{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_cryoEM = 1, surface_class = \"A_assoc\" and tier = \"Tier 1\" sorted by evidence_priority descending", "rows": [["P00451", "F8", "Coagulation factor VIII", "Tier 1", 0.873, 1, "A_assoc", 25, 60.75, 1, 0, null, null, 1, 13, "40727755,40266188,28791655,21144556,41587892,40009491,38992298,38752747,31493779,29609491,28979328,21389323,20589313", 1, "hemophilia A", 0.9108044347811838], ["P12883", "MYH7", "Myosin-7", "Tier 1", 0.871, 1, "A_assoc", 43, 74.25, 1, 0, null, null, 0, 0, null, 1, "hypertrophic cardiomyopathy", 0.9029865147265421], ["P02452", "COL1A1", "Collagen alpha-1(I) chain", "Tier 1", 0.854, 1, "A_assoc", 14, 52.72, 1, 0, null, null, 1, 3, "40407197,35905589,15132764", 1, "osteogenesis imperfecta type 2", 0.8471150130101988], ["P45379", "TNNT2", "Troponin T, cardiac muscle", "Tier 1", 0.85, 1, "A_assoc", 25, 78.31, 1, 0, null, null, 1, 4, "41020397,40313273,31782481,30979922", 1, "hypertrophic cardiomyopathy", 0.8329996050513441], ["P00747", "PLG", "Plasminogen", "Tier 1", 0.847, 1, "A_assoc", 49, 82.81, 1, 0, null, null, 1, 51, "24641476,41699153,41371773,41335958,38963794,37533140,37360033,37149949,36882463,36859809,36358641,36203210,36156780,35715131,35563278,35197258,33918821,33859620,33674695,32199927,31870256,30197987,30015643,28051346,27813404,27755560,27679852,26926041,26876003,26163061,25855589,25793507,25620243,25582325,24922319,24682699,24138169,24012635,23038812,22103403,21147843,21142878,20962041,20594164,20387790,20050927,19485299,19284310,18713263,15560078,15303967", 1, "hypoplasminogenemia", 0.8240321266100769], ["P02649", "APOE", "Apolipoprotein E", "Tier 1", 0.845, 1, "A_assoc", 29, 75.5, 1, 0, null, null, 1, 41, "41437270,41316897,41276911,40501769,38895620,38559166,38397086,38377941,38256230,36980195,36579647,35966595,35869074,35415203,35359181,34814699,34757788,34016094,31878307,31461490,31385390,29258991,24589243,22110600,41505229,40429697,39939919,36048760,32831200,30613278,29214237,24121966", 1, "coronary artery disease", 0.81626595063263], ["P12259", "F5", "Coagulation factor V", "Tier 1", 0.839, 1, "A_assoc", 17, 61.91, 1, 0, null, null, 1, 4, "32696338,15496523,24629635,17878169", 1, "thrombophilia due to activated protein C resistance", 0.7962069693286362], ["P00488", "F13A1", "Coagulation factor XIII A chain", "Tier 1", 0.838, 1, "A_assoc", 15, 90.88, 1, 0, null, null, 0, 0, null, 1, "Factor XIII subunit A deficiency", 0.7939842013132387], ["P10643", "C7", "Complement component C7", "Tier 1", 0.836, 1, "A_assoc", 8, 79.94, 1, 0, null, null, 1, 14, "39226699,36428893,35247355,33334063,29846697,29594379,26947566,26057195,24641476,23657986,22058017,15687383,13129354,12169610", 1, "Immunodeficiency due to a late component of complements deficiency", 0.7859621873711432], ["A6XGL2", "INS", "Insulin", "Tier 1", 0.835, 1, "A_assoc", 2, 47.72, 1, 0, null, null, 1, 243, "40789983,40321580,39657876,39296939,38682836,38513471,36239972,36120079,35749972,35745014,35573794,34538325,33802772,32831200,31924009,31627812,31594568,31465835,31407274,31165873,31147037,30965174,30794054,30639182,29527194,26994877,26588795,25976342,25549616,24871672,24763820,23831227,22740651,22438927,21520951,18539116,18374645,15324817,15256575,11557344,11306470,41699153,41648807,41574708,41325160,41307103,41297941,41283885,41280530,41226313,41217025,41107610,40997970,40603733,40591341,40554308,40519041,40380000,40243681,40125440,39847085,39616898,39602324,39546403,39366648,39317671,39263947,39225423,39029996,38928037,38811951,38809225,38794182,38760847,38585969,38497478,38477735,38397086,38384162,38256230,38172533,38082853,38060303,38059276,38039734,37982669,37779149,37772688,37566081", 