{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_cryoEM = 1, in_cev_map = 0 and surface_class = \"B_cargo\" sorted by evidence_priority descending", "rows": [["Q13315", "ATM", "Serine-protein kinase ATM", "Tier 1", 0.613, 1, "B_cargo", 14, null, 1, 0, null, null, 1, 9, "41867498,39253616,37656667,34733968,28838608,28706912,26176230,17386435,15181173", 0, "ataxia telangiectasia", 0.8759719859489208], ["P35670", "ATP7B", "Copper-transporting ATPase 2", "Tier 1", 0.61, 1, "B_cargo", 13, 71.69, 1, 0, null, null, 1, 1, "39737993", 0, "Wilson disease", 0.8657500553466239], ["O43602", "DCX", "Neuronal migration protein doublecortin", "Tier 1", 0.609, 1, "B_cargo", 18, 66.5, 1, 0, null, null, 0, 0, null, 0, "lissencephaly type 1 due to doublecortin gene mutation", 0.864453842605602], ["Q8NCM8", "DYNC2H1", "Cytoplasmic dynein 2 heavy chain 1", "Tier 1.5", 0.608, 1, "B_cargo", 4, 83.44, 1, 0, null, null, 0, 0, null, 0, "asphyxiating thoracic dystrophy 3", 0.8610362911667925], ["O14746", "TERT", "Telomerase reverse transcriptase", "Tier 1", 0.607, 1, "B_cargo", 23, 80.19, 1, 0, null, null, 1, 13, "41104418,40347637,40062394,39513874,39441744,37427434,36005058,35658460,33476148,28004350,24176970,22013508", 0, "dyskeratosis congenita, autosomal dominant 2", 0.8577919827748599], ["Q9Y6K1", "DNMT3A", "DNA (cytosine-5)-methyltransferase 3A", "Tier 1", 0.605, 1, "B_cargo", 43, 72.94, 1, 0, null, null, 1, 3, "39079576,31733056,23179556", 0, "acute myeloid leukemia", 0.8505245588442946], ["Q3T906", "GNPTAB", "N-acetylglucosamine-1-phosphotransferase subunits alpha/beta", "Tier 1", 0.605, 1, "B_cargo", 5, 71.62, 1, 0, null, null, 0, 0, null, 0, "mucolipidosis type III, alpha/beta", 0.8490445308315259], ["Q96RY7", "IFT140", "Intraflagellar transport protein 140 homolog", "Tier 1", 0.604, 1, "B_cargo", 4, 80.12, 1, 0, null, null, 0, 0, null, 0, "short-rib thoracic dysplasia 9 with or without polydactyly", 0.8464676938353167], ["P54098", "POLG", "DNA polymerase subunit gamma-1", "Tier 1", 0.604, 1, "B_cargo", 36, 78.94, 1, 0, null, null, 0, 0, null, 0, "mitochondrial DNA depletion syndrome 4a", 0.8474167021250057], ["O15360", "FANCA", "Fanconi anemia group A protein", "Tier 1", 0.604, 1, "B_cargo", 6, 74.88, 1, 0, null, null, 0, 0, null, 0, "Fanconi anemia complementation group A", 0.8469248580955555], ["Q92574", "TSC1", "Hamartin", "Tier 1", 0.604, 1, "B_cargo", 5, 62.06, 1, 0, null, null, 1, 1, "18974095", 0, "tuberous sclerosis", 0.8476796313298992], ["Q2NKJ3", "CTC1", "CST complex subunit CTC1", "Tier 1", 0.603, 1, "B_cargo", 7, 77.5, 1, 0, null, null, 0, 0, null, 0, "Coats plus syndrome", 0.8438631461095314], ["Q2M1P5", "KIF7", "Kinesin-like protein KIF7", "Tier 1.5", 0.603, 1, "B_cargo", 5, 67.19, 1, 0, null, null, 0, 0, null, 0, "acrocallosal syndrome", 0.8424257475739304], ["O60931", "CTNS", "Cystinosin", "Tier 1.5", 0.603, 1, "B_cargo", 6, 89.44, 1, 0, null, null, 0, 0, null, 0, "nephropathic cystinosis", 0.841818398377195], ["Q12879", "GRIN2A", "Glutamate receptor ionotropic, NMDA 2A", "Tier 1", 0.602, 1, "B_cargo", 37, 60.84, 1, 0, null, null, 0, 0, null, 0, "Landau-Kleffner syndrome", 0.8407159711916629], ["P38398", "BRCA1", "Breast cancer type 1 susceptibility