{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_cryoEM = 1, surface_class = \"A2_pm_peripheral\" and tier = \"Tier 1.5\" sorted by evidence_priority descending", "rows": [["P31040", "SDHA", "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial", "Tier 1.5", 0.785, 1, "A2_pm_peripheral", 4, 93.94, 1, 0, null, null, 0, 0, null, 1, "mitochondrial complex II deficiency, nuclear type 1", 0.815589203208636], ["Q12840", "KIF5A", "Kinesin heavy chain isoform 5A", "Tier 1.5", 0.781, 1, "A2_pm_peripheral", 4, 75.31, 1, 0, null, null, 0, 0, null, 1, "hereditary spastic paraplegia 10", 0.8029405627392309], ["O00330", "PDHX", "Pyruvate dehydrogenase protein X component, mitochondrial", "Tier 1.5", 0.779, 1, "A2_pm_peripheral", 5, 77.31, 1, 0, null, null, 0, 0, null, 1, "pyruvate dehydrogenase E3-binding protein deficiency", 0.7957753555992844], ["Q9NQG7", "HPS4", "BLOC-3 complex member HPS4", "Tier 1.5", 0.779, 1, "A2_pm_peripheral", 1, 61.66, 1, 0, null, null, 0, 0, null, 1, "Hermansky-Pudlak syndrome with pulmonary fibrosis", 0.7967575753847002], ["O00468", "AGRN", "Agrin", "Tier 1.5", 0.777, 1, "A2_pm_peripheral", 1, 68.81, 1, 0, null, null, 0, 0, null, 1, "congenital myasthenic syndrome 8", 0.7912009864338403], ["Q9ULC3", "RAB23", "Ras-related protein Rab-23", "Tier 1.5", 0.776, 1, "A2_pm_peripheral", 6, 79.56, 1, 0, null, null, 1, 1, "23618401", 1, "RAB23-related Carpenter syndrome", 0.7879955689930709], ["P32121", "ARRB2", "Beta-arrestin-2", "Tier 1.5", 0.719, 1, "A2_pm_peripheral", 1, 83.81, 1, 0, null, null, 1, 4, "24736311,40652239,29054528", 1, "cancer", 0.5962458729823639], ["O15511", "ARPC5", "Actin-related protein 2/3 complex subunit 5", "Tier 1.5", 0.699, 1, "A2_pm_peripheral", 2, 92.19, 1, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.5305805352966168], ["P30154", "PPP2R1B", "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform", "Tier 1.5", 0.699, 1, "A2_pm_peripheral", 1, 92.81, 1, 0, null, null, 0, 0, null, 1, "cancer", 0.5305484520119053], ["O00762", "UBE2C", "Ubiquitin-conjugating enzyme E2 C", "Tier 1.5", 0.689, 1, "A2_pm_peripheral", 9, 88.56, 1, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.49682303083942114], ["P31948", "STIP1", "Stress-induced-phosphoprotein 1", "Tier 1.5", 0.689, 1, "A2_pm_peripheral", 8, 89.75, 1, 0, null, null, 1, 7, "41406518,38012811,34831332,32614006,27681499,24654750,24013070", 1, "neurodegenerative disease", 0.4967711525222825], ["P21980", "TGM2", "Protein-glutamine gamma-glutamyltransferase 2", "Tier 1.5", 0.688, 1, "A2_pm_peripheral", 17, 92.88, 1, 0, null, null, 1, 1, "35980938", 1, "neurodegenerative disease", 0.49455272812698803], ["P63098", "PPP3R1", "Calcineurin subunit B type 1", "Tier 1.5", 0.673, 1, "A2_pm_peripheral", 21, 91.12, 1, 0, null, null, 1, 2, "39263947", 1, "Abnormality of the skeletal system", 0.44389060142742937], ["Q9H0A8", "COMMD4", "COMM domain-containing protein 4", "Tier 1.5", 0.663, 1, "A2_pm_peripheral", 4, 80.75, 1, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.4109063598016124], ["Q00536", "CDK16", "Cyclin-dependent kinase 16", "Tier 1.5", 0.652, 1, "A2_pm_peripheral", 3, 71.94, 1, 0, null, null, 0, 0, null, 1, "Intellectual disability", 0.3718454818549898], ["O60551", "NMT2", "Glycylpeptide N-tetradecanoyltransferase 2", "Tier 1.5", 0.651, 1, "A2_pm_peripheral", 3, 80.88, 1, 0, null, null, 0, 0, null, 1, "HIV infection", 0.37004182950305764], ["P50748", "KNTC1", "Kinetochore-associated protein 1", "Tier 1.5", 0.64, 1, "A2_pm_peripheral", 1, 71.5, 1, 0, null, null, 0, 0, null, 1, "osteoarthritis, knee", 0.3323628521281481], ["Q9UNZ2", "NSFL1C", "NSFL1 cofactor p47", "Tier 1.5", 0.638, 1, "A2_pm_peripheral", 3, 74.06, 1, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.3262410536701536], ["P49459", "UBE2A", "Ubiquitin-conjugating enzyme E2 A", "Tier 1.5", 0.626, 1, "A2_pm_peripheral", 5, 94.12, 1, 0, null, null, 0, 0, null, 0, "syndromic X-linked intellectual disability Nascimento type", 0.7867796040270276], ["A7E2V4", "ZSWIM8", "Zinc finger SWIM domain-containing protein 8", "Tier 1.5", 0.625, 1, "A2_pm_peripheral", 1, 61.94, 1, 0, null, null, 0, 0, null, 1, "aortic stenosis", 0.28253434569668473], ["P15104", "GLUL", "Glutamine synthetase", "Tier 1.5", 0.622, 1, "A2_pm_peripheral", 12, 97.5, 1, 0, null, null, 1, 4, "39533430,30085248,21282981", 0, "congenital brain dysgenesis due to glutamine synthetase deficiency", 0.7733687702812198], ["P50552", "VASP", "Vasodilator-stimulated phosphoprotein", "Tier 1.5", 0.604, 1, "A2_pm_peripheral", 11, 69.75, 1, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.21494427179372053], ["Q8IUC6", "TICAM1", "TIR domain-containing adapter molecule 1", "Tier 