{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_cryoEM = 1, in_cev_map = 0 and surface_class = \"A_assoc\" sorted by evidence_priority descending", "rows": [["Q00604", "NDP", "Norrin", "Tier 1.5", 0.707, 1, "A_assoc", 11, 83.56, 1, 0, null, null, 1, 2, "39057719,11352723", 0, "Norrie disease", 0.8566451682188412], ["O95970", "LGI1", "Leucine-rich glioma-inactivated protein 1", "Tier 1.5", 0.697, 1, "A_assoc", 9, 92.56, 1, 0, null, null, 0, 0, null, 0, "autosomal dominant epilepsy with auditory features", 0.8225657483127345], ["P29460", "IL12B", "Interleukin-12 subunit beta", "Tier 1", 0.687, 1, "A_assoc", 20, 91.12, 1, 0, null, null, 0, 0, null, 0, "psoriasis", 0.7914863943708039], ["P03971", "AMH", "Anti-Muellerian hormone", "Tier 1.5", 0.685, 1, "A_assoc", 3, 68.62, 1, 0, null, null, 1, 2, "41101154,27364573", 0, "persistent Mullerian duct syndrome", 0.7847328444470535], ["P05019", "IGF1", "Insulin-like growth factor 1", "Tier 1", 0.68, 1, "A_assoc", 32, 59.53, 1, 0, null, null, 1, 23, "38384162,35859339,35591468,33977395,33467925,32511241,31930684,26245346,24832383,23933187,23373648,16019422,41283885,39263947,38497478,33888746,15231297", 0, "growth delay due to insulin-like growth factor type 1 deficiency", 0.7650418939376437], ["Q9GZV9", "FGF23", "Fibroblast growth factor 23", "Tier 1", 0.679, 1, "A_assoc", 6, 76.62, 1, 0, null, null, 1, 11, "39007037,38079395,35415885,32065590,30297602,30197987,41226313,36705086", 0, "autosomal dominant hypophosphatemic rickets", 0.762326334964193], ["P35225", "IL13", "Interleukin-13", "Tier 1", 0.669, 1, "A_assoc", 13, 85.62, 1, 0, null, null, 1, 9, "41463156,35356877,33742062,32784904,27640094,29949702,21793788", 0, "atopic eczema", 0.7297489019498119], ["Q2MKA7", "RSPO1", "R-spondin-1", "Tier 1", 0.669, 1, "A_assoc", 12, 74.69, 1, 0, null, null, 0, 0, null, 0, "palmoplantar keratoderma-XX sex reversal-predisposition to squamous cell carcinoma syndrome", 0.7285342885472184], ["P05305", "EDN1", "Endothelin-1", "Tier 1", 0.666, 1, "A_assoc", 17, 65.19, 1, 0, null, null, 1, 2, "40438585,37198662", 0, "auriculocondylar syndrome", 0.7193561828311311], ["P12272", "PTHLH", "Parathyroid hormone-related protein", "Tier 1", 0.666, 1, "A_assoc", 11, 62.88, 1, 0, null, null, 0, 0, null, 0, "brachydactyly type E", 0.7203484375635054], ["P01270", "PTH", "Parathyroid hormone", "Tier 1", 0.664, 1, "A_assoc", 26, 72.12, 1, 0, null, null, 1, 9, "40464222,40108760,39880691,38079395,25901535,41303575,41226313", 0, "hypoparathyroidism, familial isolated 1", 0.7147450451832739], ["Q8N300", "SVBP", "Small vasohibin-binding protein", "Tier 1", 0.649, 1, "A_assoc", 24, 85.06, 1, 0, null, null, 0, 0, null, 0, "neurodevelopmental disorder with ataxia, hypotonia, and microcephaly", 0.6640118055835142], ["O95631", "NTN1", "Netrin-1", "Tier 1.5", 0.648, 1, "A_assoc", 5, 88.5, 1, 0, null, null, 0, 0, null, 0, "mirror movements 4", 0.6611393488240481], ["P05113", "IL5", "Interleukin-5", "Tier 1", 0.642, 1, "A_assoc", 5, 86.69, 1, 0, null, null, 1, 12, "40972397,35487180,35356877,34831332,32784904,32038731,29881374,28062796,26048585", 0, "asthma", 0.6399821251487101], ["Q16552", "IL17A", "Interleukin-17A", "Tier 1", 0.641, 1, "A_assoc", 44, 84.31, 1, 0, null, null, 1, 30, "42017161,41754778,41482938,41477217,40410820,39376102,38091227,38031342,37879125,37238999,36517803,36375248,36326540,35724603,32784904,32387307,31316164,27827561,24056860,21524680,20967861,37563071,34531951", 0, "psoriasis", 0.6367521314106471], ["Q9UHF0", "TAC3", "Tachykinin-3", "Tier 1", 0.63, 