protein", "Tier 1", 0.602, 1, "B_cargo", 33, 41.59, 1, 0, null, null, 1, 13, "40251554,37288783,36858016,32945515,32245065,29737162,28841982,26784987,24734899,23836560,21800393,16825284", 0, "breast cancer", 0.839035109761358], ["Q9HBG6", "IFT122", "Intraflagellar transport protein 122 homolog", "Tier 1.5", 0.602, 1, "B_cargo", 5, 82.88, 1, 0, null, null, 0, 0, null, 0, "cranioectodermal dysplasia", 0.8402296001002503], ["Q5S007", "LRRK2", "Leucine-rich repeat serine/threonine-protein kinase 2", "Tier 1", 0.6, 1, "B_cargo", 44, 77.5, 1, 0, null, null, 1, 4, "38467937,37586882,37422510,36774388", 0, "Hereditary late-onset Parkinson disease", 0.8349742982582067], ["Q15910", "EZH2", "Histone-lysine N-methyltransferase EZH2", "Tier 1", 0.6, 1, "B_cargo", 38, 76.25, 1, 0, null, null, 1, 8, "41574287,41223251,40931580,39853766,36626902,32884286,30795863,27719642", 0, "Weaver syndrome", 0.8324078192564933], ["Q9BXW9", "FANCD2", "Fanconi anemia group D2 protein", "Tier 1.5", 0.6, 1, "B_cargo", 13, 76.75, 1, 0, null, null, 0, 0, null, 0, "Fanconi anemia complementation group D2", 0.8319139646572291], ["Q05066", "SRY", "Sex-determining region Y protein", "Tier 1.5", 0.599, 1, "B_cargo", 10, 67.62, 1, 0, null, null, 1, 1, "40082426", 0, "46,XY sex reversal 1", 0.8290523705747719], ["Q96SD1", "DCLRE1C", "Protein artemis", "Tier 1", 0.598, 1, "B_cargo", 14, 69.44, 1, 0, null, null, 0, 0, null, 0, "severe combined immunodeficiency due to DCLRE1C deficiency", 0.826513936982479], ["P48431", "SOX2", "Transcription factor SOX-2", "Tier 1", 0.598, 1, "B_cargo", 13, 59.84, 1, 0, null, null, 1, 13, "41377018,40082426,37891174,37370863,36284815,34405338,31991109,31301870,28988933,26176230,23892456,18490265,15863505", 0, "anophthalmia/microphthalmia-esophageal atresia syndrome", 0.8263477268235936], ["Q9Y253", "POLH", "DNA polymerase eta", "Tier 1", 0.597, 1, "B_cargo", 100, 76.88, 1, 0, null, null, 0, 0, null, 0, "xeroderma pigmentosum variant type", 0.8236705244099821], ["Q9BYX4", "IFIH1", "Interferon-induced helicase C domain-containing protein 1", "Tier 1.5", 0.597, 1, "B_cargo", 9, 79.44, 1, 0, null, null, 1, 1, "18983163", 0, "Aicardi-Goutieres syndrome 7", 0.8235229759148853], ["P40879", "SLC26A3", "Chloride anion exchanger", "Tier 1", 0.596, 1, "B_cargo", 13, 85.06, 1, 0, null, null, 0, 0, null, 0, "congenital secretory chloride diarrhea 1", 0.8189631913308207], ["Q8NB91", "FANCB", "Fanconi anemia group B protein", "Tier 1", 0.596, 1, "B_cargo", 6, 71.0, 1, 0, null, null, 1, 1, "23836560", 0, "Fanconi anemia", 0.8195998375932156], ["Q9UJQ4", "SALL4", "Sal-like protein 4", "Tier 1", 0.595, 1, "B_cargo", 13, 51.06, 1, 0, null, null, 0, 0, null, 0, "Duane-radial ray syndrome", 0.8169322292438749], ["P29033", "GJB2", "Gap junction beta-2 protein", "Tier 1", 0.594, 1, "B_cargo", 24, 86.19, 1, 0, null, null, 0, 0, null, 0, "palmoplantar keratoderma-deafness syndrome", 0.8149616697051898], ["Q9BQ52", "ELAC2", "Zinc phosphodiesterase ELAC protein 2", "Tier 1", 0.594, 1, "B_cargo", 10, 82.81, 1, 0, null, null, 0, 0, null, 0, "combined oxidative phosphorylation defect type 17", 0.8142476181884984], ["P61244", "MAX", "Protein max", "Tier 1", 0.593, 1, "B_cargo", 12, 81.31, 1, 0, null, null, 