{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_cryoEM = 1, in_cev_map = 1 and surface_class = \"A2_pm_peripheral\" sorted by evidence_priority descending", "rows": [["P62873", "GNB1", "Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1", "Tier 1", 0.794, 1, "A2_pm_peripheral", 100, 97.06, 1, 0, null, null, 0, 0, null, 1, "intellectual disability, autosomal dominant 42", 0.8462216225099116], ["P06737", "PYGL", "Glycogen phosphorylase, liver form", "Tier 1", 0.787, 1, "A2_pm_peripheral", 19, 92.69, 1, 0, null, null, 0, 0, null, 1, "glycogen storage disease VI", 0.8220063508118274], ["P49770", "EIF2B2", "Translation initiation factor eIF2B subunit beta", "Tier 1", 0.787, 1, "A2_pm_peripheral", 25, 86.56, 1, 0, null, null, 0, 0, null, 1, "CACH syndrome", 0.824634396744653], ["P21333", "FLNA", "Filamin-A", "Tier 1", 0.786, 1, "A2_pm_peripheral", 26, 76.56, 1, 0, null, null, 0, 0, null, 1, "Melnick-Needles syndrome", 0.8200516896124751], ["P31040", "SDHA", "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial", "Tier 1.5", 0.785, 1, "A2_pm_peripheral", 4, 93.94, 1, 0, null, null, 0, 0, null, 1, "mitochondrial complex II deficiency, nuclear type 1", 0.815589203208636], ["Q01831", "XPC", "DNA repair protein complementing XP-C cells", "Tier 1", 0.782, 1, "A2_pm_peripheral", 14, 66.56, 1, 0, null, null, 0, 0, null, 1, "Xeroderma pigmentosum complementation group C", 0.8056391472748724], ["Q12840", "KIF5A", "Kinesin heavy chain isoform 5A", "Tier 1.5", 0.781, 1, "A2_pm_peripheral", 4, 75.31, 1, 0, null, null, 0, 0, null, 1, "hereditary spastic paraplegia 10", 0.8029405627392309], ["P01137", "TGFB1", "Transforming growth factor beta-1 proprotein", "Tier 1", 0.78, 1, "A2_pm_peripheral", 20, 79.56, 1, 0, null, null, 1, 4, "38132522,32370304,16775010,11856769", 1, "Camurati-Engelmann disease", 0.7995305374459716], ["O00330", "PDHX", "Pyruvate dehydrogenase protein X component, mitochondrial", "Tier 1.5", 0.779, 1, "A2_pm_peripheral", 5, 77.31, 1, 0, null, null, 0, 0, null, 1, "pyruvate dehydrogenase E3-binding protein deficiency", 0.7957753555992844], ["Q9NQG7", "HPS4", "BLOC-3 complex member HPS4", "Tier 1.5", 0.779, 1, "A2_pm_peripheral", 1, 61.66, 1, 0, null, null, 0, 0, null, 1, "Hermansky-Pudlak syndrome with pulmonary fibrosis", 0.7967575753847002], ["O00468", "AGRN", "Agrin", "Tier 1.5", 0.777, 1, "A2_pm_peripheral", 1, 68.81, 1, 0, null, null, 0, 0, null, 1, "congenital myasthenic syndrome 8", 0.7912009864338403], ["Q9ULC3", "RAB23", "Ras-related protein Rab-23", "Tier 1.5", 0.776, 1, "A2_pm_peripheral", 6, 79.56, 1, 0, null, null, 1, 1, "23618401", 1, "RAB23-related Carpenter syndrome", 0.7879955689930709], ["Q92743", "HTRA1", "Serine protease HTRA1", "Tier 1", 0.768, 1, "A2_pm_peripheral", 18, 83.25, 1, 0, null, null, 1, 1, "31988066", 1, "cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2", 0.7611877816680132], ["Q9BYI3", "HYCC1", "Hyccin", "Tier 1", 0.766, 1, "A2_pm_peripheral", 5, 67.75, 1, 0, null, null, 0, 0, null, 1, "Hypomyelination - congenital cataract", 0.7528702184568328], ["P35221", "CTNNA1", "Catenin alpha-1", "Tier 1", 0.765, 1, "A2_pm_peripheral", 10, 82.94, 1, 0, null, null, 1, 2, "40265971", 1, "Butterfly-shaped