{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_cryoEM = 1, has_known_aptamer = 1 and tier = \"Tier 1.5\" sorted by priority_score descending", "rows": [["P25445", "FAS", "Tumor necrosis factor receptor superfamily member 6", "Tier 1.5", 0.914, 7, 77.88, 1, 0, null, null, null, 1, 17, "40784034,39897575,37458448,36908619,35402075,32270033,31436946,30594071,30417194,30339905,26318819,23980164,23511245,18997060,18956014,16729304,16581027", 1, "autoimmune lymphoproliferative syndrome type 1", 0.7377210386590284], ["P21583", "KITLG", "Kit ligand", "Tier 1.5", 0.848, 6, 71.88, 1, 0, null, null, null, 1, 2, "36579647,23967247", 0, "hyperpigmentation with or without hypopigmentation, familial progressive", 0.6756727302967072], ["Q00975", "CACNA1B", "Voltage-dependent N-type calcium channel subunit alpha-1B", "Tier 1.5", 0.807, 7, 59.91, 1, 0, null, null, null, 1, 2, "31118475,25782368", 0, "Seizure", 0.7217241968702018], ["P02748", "C9", "Complement component C9", "Tier 1.5", 0.796, 9, 78.75, 1, 0, null, null, null, 1, 10, "41636061,40411682,36428893,36290981,35247355,28794177,27836219,22678933,19261617,15687383", 1, "Immunodeficiency due to a late component of complements deficiency", 0.761965409699055], ["Q13085", "ACACA", "Acetyl-CoA carboxylase 1", "Tier 1.5", 0.79, 10, 82.81, 1, 0, null, null, null, 1, 1, "41854184", 1, null, null], ["Q92633", "LPAR1", "Lysophosphatidic acid receptor 1", "Tier 1.5", 0.785, 16, 83.62, 1, 0, null, null, null, 1, 1, "32065590", 1, "Epiretinal membrane", 0.4757255248053499], ["P03971", "AMH", "Anti-Muellerian hormone", "Tier 1.5", 0.783, 3, 68.62, 1, 0, null, null, null, 1, 2, "41101154,27364573", 0, "persistent Mullerian duct syndrome", 0.7847328444470535], ["P39060", "COL18A1", "Collagen alpha-1(XVIII) chain", "Tier 1.5", 0.769, 9, 50.62, 1, 0, null, null, null, 1, 2, "36707842,23679916", 1, "Knobloch syndrome 1", 0.7867122552672962], ["P43007", "SLC1A4", "Neutral amino acid transporter A", "Tier 1.5", 0.75, 1, 80.56, 1, 0, null, null, null, 1, 6, "36219068,31989939,27571928,26811678,19046328,16139842", 1, "spastic tetraplegia-thin corpus callosum-progressive postnatal microcephaly syndrome", 0.8025684205131692], ["P08648", "ITGA5", "Integrin alpha-5", "Tier 1.5", 0.748, 14, 85.25, 1, 0, null, null, null, 1, 2, "32174798,38258032", 1, "skin disease", 0.28465651599598124], ["O60884", "DNAJA2", "DnaJ homolog subfamily A member 2", "Tier 1.5", 0.73, 1, 83.38, 1, 0, null, null, null, 1, 2, "41935727,33879515", 1, "dengue disease", 0.37068859424875583], ["Q99988", "GDF15", "Growth/differentiation factor 15", "Tier 1.5", 0.718, 4, 75.69, 1, 0, null, null, null, 1, 29, "41924874,41862097,38879214,38477735,37982669,36927042,36638554,36508319,36333824,35762561,33334063,32527800,31988066,29992704,39884764,38497478,38296402,37162508,32739349,30335547", 1, "hyperemesis gravidarum", 0.5821658682742563], ["Q00604", "NDP", "Norrin", "Tier 1.5", 0.716, 11, 83.56, 1, 0, null, null, null, 1, 2, "39057719,11352723", 0, "Norrie disease", 0.8566451682188412], ["P46094", "XCR1", "Chemokine XC receptor 1", "Tier 1.5", 0.715, 1, 84.94, 1, 0, null, null, null, 1, 1, "35212764", 0, "COVID-19", 0.459103766220463], ["P32239", "CCKBR", "Gastrin/cholecystokinin type B receptor", "Tier 1.5", 0.713, 5, 75.75, 1, 0, null, null, null, 1, 2, "33776434,27754762", 