1.5", 0.581, 1, "A2_pm_peripheral", 8, 62.78, 1, 0, null, null, 0, 0, null, 0, "Herpetic encephalitis", 0.6364986386236531], ["P26022", "PTX3", "Pentraxin-related protein PTX3", "Tier 1.5", 0.577, 1, "A2_pm_peripheral", 9, 76.75, 1, 0, null, null, 0, 0, null, 1, "polycystic ovary syndrome", 0.12287624125782433], ["P55010", "EIF5", "Eukaryotic translation initiation factor 5", "Tier 1.5", 0.577, 1, "A2_pm_peripheral", 6, 73.19, 1, 0, null, null, 0, 0, null, 1, "Abnormality of the skeletal system", 0.12225325872435809], ["P56597", "NME5", "Nucleoside diphosphate kinase 5", "Tier 1.5", 0.563, 1, "A2_pm_peripheral", 1, 90.06, 1, 0, null, null, 0, 0, null, 0, "ciliary dyskinesia, primary, 48, without situs inversus", 0.5766985649142533], ["Q9GZN1", "ACTR6", "Actin-related protein 6", "Tier 1.5", 0.533, 1, "A2_pm_peripheral", 9, 94.31, 1, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.4758409073452339], ["Q5VTH2", "CFAP126", "Protein Flattop", "Tier 1.5", 0.51, 1, "A2_pm_peripheral", 2, 72.62, 1, 0, null, null, 0, 0, null, 0, "hereditary pheochromocytoma-paraganglioma", 0.4009925718465981], ["O75182", "SIN3B", "Paired amphipathic helix protein Sin3b", "Tier 1.5", 0.501, 1, "A2_pm_peripheral", 4, 68.0, 1, 0, null, null, 1, 2, "16914451", 0, "syndromic intellectual disability", 0.37050380432141355], ["P55089", "UCN", "Urocortin", "Tier 1.5", 0.469, 1, "A2_pm_peripheral", 6, 68.25, 1, 0, null, null, 1, 3, "30221506,26488412,23248006", 0, "neurodegenerative disease", 0.26311734927710556], ["Q86UC2", "RSPH3", "Radial spoke head protein 3 homolog", "Tier 1.5", 0.39, 1, "A2_pm_peripheral", 1, 64.62, 1, 0, null, null, 0, 0, null, 0, null, null]], "truncated": false, "filtered_table_rows_count": 31, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_cryoEM\" = :p0 and \"surface_class\" = :p1 and \"tier\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "1", "p1": "A2_pm_peripheral", "p2": "Tier 1.5"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=A2_pm_peripheral&tier=Tier+1.5", "results": [{"value": 1, "label": 1, "count": 31, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A2_pm_peripheral&tier=Tier+1.5&has_structure=1", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=A2_pm_peripheral&tier=Tier+1.5", "results": [{"value": "Tier 1.5", "label": "Tier 1.5", "count": 31, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A2_pm_peripheral", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=A2_pm_peripheral&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 31, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A2_pm_peripheral&tier=Tier+1.5&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=A2_pm_peripheral&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 23, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A2_pm_peripheral&tier=Tier+1.5&has_known_aptamer=0", "selected": false}, {"value": 1, "label": 1, "count": 8, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A2_pm_peripheral&tier=Tier+1.5&has_known_aptamer=1", "selected": false}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=A2_pm_peripheral&tier=Tier+1.5", "results": [{"value": "A2_pm_peripheral", "label": "A2_pm_peripheral", "count": 31, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&tier=Tier+1.5", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=A2_pm_peripheral&tier=Tier+1.5", "results": [{"value": 1, "label": 1, "count": 22, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A2_pm_peripheral&tier=Tier+1.5&in_cev_map=1", "selected": false}, {"value": 0, "label": 0, "count": 9, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A2_pm_peripheral&tier=Tier+1.5&in_cev_map=0", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=A2_pm_peripheral&tier=Tier+1.5", "results": [{"value": 1, "label": 1, "count": 31, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A2_pm_peripheral&tier=Tier+1.5", "selected": true}], "truncated": false}}, "suggested_facets": [{"name": "evidence_priority", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A2_pm_peripheral&tier=Tier+1.5&_facet=evidence_priority"}, {"name": "pdb_count_total", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A2_pm_peripheral&tier=Tier+1.5&_facet=pdb_count_total"}, {"name": "aptamer_count_pubmed", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A2_pm_peripheral&tier=Tier+1.5&_facet=aptamer_count_pubmed"}, {"name": "opentargets_top_disease_name", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A2_pm_peripheral&tier=Tier+1.5&_facet=opentargets_top_disease_name"}], "next": null, "next_url": null, "private": false, "allow_execute_sql": true, "query_ms": 1111.9831292890012, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}