{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_cryoEM = 1, has_known_aptamer = 1 and surface_class = \"A_surface\" sorted by evidence_priority descending", "rows": [["P21359", "NF1", "Neurofibromin", "Tier 1.5", 0.965, 1, "A_surface", 26, 87.19, 1, 0, null, null, 1, 2, "32980430,22617876", 1, "neurofibromatosis type 1", 0.8844735398780649], ["P04839", "CYBB", "NADPH oxidase 2", "Tier 1", 0.959, 1, "A_surface", 6, 90.25, 1, 0, null, null, 1, 2, "24635113", 1, "chronic granulomatous disease", 0.8633132852459866], ["P29965", "CD40LG", "CD40 ligand", "Tier 1", 0.954, 1, "A_surface", 8, 82.62, 1, 0, null, null, 1, 6, "37331977,36203210,26504624", 1, "hyper-IgM syndrome type 1", 0.8451678829647167], ["P37173", "TGFBR2", "TGF-beta receptor type-2", "Tier 1", 0.952, 1, "A_surface", 22, 81.0, 1, 0, null, null, 1, 8, "32452828,30595527,29522674,29375127,26284552,23999222,22899759,11856769", 1, "Loeys-Dietz syndrome", 0.8390072008866913], ["P19438", "TNFRSF1A", "Tumor necrosis factor receptor superfamily member 1A", "Tier 1", 0.951, 1, "A_surface", 13, 71.38, 1, 0, null, null, 1, 1, "35197258", 1, "TNF receptor 1-associated periodic fever syndrome", 0.8352778213184682], ["P06744", "GPI", "Glucose-6-phosphate isomerase", "Tier 1", 0.949, 1, "A_surface", 13, 97.94, 1, 0, null, null, 1, 19, "41911185,41329468,41232387,35821507,34953205,32730952,29501157,27419372,25919296,25483705,24334484,23656757,23578283,23018995,22116094,20967861,17574575,27380815", 1, "hemolytic anemia due to glucophosphate isomerase deficiency", 0.8306909118751346], ["P36897", "TGFBR1", "TGF-beta receptor type-1", "Tier 1", 0.948, 1, "A_surface", 44, 84.19, 1, 0, null, null, 1, 1, "41089000", 1, "Loeys-Dietz syndrome 1", 0.8275292516338373], ["P22607", "FGFR3", "Fibroblast growth factor receptor 3", "Tier 1", 0.948, 1, "A_surface", 13, 74.19, 1, 0, null, null, 1, 6, "38569854,37704353,34864168,33952673,31357131", 1, "achondroplasia", 0.8270702096931246], ["P04156", "PRNP", "Major prion protein", "Tier 1", 0.947, 1, "A_surface", 70, 64.19, 1, 0, null, null, 1, 2, "39556313,34067472", 1, "Gerstmann-Straussler-Scheinker syndrome", 0.8246149684620239], ["P05106", "ITGB3", "Integrin beta-3", "Positive Control", 0.946, 1, "A_surface", 123, 87.0, 1, 1, "8T2U", "8T2V", 1, 2, "22133781,23544955", 1, "Glanzmann thrombasthenia 1", 0.8208115968652424], ["P08069", "IGF1R", "Insulin-like growth factor 1 receptor", "Tier 1", 0.945, 1, "A_surface", 46, 78.0, 1, 0, null, null, 1, 10, "40997970,39263947,33410883,30041514,23373648,16019422,15231297", 1, "growth delay due to insulin-like growth factor I resistance", 0.8166352227841136], ["P16234", "PDGFRA", "Platelet-derived growth factor receptor alpha", "Tier 1.5", 0.945, 1, "A_surface", 14, 72.69, 1, 0, null, null, 1, 4, "33334063,32127469,28010895,30594071", 1, "gastrointestinal stromal tumor", 0.8167494524079806], ["Q13563", "PKD2", "Polycystin-2", "Tier 1", 0.943, 1, "A_surface", 31, 70.12, 1, 0, null, null, 1, 3, "41315228,36126144", 1, "polycystic kidney disease 2", 0.810960823768978], ["P58335", "ANTXR2", "Anthrax toxin receptor 2", "Tier 1", 0.941, 1, "A_surface", 14, 71.81, 1, 0, null, null, 1, 4, "41503480,41083485,41020397,40313273", 1, "hyaline fibromatosis syndrome", 0.8028849863986661], ["P61073", "CXCR4", "C-X-C chemokine receptor type 4", "Tier 1", 0.94, 1, "A_surface", 33, 82.25, 1, 0, null, null, 1, 17, "40671676,40401615,39865939,39778270,37052638,35157940,33739080,31737891,31267721,31097627,28670693,26265085,25329893,22811524,22376154,12498773,41543187", 