{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_cryoEM = 1, in_cev_map = 0 and tier = \"Tier 1\" sorted by priority_score descending", "rows": [["P12263", null, null, "Tier 1", 0.9, 7, 63.59, 1, 0, null, null, null, 0, 0, null, 0, null, null], ["Q12879", "GRIN2A", "Glutamate receptor ionotropic, NMDA 2A", "Tier 1", 0.88, 37, 60.84, 1, 0, null, null, null, 0, 0, null, 0, "Landau-Kleffner syndrome", 0.8407159711916629], ["Q5T848", "GPR158", "Metabotropic glycine receptor", "Tier 1", 0.839, 6, 58.03, 1, 0, null, null, null, 0, 0, null, 0, "diverticular disease", 0.4384404783771627], ["P0DSE2", "TRB", "M1-specific T cell receptor beta chain", "Tier 1", 0.83, 5, 90.12, 1, 0, null, null, null, 0, 0, null, 0, null, null], ["A0A0E3EAY4", "env", "Envelope glycoprotein gp160", "Tier 1", 0.82, 2, null, 1, 0, null, null, null, 1, 12, "36576612,29464116,29217761,22379083,18776229,18569791,16146716,16043495,16013840,12498773,11024283,9713975", 0, null, null], ["Q9NS82", "SLC7A10", "Asc-type amino acid transporter 1", "Tier 1", 0.803, 4, 83.38, 1, 0, null, null, null, 0, 0, null, 0, "asthma", 0.5295411410172121], ["O60895", "RAMP2", "Receptor activity-modifying protein 2", "Tier 1", 0.802, 10, 80.94, 1, 0, null, null, null, 0, 0, null, 0, "diabetes mellitus", 0.4219370007650345], ["P35414", "APLNR", "Apelin receptor", "Tier 1", 0.8, 37, 81.69, 1, 0, null, null, null, 1, 1, "36126144", 0, "essential hypertension", 0.2159614840844307], ["P01909", "HLA-DQA1", "HLA class II histocompatibility antigen, DQ alpha 1 chain", "Tier 1", 0.792, 27, 87.94, 1, 0, null, null, null, 0, 0, null, 0, "Pleural Mesothelioma", 0.1228600330569846], ["Q13639", null, null, "Tier 1", 0.781, 3, 80.88, 1, 0, null, null, null, 0, 0, null, 0, "schizophrenia", 0.6060830827022777], ["O15393", null, null, "Tier 1", 0.775, 31, 79.38, 1, 0, null, null, null, 0, 0, null, 0, "COVID-19", 0.6157541390484623], ["P07911", "UMOD", "Uromodulin", "Tier 1", 0.774, 10, 82.94, 1, 0, null, null, null, 1, 4, "37533140,35446786", 0, "familial juvenile hyperuricemic nephropathy type 1", 0.8446536377993564], ["P29460", "IL12B", "Interleukin-12 subunit beta", "Tier 1", 0.769, 20, 91.12, 1, 0, null, null, null, 0, 0, null, 0, "psoriasis", 0.7914863943708039], ["P98073", null, null, "Tier 1", 0.761, 14, 81.5, 1, 0, null, null, null, 0, 0, null, 0, "congenital enteropathy due to enteropeptidase deficiency", 0.7102613227574134], ["P40225", "THPO", "Thrombopoietin", "Tier 1", 0.76, 3, 61.44, 1, 0, null, null, null, 1, 2, "38928037,30312735", 0, "thrombocythemia 1", 0.7027329039559379], ["O75762", "TRPA1", "Transient receptor potential cation channel subfamily A member 1", "Tier 1", 0.76, 17, 81.94, 1, 0, null, null, null, 0, 0, null, 0, "familial episodic pain syndrome with predominantly upper body involvement", 0.6615353934604322], ["O43614", null, null, "Tier 1", 0.75, 11, 78.94, 1, 0, null, null, null, 0, 0, null, 0, "insomnia", 0.5988748728311054], ["Q9ULV1", "FZD4", "Frizzled-4", "Tier 1", 0.745, 11, 84.31, 1, 0, null, null, null, 1, 1, "18673242", 0, "Familial exudative vitreoretinopathy", 0.8152111103672746], ["O43526", "KCNQ2", "Potassium voltage-gated channel subfamily KQT member 2", "Tier 1", 0.744, 24, 58.19, 1, 0, null, null, null, 0, 0, null, 0, "Benign familial neonatal seizures", 0.8423358217314708], ["Q8N158", "GPC2", "Glypican-2", "Tier 1", 0.744, 2, 79.06, 1, 0, null, null, null, 0, 0, null, 0, "COVID-19", 0.5409211817593593], ["O15245", "SLC22A1", "Solute carrier family 22 member 1", "Tier 1", 0.744, 16, 84.25, 1, 0, null, null, null, 0, 0, null, 0, "coronary artery disease", 0.5384890077265535], ["P40879", "SLC26A3", "Chloride anion exchanger", "Tier 1", 