1, "diabetes mellitus, permanent neonatal 4", 0.784300463357018], ["P02647", "APOA1", "Apolipoprotein A-I", "Tier 1", 0.832, 1, "A_assoc", 32, 73.56, 1, 0, null, null, 1, 10, "41773457,38397086,36756582,36340071,31493779,35517584,24008390,41925578,30834248", 1, "hypoalphalipoproteinemia, primary, 2", 0.7727382344191134], ["P02787", "TF", "Serotransferrin", "Tier 1", 0.832, 1, "A_assoc", 66, 93.12, 1, 0, null, null, 1, 114, "41863075,41824296,41799016,41495882,41477872,41473960,41261862,40903577,40848288,40677726,40598892,40491004,40205063,39794309,39713350,39644990,39605729,39605530,39605368,39605320,39519666,39374798,39271116,39117705,39082193,38776649,38568408,38517697,38352411,38293094,38130056,37769388,37480814,37387534,37219924,37190227,37177995,36797351,36778047,36636745,36334191,36200779,35811788,35668324,35659235,34755879,34534646,34524404,34465294,34448158", 1, "atransferrinemia", 0.7724190608888654], ["P27918", "CFP", "Properdin", "Tier 1", 0.828, 1, "A_assoc", 14, 83.31, 1, 0, null, null, 1, 18, "40359808,39744100,33965026,31473812,28454652,26513286,24968239,23056492,22189104,12678711,41155459,40243681,37566081,36619572,34183667,32366845,31482734,28104543", 1, "Properdin deficiency", 0.7610265174382485], ["P13671", "C6", "Complement component C6", "Tier 1", 0.826, 1, "A_assoc", 11, 79.62, 1, 0, null, null, 1, 31, "41255414,39736202,39680325,38188151,36290981,36165950,34535250,33034309,32414072,32119944,31819445,30039760,29594379,29408200,28024568,27940247,26588795,26316749,26107993,24512500,24309623,23657986,22973579,22527269,21944470,21788069,21645749,21071077,20008986,19469583,15473710", 1, "Immunodeficiency due to a late component of complements deficiency", 0.75437296887129], ["P01042", "KNG1", "Kininogen-1", "Tier 1", 0.824, 1, "A_assoc", 19, 65.88, 1, 0, null, null, 1, 3, "34248840,36980195", 1, "congenital high-molecular-weight kininogen deficiency", 0.7480490551878497], ["P03952", "KLKB1", "Plasma kallikrein", "Tier 1", 0.812, 1, "A_assoc", 22, 87.88, 1, 0, null, null, 1, 6, "40008515,36859809,33674695,28959386,28632925,23692437", 1, "inherited prekallikrein deficiency", 0.7077440022291496], ["P02768", "ALB", "Albumin", "Tier 1", 0.81, 1, "A_assoc", 100, 92.69, 1, 0, null, null, 1, 428, "40380000,38959435,38585969,38071774,33334063,27886058,42008845,41963275,41951078,41943241,41853972,41730466,41726995,41688234,41627846,41589449,41564481,41440282,41327249,41287526,41285542,41275719,41221651,41187986,41172700,41123957,41057289,41016289,40931580,40929740,40904334,40893093,40817942,40755409,40750470,40727755,40693866,40651419,40578264,40550187,40516722,40513168,40441110,40295020,40266188,40258621,40233536,40187290,40139042,40083648,40019314,39875991,39807818,39714093,39705506,39624124", 1, "hyperthyroxinemia", 0.7006021736736501], ["P01189", "POMC", "Pro-opiomelanocortin", "Tier 1", 0.809, 1, "A_assoc", 13, 57.66, 1, 0, null, null, 1, 1, "30161145", 1, "obesity