pigment dystrophy", 0.7487735496199569], ["P13797", "PLS3", "Plastin-3", "Tier 1", 0.757, 1, "A2_pm_peripheral", 6, 88.75, 1, 0, null, null, 0, 0, null, 1, "X-linked osteoporosis with fractures", 0.721756781312783], ["P84077", "ARF1", "ADP-ribosylation factor 1", "Tier 1", 0.755, 1, "A2_pm_peripheral", 36, 85.94, 1, 0, null, null, 1, 3, "30965174,11320245", 1, "periventricular nodular heterotopia 8", 0.7173626622431929], ["P07357", "C8A", "Complement component C8 alpha chain", "Tier 1", 0.75, 1, "A2_pm_peripheral", 11, 78.69, 1, 0, null, null, 0, 0, null, 1, "Immunodeficiency due to a late component of complements deficiency", 0.700643416115894], ["Q13546", "RIPK1", "Receptor-interacting serine/threonine-protein kinase 1", "Tier 1", 0.749, 1, "A2_pm_peripheral", 39, 69.75, 1, 0, null, null, 1, 2, "41290466,35919280", 1, "immunodeficiency 57", 0.698121745966467], ["P50148", "GNAQ", "Guanine nucleotide-binding protein G(q) subunit alpha", "Tier 1", 0.748, 1, "A2_pm_peripheral", 30, 93.0, 1, 0, null, null, 1, 1, "40015005", 1, "Sturge-Weber syndrome", 0.6941111530708174], ["O95786", "RIGI", "Antiviral innate immune response receptor RIG-I", "Tier 1", 0.735, 1, "A2_pm_peripheral", 44, 85.19, 1, 0, null, null, 1, 6, "34487794,33253193,32946572,31600868,26018150,22127865", 1, "Singleton-Merten dysplasia", 0.6485708110478319], ["P23921", "RRM1", "Ribonucleoside-diphosphate reductase large subunit", "Tier 1", 0.724, 1, "A2_pm_peripheral", 12, 92.25, 1, 0, null, null, 1, 1, "21955496", 1, "non-small cell lung carcinoma", 0.6122881671315019], ["P32121", "ARRB2", "Beta-arrestin-2", "Tier 1.5", 0.719, 1, "A2_pm_peripheral", 1, 83.81, 1, 0, null, null, 1, 4, "24736311,40652239,29054528", 1, "cancer", 0.5962458729823639], ["P62987", "UBA52", "Ubiquitin-ribosomal protein eL40 fusion protein", "Tier 1", 0.712, 1, "A2_pm_peripheral", 30, 93.5, 1, 0, null, null, 0, 0, null, 1, "HIV infection", 0.5745684844613109], ["P04406", "GAPDH", "Glyceraldehyde-3-phosphate dehydrogenase", "Tier 1", 0.706, 1, "A2_pm_peripheral", 21, 98.12, 1, 0, null, null, 1, 11, "39832592,39429683,35821507,28131717,26310631,23215008,37500700,16115199", 1, "neurodegenerative disease", 0.55307368855439], ["Q8NFH5", "NUP35", "Nucleoporin NUP35", "Tier 1", 0.702, 1, "A2_pm_peripheral", 5, 63.19, 1, 0, null, null, 0, 0, null, 1, "influenza", 0.5409211817593593], ["Q13033", "STRN3", "Striatin-3", "Tier 1", 0.701, 1, "A2_pm_peripheral", 4, 67.5, 1, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.5377902198332467], ["O75143", "ATG13", "Autophagy-related protein 13", "Tier 1", 0.701, 1, "A2_pm_peripheral", 13, 63.84, 1, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.5360512349298453], ["Q6IAA8", "LAMTOR1", "Ragulator complex protein LAMTOR1", "Tier 1", 0.7, 1, "A2_pm_peripheral", 22, 80.12, 1, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.5318107016634962], ["O15511", "ARPC5", "Actin-related protein 2/3 complex subunit 5", "Tier 1.5", 0.699, 1, "A2_pm_peripheral", 2, 92.19, 1, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.5305805352966168], ["P30154", "PPP2R1B", "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform", "Tier 1.5", 0.699, 1, "A2_pm_peripheral", 1, 92.81, 