{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_cryoEM = 1, has_known_aptamer = 1 and surface_class = \"B_cargo\" sorted by evidence_priority descending", "rows": [["P35520", "CBS", "Cystathionine beta-synthase", "Tier 1", 0.76, 1, "B_cargo", 19, 90.06, 1, 0, null, null, 1, 6, "41780400,40454747,39984441,39541715,30792407,8650546", 1, "classic homocystinuria", 0.8675045223052872], ["P02545", "LMNA", "Prelamin-A/C", "Tier 1", 0.758, 1, "B_cargo", 27, 76.38, 1, 0, null, null, 1, 1, "37565451", 1, "dilated cardiomyopathy", 0.8593312064339074], ["P05165", "PCCA", "Propionyl-CoA carboxylase alpha chain, mitochondrial", "Tier 1.5", 0.756, 1, "B_cargo", 25, 87.44, 1, 0, null, null, 1, 1, "36578103", 1, "propionic acidemia", 0.8530542602972598], ["P11413", "G6PD", "Glucose-6-phosphate 1-dehydrogenase", "Tier 1", 0.755, 1, "B_cargo", 25, 94.38, 1, 0, null, null, 1, 3, "41935727,20811084", 1, "anemia, nonspherocytic hemolytic, due to G6PD deficiency", 0.8516109113701843], ["P26440", "IVD", "Isovaleryl-CoA dehydrogenase, mitochondrial", "Tier 1.5", 0.754, 1, "B_cargo", 5, 93.38, 1, 0, null, null, 1, 2, "41230502,26946282", 1, "isovaleric acidemia", 0.8480603595890895], ["Q15465", "SHH", "Sonic hedgehog protein", "Tier 1", 0.753, 1, "B_cargo", 20, 78.38, 1, 0, null, null, 1, 4, "33257185,32867229,18698484,38462144", 1, "holoprosencephaly 3", 0.8433062137163501], ["P55265", "ADAR", "Double-stranded RNA-specific adenosine deaminase", "Tier 1", 0.752, 1, "B_cargo", 24, 68.38, 1, 0, null, null, 1, 8, "41910181,41791686,41772759,41497668,41267360,39673485,38583236,17000903", 1, "Aicardi-Goutieres syndrome 6", 0.8388797454328872], ["P19429", "TNNI3", "Troponin I, cardiac muscle", "Tier 1", 0.75, 1, "B_cargo", 39, 78.62, 1, 0, null, null, 1, 1, "26594036", 1, "hypertrophic cardiomyopathy", 0.8340329164680969], ["Q99714", "HSD17B10", "3-hydroxyacyl-CoA dehydrogenase type-2", "Tier 1", 0.749, 1, "B_cargo", 15, 96.88, 1, 0, null, null, 1, 1, "17917077", 1, "HSD10 mitochondrial disease", 0.828877258137219], ["P42345", "MTOR", "Serine/threonine-protein kinase mTOR", "Tier 1", 0.749, 1, "B_cargo", 70, 78.0, 1, 0, null, null, 1, 27, "41951939,41924451,41819327,41563473,40316188,39728786,37574619,35356877,34638443,34362425,33319976,33124760,32521684,32245065,32170897,31840081,33455222,28945233,28471660,25751060,25057446,24292708,24242861,22363130,22239618,19878313,17495522", 1, "Macrocephaly-intellectual disability-neurodevelopmental disorder-small thorax syndrome", 0.8296449565554538], ["Q99707", "MTR", "Methionine synthase", "Tier 1", 0.748, 1, "B_cargo", 9, 87.5, 1, 0, null, null, 1, 1, "25964329", 1, "methylcobalamin deficiency type cblG", 0.8253271986114175], ["Q9Y3A5", "SBDS", "Ribosome maturation protein SBDS", "Tier 1", 0.748, 1, "B_cargo", 6, 74.06, 1, 0, null, null, 1, 1, "19454024", 1, "Shwachman-Diamond syndrome", 0.8282172244212194], ["P55157", "MTTP", "Microsomal triglyceride transfer protein large subunit", "Tier 1.5", 0.748, 1, "B_cargo", 2, 86.56, 1, 0, null, null, 1, 1, "23770039", 1, "abetalipoproteinemia", 0.8281089516017405], ["Q53H12", "AGK", "Acylglycerol kinase, mitochondrial", "Tier 1.5", 0.747, 1, "B_cargo", 1, 87.0, 1, 0, null, null, 1, 1, "35763566", 1, "Sengers syndrome", 