due to pro-opiomelanocortin deficiency", 0.6958797353500403], ["P09871", "C1S", "Complement C1s subcomponent", "Tier 1", 0.808, 1, "A_assoc", 14, 87.88, 1, 0, null, null, 1, 1, "29635179", 1, "Ehlers-Danlos syndrome, periodontal type 2", 0.6936620421207419], ["P18206", "VCL", "Vinculin", "Tier 1", 0.808, 1, "A_assoc", 37, 86.56, 1, 0, null, null, 1, 4, "40321028,36107718,30929122,30697465", 1, "hypertrophic cardiomyopathy", 0.6924271529635582], ["P23284", "PPIB", "Peptidyl-prolyl cis-trans isomerase B", "Tier 1", 0.799, 1, "A_assoc", 8, 91.81, 1, 0, null, null, 1, 3, "35999181,24152208,22484812", 1, "osteogenesis imperfecta type 9", 0.6629329652595439], ["P48200", "IREB2", "Iron-responsive element-binding protein 2", "Tier 1", 0.799, 1, "A_assoc", 1, 86.75, 1, 0, null, null, 0, 0, null, 1, "neurodegeneration, early-onset, with choreoathetoid movements and microcytic anemia", 0.664403876125082], ["P22004", "BMP6", "Bone morphogenetic protein 6", "Tier 1", 0.795, 1, "A_assoc", 5, 68.94, 1, 0, null, null, 1, 1, "24808863", 1, "Tangier disease", 0.6511246985190833], ["P02745", "C1QA", "Complement C1q subcomponent subunit A", "Tier 1", 0.79, 1, "A_assoc", 11, 82.62, 1, 0, null, null, 0, 0, null, 1, "C1Q deficiency 1", 0.6319053256658114], ["P02747", "C1QC", "Complement C1q subcomponent subunit C", "Tier 1", 0.787, 1, "A_assoc", 11, 80.56, 1, 0, null, null, 0, 0, null, 1, "C1Q deficiency", 0.6233532074390745], ["P14210", "HGF", "Hepatocyte growth factor", "Tier 1", 0.777, 1, "A_assoc", 36, 83.5, 1, 0, null, null, 1, 64, "41873087,41601428,41123956,40189053,40041032,39853766,39355222,38963794,38923378,37965838,37075136,36935149,36826373,36477303,36126144,34424707,34165951,31967847,31825565,31595614,30444610,30353654,30312735,28627727,26658271,26592704,25223895,23615526,21546514,20594164,16225393,38925633,38876234,34142433,31381313,30237882,29944203,29416033,27679852,27363484,26131766,11753087", 1, "hearing loss, autosomal recessive", 0.5910507391848663], ["P00738", "HP", "Haptoglobin", "Tier 1", 0.771, 1, "A_assoc", 15, 84.81, 1, 0, null, null, 1, 76, "41855944,41638958,40968672,40231802,39880691,39880501,39835381,39804483,39788927,39613489,39435559,38585969,38545293,38218089,38185050,38047083,38039678,37879039,37701520,37696275,37560929,37104434,36863194,36564526,36291832,36201958,35868696,35686646,35439614,35394406,35195734,35081018,34647930,34556234,34520834,34064911,34038999,33896635,33534888,33404555,33395442,33234387,33214769,33131243,31892078,31820139,31665673,31655906,31655383,31494507,38916796,34183667,34117903", 1, "Hypercholesterolemia", 0.5684135700226365], ["A8K2U0", "A2ML1", "Alpha-2-macroglobulin-like protein 1", "Tier 1", 0.764, 1, "A_assoc", 5, 80.5, 1, 0, null, null, 0, 0, null, 1, "Otitis media", 0.5479914512784171], ["Q08043", "ACTN3", "Alpha-actinin-3", "Tier 1", 0.752, 1, "A_assoc", 3, 84.19, 1, 0, null, null, 0, 0, null, 1, "Abnormality of the skeletal system", 0.5080072819822437], ["P02788", "LTF", "Lactotransferrin", "Tier 1", 0.751, 1, "A_assoc", 34, 94.94, 1, 0, null, null, 1, 3, "33534888,33398328,30340834", 1, "tuberculosis", 0.5046393442671729], ["P05161", "ISG15", "Ubiquitin-like protein ISG15", "Tier 1", 0.74, 1, "A_assoc", 22, 85.88, 1, 0, null, null, 0, 0, null, 1, "COVID-19", 0.4668295741563516], ["Q99969", "RARRES2", "Retinoic acid