1, 0, null, null, 0, 0, null, 1, "cancer", 0.5305484520119053], ["P49662", "CASP4", "Caspase-4", "Tier 1", 0.692, 1, "A2_pm_peripheral", 9, 78.38, 1, 0, null, null, 0, 0, null, 1, "bacterial disease", 0.5062783346658307], ["Q9UBL3", "ASH2L", "Set1/Ash2 histone methyltransferase complex subunit ASH2", "Tier 1", 0.691, 1, "A2_pm_peripheral", 27, 75.25, 1, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.5019091999413609], ["O00762", "UBE2C", "Ubiquitin-conjugating enzyme E2 C", "Tier 1.5", 0.689, 1, "A2_pm_peripheral", 9, 88.56, 1, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.49682303083942114], ["P31948", "STIP1", "Stress-induced-phosphoprotein 1", "Tier 1.5", 0.689, 1, "A2_pm_peripheral", 8, 89.75, 1, 0, null, null, 1, 7, "41406518,38012811,34831332,32614006,27681499,24654750,24013070", 1, "neurodegenerative disease", 0.4967711525222825], ["P21980", "TGM2", "Protein-glutamine gamma-glutamyltransferase 2", "Tier 1.5", 0.688, 1, "A2_pm_peripheral", 17, 92.88, 1, 0, null, null, 1, 1, "35980938", 1, "neurodegenerative disease", 0.49455272812698803], ["P49327", "FASN", "Fatty acid synthase", "Tier 1", 0.68, 1, "A2_pm_peripheral", 34, 85.44, 1, 0, null, null, 1, 1, "41854184", 1, "dengue disease", 0.46815584653391107], ["P83881", "RPL36A", "Large ribosomal subunit protein eL42", "Tier 1", 0.679, 1, "A2_pm_peripheral", 30, 94.31, 1, 0, null, null, 0, 0, null, 1, "influenza", 0.4619748183558772], ["Q5VZK9", "CARMIL1", "F-actin-uncapping protein LRRC16A", "Tier 1", 0.677, 1, "A2_pm_peripheral", 3, 67.38, 1, 0, null, null, 0, 0, null, 1, "schizophrenia", 0.45718735748281236], ["Q86TV6", "TTC7B", "Tetratricopeptide repeat protein 7B", "Tier 1", 0.673, 1, "A2_pm_peripheral", 5, 85.0, 1, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.4430588960838045], ["Q16763", "UBE2S", "Ubiquitin-conjugating enzyme E2 S", "Tier 1", 0.673, 1, "A2_pm_peripheral", 9, 80.69, 1, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.44489727765466], ["P63098", "PPP3R1", "Calcineurin subunit B type 1", "Tier 1.5", 0.673, 1, "A2_pm_peripheral", 21, 91.12, 1, 0, null, null, 1, 2, "39263947", 1, "Abnormality of the skeletal system", 0.44389060142742937], ["Q16555", "DPYSL2", "Dihydropyrimidinase-related protein 2", "Tier 1", 0.671, 1, "A2_pm_peripheral", 15, 90.25, 1, 0, null, null, 0, 0, null, 1, "hypertension", 0.4377422749119531], ["P61077", "UBE2D3", "Ubiquitin-conjugating enzyme E2 D3", "Tier 1", 0.667, 1, "A2_pm_peripheral", 46, 96.38, 1, 0, null, null, 0, 0, null, 1, "hypertension", 0.4222295115574527], ["P04899", "GNAI2", "Guanine nucleotide-binding protein G(i) subunit alpha-2", "Tier 1", 0.665, 1, "A2_pm_peripheral", 34, 94.06, 1, 0, null, null, 0, 0, null, 1, "ovarian granulosa cell tumor", 0.4157773365202895], ["Q9H0A8", "COMMD4", "COMM domain-containing protein 4", "Tier 1.5", 0.663, 1, "A2_pm_peripheral", 4, 80.75, 1, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.4109063598016124], ["P08238", "HSP90AB1", "Heat shock protein HSP 90-beta", "Tier 1", 0.661, 1, "A2_pm_peripheral", 32, 84.31, 1, 0, null, null, 1, 1, "35921069", 1, "multiple myeloma", 0.40496963397728575], ["Q8N3R9", "PALS1", "Protein PALS1", "Tier 1", 0.652, 1, "A2_pm_peripheral", 