{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_cryoEM = 1, in_cev_map = 0 and surface_class = \"unknown\" sorted by evidence_priority descending", "rows": [["P08034", null, null, "Tier 1", 0.604, 1, "unknown", 15, 80.25, 1, 0, null, null, 0, 0, null, 0, "Charcot-Marie-Tooth disease X-linked dominant 1", 0.8483281160610058], ["P23415", null, null, "Tier 1", 0.597, 1, "unknown", 9, 84.0, 1, 0, null, null, 0, 0, null, 0, "hereditary hyperekplexia", 0.822516157871453], ["Q13422", null, null, "Tier 1", 0.591, 1, "unknown", 10, 47.75, 1, 0, null, null, 0, 0, null, 0, "pancytopenia due to IKZF1 mutations", 0.8043234687306351], ["P01185", null, null, "Tier 1.5", 0.585, 1, "unknown", 5, 79.44, 1, 0, null, null, 0, 0, null, 0, "neurohypophyseal diabetes insipidus", 0.7825664629740794], ["P48067", "SLC6A9", "Sodium- and chloride-dependent glycine transporter 1", "Tier 1", 0.582, 1, "unknown", 9, 81.12, 1, 0, null, null, 0, 0, null, 0, "atypical glycine encephalopathy", 0.7733051820377859], ["P29973", null, null, "Tier 1", 0.566, 1, "unknown", 19, 76.25, 1, 0, null, null, 0, 0, null, 0, "retinitis pigmentosa", 0.7206608041231198], ["P98073", null, null, "Tier 1", 0.563, 1, "unknown", 14, 81.5, 1, 0, null, null, 0, 0, null, 0, "congenital enteropathy due to enteropeptidase deficiency", 0.7102613227574134], ["Q5SWA1", null, null, "Tier 1.5", 0.54, 1, "unknown", 5, 49.03, 1, 0, null, null, 0, 0, null, 0, "microcephaly, short stature, and impaired glucose metabolism 2", 0.6334721902580683], ["O15393", null, null, "Tier 1", 0.535, 1, "unknown", 31, 79.38, 1, 0, null, null, 0, 0, null, 0, "COVID-19", 0.6157541390484623], ["Q13639", null, null, "Tier 1", 0.532, 1, "unknown", 3, 80.88, 1, 0, null, null, 0, 0, null, 0, "schizophrenia", 0.6060830827022777], ["O43614", null, null, "Tier 1", 0.53, 1, "unknown", 11, 78.94, 1, 0, null, null, 0, 0, null, 0, "insomnia", 0.5988748728311054], ["O43543", null, null, "Tier 1.5", 0.529, 1, "unknown", 16, 87.12, 1, 0, null, null, 0, 0, null, 0, "spermatogenic failure 50", 0.5955217891975265], ["O75616", "ERAL1", "GTPase Era, mitochondrial", "Tier 1", 0.504, 1, "unknown", 2, 77.94, 1, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.5128349940245936], ["Q15291", null, null, "Tier 1", 0.5, 1, "unknown", 27, 77.75, 1, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.500512770014237], ["P25025", null, null, "Tier 1", 0.499, 1, "unknown", 18, 79.56, 1, 0, null, null, 0, 0, null, 0, "WHIM syndrome 2", 0.4956521666475962], ["P06307", null, null, "Tier 1", 0.487, 1, "unknown", 9, 65.12, 1, 0, null, null, 0, 0, null, 0, "Abnormality of the skeletal system", 0.45523854320041374], ["Q6NW34", "RMP64", "Ribonuclease MRP subunit P64", "Tier 1.5", 0.485, 1, "unknown", 3, 64.0, 1, 0, null, null, 0, 0, null, 0, "anauxetic dysplasia 3", 0.44914218451265836], ["Q9UNN5", null, null, "Tier 1", 0.475, 1, "unknown", 16, 77.0, 1, 0, null, null, 0, 0, null, 0, "atrial fibrillation", 0.41761152415302133], ["Q9NVH2", null, null, "Tier 1", 0.465, 1, "unknown", 8, 88.06, 1, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.38183943401611947], ["Q86X95", "CIRSR", "Corepressor of RBPJ and splicing regulator", "Tier 1", 0.463, 1, "unknown", 2, 59.72, 1, 0, null, null, 0, 0, null, 0, "major depressive disorder", 0.3767349972483621], ["Q14416", null, null, "Tier 1", 0.461, 1, "unknown", 31, 85.69, 1, 0, null, null, 0, 0, null, 0, "schizophrenia", 0.36850365898315596], ["P13725", null, null, "Tier 1", 0.446, 1, "unknown", 3, 78.75, 1, 0, null, null, 0, 0, null, 0, "coronary artery disease", 0.3209548186332283], ["P32248", null, null, "Tier 1", 0.445, 1, "unknown", 7, 78.38, 1, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.31793347108990094], ["Q03188", null, null, "Tier 1", 0.437, 1, "unknown", 14, 48.03, 1, 0, null, null, 0, 0, null, 0, "pernicious anemia", 0.28985906769534225], ["Q32NC0", "RMP24", "Ribonuclease MRP protein subunit p24", "Tier 1.5", 0.43, 1, "unknown", 3, 74.06, 1, 0, null, null, 0, 0, null, 0, "connective tissue disease", 0.2652381012117321], ["Q9NY61", null, null, "Tier 1.5", 0.424, 1, "unknown", 3, 64.81, 1, 0, null, null, 0, 0, null, 0, "skin neoplasm", 0.24706398094697377], ["P02778", null, null, "Tier 1", 0.387, 1, "unknown", 6, 89.56, 1, 0, null, null, 0, 0, null, 0, "rheumatoid arthritis", 0.1225158134105281], ["A8MTA8", "CIMIP2B", "Ciliary microtubule inner protein 2B", "Tier 1", 0.383, 1, "unknown", 2, 68.75, 1, 0, null, null, 0, 0, null, 0, "Meckel syndrome", 0.11087395640541053], ["P49842", "WHR1", "Winged helix repair factor 1", "Tier 1.5", 0.361, 1, "unknown", 5, 87.44, 1, 0, null, null, 0, 0, null, 0, "melanoma", 0.036990092138582946], ["A0A5C2GQT9", null, null, "Tier 1", 0.35, 1, "unknown", 5, 96.38, 1, 0, null, null, 0, 0, null, 0, null, null], ["P0DOX7", null, "Immunoglobulin kappa light chain", "Tier 1", 0.35, 1, "unknown", 14, 96.19, 1, 0, null, null, 0, 0, null, 