{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_cryoEM = 1, in_cev_map = 0 and surface_class = \"A2_pm_peripheral\" sorted by evidence_priority descending", "rows": [["Q4FZB7", "KMT5B", "Histone-lysine N-methyltransferase KMT5B", "Tier 1", 0.628, 1, "A2_pm_peripheral", 10, 54.91, 1, 0, null, null, 0, 0, null, 0, "intellectual disability, autosomal dominant 51", 0.7943209483524042], ["Q5JVL4", "EFHC1", "EF-hand domain-containing protein 1", "Tier 1", 0.626, 1, "A2_pm_peripheral", 2, 83.88, 1, 0, null, null, 0, 0, null, 0, "juvenile myoclonic epilepsy", 0.7858434985198706], ["P49459", "UBE2A", "Ubiquitin-conjugating enzyme E2 A", "Tier 1.5", 0.626, 1, "A2_pm_peripheral", 5, 94.12, 1, 0, null, null, 0, 0, null, 0, "syndromic X-linked intellectual disability Nascimento type", 0.7867796040270276], ["P15104", "GLUL", "Glutamine synthetase", "Tier 1.5", 0.622, 1, "A2_pm_peripheral", 12, 97.5, 1, 0, null, null, 1, 4, "39533430,30085248,21282981", 0, "congenital brain dysgenesis due to glutamine synthetase deficiency", 0.7733687702812198], ["Q9NPP4", "NLRC4", "NLR family CARD domain-containing protein 4", "Tier 1", 0.619, 1, "A2_pm_peripheral", 6, 85.12, 1, 0, null, null, 0, 0, null, 0, "periodic fever-infantile enterocolitis-autoinflammatory syndrome", 0.7635956406357429], ["P10636", "MAPT", "Microtubule-associated protein tau", "Tier 1", 0.618, 1, "A2_pm_peripheral", 100, 49.22, 1, 0, null, null, 1, 9, "40380000,39241336,38585969,38397086,37003060,31900535,30004544,29268187", 0, "Pick disease", 0.7600399335134378], ["P35716", "SOX11", "Transcription factor SOX-11", "Tier 1", 0.614, 1, "A2_pm_peripheral", 4, 56.41, 1, 0, null, null, 0, 0, null, 0, "intellectual developmental disorder with microcephaly and with or without ocular malformations or hypogonadotropic hypogonadism", 0.7470288070793535], ["P41159", "LEP", "Leptin", "Tier 1", 0.606, 1, "A2_pm_peripheral", 10, 81.12, 1, 0, null, null, 1, 14, "40330320,40008515,39263947,37331044,36508319,36173490,35884340,34016094,33650854,32527800,27530235,26529285,23232067,20594164", 0, "obesity due to congenital leptin deficiency", 0.7197450249224271], ["Q8IUC6", "TICAM1", "TIR domain-containing adapter molecule 1", "Tier 1.5", 0.581, 1, "A2_pm_peripheral", 8, 62.78, 1, 0, null, null, 0, 0, null, 0, "Herpetic encephalitis", 0.6364986386236531], ["P56597", "NME5", "Nucleoside diphosphate kinase 5", "Tier 1.5", 0.563, 1, "A2_pm_peripheral", 1, 90.06, 1, 0, null, null, 0, 0, null, 0, "ciliary dyskinesia, primary, 48, without situs inversus", 0.5766985649142533], ["Q9BVS4", "RIOK2", "Serine/threonine-protein kinase RIO2", "Tier 1", 0.552, 1, "A2_pm_peripheral", 10, 67.38, 1, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.539818754658029], ["Q9NXF7", "DCAF16", "DDB1- and CUL4-associated factor 16", "Tier 1", 0.548, 1, "A2_pm_peripheral", 2, 38.19, 1, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.5251061120759617], ["O43663", "PRC1", "Protein regulator of cytokinesis 1", "Tier 1", 0.544, 1, "A2_pm_peripheral", 6, 78.94, 1, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.5139662839321523], ["Q9GZN1", "ACTR6", "Actin-related protein 6", "Tier 1.5", 0.533, 1, "A2_pm_peripheral", 9, 94.31, 1, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.4758409073452339], ["P43351", "RAD52", "DNA repair protein RAD52 homolog", "Tier 1", 0.528, 1, "A2_pm_peripheral", 11, 69.62, 1, 0, null, null, 1, 6, "37288783,32945515,31495919,26784987,24500205,23836560", 0, "Abnormality of the skeletal system", 0.45994164258033876], ["Q9UK80", "USP21", "Ubiquitin carboxyl-terminal hydrolase 21", "Tier 1", 0.524, 1, "A2_pm_peripheral", 4, 69.75, 1, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.44616960950164986], ["O15519", "CFLAR", "CASP8 and FADD-like apoptosis regulator", "Tier 1", 0.523, 1, "A2_pm_peripheral", 17, 78.31, 1, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.4419421569940659], ["Q5VTH2", "CFAP126", "Protein