{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_cryoEM = 1, surface_class = \"A2_pm_peripheral\" and tier = \"Tier 1\" sorted by evidence_priority descending", "rows": [["P62873", "GNB1", "Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1", "Tier 1", 0.794, 1, "A2_pm_peripheral", 100, 97.06, 1, 0, null, null, 0, 0, null, 1, "intellectual disability, autosomal dominant 42", 0.8462216225099116], ["P06737", "PYGL", "Glycogen phosphorylase, liver form", "Tier 1", 0.787, 1, "A2_pm_peripheral", 19, 92.69, 1, 0, null, null, 0, 0, null, 1, "glycogen storage disease VI", 0.8220063508118274], ["P49770", "EIF2B2", "Translation initiation factor eIF2B subunit beta", "Tier 1", 0.787, 1, "A2_pm_peripheral", 25, 86.56, 1, 0, null, null, 0, 0, null, 1, "CACH syndrome", 0.824634396744653], ["P21333", "FLNA", "Filamin-A", "Tier 1", 0.786, 1, "A2_pm_peripheral", 26, 76.56, 1, 0, null, null, 0, 0, null, 1, "Melnick-Needles syndrome", 0.8200516896124751], ["Q01831", "XPC", "DNA repair protein complementing XP-C cells", "Tier 1", 0.782, 1, "A2_pm_peripheral", 14, 66.56, 1, 0, null, null, 0, 0, null, 1, "Xeroderma pigmentosum complementation group C", 0.8056391472748724], ["P01137", "TGFB1", "Transforming growth factor beta-1 proprotein", "Tier 1", 0.78, 1, "A2_pm_peripheral", 20, 79.56, 1, 0, null, null, 1, 4, "38132522,32370304,16775010,11856769", 1, "Camurati-Engelmann disease", 0.7995305374459716], ["Q92743", "HTRA1", "Serine protease HTRA1", "Tier 1", 0.768, 1, "A2_pm_peripheral", 18, 83.25, 1, 0, null, null, 1, 1, "31988066", 1, "cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2", 0.7611877816680132], ["Q9BYI3", "HYCC1", "Hyccin", "Tier 1", 0.766, 1, "A2_pm_peripheral", 5, 67.75, 1, 0, null, null, 0, 0, null, 1, "Hypomyelination - congenital cataract", 0.7528702184568328], ["P35221", "CTNNA1", "Catenin alpha-1", "Tier 1", 0.765, 1, "A2_pm_peripheral", 10, 82.94, 1, 0, null, null, 1, 2, "40265971", 1, "Butterfly-shaped pigment dystrophy", 0.7487735496199569], ["P13797", "PLS3", "Plastin-3", "Tier 1", 0.757, 1, "A2_pm_peripheral", 6, 88.75, 1, 0, null, null, 0, 0, null, 1, "X-linked osteoporosis with fractures", 0.721756781312783], ["P84077", "ARF1", "ADP-ribosylation factor 1", "Tier 1", 0.755, 1, "A2_pm_peripheral", 36, 85.94, 1, 0, null, null, 1, 3, "30965174,11320245", 1, "periventricular nodular heterotopia 8", 0.7173626622431929], ["P07357", "C8A", "Complement component C8 alpha chain", "Tier 1", 0.75, 1, "A2_pm_peripheral", 11, 78.69, 1, 0, null, null, 0, 0, null, 1, "Immunodeficiency due to a late component of complements deficiency", 0.700643416115894], ["Q13546", "RIPK1", "Receptor-interacting serine/threonine-protein kinase 1", "Tier 1", 0.749, 1, "A2_pm_peripheral", 39, 69.75, 1, 0, null, null, 1, 2, "41290466,35919280", 1, "immunodeficiency 57", 0.698121745966467], ["P50148", "GNAQ", "Guanine nucleotide-binding protein G(q) subunit alpha", "Tier 1", 0.748, 1, "A2_pm_peripheral", 30, 93.0, 1, 0, null, null, 1, 1, "40015005", 1, "Sturge-Weber syndrome", 0.6941111530708174], ["O95786", "RIGI", "Antiviral innate immune response receptor RIG-I", "Tier 1", 0.735, 1, "A2_pm_peripheral", 44, 85.19, 1, 0, null, null, 1, 6, "34487794,33253193,32946572,31600868,26018150,22127865", 1, "Singleton-Merten dysplasia", 0.6485708110478319], ["P23921", "RRM1", "Ribonucleoside-diphosphate reductase large subunit", "Tier 1", 0.724, 1, "A2_pm_peripheral", 12, 92.25, 1, 0, null, null, 1, 1, "21955496", 1, "non-small cell lung carcinoma", 0.6122881671315019], ["P62987", "UBA52", "Ubiquitin-ribosomal protein eL40 fusion protein", "Tier 1", 0.712, 1, "A2_pm_peripheral", 30, 93.5, 1, 0, null, null, 0, 0, null, 1, "HIV infection", 0.5745684844613109], ["P04406", "GAPDH", "Glyceraldehyde-3-phosphate dehydrogenase", "Tier 1", 0.706, 1, "A2_pm_peripheral", 21, 98.12, 1, 0, null, null, 1, 11, "39832592,39429683,35821507,28131717,26310631,23215008,37500700,16115199", 1, "neurodegenerative disease", 0.55307368855439], ["Q8NFH5", "NUP35", "Nucleoporin NUP35", "Tier 1", 0.702, 1, "A2_pm_peripheral", 5, 63.19, 1, 0, null, null, 0, 0, null, 1, "influenza", 0.5409211817593593], ["Q13033", "STRN3", "Striatin-3", "Tier 1", 0.701, 1, "A2_pm_peripheral", 4, 67.5, 1, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.5377902198332467], ["O75143", "ATG13", "Autophagy-related protein 13", "Tier 1", 0.701, 1, "A2_pm_peripheral", 13, 63.84, 1, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.5360512349298453], ["Q6IAA8", "LAMTOR1", "Ragulator complex protein LAMTOR1", "Tier 1", 0.7, 1, "A2_pm_peripheral", 22, 80.12, 1, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.5318107016634962], ["P49662", "CASP4", "Caspase-4", "Tier 1", 0.692, 1, "A2_pm_peripheral", 9, 78.38, 1, 0, null, null, 0, 0, null, 1, "bacterial disease", 0.5062783346658307], ["Q9UBL3", "ASH2L", "Set1/Ash2 histone methyltransferase complex subunit ASH2", "Tier 1", 0.691, 1, "A2_pm_peripheral", 27, 75.25, 1, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.5019091999413609], ["P49327", "FASN", "Fatty acid synthase", "Tier 1", 0.68, 1, "A2_pm_peripheral", 34, 85.44, 1, 0, null, null, 1, 1, "41854184", 1, "dengue disease", 0.46815584653391107], ["P83881", "RPL36A", "Large ribosomal subunit protein eL42", "Tier 1", 0.679, 1, "A2_pm_peripheral", 30, 94.31, 1, 0, null, null, 0, 0, null, 1, "influenza", 0.4619748183558772], ["Q5VZK9", "CARMIL1", "F-actin-uncapping protein LRRC16A", "Tier 1", 0.677, 1, "A2_pm_peripheral", 3, 67.38, 1, 0, null, null, 0, 0, null, 1, "schizophrenia", 0.45718735748281236], ["Q86TV6", "TTC7B", "Tetratricopeptide repeat protein 7B", "Tier 1", 0.673, 1, "A2_pm_peripheral", 5, 85.0, 1, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.4430588960838045], ["Q16763", "UBE2S", "Ubiquitin-conjugating enzyme E2 S", "Tier 1", 0.673, 1, "A2_pm_peripheral", 9, 80.69, 1, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.44489727765466], ["Q16555", "DPYSL2", "Dihydropyrimidinase-related protein 2", "Tier 1", 0.671, 1, "A2_pm_peripheral", 15, 90.25, 1, 0, null, null, 0, 0, null, 1, "hypertension", 0.4377422749119531], ["P61077", "UBE2D3", "Ubiquitin-conjugating enzyme E2 D3", "Tier 1", 0.667, 1, "A2_pm_peripheral", 46, 96.38, 1, 0, null, null, 0, 0, null, 1, "hypertension", 0.4222295115574527], ["P04899", "GNAI2", "Guanine nucleotide-binding protein G(i) subunit alpha-2", "Tier 1", 0.665, 1, "A2_pm_peripheral", 34, 94.06, 1, 0, null, null, 0, 0, null, 1, "ovarian granulosa cell tumor", 0.4157773365202895], ["P08238", "HSP90AB1", "Heat shock protein HSP 90-beta", "Tier 1", 0.661, 1, "A2_pm_peripheral", 32, 84.31, 1, 0, null, null, 1, 1, "35921069", 1, "multiple myeloma", 0.40496963397728575], ["Q8N3R9", "PALS1", "Protein PALS1", "Tier 1", 0.652, 1, "A2_pm_peripheral", 9, 77.19, 1, 0, null, null, 0, 0, null, 1, "COVID-19", 0.3720065057444545], ["P06702", "S100A9", "Protein S100-A9", "Tier 1", 0.651, 1, "A2_pm_peripheral", 13, 94.31, 1, 0, null, null, 1, 9, "41924874,41505229,41477217,40215752,39317671,37879125,35724603,33534888,32478041", 1, "inborn error of immunity", 0.36994943453938645], ["Q92797", "SYMPK", "Symplekin", "Tier 1", 0.651, 1, "A2_pm_peripheral", 13, 74.56, 1, 0, null, null, 0, 0, null, 1, "dengue disease", 0.3695798546847018], ["Q16658", "FSCN1", "Fascin", "Tier 1", 0.642, 1, "A2_pm_peripheral", 28, 94.19, 1, 0, null, null, 0, 0, null, 1, "ankylosing spondylitis", 0.3390409466148633], ["Q4FZB7", "KMT5B", "Histone-lysine N-methyltransferase KMT5B", "Tier 1", 0.628, 1, "A2_pm_peripheral", 10, 54.91, 1, 0, null, null, 0, 0, null, 0, "intellectual disability, autosomal dominant 51", 0.7943209483524042], ["Q5JVL4", "EFHC1", "EF-hand domain-containing protein 1", "Tier 1", 0.626, 1, "A2_pm_peripheral", 2, 83.88, 1, 0, null, null, 0, 0, null, 0, "juvenile myoclonic epilepsy", 0.7858434985198706], ["Q15019", "SEPTIN2", "Septin-2", "Tier 1", 0.621, 1, "A2_pm_peripheral", 7, 81.81, 1, 0, null, null, 0, 0, null, 1, "osteoarthritis, hip", 0.2686294007302314], ["Q9NPP4", "NLRC4", "NLR family CARD domain-containing protein 4", "Tier 1", 0.619, 1, "A2_pm_peripheral", 6, 85.12, 1, 0, null, null, 0, 0, null, 0, "periodic fever-infantile enterocolitis-autoinflammatory syndrome", 0.7635956406357429], ["P10636", "MAPT", "Microtubule-associated protein tau", "Tier 1", 0.618, 1, "A2_pm_peripheral", 100, 49.22, 1, 0, null, null, 1, 9, "40380000,39241336,38585969,38397086,37003060,31900535,30004544,29268187", 0, "Pick disease", 0.7600399335134378], ["P35716", "SOX11", "Transcription factor SOX-11", "Tier 1", 