{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_cryoEM = 1, surface_class = \"A_assoc\" and tier = \"Tier 1.5\" sorted by evidence_priority descending", "rows": [["P04180", "LCAT", "Phosphatidylcholine-sterol acyltransferase", "Tier 1.5", 0.848, 1, "A_assoc", 7, 86.75, 1, 0, null, null, 0, 0, null, 1, "Fish-eye disease", 0.8273460309828392], ["Q15582", "TGFBI", "Transforming growth factor-beta-induced protein ig-h3", "Tier 1.5", 0.847, 1, "A_assoc", 10, 90.25, 1, 0, null, null, 0, 0, null, 1, "lattice corneal dystrophy type I", 0.8242841141270143], ["P07225", "PROS1", "Vitamin K-dependent protein S", "Tier 1.5", 0.847, 1, "A_assoc", 3, 82.94, 1, 0, null, null, 1, 2, "36859809,33674695", 1, "thrombophilia due to protein S deficiency, autosomal dominant", 0.8240418292042652], ["P07942", "LAMB1", "Laminin subunit beta-1", "Tier 1.5", 0.84, 1, "A_assoc", 3, 76.69, 1, 0, null, null, 0, 0, null, 1, "cobblestone lissencephaly without muscular or ocular involvement", 0.8016665947624902], ["P39060", "COL18A1", "Collagen alpha-1(XVIII) chain", "Tier 1.5", 0.836, 1, "A_assoc", 9, 50.62, 1, 0, null, null, 1, 2, "36707842,23679916", 1, "Knobloch syndrome 1", 0.7867122552672962], ["P35858", "IGFALS", "Insulin-like growth factor-binding protein complex acid labile subunit", "Tier 1.5", 0.833, 1, "A_assoc", 1, 90.56, 1, 0, null, null, 0, 0, null, 1, "Reduced insulin like growth factor binding protein acid labile subunit concentration", 0.7760522769257892], ["P02748", "C9", "Complement component C9", "Tier 1.5", 0.829, 1, "A_assoc", 9, 78.75, 1, 0, null, null, 1, 10, "41636061,40411682,36428893,36290981,35247355,28794177,27836219,22678933,19261617,15687383", 1, "Immunodeficiency due to a late component of complements deficiency", 0.761965409699055], ["O15230", "LAMA5", "Laminin subunit alpha-5", "Tier 1.5", 0.828, 1, "A_assoc", 2, 79.12, 1, 0, null, null, 0, 0, null, 1, "nephrotic syndrome, IIa 26", 0.7594872666460903], ["O60568", "PLOD3", "Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3", "Tier 1.5", 0.815, 1, "A_assoc", 18, 91.38, 1, 0, null, null, 0, 0, null, 1, "bone fragility with contractures, arterial rupture, and deafness", 0.7159150369336311], ["Q99988", "GDF15", "Growth/differentiation factor 15", "Tier 1.5", 0.775, 1, "A_assoc", 4, 75.69, 1, 0, null, null, 1, 29, "41924874,41862097,38879214,38477735,37982669,36927042,36638554,36508319,36333824,35762561,33334063,32527800,31988066,29992704,39884764,38497478,38296402,37162508,32739349,30335547", 1, "hyperemesis gravidarum", 0.5821658682742563], ["P10646", "TFPI", "Tissue factor pathway inhibitor", "Tier 1.5", 0.768, 1, "A_assoc", 9, 73.62, 1, 0, null, null, 1, 28, "32366845,32224381,30994257,30302740,27563744,27196067,24263002,23528042,22951415,22658294,22632032,22239993,21696535,21389323,8578509,25521966,24319161", 1, "hemophilia A", 0.5591056672248635], ["P02771", "AFP", "Alpha-fetoprotein", "Tier 1.5", 0.765, 1, "A_assoc", 5, 88.94, 1, 0, null, null, 1, 195, "41849903,41732103,41688234,41327249,41051792,40839965,40750207,40684729,40578247,40383027,40381048,40347636,40262341,40216053,39982565,39942588,39890683,39771616,39479488,39383727,39305942,39167423,39140150,39082193,39067928,39007743,38904836,38852341,38356334,37836778,37709445,37606762,37366993,37303825,37295202,37284243,37228865,37104032,36989661,36979562,36842207,36693188,36512161,36389169,36290918,36240195,36130652,35969067,35793076,35747812,41637558,41575587,41123957,41103270,40349714,40286895,38899396,37325361", 