1, "WHIM syndrome", 0.8009225456235435], ["P15529", "CD46", "Membrane cofactor protein", "Tier 1.5", 0.934, 1, "A_surface", 7, 82.12, 1, 0, null, null, 1, 9, "35114109,34248841,31761039,31077760,27734375,19915929,17046833,11084032", 1, "atypical hemolytic-uremic syndrome with MCP/CD46 anomaly", 0.7798469882597787], ["P13987", "CD59", "CD59 glycoprotein", "Tier 1", 0.932, 1, "A_surface", 17, 79.31, 1, 0, null, null, 1, 1, "19915929", 1, "primary CD59 deficiency", 0.7738276843579196], ["P02511", "CRYAB", "Alpha-crystallin B chain", "Tier 1", 0.925, 1, "A_surface", 21, 75.75, 1, 0, null, null, 1, 2, "28720498,23530262", 1, "myofibrillar myopathy 2", 0.7505030087389963], ["Q14432", "PDE3A", "cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A", "Tier 1", 0.924, 1, "A_surface", 9, 60.25, 1, 0, null, null, 1, 1, "34456709", 1, "Brachydactyly - arterial hypertension", 0.7468849549430213], ["P25445", "FAS", "Tumor necrosis factor receptor superfamily member 6", "Tier 1.5", 0.921, 1, "A_surface", 7, 77.88, 1, 0, null, null, 1, 17, "40784034,39897575,37458448,36908619,35402075,32270033,31436946,30594071,30417194,30339905,26318819,23980164,23511245,18997060,18956014,16729304,16581027", 1, "autoimmune lymphoproliferative syndrome type 1", 0.7377210386590284], ["P07204", "THBD", "Thrombomodulin", "Tier 1", 0.92, 1, "A_surface", 13, 78.62, 1, 0, null, null, 1, 5, "41988704,34708097,28549218,21526769,7622501", 1, "thrombomodulin-related bleeding disorder", 0.7323266135403641], ["Q9H244", "P2RY12", "P2Y purinoceptor 12", "Tier 1", 0.919, 1, "A_surface", 5, 84.44, 1, 0, null, null, 1, 2, "32679592,19509485", 1, "platelet-type bleeding disorder 8", 0.7304079345653686], ["P08575", "PTPRC", "Receptor-type tyrosine-protein phosphatase C", "Tier 1", 0.916, 1, "A_surface", 6, 76.06, 1, 0, null, null, 1, 1, "25251012", 1, "immunodeficiency 104", 0.7200430416648742], ["Q9UNQ0", "ABCG2", "Broad substrate specificity ATP-binding cassette transporter ABCG2", "Tier 1", 0.915, 1, "A_surface", 29, 85.25, 1, 0, null, null, 1, 8, "40873307,36807620,35544739,33833512,31180052,31085078,26176230,24319544", 1, "gout", 0.7158028003520317], ["P13612", "ITGA4", "Integrin alpha-4", "Tier 1", 0.914, 1, "A_surface", 7, 84.44, 1, 0, null, null, 1, 3, "30065768,28670693,26504766", 1, "Crohn's disease", 0.7134551179424343], ["O75581", "LRP6", "Low-density lipoprotein receptor-related protein 6", "Tier 1", 0.911, 1, "A_surface", 27, 79.19, 1, 0, null, null, 1, 5, "42031715,37175248,18673242", 1, "tooth agenesis, selective, 7", 0.7022725510765017], ["P40189", "IL6ST", "Interleukin-6 receptor subunit beta", "Tier 1", 0.911, 1, "A_surface", 20, 74.62, 1, 0, null, null, 1, 2, "39571081,22258147", 1, "Autosomal recessive hyper-IgE syndrome", 0.7027634038262931], ["Q15303", "ERBB4", "Receptor tyrosine-protein kinase erbB-4", "Tier 1", 0.903, 1, "A_surface", 14, 73.12, 1, 0, null, null, 1, 3, "32592467,30697465,23990977", 1, "non-small cell lung carcinoma", 0.6754899662390331], ["O15455", "TLR3", "Toll-like receptor 3", "Tier 1", 0.899, 1, "A_surface", 20, 90.62, 1, 0, null, null, 1, 7, "26018150,25528762,17150912,17150911", 1, "Herpetic encephalitis", 0.6617401048830444], ["P07550", "ADRB2", "Beta-2 adrenergic receptor", "Tier 1", 0.89, 1, "A_surface", 100, 79.12, 1, 0, null, null, 1, 2, "41637639,32376022", 1, "asthma", 0.634300392456126], ["P11836", "MS4A1", "B-lymphocyte