1, "A_assoc", 2, 64.88, 1, 0, null, null, 0, 0, null, 0, "hypogonadotropic hypogonadism 10 with or without anosmia", 0.5995324402695232], ["Q6IBW4", "NCAPH2", "Condensin-2 complex subunit H2", "Tier 1.5", 0.62, 1, "A_assoc", 1, 62.41, 1, 0, null, null, 0, 0, null, 0, "cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 1", 0.5674645203025676], ["P07492", "GRP", "Gastrin-releasing peptide", "Tier 1", 0.619, 1, "A_assoc", 9, 63.94, 1, 0, null, null, 1, 6, "38890976,38659329,37500079,29027923,41810845,23179274", 0, "type 2 diabetes mellitus", 0.5648167305980163], ["Q15726", "KISS1", "Metastasis-suppressor KiSS-1", "Tier 1.5", 0.618, 1, "A_assoc", 2, 59.41, 1, 0, null, null, 1, 1, "35026192", 0, "hypogonadotropic hypogonadism", 0.5608645918536114], ["P22466", "GAL", "Galanin peptides", "Tier 1.5", 0.613, 1, "A_assoc", 10, 66.56, 1, 0, null, null, 1, 27, "40382399,40371468,39772541,39705316,39681229,39430968,39329806,39263318,38487245,38314707,37737989,37610431,37512948,36795559,36194889,34944985,34635237,33769582,33006019,32502344,31778957,31173420,30650243,29808997,25940316,21850727,9546673", 0, "temporal lobe epilepsy", 0.5442263564708273], ["P56704", "WNT3A", "Protein Wnt-3a", "Tier 1", 0.608, 1, "A_assoc", 4, 88.31, 1, 0, null, null, 1, 1, "37231925", 0, "neurodegenerative disease", 0.5271953966006525], ["O00585", "CCL21", "C-C motif chemokine 21", "Tier 1", 0.608, 1, "A_assoc", 5, 72.69, 1, 0, null, null, 1, 2, "36314402,29733244", 0, "rheumatoid arthritis", 0.5266345093424485], ["P78556", "CCL20", "C-C motif chemokine 20", "Tier 1", 0.6, 1, "A_assoc", 6, 88.69, 1, 0, null, null, 1, 1, "36375248", 0, "inflammatory bowel disease", 0.4987938599485985], ["P60568", "IL2", "Interleukin-2", "Tier 1", 0.6, 1, "A_assoc", 37, 84.12, 1, 0, null, null, 1, 45, "41754959,40972397,40761795,40447990,38081519,37805109,37141264,37110712,37074914,34511903,34386332,32784904,32574155,32280743,31383650,31270926,30800133,29556342,29055191,28129128,27959341,27878687,27819142,27529794,27179422,26048585,25919090,24682172,35756119,30883749,29244152,24968026,24418663,18319343,12900522", 0, "asthma", 0.5009876866575907], ["P10997", "IAPP", "Islet amyloid polypeptide", "Tier 1", 0.589, 1, "A_assoc", 76, 78.31, 1, 0, null, null, 1, 9, "40602090,26881276,25659966,18090326,16462265", 0, "AL amyloidosis", 0.4629911629562602], ["P13500", "CCL2", "C-C motif chemokine 2", "Tier 1", 0.584, 1, "A_assoc", 14, 86.94, 1, 0, null, null, 1, 34, "42007960,41360349,41207524,39422353,39317671,38016488,34440571,32784904,31267721,31039360,30056058,29111236,28385802,28315675,28186566,27878687,27392463,26868748,25970072,25901662,25457849,25457848,25236655,24694577,24561613,24481979,21813474,21147843,19156777,18997060,18776253,18258851,11591377,36508319", 0, "Crohn's disease", 0.44619484388731423], ["Q63HQ2", "EGFLAM", "Pikachurin", "Tier 1.5", 0.574, 1, "A_assoc", 3, 80.56, 1, 0, null, null, 0, 0, null, 0, "mathematical ability", 0.41387833248094535], ["Q8NEV9", "IL27", "Interleukin-27 subunit alpha", "Tier 1.5", 0.573, 1, "A_assoc", 4, 75.62, 1, 0, null, null, 1, 2, "35859339,32784904", 0, "Crohn's disease", 0.40963715551754365], ["P01275", "GCG", "Pro-glucagon", "Tier 1", 0.562, 1, "A_assoc", 42, 68.94, 1, 0, null, null, 1, 4, "40563394,37298475,22915350,22658959", 0, "psoriasis", 0.37425807740488537], ["P06850", "CRH", "Corticoliberin", "Tier 1", 0.562, 1, "A_assoc", 5, 61.97, 1, 0, null, null, 0, 0, null, 0, "autosomal dominant nocturnal frontal lobe epilepsy", 0.37224647599732263], ["P48061", "CXCL12", "Stromal