{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_cryoEM = 1, in_cev_map = 1 and tier = \"Tier 1\" sorted by priority_score descending", "rows": [["O75581", "LRP6", "Low-density lipoprotein receptor-related protein 6", "Tier 1", 0.865, 27, 79.19, 1, 0, null, null, null, 1, 5, "42031715,37175248,18673242", 1, "tooth agenesis, selective, 7", 0.7022725510765017], ["P43005", "SLC1A1", "Excitatory amino acid transporter 3", "Tier 1", 0.805, 22, 80.12, 1, 0, null, null, null, 0, 0, null, 1, "dicarboxylic aminoaciduria", 0.6273449709512636], ["P51679", "CCR4", "C-C chemokine receptor type 4", "Tier 1", 0.804, 7, 80.75, 1, 0, null, null, null, 1, 3, "41518674,39071952,29103909", 1, "mycosis fungoides", 0.5404546856597274], ["P00488", "F13A1", "Coagulation factor XIII A chain", "Tier 1", 0.799, 15, 90.88, 1, 0, null, null, null, 0, 0, null, 1, "Factor XIII subunit A deficiency", 0.7939842013132387], ["P13671", "C6", "Complement component C6", "Tier 1", 0.795, 11, 79.62, 1, 0, null, null, null, 1, 31, "41255414,39736202,39680325,38188151,36290981,36165950,34535250,33034309,32414072,32119944,31819445,30039760,29594379,29408200,28024568,27940247,26588795,26316749,26107993,24512500,24309623,23657986,22973579,22527269,21944470,21788069,21645749,21071077,20008986,19469583,15473710", 1, "Immunodeficiency due to a late component of complements deficiency", 0.75437296887129], ["P06731", "CEACAM5", "Cell adhesion molecule CEACAM5", "Tier 1", 0.795, 6, 87.12, 1, 0, null, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.45156128674958135], ["P04156", "PRNP", "Major prion protein", "Tier 1", 0.785, 70, 64.19, 1, 0, null, null, null, 1, 2, "39556313,34067472", 1, "Gerstmann-Straussler-Scheinker syndrome", 0.8246149684620239], ["P14210", "HGF", "Hepatocyte growth factor", "Tier 1", 0.78, 36, 83.5, 1, 0, null, null, null, 1, 64, "41873087,41601428,41123956,40189053,40041032,39853766,39355222,38963794,38923378,37965838,37075136,36935149,36826373,36477303,36126144,34424707,34165951,31967847,31825565,31595614,30444610,30353654,30312735,28627727,26658271,26592704,25223895,23615526,21546514,20594164,16225393,38925633,38876234,34142433,31381313,30237882,29944203,29416033,27679852,27363484,26131766,11753087", 1, "hearing loss, autosomal recessive", 0.5910507391848663], ["P04839", "CYBB", "NADPH oxidase 2", "Tier 1", 0.776, 6, 90.25, 1, 0, null, null, null, 1, 2, "24635113", 1, "chronic granulomatous disease", 0.8633132852459866], ["P02747", "C1QC", "Complement C1q subcomponent subunit C", "Tier 1", 0.762, 11, 80.56, 1, 0, null, null, null, 0, 0, null, 1, "C1Q deficiency", 0.6233532074390745], ["Q02817", "MUC2", "Mucin-2", "Tier 1", 0.76, 12, null, 1, 0, null, null, null, 0, 0, null, 1, null, null], ["P01189", "POMC", "Pro-opiomelanocortin", "Tier 1", 0.76, 13, 57.66, 1, 0, null, null, null, 1, 1, "30161145", 1, "obesity due to pro-opiomelanocortin deficiency", 0.6958797353500403], ["P07360", null, null, "Tier 1", 0.755, 15, 89.75, 1, 0, null, null, null, 0, 0, null, 1, "complement deficiency", 0.3695798546847018], ["P55899", "FCGRT", "IgG receptor FcRn large subunit p51", "Tier 1", 0.752, 31, 85.0, 1, 0, null, null, null, 0, 0, null, 1, "Myasthenia gravis", 0.5932721106551206], ["P0C0L4", "C4A", "Complement C4-A", "Tier 1", 0.74, 12, 83.44, 1, 0, null, null, null, 1, 4, "37566081,36619572,34739903,31019918", 1, null, null], ["P15144", "ANPEP", "Aminopeptidase N", "Tier 1", 0.74, 15, 93.06, 1, 0, null, null, null, 1, 1, "33554306", 1, "cholelithiasis", 0.5030146927270738], ["Q03405", "PLAUR", "Urokinase plasminogen activator surface receptor", "Tier 1", 0.738, 13, 81.44, 1, 0, null, null, null, 1, 2, "37533140", 1, "Abdominal Aortic Aneurysm", 0.4819526979346149], ["P11215", "ITGAM", "Integrin alpha-M", "Tier 1", 0.72, 30, 86.25, 1, 0, null, null, null, 0, 0, null, 1, "systemic lupus erythematosus", 0.30502849242596436], ["Q9NV96", "TMEM30A", "Cell cycle control protein 50A", "Tier 1", 0.71, 33, 89.5, 1, 0, null, null, null, 0, 0, null, 1, "atrial fibrillation", 0.31177132249681394], ["P13987", "CD59", "CD59 glycoprotein", "Tier 1", 0.705, 17, 79.31, 1, 0, null, null, null, 1, 1, "19915929", 1, "primary CD59 deficiency", 0.7738276843579196], ["O60486", "PLXNC1", "Plexin-C1", "Tier 1", 0.703, 4, 79.06, 1, 0, null, null, null, 0, 