antigen CD20", "Tier 1", 0.888, 1, "A_surface", 10, 70.5, 1, 0, null, null, 1, 2, "39865939,29561802", 1, "chronic lymphocytic leukemia", 0.6275806230802832], ["P02786", "TFRC", "Transferrin receptor protein 1", "Tier 1.5", 0.887, 1, "A_surface", 22, 86.69, 1, 0, null, null, 1, 3, "39831311,29046922,32527800", 1, "TFRC-related combined immunodeficiency", 0.623449899069336], ["P01133", "EGF", "Pro-epidermal growth factor", "Tier 1", 0.886, 1, "A_surface", 13, 70.31, 1, 0, null, null, 1, 34, "41906877,41873087,41693575,39408993,38904251,38837175,37423441,35213974,34893239,32511241,32200913,31990606,31004648,30809312,36132464,28842588,28029038,27301192,26504624,25450403,25261371,24777583,23531534,23104156,21999227,21687663,21576228,19420593,19063705,20641927,15037656,13680379,12842895,12173045", 1, "cancer", 0.6205045573389423], ["P60033", "CD81", "CD81 antigen", "Tier 1", 0.885, 1, "A_surface", 16, 87.38, 1, 0, null, null, 1, 5, "34505435,32730952,28959386,23877701,19997645", 1, "immunodeficiency, common variable, 6", 0.6168240011812034], ["P51679", "CCR4", "C-C chemokine receptor type 4", "Tier 1", 0.862, 1, "A_surface", 7, 80.75, 1, 0, null, null, 1, 3, "41518674,39071952,29103909", 1, "mycosis fungoides", 0.5404546856597274], ["P05362", "ICAM1", "Intercellular adhesion molecule 1", "Tier 1", 0.859, 1, "A_surface", 14, 88.44, 1, 0, null, null, 1, 43, "41699153,40650261,40539828,40329889,39154820,37052638,36508319,35312740,35212764,34038704,32884147,32784904,30697465,30617526,28631505,27132231,25582325,25368913,21147843,20665479,12714656,11320245,10097084,9740353,9200462,8932275", 1, "neurodegenerative disease", 0.5292405353144124], ["Q9NNX6", "CD209", "CD209 antigen", "Tier 1", 0.858, 1, "A_surface", 14, 71.44, 1, 0, null, null, 1, 1, "37017594", 1, "dengue disease", 0.5252368050139995], ["O95858", "TSPAN15", "Tetraspanin-15", "Tier 1", 0.855, 1, "A_surface", 3, 87.56, 1, 0, null, null, 1, 1, "37047289", 1, "venous thromboembolism", 0.5182425801223098], ["P11717", "IGF2R", "Cation-independent mannose-6-phosphate receptor", "Tier 1", 0.853, 1, "A_surface", 24, 73.12, 1, 0, null, null, 1, 5, "40554308,39225423,38059276,36126144,32040773", 1, "coronary artery disease", 0.511249370339317], ["P15144", "ANPEP", "Aminopeptidase N", "Tier 1", 0.851, 1, "A_surface", 15, 93.06, 1, 0, null, null, 1, 1, "33554306", 1, "cholelithiasis", 0.5030146927270738], ["Q03405", "PLAUR", "Urokinase plasminogen activator surface receptor", "Tier 1", 0.845, 1, "A_surface", 13, 81.44, 1, 0, null, null, 1, 2, "37533140", 1, "Abdominal Aortic Aneurysm", 0.4819526979346149], ["Q07108", "CD69", "Early activation antigen CD69", "Tier 1", 0.844, 1, "A_surface", 6, 82.12, 1, 0, null, null, 1, 5, "40448637,39048513,37110712,32401486,16331266", 1, "hypothyroidism", 0.48068618377072814], ["Q92633", "LPAR1", "Lysophosphatidic acid receptor 1", "Tier 1.5", 0.843, 1, "A_surface", 16, 83.62, 1, 0, null, null, 1, 1, "32065590", 1, "Epiretinal membrane", 0.4757255248053499], ["P08174", "CD55", "Complement decay-accelerating factor", "Tier 1", 0.84, 1, "A_surface", 33, 78.25, 1, 0, null, null, 1, 3, "33398182,19915929,37566081", 1, "Protein-losing enteropathy", 0.46728275901717004], ["P01871", "IGHM", "Immunoglobulin heavy constant mu", "Tier 1", 0.839, 1, "A_surface", 30, 85.44, 1, 0, null, null, 1, 3, "33981223,16825284", 1, "agammaglobulinemia", 0.4624778576025314], ["O75084", "FZD7", "Frizzled-7", "Tier 1", 0.837, 1, "A_surface", 