "Leptin", "Tier 1", 0.606, 1, "A2_pm_peripheral", 10, 81.12, 1, 0, null, null, 1, 14, "40330320,40008515,39263947,37331044,36508319,36173490,35884340,34016094,33650854,32527800,27530235,26529285,23232067,20594164", 0, "obesity due to congenital leptin deficiency", 0.7197450249224271], ["P43351", "RAD52", "DNA repair protein RAD52 homolog", "Tier 1", 0.528, 1, "A2_pm_peripheral", 11, 69.62, 1, 0, null, null, 1, 6, "37288783,32945515,31495919,26784987,24500205,23836560", 0, "Abnormality of the skeletal system", 0.45994164258033876], ["O75182", "SIN3B", "Paired amphipathic helix protein Sin3b", "Tier 1.5", 0.501, 1, "A2_pm_peripheral", 4, 68.0, 1, 0, null, null, 1, 2, "16914451", 0, "syndromic intellectual disability", 0.37050380432141355], ["P55089", "UCN", "Urocortin", "Tier 1.5", 0.469, 1, "A2_pm_peripheral", 6, 68.25, 1, 0, null, null, 1, 3, "30221506,26488412,23248006", 0, "neurodegenerative disease", 0.26311734927710556]], "truncated": false, "filtered_table_rows_count": 23, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_cryoEM\" = :p0 and \"has_known_aptamer\" = :p1 and \"surface_class\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "1", "p1": "1", "p2": "A2_pm_peripheral"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=A2_pm_peripheral", "results": [{"value": 1, "label": 1, "count": 23, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=A2_pm_peripheral&has_structure=1", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=A2_pm_peripheral", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 15, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=A2_pm_peripheral&tier=Tier+1", "selected": false}, {"value": "Tier 1.5", "label": "Tier 1.5", "count": 8, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=A2_pm_peripheral&tier=Tier+1.5", "selected": false}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=A2_pm_peripheral", "results": [{"value": 0, "label": 0, "count": 23, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=A2_pm_peripheral&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=A2_pm_peripheral", "results": [{"value": 1, "label": 1, "count": 23, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A2_pm_peripheral", "selected": true}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=A2_pm_peripheral", "results": [{"value": "A2_pm_peripheral", "label": "A2_pm_peripheral", "count": 23, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=A2_pm_peripheral", "results": [{"value": 1, "label": 1, "count": 17, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=A2_pm_peripheral&in_cev_map=1", "selected": false}, {"value": 0, "label": 0, "count": 6, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=A2_pm_peripheral&in_cev_map=0", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=A2_pm_peripheral", "results": [{"value": 1, "label": 1, "count": 23, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A2_pm_peripheral", "selected": true}], "truncated": false}}, "suggested_facets": [{"name": "pdb_count_total", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=A2_pm_peripheral&_facet=pdb_count_total"}, {"name": "alphafold_mean_pLDDT", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=A2_pm_peripheral&_facet=alphafold_mean_pLDDT"}, {"name": "aptamer_count_pubmed", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=A2_pm_peripheral&_facet=aptamer_count_pubmed"}, {"name": "opentargets_top_disease_name", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=A2_pm_peripheral&_facet=opentargets_top_disease_name"}], "next": null, "next_url": null, "private": false, "allow_execute_sql": true, "query_ms": 1081.757543142885, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}