0, null, null], ["P23724", "PRE7", "Proteasome subunit beta type-6", "Tier 1", 0.35, 1, "unknown", 30, 94.62, 1, 0, null, null, 0, 0, null, 0, null, null], ["P25043", "PUP1", "Proteasome subunit beta type-2", "Tier 1", 0.35, 1, "unknown", 30, 93.62, 1, 0, null, null, 0, 0, null, 0, null, null], ["Q6GMX0", null, "Ig-like domain-containing protein", "Tier 1", 0.35, 1, "unknown", 11, 92.31, 1, 0, null, null, 0, 0, null, 0, null, null], ["Q7Z3Y4", null, "Ig-like domain-containing protein", "Tier 1", 0.35, 1, "unknown", 23, 92.38, 1, 0, null, null, 0, 0, null, 0, null, null], ["P0DOX5", null, "Immunoglobulin gamma-1 heavy chain", "Tier 1", 0.35, 1, "unknown", 100, 91.62, 1, 0, null, null, 0, 0, null, 0, null, null], ["Q8TCD0", null, "Ig-like domain-containing protein", "Tier 1", 0.35, 1, "unknown", 38, 91.5, 1, 0, null, null, 0, 0, null, 0, null, null], ["B9EE38", "NADH3", "NADH-ubiquinone oxidoreductase chain 3", "Tier 1", 0.35, 1, "unknown", 2, 90.25, 1, 0, null, null, 0, 0, null, 0, null, null], ["A0A6J0Y1Z7", null, null, "Tier 1", 0.35, 1, "unknown", 1, 89.25, 1, 0, null, null, 0, 0, null, 0, null, null], ["P16218", "celH", "Endoglucanase H", "Tier 1", 0.35, 1, "unknown", 23, 88.94, 1, 0, null, null, 0, 0, null, 0, null, null], ["Q6N089", "DKFZp686P15220", "Ig-like domain-containing protein", "Tier 1", 0.35, 1, "unknown", 17, 87.69, 1, 0, null, null, 0, 0, null, 0, null, null], ["Q6MZV7", "DKFZp686C11235", null, "Tier 1", 0.35, 1, "unknown", 16, 87.25, 1, 0, null, null, 0, 0, null, 0, null, null], ["S6B291", null, null, "Tier 1", 0.35, 1, "unknown", 30, 86.88, 1, 0, null, null, 0, 0, null, 0, null, null], ["P03069", "GCN4", "General control transcription factor GCN4", "Tier 1", 0.35, 1, "unknown", 100, 66.69, 1, 0, null, null, 1, 7, "37192858,36832059,36220266,34916251,34213110,31757757,15701809", 0, null, null], ["P12263", null, null, "Tier 1", 0.35, 1, "unknown", 7, 63.59, 1, 0, null, null, 0, 0, null, 0, null, null], ["A0A5P9VSM8", null, "Replicase", "Tier 1", 0.35, 1, "unknown", 7, null, 1, 0, null, null, 1, 9, "38027068,34660818,26336964,23596299,22819625,21440279,20980498,16314308,7578085", 0, null, null], ["A0A5P9VSM6", null, null, "Tier 1", 0.35, 1, "unknown", 6, null, 1, 0, null, null, 0, 0, null, 0, null, null]], "truncated": false, "filtered_table_rows_count": 47, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_cryoEM\" = :p0 and \"in_cev_map\" = :p1 and \"surface_class\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "1", "p1": "0", "p2": "unknown"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=unknown", "results": [{"value": 1, "label": 1, "count": 47, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=unknown&has_structure=1", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=unknown", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 40, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=unknown&tier=Tier+1", "selected": false}, {"value": "Tier 1.5", "label": "Tier 1.5", "count": 7, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=unknown&tier=Tier+1.5", "selected": false}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=unknown", "results": [{"value": 0, "label": 0, "count": 47, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=unknown&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=unknown", "results": [{"value": 0, "label": 0, "count": 45, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=unknown&has_known_aptamer=0", "selected": false}, {"value": 1, "label": 1, "count": 2, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=unknown&has_known_aptamer=1", "selected": false}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=unknown", "results": [{"value": "unknown", "label": "unknown", "count": 47, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=unknown", "results": [{"value": 0, "label": 0, "count": 47, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=unknown", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=unknown", "results": [{"value": 1, "label": 1, "count": 47, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=unknown", "selected": true}], "truncated": false}}, "suggested_facets": [{"name": "protein_name", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=unknown&_facet=protein_name"}, {"name": "evidence_priority", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=unknown&_facet=evidence_priority"}, {"name": "pdb_count_total", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=unknown&_facet=pdb_count_total"}, {"name": "aptamer_count_pubmed", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=unknown&_facet=aptamer_count_pubmed"}, {"name": "opentargets_top_disease_name", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&surface_class=unknown&_facet=opentargets_top_disease_name"}], "next": null, "next_url": null, "private": false, "allow_execute_sql": true, "query_ms": 387.47389102354646, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}