1, 288, "41934996,41833970,41619462,41469028,41439640,41422825,41237904,41213249,41083647,41002303,40921876,40905551,40902004,40864593,40850274,40840129,40642767,40491004,40383336,40356230,40164941,40097648,40011207,39923524,39890743,39852074,39828650,39630145,39605530,39566329,39420595,39360861,39225197,39117896,39115976,39103298,39056617,38968658,38920574,38907914,38899396,38846799,38682443,38573322,38542416,38385442,38359718,38348887,38217658,38103284", 0, "pheochromocytoma", 0.8086574254358271], ["Q9UPT6", "MAPK8IP3", "C-Jun-amino-terminal kinase-interacting protein 3", "Tier 1", 0.593, 1, "B_cargo", 5, 62.03, 1, 0, null, null, 0, 0, null, 0, "neurodevelopmental disorder with or without variable brain abnormalities; NEDBA", 0.8115235837032309], ["Q8WVM7", "STAG1", "Cohesin subunit SA-1", "Tier 1", 0.592, 1, "B_cargo", 20, 78.56, 1, 0, null, null, 0, 0, null, 0, "intellectual disability, autosomal dominant 47", 0.8075622605545107], ["Q5TBB1", "RNASEH2B", "Ribonuclease H2 subunit B", "Tier 1", 0.592, 1, "B_cargo", 4, 76.31, 1, 0, null, null, 0, 0, null, 0, "Aicardi-Gouti\u00e8res syndrome", 0.8070167548553762], ["Q8IXJ9", "ASXL1", "Polycomb group protein ASXL1", "Tier 1.5", 0.592, 1, "B_cargo", 4, 42.22, 1, 0, null, null, 0, 0, null, 0, "Bohring-Opitz syndrome", 0.8082443730060624], ["Q9NW38", "FANCL", "E3 ubiquitin-protein ligase FANCL", "Tier 1.5", 0.592, 1, "B_cargo", 8, 91.31, 1, 0, null, null, 0, 0, null, 0, "Fanconi anemia complementation group L", 0.8062585405338945], ["Q13635", "PTCH1", "Protein patched homolog 1", "Tier 1", 0.591, 1, "B_cargo", 16, 73.88, 1, 0, null, null, 0, 0, null, 0, "nevoid basal cell carcinoma syndrome", 0.8042006866265059], ["Q09472", "EP300", "Histone acetyltransferase p300", "Tier 1", 0.591, 1, "B_cargo", 60, 53.25, 1, 0, null, null, 1, 2, "39429683,28539359", 0, "Rubinstein-Taybi syndrome due to EP300 haploinsufficiency", 0.8025866884926094], ["Q03164", "KMT2A", "Histone-lysine N-methyltransferase 2A", "Tier 1", 0.591, 1, "B_cargo", 60, null, 1, 0, null, null, 1, 1, "33606679", 0, "Wiedemann-Steiner syndrome", 0.802084366673722], ["Q9UJV9", "DDX41", "Probable ATP-dependent RNA helicase DDX41", "Tier 1", 0.59, 1, "B_cargo", 5, 77.94, 1, 0, null, null, 0, 0, null, 0, "DDX41-related hematologic malignancy predisposition syndrome", 0.8011142376308067], ["Q7Z6J9", "TSEN54", "tRNA-splicing endonuclease subunit Sen54", "Tier 1", 0.59, 1, "B_cargo", 5, 72.38, 1, 0, null, null, 0, 0, null, 0, "pontocerebellar hypoplasia type 4", 0.8013423073419832], ["Q13415", "ORC1", "Origin recognition complex subunit 1", "Tier 1", 0.59, 1, "B_cargo", 14, 67.38, 1, 0, null, null, 0, 0, null, 0, "Ear-patella-short stature syndrome", 0.7989950785999808], ["Q9NRG9", "AAAS", "Aladin", "Tier 1.5", 0.59, 1, "B_cargo", 2, 75.25, 1, 0, null, null, 1, 2, "39798364,30768874", 0, "triple-A syndrome", 0.8009946434571534], ["P49917", "LIG4", "DNA ligase 4", "Tier 1", 0.589, 1, "B_cargo", 31, 88.19, 1, 0, null, null, 0, 0, null, 0, "LIG4 syndrome", 0.7958751373450337], ["Q9NUX5", "POT1", "Protection of telomeres protein 1", "Tier 1", 0.589, 1, "B_cargo", 14, 87.38, 1, 0, null, null, 1, 3, "41867726,25934589,21772997", 0, "tumor predisposition syndrome 3", 