13, 83.19, 1, 0, null, null, 1, 2, "18673242,22363130", 1, "Abnormality of the skeletal system", 0.45589181219776254], ["P01833", "PIGR", "Polymeric immunoglobulin receptor", "Tier 1", 0.833, 1, "A_surface", 16, 76.69, 1, 0, null, null, 1, 2, "31640794,29277631", 1, "clear cell renal carcinoma", 0.44260204134234277], ["O60462", "NRP2", "Neuropilin-2", "Tier 1", 0.825, 1, "A_surface", 16, 78.62, 1, 0, null, null, 1, 2, "41915779", 1, "esophageal disease", 0.41662112843122434], ["P13569", "CFTR", "Cystic fibrosis transmembrane conductance regulator", "Tier 1", 0.824, 1, "A_surface", 58, 75.62, 1, 0, null, null, 1, 10, "41148207,31029337,30595527,22483890,15657417", 0, "cystic fibrosis", 0.9133535862571094], ["P02724", "GYPA", "Glycophorin-A", "Tier 1", 0.813, 1, "A_surface", 16, 59.41, 1, 0, null, null, 1, 1, "40599565", 1, "malaria", 0.37656968762740295]], "truncated": false, "filtered_table_rows_count": 120, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_cryoEM\" = :p0 and \"has_known_aptamer\" = :p1 and \"surface_class\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "1", "p1": "1", "p2": "A_surface"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=A_surface", "results": [{"value": 1, "label": 1, "count": 120, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=A_surface&has_structure=1", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=A_surface", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 87, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=A_surface&tier=Tier+1", "selected": false}, {"value": "Tier 1.5", "label": "Tier 1.5", "count": 32, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=A_surface&tier=Tier+1.5", "selected": false}, {"value": "Positive Control", "label": "Positive Control", "count": 1, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=A_surface&tier=Positive+Control", "selected": false}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=A_surface", "results": [{"value": 0, "label": 0, "count": 119, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=A_surface&has_activation_state_pdb_pair=0", "selected": false}, {"value": 1, "label": 1, "count": 1, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=A_surface&has_activation_state_pdb_pair=1", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=A_surface", "results": [{"value": 1, "label": 1, "count": 120, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A_surface", "selected": true}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=A_surface", "results": [{"value": "A_surface", "label": "A_surface", "count": 120, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=A_surface", "results": [{"value": 0, "label": 0, "count": 60, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=A_surface&in_cev_map=0", "selected": false}, {"value": 1, "label": 1, "count": 60, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=A_surface&in_cev_map=1", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=A_surface", "results": [{"value": 1, "label": 1, "count": 120, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface", "selected": true}], "truncated": false}}, "suggested_facets": [{"name": "aptamer_count_pubmed", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=A_surface&_facet=aptamer_count_pubmed"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=A_surface&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 644.789831712842, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}