0, "gastroesophageal reflux disease", 0.4256110167566802], ["P25106", "ACKR3", "Atypical chemokine receptor 3", "Tier 1.5", 0.71, 14, 82.44, 1, 0, null, null, null, 1, 2, "40401615,28670693", 0, "oculomotor-abducens synkinesis", 0.49893280382434735], ["P07225", "PROS1", "Vitamin K-dependent protein S", "Tier 1.5", 0.7, 3, 82.94, 1, 0, null, null, null, 1, 2, "36859809,33674695", 1, "thrombophilia due to protein S deficiency, autosomal dominant", 0.8240418292042652], ["P21359", "NF1", "Neurofibromin", "Tier 1.5", 0.695, 26, 87.19, 1, 0, null, null, null, 1, 2, "32980430,22617876", 1, "neurofibromatosis type 1", 0.8844735398780649], ["Q96RJ3", "TNFRSF13C", "Tumor necrosis factor receptor superfamily member 13C", "Tier 1.5", 0.681, 8, 63.03, 1, 0, null, null, null, 1, 1, "23470998", 0, "immunodeficiency, common variable, 4", 0.660711678987284], ["P98155", "VLDLR", "Very low-density lipoprotein receptor", "Tier 1.5", 0.66, 27, 75.69, 1, 0, null, null, null, 1, 1, "19188685", 1, "Dysequilibrium syndrome", 0.790164037509625], ["P16234", "PDGFRA", "Platelet-derived growth factor receptor alpha", "Tier 1.5", 0.652, 14, 72.69, 1, 0, null, null, null, 1, 4, "33334063,32127469,28010895,30594071", 1, "gastrointestinal stromal tumor", 0.8167494524079806], ["P08100", "RHO", "Rhodopsin", "Tier 1.5", 0.645, 4, 88.75, 1, 0, null, null, null, 1, 45, "41963275,41924874,41636061,40808302,40642289,40330320,40045571,39863313,39788632,38070612,37191882,36705086,36696850,36095194,36049339,35622174,34709779,34471566,32696702,32479610,32319623,32119944,31737572,31588238,31535128,29570714,29281176,28648779,27893356,25645980,23757206,23701883,25033804,22689339,22302221,22121695,19766091,19389625,16419035,12123800,8743323,7678562,19188685,18230760", 0, "retinitis pigmentosa", 0.8481942240861982], ["P07237", "P4HB", "Protein disulfide-isomerase", "Tier 1.5", 0.644, 14, 88.5, 1, 0, null, null, null, 1, 2, "31625090,28952381", 1, "Cole-Carpenter syndrome", 0.7447295842045853], ["P15391", "CD19", "B-lymphocyte antigen CD19", "Tier 1.5", 0.642, 4, 62.22, 1, 0, null, null, null, 1, 13, "41079126,40652441,38661725,38148412,36095289,35829681,34680368,34364920,32401486,31912987,29928472,21127492", 0, "immunodeficiency, common variable, 3", 0.6821072538733047], ["Q8NEV9", "IL27", "Interleukin-27 subunit alpha", "Tier 1.5", 0.641, 4, 75.62, 1, 0, null, null, null, 1, 2, "35859339,32784904", 0, "Crohn's disease", 0.40963715551754365], ["P45844", "ABCG1", "ATP-binding cassette sub-family G member 1", "Tier 1.5", 0.639, 5, 81.12, 1, 0, null, null, null, 1, 1, "41854184", 0, "neurodegenerative disease", 0.3915225348167794], ["P51654", "GPC3", "Glypican-3", "Tier 1.5", 0.636, 4, 75.06, 1, 0, null, null, null, 1, 65, "42083729,41790019,41653459,41045695,40825648,40722645,39998646,39874791,39608318,39427046,38910291,38787447,38621313,38368644,37665421,36903516,36457288,36317566,36072763,35788872,35699181,35477501,35051745,34974867,34306031,33254049,33080969,32356075,30347351,30122918,29675356,29605994,29277631,27601357,28263753", 0, "Simpson-Golabi-Behmel syndrome type 1", 0.762708583613362], ["P31785", "IL2RG", "Cytokine receptor common subunit gamma", "Tier 1.5", 0.635, 14, 75.5, 1, 0, null, null, null, 1, 2, "30800133,33869115", 0, "gamma chain deficiency", 0.8469997000418428], ["O75976", "CPD", "Carboxypeptidase