0.8231275438888749], ["P11498", "PC", "Pyruvate carboxylase, mitochondrial", "Tier 1", 0.746, 1, "B_cargo", 10, 90.38, 1, 0, null, null, 1, 607, "42025735,42015877,41963040,41956254,41946336,41942404,41940259,41852458,41850902,41813080,41806728,41801682,41791686,41786503,41742365,41713118,41686726,41679186,41671824,41621292,41586771,41570502,41545126,41519040,41453347,41447218,41444487,41422636,41401493,41328792,41294729,41275818,41275550,41268823,41207524,41167900,41155928,41149351,41135241,41103270,41061457,41030495,41002305,40992058,40978513,40974925,40968085,40952515,40942102,40936186", 1, "pyruvate carboxylase deficiency disease", 0.8195584644258792], ["Q13148", "TARDBP", "TAR DNA-binding protein 43", "Tier 1", 0.746, 1, "B_cargo", 44, 65.19, 1, 0, null, null, 1, 7, "39548508,34469713,26915990,37671010,35739092,23264567", 1, "amyotrophic lateral sclerosis", 0.8196962822149189], ["P46531", "NOTCH1", "Neurogenic locus notch homolog protein 1", "Tier 1", 0.746, 1, "B_cargo", 29, 59.59, 1, 0, null, null, 1, 4, "38559166,34431568,33614227,28685750", 1, "Adams-Oliver syndrome", 0.8199672000988557], ["P60709", "ACTB", "Actin, cytoplasmic 1", "Negative Control", 0.745, 1, "B_cargo", 30, 95.19, 1, 0, null, null, 1, 3, "40413753,38783134,34598060", 1, "Baraitser-Winter syndrome 1", 0.8169087711684756], ["P26358", "DNMT1", "DNA (cytosine-5)-methyltransferase 1", "Tier 1", 0.744, 1, "B_cargo", 27, 77.81, 1, 0, null, null, 1, 12, "41635784,39079576,38762976,36609400,31733056,29554483,23179556", 1, "autosomal dominant cerebellar ataxia, deafness and narcolepsy", 0.8134195803175972], ["P35637", "FUS", "RNA-binding protein FUS", "Tier 1", 0.744, 1, "B_cargo", 23, 53.59, 1, 0, null, null, 1, 8, "40394046,35592098,28701145,15132764,12927206", 1, "sporadic amyotrophic lateral sclerosis", 0.8117088043931799], ["P42224", "STAT1", "Signal transducer and activator of transcription 1-alpha/beta", "Tier 1.5", 0.744, 1, "B_cargo", 10, 87.25, 1, 0, null, null, 1, 5, "41290466,38569854,31879964,31702021,21433395", 1, "Chronic mucocutaneous candidosis", 0.8147374964880533], ["P07602", "PSAP", "Prosaposin", "Tier 1", 0.743, 1, "B_cargo", 20, 73.75, 1, 0, null, null, 1, 1, "41889102", 1, "Gaucher disease due to saposin C deficiency", 0.8100495894070405], ["Q13501", "SQSTM1", "Sequestosome-1", "Tier 1", 0.743, 1, "B_cargo", 26, 67.25, 1, 0, null, null, 1, 4, "40413753,32225060", 1, "amyotrophic lateral sclerosis", 0.809360678421687], ["Q9UHD2", "TBK1", "Serine/threonine-protein kinase TBK1", "Tier 1", 0.742, 1, "B_cargo", 25, 89.69, 1, 0, null, null, 1, 1, "40413753", 1, "frontotemporal dementia and/or amyotrophic lateral sclerosis 4", 0.8079405505675022], ["P55072", "VCP", "Transitional endoplasmic reticulum ATPase", "Tier 1", 0.741, 1, "B_cargo", 100, 82.56, 1, 0, null, null, 1, 1, "40972397", 1, "inclusion body myopathy with Paget disease of bone and frontotemporal dementia type 1", 0.8028131613498347], ["P05067", "APP", "Amyloid-beta precursor protein", "Tier 1", 0.741, 1, "B_cargo", 100, 67.38, 1, 0, null, null, 1, 