0, null, 1, "asthma", 0.532656225351722], ["Q12884", "FAP", "Prolyl endopeptidase FAP", "Tier 1", 0.7, 4, 95.62, 1, 0, null, null, null, 1, 7, "40046817,39710916,39026723,37192373,36838669,36494579,35879297", 1, "psoriasis", 0.40173767366839236], ["P00738", "HP", "Haptoglobin", "Tier 1", 0.695, 15, 84.81, 1, 0, null, null, null, 1, 76, "41855944,41638958,40968672,40231802,39880691,39880501,39835381,39804483,39788927,39613489,39435559,38585969,38545293,38218089,38185050,38047083,38039678,37879039,37701520,37696275,37560929,37104434,36863194,36564526,36291832,36201958,35868696,35686646,35439614,35394406,35195734,35081018,34647930,34556234,34520834,34064911,34038999,33896635,33534888,33404555,33395442,33234387,33214769,33131243,31892078,31820139,31665673,31655906,31655383,31494507,38916796,34183667,34117903", 1, "Hypercholesterolemia", 0.5684135700226365], ["O95858", "TSPAN15", "Tetraspanin-15", "Tier 1", 0.692, 3, 87.56, 1, 0, null, null, null, 1, 1, "37047289", 1, "venous thromboembolism", 0.5182425801223098], ["P00451", "F8", "Coagulation factor VIII", "Tier 1", 0.691, 25, 60.75, 1, 0, null, null, null, 1, 13, "40727755,40266188,28791655,21144556,41587892,40009491,38992298,38752747,31493779,29609491,28979328,21389323,20589313", 1, "hemophilia A", 0.9108044347811838], ["Q8NBJ9", null, null, "Tier 1", 0.688, 7, 80.25, 1, 0, null, null, null, 0, 0, null, 1, "hypothyroidism", 0.32686531914177924], ["P50148", "GNAQ", "Guanine nucleotide-binding protein G(q) subunit alpha", "Tier 1", 0.685, 30, 93.0, 1, 0, null, null, null, 1, 1, "40015005", 1, "Sturge-Weber syndrome", 0.6941111530708174], ["Q14213", null, null, "Tier 1", 0.683, 4, 87.62, 1, 0, null, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.42776938116451996], ["P63092", "GNAS", "Guanine nucleotide-binding protein G(s) subunit alpha isoforms short", "Tier 1", 0.683, 100, 91.31, 1, 0, null, null, null, 0, 0, null, 1, "pseudohypoparathyroidism type 1A", 0.826829760867455], ["P12259", "F5", "Coagulation factor V", "Tier 1", 0.68, 17, 61.91, 1, 0, null, null, null, 1, 4, "32696338,15496523,24629635,17878169", 1, "thrombophilia due to activated protein C resistance", 0.7962069693286362], ["P61073", "CXCR4", "C-X-C chemokine receptor type 4", "Tier 1", 0.68, 33, 82.25, 1, 0, null, null, null, 1, 17, "40671676,40401615,39865939,39778270,37052638,35157940,33739080,31737891,31267721,31097627,28670693,26265085,25329893,22811524,22376154,12498773,41543187", 1, "WHIM syndrome", 0.8009225456235435], ["Q9UNN8", "PROCR", "Endothelial protein C receptor", "Tier 1", 0.68, 13, 86.44, 1, 0, null, null, null, 0, 0, null, 1, "venous thromboembolism", 0.5497662282245215], ["P13501", "CCL5", "C-C motif chemokine 5", "Tier 1", 0.68, 23, 88.44, 1, 0, null, null, null, 1, 6, "41371773,39422353,32784904,30578658,29111236,27392463", 1, "neoplasm", 0.12028522937584413], ["P49913", "CAMP", "Cathelicidin antimicrobial peptide", "Tier 1", 0.675, 20, 80.0, 1, 0, null, null, null, 1, 30, "41316897,40997974,40501769,39429683,39045230,38471488,37947789,35479481,34957366,33832411,31940088,31099939,26843427,26358810,25659966,25437358,25390494,25048161,25044725,24814025,24325980,23748105,23744070,21673794,18165929,12569622,10913311,10780486,37400771", 1, "prostate carcinoma", 0.11970033909944687], ["P01137", "TGFB1", "Transforming growth factor beta-1 proprotein", "Tier 1", 0.665, 20, 79.56, 1, 0, null, null, null, 1, 4, "38132522,32370304,16775010,11856769", 1, "Camurati-Engelmann disease", 0.7995305374459716], ["P15151", "PVR", "Poliovirus receptor", "Tier 1", 0.66, 13, 84.88, 1, 0, null, null, null, 1, 3, "37958909,36598052,16419035", 1, "Alzheimer disease", 0.3596586826147091], ["Q14344", "GNA13", "Guanine nucleotide-binding protein subunit alpha-13", "Tier 1", 0.66, 17, 91.44, 1, 0, null, null, null, 0, 0, null, 1, "lymphoma", 0.37253457492562664], ["P03952", "KLKB1", "Plasma kallikrein", "Tier 1", 0.656, 22, 87.88, 1, 0, null, null, null, 1, 6, "40008515,36859809,33674695,28959386,28632925,23692437", 1, "inherited prekallikrein deficiency", 0.7077440022291496], ["P37173", "TGFBR2", "TGF-beta receptor type-2", "Tier 1", 0.654, 22, 81.0, 1, 0, null, null, null, 1, 8, "32452828,30595527,29522674,29375127,26284552,23999222,22899759,11856769", 1, "Loeys-Dietz syndrome", 