cell-derived factor 1", "Tier 1", 0.56, 1, "A_assoc", 34, 83.25, 1, 0, null, null, 1, 36, "41951573,41931849,41907643,41527798,40401615,40008515,39865939,39263947,38806504,38477735,32784904,31267721,31097627,30465210,30385042,29111236,28963140,28670693,27940247,27924617,27392463,26265085,25560701,25236655,24526776,24277076,23615526,22376154,21147843,41963275", 0, "HIV-1 infection", 0.3675509850165065], ["Q7L8A9", "VASH1", "Tubulinyl-Tyr carboxypeptidase 1", "Tier 1", 0.559, 1, "A_assoc", 14, 78.25, 1, 0, null, null, 0, 0, null, 0, "Abnormality of the skeletal system", 0.36366533692746233], ["P18509", "ADCYAP1", "Pituitary adenylate cyclase-activating polypeptide", "Tier 1", 0.559, 1, "A_assoc", 12, 62.56, 1, 0, null, null, 0, 0, null, 0, "alcohol drinking", 0.36407172744864225], ["P01282", "VIP", "VIP peptides", "Tier 1.5", 0.55, 1, "A_assoc", 5, 67.62, 1, 0, null, null, 1, 24, "41292425,40957130,40403614,40056883,39952883,38763821,37527574,36669289,36129574,35879297,35436736,33990848,33688885,31689596,31403149,30167802,30069577,29708252,28441340,27542489,27334718,27088368,26802746,25782595", 0, "uterine fibroid", 0.3332844575068197], ["P61278", "SST", "Somatostatin", "Tier 1", 0.549, 1, "A_assoc", 10, 65.81, 1, 0, null, null, 1, 14, "41851736,41043050,40363817,39451684,37992929,31793775,19755178,38709872,37198662,30644734,28542563,20388107,17585951,21625282", 0, "Abruptio Placentae", 0.32971414126477894], ["P01303", "NPY", "Pro-neuropeptide Y", "Tier 1", 0.548, 1, "A_assoc", 10, 75.62, 1, 0, null, null, 1, 8, "40040002,38709872,38654828,38033269,33297678,29923734,15984861,11756401", 0, "Nephropathy", 0.3251645152074003], ["P20809", "IL11", "Interleukin-11", "Tier 1", 0.545, 1, "A_assoc", 8, 82.62, 1, 0, null, null, 1, 8, "39408993,39263947,28791655,27878687,25696907,24629635", 0, "osteoarthritis, hip", 0.31754029889853136], ["O15240", "VGF", "Neurosecretory protein VGF", "Tier 1", 0.545, 1, "A_assoc", 5, 60.44, 1, 0, null, null, 0, 0, null, 0, "Abnormality of the skeletal system", 0.3156209584671744], ["P0DMC3", "APELA", "Apelin receptor early endogenous ligand", "Tier 1", 0.544, 1, "A_assoc", 3, 72.56, 1, 0, null, null, 0, 0, null, 0, "attention deficit hyperactivity disorder", 0.3148526492327248], ["O14960", "LECT2", "Leukocyte cell-derived chemotaxin-2", "Tier 1.5", 0.542, 1, "A_assoc", 4, 92.44, 1, 0, null, null, 1, 2, "35045701", 0, "neurodegenerative disease", 0.30565036648724025], ["P48645", "NMU", "Neuromedin-U", "Tier 1", 0.541, 1, "A_assoc", 3, 62.72, 1, 0, null, null, 1, 2, "32339148,30826654", 0, "hypertension", 0.30207473951583863], ["Q06141", "REG3A", "Regenerating islet-derived protein 3-alpha", "Tier 1.5", 0.539, 1, "A_assoc", 4, 89.0, 1, 0, null, null, 1, 2, "39695715,24771595", 0, "alcohol drinking", 0.29724052454892086], ["P30990", "NTS", "Neurotensin/neuromedin N", "Tier 1", 0.53, 1, "A_assoc", 11, 61.34, 1, 0, null, null, 1, 38, "41846533,41572478,41548876,41047530,40992279,40326235,39631853,39413601,38897014,38131768,36907299,36735817,36228172,36222059,36084454,36067715,35926421,35279502,34971987,34215054,33412470,33404751,32558232,31919610,31187249,31163397,30771936,30724076,30339976,26916821,26382019,32260691,20597503,19740763,18082623,17150545,12054450,9425088", 0, "Alzheimer disease", 0.26512620584304225], ["P15018", "LIF", "Leukemia inhibitory factor", "Tier 1", 0.523, 1, "A_assoc", 5, 87.12, 1, 0, null, null, 1, 