D", "Tier 1.5", 0.625, 3, 82.5, 1, 0, null, null, null, 1, 1, "36457699", 1, "neurodegenerative disease", 0.34777406871587735], ["O95342", "ABCB11", "Bile salt export pump", "Tier 1.5", 0.624, 8, 83.12, 1, 0, null, null, null, 1, 1, "36313979", 0, "progressive familial intrahepatic cholestasis type 2", 0.8372060401943777], ["P49238", "CX3CR1", "CX3C chemokine receptor 1", "Tier 1.5", 0.62, 2, 80.5, 1, 0, null, null, null, 1, 2, "28727998", 0, "age-related macular degeneration", 0.4006854573775187], ["Q06141", "REG3A", "Regenerating islet-derived protein 3-alpha", "Tier 1.5", 0.62, 4, 89.0, 1, 0, null, null, null, 1, 2, "39695715,24771595", 0, "alcohol drinking", 0.29724052454892086], ["Q9ULC3", "RAB23", "Ras-related protein Rab-23", "Tier 1.5", 0.619, 6, 79.56, 1, 0, null, null, null, 1, 1, "23618401", 1, "RAB23-related Carpenter syndrome", 0.7879955689930709], ["Q07325", "CXCL9", "C-X-C motif chemokine 9", "Tier 1.5", 0.617, 1, 87.44, 1, 0, null, null, null, 1, 7, "42046114,37395276,35204399,35018777,33742062,27959341,27819142", 0, "neoplasm", 0.1199067650750674], ["P01876", "IGHA1", "Immunoglobulin heavy constant alpha 1", "Tier 1.5", 0.612, 14, 81.88, 1, 0, null, null, null, 1, 2, "37325361", 1, "IGA glomerulonephritis", 0.12053726815801102], ["O43866", "CD5L", "CD5 antigen-like", "Tier 1.5", 0.61, 4, 85.88, 1, 0, null, null, null, 1, 3, "40215752,37100807", 1, "functional neutrophil defect", 0.3529395470693119], ["P41146", "OPRL1", "Nociceptin receptor", "Tier 1.5", 0.61, 4, 82.31, 1, 0, null, null, null, 1, 1, "14970396", 0, "neurodegenerative disease", 0.4039002828932129], ["P23368", "ME2", "NAD-dependent malic enzyme, mitochondrial", "Tier 1.5", 0.61, 18, 94.38, 1, 0, null, null, null, 1, 2, "39602246,29779113", 1, "diabetes mellitus", 0.277416610655893], ["P15529", "CD46", "Membrane cofactor protein", "Tier 1.5", 0.608, 7, 82.12, 1, 0, null, null, null, 1, 9, "35114109,34248841,31761039,31077760,27734375,19915929,17046833,11084032", 1, "atypical hemolytic-uremic syndrome with MCP/CD46 anomaly", 0.7798469882597787], ["P55157", "MTTP", "Microsomal triglyceride transfer protein large subunit", "Tier 1.5", 0.608, 2, 86.56, 1, 0, null, null, null, 1, 1, "23770039", 1, "abetalipoproteinemia", 0.8281089516017405], ["P04201", "MAS1", "Proto-oncogene Mas", "Tier 1.5", 0.605, 3, 83.5, 1, 0, null, null, null, 1, 10, "40518278,34016094,30415442,27936442,23618401", 0, "Abnormality of the skeletal system", 0.40450059258174326], ["P10646", "TFPI", "Tissue factor pathway inhibitor", "Tier 1.5", 0.605, 9, 73.62, 1, 0, null, null, null, 1, 28, "32366845,32224381,30994257,30302740,27563744,27196067,24263002,23528042,22951415,22658294,22632032,22239993,21696535,21389323,8578509,25521966,24319161", 1, "hemophilia A", 0.5591056672248635], ["P41231", "P2RY2", "P2Y purinoceptor 2", "Tier 1.5", 0.605, 3, 78.88, 1, 0, null, null, null, 1, 1, "33911033", 0, "nontoxic goiter", 0.43556889579550895], ["Q8NER1", "TRPV1", "Transient receptor potential cation channel subfamily V member 1", "Tier 1.5", 0.6, 8, 71.94, 1, 0, null, null, null, 1, 2, "40855286,28604222", 0, "migraine disorder", 0.6269329225883602], ["P0DSE1", "TRA", "M1-specific T cell receptor alpha chain", "Tier 1.5", 0.6, 3, 88.81, 1, 0, null, null, null, 1, 7, "41693575,41636061,39837202,37015819,28860472,25844955,19457263", 