{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_cryoEM = 1, in_cev_map = 1 and tier = \"Tier 1.5\" sorted by priority_score descending", "rows": [["P25445", "FAS", "Tumor necrosis factor receptor superfamily member 6", "Tier 1.5", 0.914, 7, 77.88, 1, 0, null, null, null, 1, 17, "40784034,39897575,37458448,36908619,35402075,32270033,31436946,30594071,30417194,30339905,26318819,23980164,23511245,18997060,18956014,16729304,16581027", 1, "autoimmune lymphoproliferative syndrome type 1", 0.7377210386590284], ["Q02094", "RHAG", "Ammonium transporter Rh type A", "Tier 1.5", 0.841, 8, 95.62, 1, 0, null, null, null, 0, 0, null, 1, "Rh deficiency syndrome", 0.764209214915708], ["Q14392", "LRRC32", "Transforming growth factor beta activator LRRC32", "Tier 1.5", 0.838, 6, 86.06, 1, 0, null, null, null, 0, 0, null, 1, "cleft palate, proliferative retinopathy, and developmental delay", 0.5770707112957068], ["P12532", "CKMT1A", "Creatine kinase U-type, mitochondrial", "Tier 1.5", 0.83, 9, 89.31, 1, 0, null, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.5385822922582763], ["P54709", "ATP1B3", "Sodium/potassium-transporting ATPase subunit beta-3", "Tier 1.5", 0.81, 7, 89.69, 1, 0, null, null, null, 0, 0, null, 1, "congestive heart failure", 0.5999952111132625], ["P02748", "C9", "Complement component C9", "Tier 1.5", 0.796, 9, 78.75, 1, 0, null, null, null, 1, 10, "41636061,40411682,36428893,36290981,35247355,28794177,27836219,22678933,19261617,15687383", 1, "Immunodeficiency due to a late component of complements deficiency", 0.761965409699055], ["Q13085", "ACACA", "Acetyl-CoA carboxylase 1", "Tier 1.5", 0.79, 10, 82.81, 1, 0, null, null, null, 1, 1, "41854184", 1, null, null], ["Q92633", "LPAR1", "Lysophosphatidic acid receptor 1", "Tier 1.5", 0.785, 16, 83.62, 1, 0, null, null, null, 1, 1, "32065590", 1, "Epiretinal membrane", 0.4757255248053499], ["P39060", "COL18A1", "Collagen alpha-1(XVIII) chain", "Tier 1.5", 0.769, 9, 50.62, 1, 0, null, null, null, 1, 2, "36707842,23679916", 1, "Knobloch syndrome 1", 0.7867122552672962], ["O60568", "PLOD3", "Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3", "Tier 1.5", 0.762, 18, 91.38, 1, 0, null, null, null, 0, 0, null, 1, "bone fragility with contractures, arterial rupture, and deafness", 0.7159150369336311], ["P41440", "SLC19A1", "Reduced folate transporter", "Tier 1.5", 0.755, 19, 72.06, 1, 0, null, null, null, 0, 0, null, 1, "Knobloch syndrome", 0.5526223217595396], ["P43007", "SLC1A4", "Neutral amino acid transporter A", "Tier 1.5", 0.75, 1, 80.56, 1, 0, null, null, null, 1, 6, "36219068,31989939,27571928,26811678,19046328,16139842", 1, "spastic tetraplegia-thin corpus callosum-progressive postnatal microcephaly syndrome", 0.8025684205131692], ["P26022", "PTX3", "Pentraxin-related protein PTX3", "Tier 1.5", 0.75, 9, 76.75, 1, 0, null, null, null, 0, 0, null, 1, "polycystic ovary syndrome", 0.12287624125782433], ["P08648", "ITGA5", "Integrin alpha-5", "Tier 1.5", 0.748, 14, 85.25, 1, 0, null, null, null, 1, 2, "32174798,38258032", 1, "skin disease", 0.28465651599598124], ["Q9Y653", "ADGRG1", "Adhesion G-protein coupled receptor G1", "Tier 1.5", 0.743, 1, 77.88, 1, 0, null, null, null, 0, 0, null, 1, "bilateral frontoparietal polymicrogyria", 0.8322298896713178], ["O60884", "DNAJA2", "DnaJ homolog subfamily A member 2", "Tier 1.5", 0.73, 1, 83.38, 1, 0, null, null, null, 1, 2, "41935727,33879515", 1, "dengue disease", 0.37068859424875583], ["P07942", "LAMB1", "Laminin subunit beta-1", "Tier 1.5", 0.72, 3, 76.69, 1, 0, null, null, null, 0, 0, null, 1, "cobblestone lissencephaly without muscular or ocular involvement", 0.8016665947624902], ["Q99988", "GDF15", "Growth/differentiation factor 15", "Tier 1.5", 0.718, 4, 75.69, 1, 0, null, null, null, 1, 29, "41924874,41862097,38879214,38477735,37982669,36927042,36638554,36508319,36333824,35762561,33334063,32527800,31988066,29992704,39884764,38497478,38296402,37162508,32739349,30335547", 1, "hyperemesis gravidarum", 0.5821658682742563], ["Q9NR82", "KCNQ5", "Potassium voltage-gated channel subfamily