63, "40845665,40781183,40398131,40392609,40168709,39916963,39815389,39609809,39558155,39462761,39293375,39224911,38895620,38476032,38397086,38256230,38101030,37791572,37770666,37504144,36963325,36709587,36651835,36149663,35910789,35762921,35546375,35215961,34832326,34696413,34282416,33756331,33657486,33334063,33104885,32905362,32339154,31641824,31606675,31560515,31513457,31259533,31192585,30959405,30715838,29193172,28965053,28054670,27834794,26476448", 1, "Alzheimer disease", 0.8042536996738855], ["P43007", "SLC1A4", "Neutral amino acid transporter A", "Tier 1.5", 0.741, 1, "B_cargo", 1, 80.56, 1, 0, null, null, 1, 6, "36219068,31989939,27571928,26811678,19046328,16139842", 1, "spastic tetraplegia-thin corpus callosum-progressive postnatal microcephaly syndrome", 0.8025684205131692], ["P37840", "SNCA", "Alpha-synuclein", "Tier 1", 0.74, 1, "B_cargo", 100, 75.19, 1, 0, null, null, 1, 62, "40140103,38917326,38397086,38256230,37586882,36403906,35164441,33079553,31627816,26096948,41212423,40914014,40602043,40489035,40337966,39777233,39377064,38728058,37956285,37821404,37782556,37534999,37506391,37433867,37160866,37037631,36774388,36348612,36339626,35994742,35861142,35581077,35500203,34410317,33934227,33889925,35019576,32349285,32292959,32129373,31900535,31886023,31825201,31437653,31207024,30278340,30051958,29858057,29700982,29104136,23264567", 1, "Hereditary late-onset Parkinson disease", 0.8010568055473846], ["P43694", "GATA4", "Transcription factor GATA-4", "Tier 1", 0.739, 1, "B_cargo", 3, 57.22, 1, 0, null, null, 1, 1, "37762684", 1, "atrial septal defect 2", 0.7972225107836246], ["P02792", "FTL", "Ferritin light chain", "Tier 1", 0.738, 1, "B_cargo", 16, 96.69, 1, 0, null, null, 1, 1, "37563071", 1, "hereditary hyperferritinemia with congenital cataracts", 0.7935576882994914], ["P10515", "DLAT", "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial", "Tier 1", 0.738, 1, "B_cargo", 13, 72.0, 1, 0, null, null, 1, 1, "41255424", 1, "pyruvate dehydrogenase E2 deficiency", 0.7949601730853583], ["P98155", "VLDLR", "Very low-density lipoprotein receptor", "Tier 1.5", 0.737, 1, "B_cargo", 27, 75.69, 1, 0, null, null, 1, 1, "19188685", 1, "Dysequilibrium syndrome", 0.790164037509625], ["Q08209", "PPP3CA", "Protein phosphatase 3 catalytic subunit alpha", "Tier 1", 0.735, 1, "B_cargo", 21, 85.5, 1, 0, null, null, 1, 1, "23579184", 1, "developmental and epileptic encephalopathy 91", 0.7846168061843352], ["Q9NP81", "SARS2", "Serine--tRNA ligase, mitochondrial", "Tier 1", 0.734, 1, "B_cargo", 6, 90.5, 1, 0, null, null, 1, 438, "41873762,41851736,41791686,41775871,41686152,41680122,41674662,41652223,41651417,41576434,41541792,41541267,41517950,41501248,41498844,41430764,41413958,41352973,41303663,41274248,41272150,41265758,41245639,41228803,41210733,41191496,41157905,41112192,41092787,41078774,41053637,41043050,41002345,40974925,40959948,40935807,40693866,40642289,40586934,40563445,40547623,40522066,40516427,40512469,40481269,40333723,40321580,40292706,40289185,40227272", 1, "hyperuricemia-pulmonary hypertension-renal failure-alkalosis syndrome", 0.7805632256445381], ["Q15813", "TBCE", "Tubulin-specific chaperone E", "Tier 1.5", 0.732, 1, "B_cargo", 6, 89.19, 1, 0, null, null, 1, 1, "34448574", 1, "hypoparathyroidism-retardation-dysmorphism syndrome", 0.7744447925917005], ["Q7RTN6", "STRADA", "STE20-related kinase adapter protein alpha", "Tier 1", 0.728, 1, "B_cargo", 4, 80.0, 1, 0, null, null, 1, 