receptor responder protein 2", "Tier 1", 0.739, 1, "A_assoc", 12, 86.31, 1, 0, null, null, 1, 2, "38238732,31878307", 1, "Abnormality of the skeletal system", 0.4617522712277723], ["Q9BVC4", "MLST8", "Target of rapamycin complex subunit LST8", "Tier 1", 0.733, 1, "A_assoc", 45, 91.62, 1, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.4440338170862142], ["Q12884", "FAP", "Prolyl endopeptidase FAP", "Tier 1", 0.721, 1, "A_assoc", 4, 95.62, 1, 0, null, null, 1, 7, "40046817,39710916,39026723,37192373,36838669,36494579,35879297", 1, "psoriasis", 0.40173767366839236], ["P05109", "S100A8", "Protein S100-A8", "Tier 1", 0.711, 1, "A_assoc", 13, 93.06, 1, 0, null, null, 1, 5, "41654945,41111484,32964813,32478041,22353892", 1, "inborn error of immunity", 0.37050380432141355], ["P01011", "SERPINA3", "Alpha-1-antichymotrypsin", "Tier 1", 0.703, 1, "A_assoc", 26, 85.19, 1, 0, null, null, 1, 4, "31878307,30553167,27836219,36980195", 1, "prostate carcinoma", 0.34451913095860076], ["P29460", "IL12B", "Interleukin-12 subunit beta", "Tier 1", 0.687, 1, "A_assoc", 20, 91.12, 1, 0, null, null, 0, 0, null, 0, "psoriasis", 0.7914863943708039], ["P05019", "IGF1", "Insulin-like growth factor 1", "Tier 1", 0.68, 1, "A_assoc", 32, 59.53, 1, 0, null, null, 1, 23, "38384162,35859339,35591468,33977395,33467925,32511241,31930684,26245346,24832383,23933187,23373648,16019422,41283885,39263947,38497478,33888746,15231297", 0, "growth delay due to insulin-like growth factor type 1 deficiency", 0.7650418939376437], ["Q9GZV9", "FGF23", "Fibroblast growth factor 23", "Tier 1", 0.679, 1, "A_assoc", 6, 76.62, 1, 0, null, null, 1, 11, "39007037,38079395,35415885,32065590,30297602,30197987,41226313,36705086", 0, "autosomal dominant hypophosphatemic rickets", 0.762326334964193], ["P35225", "IL13", "Interleukin-13", "Tier 1", 0.669, 1, "A_assoc", 13, 85.62, 1, 0, null, null, 1, 9, "41463156,35356877,33742062,32784904,27640094,29949702,21793788", 0, "atopic eczema", 0.7297489019498119], ["P01023", "A2M", "Alpha-2-macroglobulin", "Tier 1", 0.669, 1, "A_assoc", 13, 81.5, 1, 0, null, null, 1, 2, "24121966,9382799", 1, "refractive error", 0.2285030343788678], ["Q2MKA7", "RSPO1", "R-spondin-1", "Tier 1", 0.669, 1, "A_assoc", 12, 74.69, 1, 0, null, null, 0, 0, null, 0, "palmoplantar keratoderma-XX sex reversal-predisposition to squamous cell carcinoma syndrome", 0.7285342885472184], ["P05305", "EDN1", "Endothelin-1", "Tier 1", 0.666, 1, "A_assoc", 17, 65.19, 1, 0, null, null, 1, 2, "40438585,37198662", 0, "auriculocondylar syndrome", 0.7193561828311311], ["P12272", "PTHLH", "Parathyroid hormone-related protein", "Tier 1", 0.666, 1, "A_assoc", 11, 62.88, 1, 0, null, null, 0, 0, null, 0, "brachydactyly type E", 0.7203484375635054], ["P01270", "PTH", "Parathyroid hormone", "Tier 1", 0.664, 1, "A_assoc", 26, 72.12, 1, 0, null, null, 1, 9, "40464222,40108760,39880691,38079395,25901535,41303575,41226313", 0, "hypoparathyroidism, familial isolated 1", 0.7147450451832739], ["Q8N300", "SVBP", "Small vasohibin-binding protein", "Tier 1", 0.649, 1, "A_assoc", 24, 85.06, 1, 0, null, null, 0, 0, null, 0, "neurodevelopmental disorder with ataxia, hypotonia, and microcephaly", 0.6640118055835142], ["P05113", "IL5", "Interleukin-5", "Tier 1", 0.642, 1, "A_assoc", 5, 86.69, 1, 0, null, null, 1, 