0.7983039512174813], ["P46020", "PHKA1", "Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform", "Tier 1.5", 0.589, 1, "B_cargo", 10, 81.69, 1, 0, null, null, 0, 0, null, 0, "glycogen storage disease IXd", 0.7957863874816654], ["Q8WX94", "NLRP7", "NACHT, LRR and PYD domains-containing protein 7", "Tier 1.5", 0.589, 1, "B_cargo", 3, 82.25, 1, 0, null, null, 0, 0, null, 0, "hydatidiform mole, recurrent, 1", 0.7978415742308576], ["Q96EX3", "DYNC2I2", "Cytoplasmic dynein 2 intermediate chain 2", "Tier 1", 0.588, 1, "B_cargo", 4, 82.06, 1, 0, null, null, 0, 0, null, 0, "Short rib-polydactyly syndrome, Verma-Naumoff type", 0.7942611241080781], ["O96028", "NSD2", "Histone-lysine N-methyltransferase NSD2", "Tier 1", 0.588, 1, "B_cargo", 19, 65.62, 1, 0, null, null, 0, 0, null, 0, "Rauch-Steindl syndrome", 0.7919900106594773], ["Q9UBR1", "UPB1", "Beta-ureidopropionase", "Tier 1.5", 0.588, 1, "B_cargo", 2, 97.0, 1, 0, null, null, 0, 0, null, 0, "beta-ureidopropionase deficiency", 0.7918900848494692]], "truncated": false, "filtered_table_rows_count": 383, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_cryoEM\" = :p0 and \"in_cev_map\" = :p1 and \"surface_class\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "1", "p1": "0", "p2": "B_cargo"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=B_cargo", "results": [{"value": 1, "label": 1, "count": 383, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=B_cargo&has_structure=1", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=B_cargo", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 259, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=B_cargo&tier=Tier+1", "selected": false}, {"value": "Tier 1.5", "label": "Tier 1.5", "count": 124, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=B_cargo&tier=Tier+1.5", "selected": false}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=B_cargo", "results": [{"value": 0, "label": 0, "count": 383, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=B_cargo&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=B_cargo", "results": [{"value": 0, "label": 0, "count": 316, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=B_cargo&has_known_aptamer=0", "selected": false}, {"value": 1, "label": 1, "count": 67, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=B_cargo&has_known_aptamer=1", "selected": false}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=B_cargo", "results": [{"value": "B_cargo", "label": "B_cargo", "count": 383, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=B_cargo", "results": [{"value": 0, "label": 0, "count": 383, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=B_cargo", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=B_cargo", "results": [{"value": 1, "label": 1, "count": 383, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=B_cargo", "selected": true}], "truncated": false}}, "suggested_facets": [{"name": "aptamer_count_pubmed", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=B_cargo&_facet=aptamer_count_pubmed"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=B_cargo&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 1716.8700136244297, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}