KQT member 5", "Tier 1.5", 0.711, 5, 56.41, 1, 0, null, null, null, 0, 0, null, 1, "intellectual disability, autosomal dominant 46", 0.7086662845211597], ["P14770", "GP9", "Platelet glycoprotein IX", "Tier 1.5", 0.702, 2, 84.69, 1, 0, null, null, null, 0, 0, null, 1, "Bernard-Soulier syndrome", 0.8233582238860002], ["P07225", "PROS1", "Vitamin K-dependent protein S", "Tier 1.5", 0.7, 3, 82.94, 1, 0, null, null, null, 1, 2, "36859809,33674695", 1, "thrombophilia due to protein S deficiency, autosomal dominant", 0.8240418292042652], ["P21359", "NF1", "Neurofibromin", "Tier 1.5", 0.695, 26, 87.19, 1, 0, null, null, null, 1, 2, "32980430,22617876", 1, "neurofibromatosis type 1", 0.8844735398780649], ["P01825", "IGHV4-59", "Immunoglobulin heavy variable 4-59", "Tier 1.5", 0.69, 3, 91.56, 1, 0, null, null, null, 0, 0, null, 1, "cutaneous Leishmaniasis", 0.5868213846274001], ["Q6NT16", "SLC18B1", "MFS-type transporter SLC18B1", "Tier 1.5", 0.688, 4, 84.62, 1, 0, null, null, null, 0, 0, null, 1, "Parkinson disease", 0.276931649354752], ["Q99250", "SCN2A", "Sodium channel protein type 2 subunit alpha", "Tier 1.5", 0.685, 5, 68.81, 1, 0, null, null, null, 0, 0, null, 1, "developmental and epileptic encephalopathy, 11", 0.8388748085806758], ["Q15582", "TGFBI", "Transforming growth factor-beta-induced protein ig-h3", "Tier 1.5", 0.682, 10, 90.25, 1, 0, null, null, null, 0, 0, null, 1, "lattice corneal dystrophy type I", 0.8242841141270143], ["Q8TD43", "TRPM4", "Transient receptor potential cation channel subfamily M member 4", "Tier 1.5", 0.68, 25, 77.44, 1, 0, null, null, null, 0, 0, null, 1, "Familial progressive cardiac conduction defect", 0.7868180621357534], ["O75935", "DCTN3", "Dynactin subunit 3", "Tier 1.5", 0.68, 1, 88.38, 1, 0, null, null, null, 0, 0, null, 1, "viral disease", 0.03700998752471888], ["P05023", "ATP1A1", "Sodium/potassium-transporting ATPase subunit alpha-1", "Tier 1.5", 0.679, 10, 88.69, 1, 0, null, null, null, 0, 0, null, 1, "Charcot-Marie-tooth disease, axonal, type 2DD", 0.7868851290226483], ["Q92536", "SLC7A6", "Y+L amino acid transporter 2", "Tier 1.5", 0.678, 2, 83.19, 1, 0, null, null, null, 0, 0, null, 1, "Abnormality of the skeletal system", 0.48544421359843914], ["P18564", "ITGB6", "Integrin beta-6", "Tier 1.5", 0.675, 14, 82.88, 1, 0, null, null, null, 0, 0, null, 1, "Hypoplastic amelogenesis imperfecta", 0.6045342804405103], ["P36021", "SLC16A2", "Monocarboxylate transporter 8", "Tier 1.5", 0.675, 7, 79.56, 1, 0, null, null, null, 0, 0, null, 1, "Allan-Herndon-Dudley syndrome", 0.8533069932022032], ["P32241", "VIPR1", "Vasoactive intestinal polypeptide receptor 1", "Tier 1.5", 0.667, 17, 76.0, 1, 0, null, null, null, 0, 0, null, 1, "diverticular disease", 0.2747596866638145], ["O95563", "MPC2", "Mitochondrial pyruvate carrier 2", "Tier 1.5", 0.665, 17, 89.44, 1, 0, null, null, null, 0, 0, null, 1, "mitochondrial pyruvate carrier deficiency", 0.18534429712437792], ["O15554", "KCNN4", "Intermediate conductance calcium-activated potassium channel protein 4", "Tier 1.5", 0.661, 17, 84.19, 1, 0, null, null, null, 0, 0, null, 1, "dehydrated hereditary stomatocytosis", 0.7145864899974032], ["P98155", "VLDLR", "Very low-density lipoprotein receptor", "Tier 1.5", 0.66, 27, 75.69, 1, 0, null, null, null, 1, 1, "19188685", 1, "Dysequilibrium syndrome", 0.790164037509625], ["P13637", "ATP1A3", "Sodium/potassium-transporting ATPase subunit alpha-3", "Tier 1.5", 0.654, 5, 88.81, 1, 0, null, null, null, 0, 0, null, 1, "alternating hemiplegia of childhood 2", 0.842328126568451], ["Q14524", "SCN5A", "Sodium channel protein type 5 subunit alpha", "Tier 1.5", 0.654, 16, 67.25, 1, 0, null, null, null, 0, 0, null, 1, "long QT syndrome 3", 0.8448298602976083], ["P16234", "PDGFRA", "Platelet-derived growth factor receptor alpha", "Tier 1.5", 0.652, 14, 72.69, 1, 0, null, null, null, 1, 4, "33334063,32127469,28010895,30594071", 1, "gastrointestinal stromal tumor", 0.8167494524079806], ["O60449", "LY75", "Lymphocyte antigen 75", "Tier 1.5", 0.65, 4, 75.62, 1, 0, null, null, null, 0, 0, null, 