38, "41611413,38359901,37549567,37175248,36838669,33640806,32253765,31791592,31357280,30771937,30037541,29289340,28963578,28763192,27855943,26877178,26764106,26695234,26344338,26113415,25335821,25311485,25035238,24716781,22648816,22471443,27335672,20673578,20151395,19803140,18646283,17315151,16331583,16053313,11791582,9823713,39571081,31461490", 0, "alcohol drinking", 0.24197086949132446], ["P01350", "GAST", "Gastrin", "Tier 1", 0.523, 1, "A_assoc", 4, 64.88, 1, 0, null, null, 1, 2, "41810845,23179274", 0, "neurodegenerative disease", 0.24399028152288016], ["M5A8F1", "ERVH48-1", "Suppressyn", "Tier 1.5", 0.519, 1, "A_assoc", 1, 74.94, 1, 0, null, null, 0, 0, null, 0, "hypertension", 0.23115391486595976], ["P01178", "OXT", "Oxytocin-neurophysin 1", "Tier 1.5", 0.514, 1, "A_assoc", 4, 83.81, 1, 0, null, null, 1, 1, "34649198", 0, "neurodegenerative disease", 0.21368454441108417], ["Q5T4W7", "ARTN", "Artemin", "Tier 1.5", 0.512, 1, "A_assoc", 5, 75.0, 1, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.20507822956537197], ["P01286", "GHRH", "Somatoliberin", "Tier 1", 0.51, 1, "A_assoc", 3, 77.75, 1, 0, null, null, 1, 1, "35061691", 0, "urinary tract obstruction", 0.2012239584361017], ["P09683", "SCT", "Secretin", "Tier 1.5", 0.495, 1, "A_assoc", 3, 65.88, 1, 0, null, null, 1, 2, "17495522,7752141", 0, "idiopathic pulmonary fibrosis", 0.14866387905285056]], "truncated": false, "filtered_table_rows_count": 65, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_cryoEM\" = :p0 and \"in_cev_map\" = :p1 and \"surface_class\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "1", "p1": "0", "p2": "A_assoc"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=A_assoc", "results": [{"value": 1, "label": 1, "count": 65, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=A_assoc&has_structure=1", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=A_assoc", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 45, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=A_assoc&tier=Tier+1", "selected": false}, {"value": "Tier 1.5", "label": "Tier 1.5", "count": 20, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=A_assoc&tier=Tier+1.5", "selected": false}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=A_assoc", "results": [{"value": 0, "label": 0, "count": 65, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=A_assoc&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=A_assoc", "results": [{"value": 1, "label": 1, "count": 40, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=A_assoc&has_known_aptamer=1", "selected": false}, {"value": 0, "label": 0, "count": 25, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=A_assoc&has_known_aptamer=0", "selected": false}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=A_assoc", "results": [{"value": "A_assoc", "label": "A_assoc", "count": 65, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=A_assoc", "results": [{"value": 0, "label": 0, "count": 65, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A_assoc", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=A_assoc", "results": [{"value": 1, "label": 1, "count": 65, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=A_assoc", "selected": true}], "truncated": false}}, "suggested_facets": [{"name": "pdb_count_total", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=A_assoc&_facet=pdb_count_total"}, {"name": "aptamer_count_pubmed", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=A_assoc&_facet=aptamer_count_pubmed"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=A_assoc&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 499.39258210361004, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}