0.742, 13, 85.06, 1, 0, null, null, null, 0, 0, null, 0, "congenital secretory chloride diarrhea 1", 0.8189631913308207], ["P21730", "C5AR1", "C5a anaphylatoxin chemotactic receptor 1", "Tier 1", 0.741, 19, 85.75, 1, 0, null, null, null, 1, 5, "33495506,29981048,29327939,28288993,25901944", 0, "anti-neutrophil cytoplasmic antibody-associated vasculitis", 0.5076734733894334], ["D7RIG0", "HLA-DRB1", null, "Tier 1", 0.74, 10, 84.94, 1, 0, null, null, null, 0, 0, null, 0, null, null], ["A0A1B0GX56", "TRDV1", "T cell receptor delta variable 1", "Tier 1", 0.737, 7, 90.69, 1, 0, null, null, null, 0, 0, null, 0, "colorectal carcinoma", 0.07391597093694036], ["Q14028", "CNGB1", "Cyclic nucleotide-gated channel beta-1", "Tier 1", 0.734, 11, 57.66, 1, 0, null, null, null, 0, 0, null, 0, "retinitis pigmentosa", 0.7931901344765326], ["P41145", "OPRK1", "Kappa-type opioid receptor", "Tier 1", 0.725, 28, 79.5, 1, 0, null, null, null, 0, 0, null, 0, "alcohol dependence", 0.6106562988740131], ["P23416", "GLRA2", "Glycine receptor subunit alpha-2", "Tier 1", 0.723, 13, 83.81, 1, 0, null, null, null, 0, 0, null, 0, "intellectual developmental disorder, X-linked, syndromic, Pilorge type", 0.7805605973560554], ["B7Z8K6", "TRDC", "T cell receptor delta constant", "Tier 1", 0.72, 12, 81.38, 1, 0, null, null, null, 0, 0, null, 0, null, null], ["P29033", "GJB2", "Gap junction beta-2 protein", "Tier 1", 0.72, 24, 86.19, 1, 0, null, null, null, 0, 0, null, 0, "palmoplantar keratoderma-deafness syndrome", 0.8149616697051898], ["Q695T7", "SLC6A19", "Sodium-dependent neutral amino acid transporter B(0)AT1", "Tier 1", 0.715, 19, 90.0, 1, 0, null, null, null, 0, 0, null, 0, "Hartnup disease", 0.8464240093600148], ["A0A0B4J271", "TRAV12-3", "T cell receptor alpha variable 12-3", "Tier 1", 0.715, 12, 92.56, 1, 0, null, null, null, 0, 0, null, 0, "ulcerative colitis", 0.003139210371371825], ["P20809", "IL11", "Interleukin-11", "Tier 1", 0.712, 8, 82.62, 1, 0, null, null, null, 1, 8, "39408993,39263947,28791655,27878687,25696907,24629635", 0, "osteoarthritis, hip", 0.31754029889853136], ["P49019", "HCAR3", "Hydroxycarboxylic acid receptor 3", "Tier 1", 0.709, 11, 79.19, 1, 0, null, null, null, 0, 0, null, 0, "Oral ulcer", 0.3943093179045574], ["O15342", "ATP6V0E1", "V-type proton ATPase subunit e 1", "Tier 1", 0.708, 9, 92.88, 1, 0, null, null, null, 0, 0, null, 0, "multiple myeloma", 0.18220286553988743], ["Q9BXJ8", "TMEM120A", "Transmembrane protein 120A", "Tier 1", 0.706, 5, 89.25, 1, 0, null, null, null, 0, 0, null, 0, "congenital adrenal hyperplasia due to cytochrome P450 oxidoreductase deficiency", 0.1609725589293368], ["P22888", "LHCGR", "Lutropin-choriogonadotropic hormone receptor", "Tier 1", 0.698, 4, 80.12, 1, 0, null, null, null, 0, 0, null, 0, "Leydig cell hypoplasia, type 1", 0.783461117057047], ["P30989", "NTSR1", "Neurotensin receptor type 1", "Tier 1", 0.695, 24, 79.62, 1, 0, null, null, null, 0, 0, null, 0, "Cough", 0.31206841983343936], ["Q07699", "SCN1B", "Sodium channel regulatory subunit beta-1", "Tier 1", 0.695, 36, 87.06, 1, 0, null, null, null, 0, 0, null, 0, "Generalized epilepsy with febrile seizures-plus", 0.7638796221342504], ["P15309", "ACP3", "Prostatic acid phosphatase", "Tier 1", 0.695, 17, 92.25, 1, 0, null, null, null, 1, 3, "41890985,25591398", 0, "prostate cancer", 0.5521391557206573], ["P48061", "CXCL12", "Stromal cell-derived factor 1", "Tier 1", 0.685, 34, 83.25, 1, 0, null, null, null, 1, 36, "41951573,41931849,41907643,41527798,40401615,40008515,39865939,39263947,38806504,38477735,32784904,31267721,31097627,30465210,30385042,29111236,28963140,28670693,27940247,27924617,27392463,26265085,25560701,25236655,24526776,24277076,23615526,22376154,21147843,41963275", 