0, null, null], ["P02786", "TFRC", "Transferrin receptor protein 1", "Tier 1.5", 0.587, 22, 86.69, 1, 0, null, null, null, 1, 3, "39831311,29046922,32527800", 1, "TFRC-related combined immunodeficiency", 0.623449899069336], ["P31948", "STIP1", "Stress-induced-phosphoprotein 1", "Tier 1.5", 0.585, 8, 89.75, 1, 0, null, null, null, 1, 7, "41406518,38012811,34831332,32614006,27681499,24654750,24013070", 1, "neurodegenerative disease", 0.4967711525222825], ["Q15813", "TBCE", "Tubulin-specific chaperone E", "Tier 1.5", 0.582, 6, 89.19, 1, 0, null, null, null, 1, 1, "34448574", 1, "hypoparathyroidism-retardation-dysmorphism syndrome", 0.7744447925917005], ["P55259", "GP2", "Pancreatic secretory granule membrane major glycoprotein GP2", "Tier 1.5", 0.577, 4, 78.62, 1, 0, null, null, null, 1, 3, "36902059,25483705,24334484", 0, "type 2 diabetes mellitus", 0.5235291484788168], ["P08887", "IL6R", "Interleukin-6 receptor subunit alpha", "Tier 1.5", 0.575, 10, 77.88, 1, 0, null, null, null, 1, 18, "40853309,38152968,37034659,36579647,35890412,33590853,33340765,32515246,29211023,28929152,26552813,26383776,24481022,24440854,23235494,22503683,22258147,22094809", 0, "rheumatoid arthritis", 0.7269057706798291]], "truncated": false, "filtered_table_rows_count": 102, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "priority_score", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "drug_count_approved", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, priority_score, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, drug_count_approved, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_cryoEM\" = :p0 and \"has_known_aptamer\" = :p1 and \"tier\" = :p2 order by priority_score desc limit 51", "params": {"p0": "1", "p1": "1", "p2": "Tier 1.5"}}, "facet_results": {"tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&tier=Tier+1.5", "results": [{"value": "Tier 1.5", "label": "Tier 1.5", "count": 102, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 102, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&tier=Tier+1.5&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&tier=Tier+1.5", "results": [{"value": 1, "label": 1, "count": 102, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&tier=Tier+1.5", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&tier=Tier+1.5", "results": [{"value": 1, "label": 1, "count": 52, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&tier=Tier+1.5&in_cev_map=1", "selected": false}, {"value": 0, "label": 0, "count": 50, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&tier=Tier+1.5&in_cev_map=0", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&tier=Tier+1.5", "results": [{"value": 1, "label": 1, "count": 102, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&tier=Tier+1.5", "selected": true}], "truncated": false}}, "suggested_facets": [{"name": "pdb_count_total", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&tier=Tier+1.5&_facet=pdb_count_total"}, {"name": "aptamer_count_pubmed", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&tier=Tier+1.5&_facet=aptamer_count_pubmed"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&has_known_aptamer=1&tier=Tier+1.5&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 263.8492409969331, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}