9, 77.19, 1, 0, null, null, 0, 0, null, 1, "COVID-19", 0.3720065057444545], ["Q00536", "CDK16", "Cyclin-dependent kinase 16", "Tier 1.5", 0.652, 1, "A2_pm_peripheral", 3, 71.94, 1, 0, null, null, 0, 0, null, 1, "Intellectual disability", 0.3718454818549898], ["P06702", "S100A9", "Protein S100-A9", "Tier 1", 0.651, 1, "A2_pm_peripheral", 13, 94.31, 1, 0, null, null, 1, 9, "41924874,41505229,41477217,40215752,39317671,37879125,35724603,33534888,32478041", 1, "inborn error of immunity", 0.36994943453938645]], "truncated": false, "filtered_table_rows_count": 61, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_cryoEM\" = :p0 and \"in_cev_map\" = :p1 and \"surface_class\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "1", "p1": "1", "p2": "A2_pm_peripheral"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=1&surface_class=A2_pm_peripheral", "results": [{"value": 1, "label": 1, "count": 61, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=1&surface_class=A2_pm_peripheral&has_structure=1", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=1&surface_class=A2_pm_peripheral", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 39, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=1&surface_class=A2_pm_peripheral&tier=Tier+1", "selected": false}, {"value": "Tier 1.5", "label": "Tier 1.5", "count": 22, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=1&surface_class=A2_pm_peripheral&tier=Tier+1.5", "selected": false}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=1&surface_class=A2_pm_peripheral", "results": [{"value": 0, "label": 0, "count": 61, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=1&surface_class=A2_pm_peripheral&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=1&surface_class=A2_pm_peripheral", "results": [{"value": 0, "label": 0, "count": 44, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=1&surface_class=A2_pm_peripheral&has_known_aptamer=0", "selected": false}, {"value": 1, "label": 1, "count": 17, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=1&surface_class=A2_pm_peripheral&has_known_aptamer=1", "selected": false}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=1&surface_class=A2_pm_peripheral", "results": [{"value": "A2_pm_peripheral", "label": "A2_pm_peripheral", "count": 61, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=1", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=1&surface_class=A2_pm_peripheral", "results": [{"value": 1, "label": 1, "count": 61, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A2_pm_peripheral", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=1&surface_class=A2_pm_peripheral", "results": [{"value": 1, "label": 1, "count": 61, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=1&surface_class=A2_pm_peripheral", "selected": true}], "truncated": false}}, "suggested_facets": [{"name": "aptamer_count_pubmed", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=1&surface_class=A2_pm_peripheral&_facet=aptamer_count_pubmed"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=1&surface_class=A2_pm_peripheral&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 1106.605222914368, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}