12, "40972397,35487180,35356877,34831332,32784904,32038731,29881374,28062796,26048585", 0, "asthma", 0.6399821251487101], ["Q16552", "IL17A", "Interleukin-17A", "Tier 1", 0.641, 1, "A_assoc", 44, 84.31, 1, 0, null, null, 1, 30, "42017161,41754778,41482938,41477217,40410820,39376102,38091227,38031342,37879125,37238999,36517803,36375248,36326540,35724603,32784904,32387307,31316164,27827561,24056860,21524680,20967861,37563071,34531951", 0, "psoriasis", 0.6367521314106471], ["P49913", "CAMP", "Cathelicidin antimicrobial peptide", "Tier 1", 0.636, 1, "A_assoc", 20, 80.0, 1, 0, null, null, 1, 30, "41316897,40997974,40501769,39429683,39045230,38471488,37947789,35479481,34957366,33832411,31940088,31099939,26843427,26358810,25659966,25437358,25390494,25048161,25044725,24814025,24325980,23748105,23744070,21673794,18165929,12569622,10913311,10780486,37400771", 1, "prostate carcinoma", 0.11970033909944687], ["Q9UHF0", "TAC3", "Tachykinin-3", "Tier 1", 0.63, 1, "A_assoc", 2, 64.88, 1, 0, null, null, 0, 0, null, 0, "hypogonadotropic hypogonadism 10 with or without anosmia", 0.5995324402695232]], "truncated": false, "filtered_table_rows_count": 85, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_cryoEM\" = :p0 and \"surface_class\" = :p1 and \"tier\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "1", "p1": "A_assoc", "p2": "Tier 1"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=A_assoc&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 85, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A_assoc&tier=Tier+1&has_structure=1", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=A_assoc&tier=Tier+1", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 85, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A_assoc", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=A_assoc&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 85, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A_assoc&tier=Tier+1&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=A_assoc&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 59, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A_assoc&tier=Tier+1&has_known_aptamer=1", "selected": false}, {"value": 0, "label": 0, "count": 26, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A_assoc&tier=Tier+1&has_known_aptamer=0", "selected": false}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=A_assoc&tier=Tier+1", "results": [{"value": "A_assoc", "label": "A_assoc", "count": 85, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&tier=Tier+1", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=A_assoc&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 45, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A_assoc&tier=Tier+1&in_cev_map=0", "selected": false}, {"value": 1, "label": 1, "count": 40, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A_assoc&tier=Tier+1&in_cev_map=1", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=A_assoc&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 85, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_assoc&tier=Tier+1", "selected": true}], "truncated": false}}, "suggested_facets": [], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A_assoc&tier=Tier+1&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 1375.958668999374, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}