Flattop", "Tier 1.5", 0.51, 1, "A2_pm_peripheral", 2, 72.62, 1, 0, null, null, 0, 0, null, 0, "hereditary pheochromocytoma-paraganglioma", 0.4009925718465981], ["O75182", "SIN3B", "Paired amphipathic helix protein Sin3b", "Tier 1.5", 0.501, 1, "A2_pm_peripheral", 4, 68.0, 1, 0, null, null, 1, 2, "16914451", 0, "syndromic intellectual disability", 0.37050380432141355], ["O00451", "GFRA2", "GDNF family receptor alpha-2", "Tier 1", 0.487, 1, "A2_pm_peripheral", 5, 75.0, 1, 0, null, null, 0, 0, null, 0, "poisoning", 0.32401333746089783], ["P59768", "GNG2", "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2", "Tier 1", 0.485, 1, "A2_pm_peripheral", 100, 89.56, 1, 0, null, null, 0, 0, null, 0, "multiple sclerosis", 0.3157760490336847], ["P55089", "UCN", "Urocortin", "Tier 1.5", 0.469, 1, "A2_pm_peripheral", 6, 68.25, 1, 0, null, null, 1, 3, "30221506,26488412,23248006", 0, "neurodegenerative disease", 0.26311734927710556], ["Q86UC2", "RSPH3", "Radial spoke head protein 3 homolog", "Tier 1.5", 0.39, 1, "A2_pm_peripheral", 1, 64.62, 1, 0, null, null, 0, 0, null, 0, null, null]], "truncated": false, "filtered_table_rows_count": 23, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_cryoEM\" = :p0 and \"in_cev_map\" = :p1 and \"surface_class\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "1", "p1": "0", "p2": "A2_pm_peripheral"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=A2_pm_peripheral", "results": [{"value": 1, "label": 1, "count": 23, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=A2_pm_peripheral&has_structure=1", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=A2_pm_peripheral", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 14, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=A2_pm_peripheral&tier=Tier+1", "selected": false}, {"value": "Tier 1.5", "label": "Tier 1.5", "count": 9, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=A2_pm_peripheral&tier=Tier+1.5", "selected": false}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=A2_pm_peripheral", "results": [{"value": 0, "label": 0, "count": 23, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=A2_pm_peripheral&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=A2_pm_peripheral", "results": [{"value": 0, "label": 0, "count": 17, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=A2_pm_peripheral&has_known_aptamer=0", "selected": false}, {"value": 1, "label": 1, "count": 6, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=A2_pm_peripheral&has_known_aptamer=1", "selected": false}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=A2_pm_peripheral", "results": [{"value": "A2_pm_peripheral", "label": "A2_pm_peripheral", "count": 23, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=A2_pm_peripheral", "results": [{"value": 0, "label": 0, "count": 23, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A2_pm_peripheral", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=A2_pm_peripheral", "results": [{"value": 1, "label": 1, "count": 23, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=A2_pm_peripheral", "selected": true}], "truncated": false}}, "suggested_facets": [{"name": "evidence_priority", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=A2_pm_peripheral&_facet=evidence_priority"}, {"name": "pdb_count_total", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=A2_pm_peripheral&_facet=pdb_count_total"}, {"name": "aptamer_count_pubmed", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=A2_pm_peripheral&_facet=aptamer_count_pubmed"}, {"name": "opentargets_top_disease_name", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=A2_pm_peripheral&_facet=opentargets_top_disease_name"}], "next": null, "next_url": null, "private": false, "allow_execute_sql": true, "query_ms": 1101.155478041619, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}