0.8390072008866913], ["Q5JWF2", "GNAS", "Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas", "Tier 1", 0.653, 9, 56.72, 1, 0, null, null, null, 0, 0, null, 1, "pseudohypoparathyroidism type 1A", 0.826829760867455], ["P02724", "GYPA", "Glycophorin-A", "Tier 1", 0.653, 16, 59.41, 1, 0, null, null, null, 1, 1, "40599565", 1, "malaria", 0.37656968762740295], ["P46531", "NOTCH1", "Neurogenic locus notch homolog protein 1", "Tier 1", 0.652, 29, 59.59, 1, 0, null, null, null, 1, 4, "38559166,34431568,33614227,28685750", 1, "Adams-Oliver syndrome", 0.8199672000988557], ["P60033", "CD81", "CD81 antigen", "Tier 1", 0.652, 16, 87.38, 1, 0, null, null, null, 1, 5, "34505435,32730952,28959386,23877701,19997645", 1, "immunodeficiency, common variable, 6", 0.6168240011812034], ["Q13936", "CACNA1C", "Voltage-dependent L-type calcium channel subunit alpha-1C", "Tier 1", 0.65, 33, 61.94, 1, 0, null, null, null, 0, 0, null, 1, "Timothy syndrome", 0.8227725490420764], ["P01344", "IGF2", "Insulin-like growth factor 2", "Tier 1", 0.643, 16, 59.03, 1, 0, null, null, null, 1, 13, "38059276,33977395,33467925,31570709,28281528,23373648,19391177,40554308,39225423,32040773", 1, "Silver-Russell syndrome", 0.7290427440273365], ["P06702", "S100A9", "Protein S100-A9", "Tier 1", 0.637, 13, 94.31, 1, 0, null, null, null, 1, 9, "41924874,41505229,41477217,40215752,39317671,37879125,35724603,33534888,32478041", 1, "inborn error of immunity", 0.36994943453938645], ["P20963", "CD247", "T-cell surface glycoprotein CD3 zeta chain", "Tier 1", 0.635, 38, 62.41, 1, 0, null, null, null, 0, 0, null, 1, "immunodeficiency 25", 0.7436838111879828], ["P54289", "CACNA2D1", "Voltage-dependent calcium channel subunit alpha-2/delta-1", "Tier 1", 0.635, 30, 86.56, 1, 0, null, null, null, 0, 0, null, 1, "Seizure", 0.6942469435259896], ["P05109", "S100A8", "Protein S100-A8", "Tier 1", 0.635, 13, 93.06, 1, 0, null, null, null, 1, 5, "41654945,41111484,32964813,32478041,22353892", 1, "inborn error of immunity", 0.37050380432141355], ["P49790", "NUP153", "Nuclear pore complex protein Nup153", "Tier 1", 0.63, 12, 43.59, 1, 0, null, null, null, 0, 0, null, 1, "HIV infection", 0.5431773609684529]], "truncated": false, "filtered_table_rows_count": 647, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "priority_score", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "drug_count_approved", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, priority_score, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, drug_count_approved, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_cryoEM\" = :p0 and \"in_cev_map\" = :p1 and \"tier\" = :p2 order by priority_score desc limit 51", "params": {"p0": "1", "p1": "1", "p2": "Tier 1"}}, "facet_results": {"tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=1&tier=Tier+1", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 647, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=1", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=1&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 646, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=1&tier=Tier+1&has_activation_state_pdb_pair=0", "selected": false}, {"value": 1, "label": 1, "count": 1, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=1&tier=Tier+1&has_activation_state_pdb_pair=1", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=1&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 448, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=1&tier=Tier+1&has_known_aptamer=0", "selected": false}, {"value": 1, "label": 1, "count": 199, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=1&tier=Tier+1&has_known_aptamer=1", "selected": false}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=1&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 647, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&tier=Tier+1", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=1&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 647, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=1&tier=Tier+1", "selected": true}], "truncated": false}}, "suggested_facets": [], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=1&tier=Tier+1&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 438.97577499592444, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}