0, "HIV-1 infection", 0.3675509850165065], ["Q6NW40", "RGMB", "Repulsive guidance molecule B", "Tier 1", 0.683, 11, 79.44, 1, 0, null, null, null, 1, 1, "39263947", 0, "Abnormality of the skeletal system", 0.42535629367019584], ["Q96RJ0", "TAAR1", "Trace amine-associated receptor 1", "Tier 1", 0.68, 17, 90.06, 1, 0, null, null, null, 0, 0, null, 0, "schizophrenia", 0.41827765417829765], ["Q14973", "SLC10A1", "Hepatic sodium/bile acid cotransporter", "Tier 1", 0.679, 11, 83.5, 1, 0, null, null, null, 0, 0, null, 0, "hypercholanemia, familial, 2", 0.6937781800382379], ["Q9UEF7", "KL", "Klotho", "Tier 1", 0.676, 6, 89.06, 1, 0, null, null, null, 1, 19, "41978019,41851110,41038766,40370992,39975897,39909827,38500260,38233588,37584531,36891771,36535944,35770801,35360393,34375633,33536505,31511614,25325398,18569791,40514411", 0, "type 2 diabetes mellitus", 0.5587488336100863], ["O15399", "GRIN2D", "Glutamate receptor ionotropic, NMDA 2D", "Tier 1", 0.675, 13, 63.22, 1, 0, null, null, null, 0, 0, null, 0, "developmental and epileptic encephalopathy, 46", 0.7529662497608808], ["P51681", "CCR5", "C-C chemokine receptor type 5", "Tier 1", 0.674, 25, 85.38, 1, 0, null, null, null, 1, 23, "36576612,33981364,29678881,29556342,29301363,27807347,27652575,26965267,25794434,25754473,25329893,23629001,22811524,21576818,18799178,16631118,16227301,15813986,14610191,12498773", 0, "HIV infection", 0.7442590579227027], ["Q05586", "GRIN1", "Glutamate receptor ionotropic, NMDA 1", "Tier 1", 0.67, 84, 82.88, 1, 0, null, null, null, 0, 0, null, 0, "neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant", 0.8446685494288694], ["Q99679", "GPR21", "Probable G-protein coupled receptor 21", "Tier 1", 0.67, 5, 83.12, 1, 0, null, null, null, 0, 0, null, 0, "type 2 diabetes mellitus", 0.10141298237734184], ["Q8TDV5", "GPR119", "Glucose-dependent insulinotropic receptor", "Tier 1", 0.67, 9, 86.75, 1, 0, null, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.2992783744181862]], "truncated": false, "filtered_table_rows_count": 522, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "priority_score", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "drug_count_approved", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, priority_score, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, drug_count_approved, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_cryoEM\" = :p0 and \"in_cev_map\" = :p1 and \"tier\" = :p2 order by priority_score desc limit 51", "params": {"p0": "1", "p1": "0", "p2": "Tier 1"}}, "facet_results": {"tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&tier=Tier+1", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 522, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 522, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&tier=Tier+1&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 397, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&tier=Tier+1&has_known_aptamer=0", "selected": false}, {"value": 1, "label": 1, "count": 125, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&tier=Tier+1&has_known_aptamer=1", "selected": false}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 522, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&tier=Tier+1", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 522, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&tier=Tier+1", "selected": true}], "truncated": false}}, "suggested_facets": [], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=0&tier=Tier+1&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 427.4501610052539, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}