0.614, 1, "A2_pm_peripheral", 4, 56.41, 1, 0, null, null, 0, 0, null, 0, "intellectual developmental disorder with microcephaly and with or without ocular malformations or hypogonadotropic hypogonadism", 0.7470288070793535], ["P41159", "LEP", "Leptin", "Tier 1", 0.606, 1, "A2_pm_peripheral", 10, 81.12, 1, 0, null, null, 1, 14, "40330320,40008515,39263947,37331044,36508319,36173490,35884340,34016094,33650854,32527800,27530235,26529285,23232067,20594164", 0, "obesity due to congenital leptin deficiency", 0.7197450249224271], ["Q9Y5K8", "ATP6V1D", "V-type proton ATPase subunit D", "Tier 1", 0.552, 1, "A2_pm_peripheral", 8, 86.25, 1, 0, null, null, 0, 0, null, 1, "Alzheimer disease", 0.03916204989460526], ["Q9BVS4", "RIOK2", "Serine/threonine-protein kinase RIO2", "Tier 1", 0.552, 1, "A2_pm_peripheral", 10, 67.38, 1, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.539818754658029], ["Q9NXF7", "DCAF16", "DDB1- and CUL4-associated factor 16", "Tier 1", 0.548, 1, "A2_pm_peripheral", 2, 38.19, 1, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.5251061120759617], ["O43663", "PRC1", "Protein regulator of cytokinesis 1", "Tier 1", 0.544, 1, "A2_pm_peripheral", 6, 78.94, 1, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.5139662839321523], ["P43351", "RAD52", "DNA repair protein RAD52 homolog", "Tier 1", 0.528, 1, "A2_pm_peripheral", 11, 69.62, 1, 0, null, null, 1, 6, "37288783,32945515,31495919,26784987,24500205,23836560", 0, "Abnormality of the skeletal system", 0.45994164258033876], ["Q9UK80", "USP21", "Ubiquitin carboxyl-terminal hydrolase 21", "Tier 1", 0.524, 1, "A2_pm_peripheral", 4, 69.75, 1, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.44616960950164986]], "truncated": false, "filtered_table_rows_count": 53, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_cryoEM\" = :p0 and \"surface_class\" = :p1 and \"tier\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "1", "p1": "A2_pm_peripheral", "p2": "Tier 1"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=A2_pm_peripheral&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 53, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A2_pm_peripheral&tier=Tier+1&has_structure=1", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=A2_pm_peripheral&tier=Tier+1", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 53, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A2_pm_peripheral", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=A2_pm_peripheral&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 53, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A2_pm_peripheral&tier=Tier+1&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=A2_pm_peripheral&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 38, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A2_pm_peripheral&tier=Tier+1&has_known_aptamer=0", "selected": false}, {"value": 1, "label": 1, "count": 15, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A2_pm_peripheral&tier=Tier+1&has_known_aptamer=1", "selected": false}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=A2_pm_peripheral&tier=Tier+1", "results": [{"value": "A2_pm_peripheral", "label": "A2_pm_peripheral", "count": 53, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&tier=Tier+1", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=A2_pm_peripheral&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 39, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A2_pm_peripheral&tier=Tier+1&in_cev_map=1", "selected": false}, {"value": 0, "label": 0, "count": 14, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A2_pm_peripheral&tier=Tier+1&in_cev_map=0", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=A2_pm_peripheral&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 53, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A2_pm_peripheral&tier=Tier+1", "selected": true}], "truncated": false}}, "suggested_facets": [{"name": "aptamer_count_pubmed", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A2_pm_peripheral&tier=Tier+1&_facet=aptamer_count_pubmed"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A2_pm_peripheral&tier=Tier+1&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 515.4048097319901, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}