7, "37175549,35456960,33676711,31862491,31822733,26264345,25636022", 1, "polyhydramnios, megalencephaly, and symptomatic epilepsy", 0.7604002763758355], ["Q13043", "STK4", "Serine/threonine-protein kinase 4", "Tier 1.5", 0.728, 1, "B_cargo", 16, 75.94, 1, 0, null, null, 1, 1, "31707227", 1, "combined immunodeficiency due to STK4 deficiency", 0.7613382040802787], ["P61011", "SRP54", "Signal recognition particle subunit SRP54", "Tier 1", 0.727, 1, "B_cargo", 9, 79.25, 1, 0, null, null, 1, 1, "40172085", 1, "neutropenia, severe congenital, 8, autosomal dominant", 0.7555049061942504], ["P29992", "GNA11", "Guanine nucleotide-binding protein subunit alpha-11", "Tier 1", 0.726, 1, "B_cargo", 13, 92.94, 1, 0, null, null, 1, 1, "40015005", 1, "Familial isolated hypoparathyroidism", 0.752195363550312], ["P49257", "LMAN1", "Protein ERGIC-53", "Tier 1", 0.723, 1, "B_cargo", 18, 79.38, 1, 0, null, null, 1, 1, "12604659", 1, "factor V and factor VIII, combined deficiency of, type 1", 0.7437604514578838], ["P07237", "P4HB", "Protein disulfide-isomerase", "Tier 1.5", 0.723, 1, "B_cargo", 14, 88.5, 1, 0, null, null, 1, 2, "31625090,28952381", 1, "Cole-Carpenter syndrome", 0.7447295842045853], ["Q86WV6", "STING1", "Stimulator of interferon genes protein", "Tier 1", 0.722, 1, "B_cargo", 100, 83.75, 1, 0, null, null, 1, 10, "41781380,41742243,41657042,41543229,41125194,40476560,40413753,39922441,39586211,38898748", 1, "STING-associated vasculopathy with onset in infancy", 0.740865633793155], ["Q9H6X2", "ANTXR1", "Anthrax toxin receptor 1", "Tier 1", 0.719, 1, "B_cargo", 5, 72.44, 1, 0, null, null, 1, 2, "25841381,38045440", 1, "GAPO syndrome", 0.7284229063774266], ["P01344", "IGF2", "Insulin-like growth factor 2", "Tier 1", 0.719, 1, "B_cargo", 16, 59.03, 1, 0, null, null, 1, 13, "38059276,33977395,33467925,31570709,28281528,23373648,19391177,40554308,39225423,32040773", 1, "Silver-Russell syndrome", 0.7290427440273365], ["P78527", "PRKDC", "DNA-dependent protein kinase catalytic subunit", "Tier 1", 0.718, 1, "B_cargo", 48, null, 1, 0, null, null, 1, 3, "36494579,21555850,9477961", 1, "severe combined immunodeficiency due to DNA-PKcs deficiency", 0.7274518381609374], ["P04040", "CAT", "Catalase", "Tier 1", 0.716, 1, "B_cargo", 17, 95.81, 1, 0, null, null, 1, 123, "41862624,41406692,40921876,40449637,40373412,40245514,40135680,39736206,39617230,39494521,39216635,38968658,38830056,38257841,38006953,37944280,37921634,37572292,37457170,37263189,36988581,36963555,36852949,36290911,36202193,36083615,35133042,35037525,35029036,34740116,34597992,33716125,32676707,31750459,31635027,31129134,31125817,31089784,30908871,30172319,29863725,29373502,28499498,27766362,27669644,26920780,26707270,26615953,26552825,26515644,41981590,40916920,40876379,40823979,40136939,39871473,39116770,38951214,38692792,38678841,38479142,38466144,38269029,37277963,37058901,37057846,37003060,36716668,36109814,35338966,34976356,34490870,34403860,33725073,33671292,33369762,32937727,32161750,30900705,30303384,29969227,29562606,28689078,24913871,24813911,24275801,23669044,22965726,22411871", 1, "acatalasia", 0.7191143125221583], ["Q9NPE3", "NOP10", "H/ACA ribonucleoprotein complex subunit 3", "Tier 1", 0.716, 1, "B_cargo", 7, 94.5, 1, 0, null, null, 1, 