1, "Abruptio Placentae", 0.31953367678705413], ["O00468", "AGRN", "Agrin", "Tier 1.5", 0.649, 1, 68.81, 1, 0, null, null, null, 0, 0, null, 1, "congenital myasthenic syndrome 8", 0.7912009864338403], ["Q15027", "ACAP1", "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1", "Tier 1.5", 0.649, 7, 84.38, 1, 0, null, null, null, 0, 0, null, 1, "hypothyroidism", 0.4891091360736571], ["O00478", "BTN3A3", "Butyrophilin subfamily 3 member A3", "Tier 1.5", 0.648, 9, 82.81, 1, 0, null, null, null, 0, 0, null, 1, "neoplasm", 0.07870866954589865], ["P07237", "P4HB", "Protein disulfide-isomerase", "Tier 1.5", 0.644, 14, 88.5, 1, 0, null, null, null, 1, 2, "31625090,28952381", 1, "Cole-Carpenter syndrome", 0.7447295842045853], ["Q8TEM1", "NUP210", "Nuclear pore membrane glycoprotein 210", "Tier 1.5", 0.644, 2, 79.56, 1, 0, null, null, null, 0, 0, null, 1, "HIV infection", 0.5409211817593593], ["Q9Y4R8", "TELO2", "Telomere length regulation protein TEL2 homolog", "Tier 1.5", 0.64, 3, 83.88, 1, 0, null, null, null, 0, 0, null, 1, "TELO2-related intellectual disability-neurodevelopmental disorder", 0.7971337980726797], ["O60443", "GSDME", "Gasdermin-E", "Tier 1.5", 0.638, 2, 77.44, 1, 0, null, null, null, 0, 0, null, 1, "autosomal dominant nonsyndromic hearing loss", 0.6288670542083885], ["P00846", "MT-ATP6", "ATP synthase F(0) complex subunit a", "Tier 1.5", 0.636, 10, 88.94, 1, 0, null, null, null, 0, 0, null, 1, "NARP syndrome", 0.760749518172638], ["P21731", "TBXA2R", "Thromboxane A2 receptor", "Tier 1.5", 0.634, 6, 86.25, 1, 0, null, null, null, 0, 0, null, 1, "bleeding diathesis due to thromboxane synthesis deficiency", 0.639967145559869], ["O75976", "CPD", "Carboxypeptidase D", "Tier 1.5", 0.625, 3, 82.5, 1, 0, null, null, null, 1, 1, "36457699", 1, "neurodegenerative disease", 0.34777406871587735]], "truncated": false, "filtered_table_rows_count": 239, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "priority_score", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "drug_count_approved", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, priority_score, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, drug_count_approved, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_cryoEM\" = :p0 and \"in_cev_map\" = :p1 and \"tier\" = :p2 order by priority_score desc limit 51", "params": {"p0": "1", "p1": "1", "p2": "Tier 1.5"}}, "facet_results": {"tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=1&tier=Tier+1.5", "results": [{"value": "Tier 1.5", "label": "Tier 1.5", "count": 239, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=1", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=1&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 239, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=1&tier=Tier+1.5&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=1&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 187, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=1&tier=Tier+1.5&has_known_aptamer=0", "selected": false}, {"value": 1, "label": 1, "count": 52, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=1&tier=Tier+1.5&has_known_aptamer=1", "selected": false}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=1&tier=Tier+1.5", "results": [{"value": 1, "label": 1, "count": 239, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&tier=Tier+1.5", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&in_cev_map=1&tier=Tier+1.5", "results": [{"value": 1, "label": 1, "count": 239, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=1&tier=Tier+1.5", "selected": true}], "truncated": false}}, "suggested_facets": [{"name": "pdb_count_total", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=1&tier=Tier+1.5&_facet=pdb_count_total"}, {"name": "aptamer_count_pubmed", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=1&tier=Tier+1.5&_facet=aptamer_count_pubmed"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&in_cev_map=1&tier=Tier+1.5&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 485.85422500036657, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}