1, "21893585", 1, "dyskeratosis congenita, autosomal recessive 1", 0.7184232895097743], ["P11802", "CDK4", "Cyclin-dependent kinase 4", "Tier 1", 0.714, 1, "B_cargo", 15, 86.81, 1, 1, "2W96", "3G33", 1, 2, "41535871,21059336", 1, "melanoma, cutaneous malignant, susceptibility to, 3", 0.7141203476842687], ["Q96SW2", "CRBN", "Protein cereblon", "Tier 1", 0.712, 1, "B_cargo", 90, 86.62, 1, 0, null, null, 1, 1, "38131089", 1, "multiple myeloma", 0.7061408884959351], ["Q13158", "FADD", "FAS-associated death domain protein", "Tier 1.5", 0.708, 1, "B_cargo", 18, 72.12, 1, 0, null, null, 1, 3, "36309655,30594071,26318819", 1, "FADD-related immunodeficiency", 0.6932338529214827]], "truncated": false, "filtered_table_rows_count": 202, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_cryoEM\" = :p0 and \"has_known_aptamer\" = :p1 and \"surface_class\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "1", "p1": "1", "p2": "B_cargo"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=B_cargo", "results": [{"value": 1, "label": 1, "count": 202, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=B_cargo&has_structure=1", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=B_cargo", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 160, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=B_cargo&tier=Tier+1", "selected": false}, {"value": "Tier 1.5", "label": "Tier 1.5", "count": 41, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=B_cargo&tier=Tier+1.5", "selected": false}, {"value": "Negative Control", "label": "Negative Control", "count": 1, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=B_cargo&tier=Negative+Control", "selected": false}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=B_cargo", "results": [{"value": 0, "label": 0, "count": 201, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=B_cargo&has_activation_state_pdb_pair=0", "selected": false}, {"value": 1, "label": 1, "count": 1, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=B_cargo&has_activation_state_pdb_pair=1", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=B_cargo", "results": [{"value": 1, "label": 1, "count": 202, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=B_cargo", "selected": true}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=B_cargo", "results": [{"value": "B_cargo", "label": "B_cargo", "count": 202, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=B_cargo", "results": [{"value": 1, "label": 1, "count": 135, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=B_cargo&in_cev_map=1", "selected": false}, {"value": 0, "label": 0, "count": 67, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=B_cargo&in_cev_map=0", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=B_cargo", "results": [{"value": 1, "label": 1, "count": 202, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=B_cargo", "selected": true}], "truncated": false}}, "suggested_facets": [{"name": "aptamer_count_pubmed", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=B_cargo&_facet=aptamer_count_pubmed"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&surface_class=B_cargo&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 1423.2871257700026, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}