1, "Congenital deficiency in alpha-fetoprotein", 0.5500580170557311], ["P24593", "IGFBP5", "Insulin-like growth factor-binding protein 5", "Tier 1.5", 0.711, 1, "A_assoc", 3, 76.06, 1, 0, null, null, 1, 4, "39317671,31930684", 1, "hypothyroidism", 0.3702458751451027], ["Q00604", "NDP", "Norrin", "Tier 1.5", 0.707, 1, "A_assoc", 11, 83.56, 1, 0, null, null, 1, 2, "39057719,11352723", 0, "Norrie disease", 0.8566451682188412], ["O43866", "CD5L", "CD5 antigen-like", "Tier 1.5", 0.706, 1, "A_assoc", 4, 85.88, 1, 0, null, null, 1, 3, "40215752,37100807", 1, "functional neutrophil defect", 0.3529395470693119], ["P10145", "CXCL8", "Interleukin-8", "Tier 1.5", 0.706, 1, "A_assoc", 21, 88.06, 1, 0, null, null, 1, 15, "39564692,35821507,31985806,29268188,41866852,37732574,37016361,36037714,35197258,34884636,25998051,24129312", 1, "coronary artery disease", 0.35357870191996843], ["P80162", "CXCL6", "C-X-C motif chemokine 6", "Tier 1.5", 0.699, 1, "A_assoc", 2, 81.0, 1, 0, null, null, 1, 3, "40008515,36649818,32628701", 1, "neurodegenerative disease", 0.3309117033683961], ["O95970", "LGI1", "Leucine-rich glioma-inactivated protein 1", "Tier 1.5", 0.697, 1, "A_assoc", 9, 92.56, 1, 0, null, null, 0, 0, null, 0, "autosomal dominant epilepsy with auditory features", 0.8225657483127345], ["P03971", "AMH", "Anti-Muellerian hormone", "Tier 1.5", 0.685, 1, "A_assoc", 3, 68.62, 1, 0, null, null, 1, 2, "41101154,27364573", 0, "persistent Mullerian duct syndrome", 0.7847328444470535], ["P19876", "CXCL3", "C-X-C motif chemokine 3", "Tier 1.5", 0.679, 1, "A_assoc", 2, 81.88, 1, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.26311734927710556], ["P19875", "CXCL2", "C-X-C motif chemokine 2", "Tier 1.5", 0.674, 1, "A_assoc", 4, 81.62, 1, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.24624512698601778], ["O95631", "NTN1", "Netrin-1", "Tier 1.5", 0.648, 1, "A_assoc", 5, 88.5, 1, 0, null, null, 0, 0, null, 0, "mirror movements 4", 0.6611393488240481], ["Q9NWU2", "GID8", "Glucose-induced degradation protein 8 homolog", "Tier 1.5", 0.631, 1, "A_assoc", 1, 91.94, 1, 0, null, null, 0, 0, null, 1, "Abnormality of the skeletal system", 0.10187555420552867], ["Q6IBW4", "NCAPH2", "Condensin-2 complex subunit H2", "Tier 1.5", 0.62, 1, "A_assoc", 1, 62.41, 1, 0, null, null, 0, 0, null, 0, "cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 1", 0.5674645203025676], ["Q15726", "KISS1", "Metastasis-suppressor KiSS-1", "Tier 1.5", 0.618, 1, "A_assoc", 2, 59.41, 1, 0, null, null, 1, 1, "35026192", 0, "hypogonadotropic hypogonadism", 0.5608645918536114], ["P22466", "GAL", "Galanin peptides", "Tier 1.5", 0.613, 1, "A_assoc", 10, 66.56, 1, 0, null, null, 1, 27, "40382399,40371468,39772541,39705316,39681229,39430968,39329806,39263318,38487245,38314707,37737989,37610431,37512948,36795559,36194889,34944985,34635237,33769582,33006019,32502344,31778957,31173420,30650243,29808997,25940316,21850727,9546673", 0, "temporal lobe epilepsy", 0.5442263564708273], ["Q63HQ2", "EGFLAM", "Pikachurin", "Tier 1.5", 0.574, 1, "A_assoc", 3, 80.56, 1, 0, null, null, 0, 0, null, 0, "mathematical ability", 0.41387833248094535], ["Q8NEV9", "IL27", "Interleukin-27 subunit alpha", "Tier 1.5", 0.573, 1, "A_assoc", 4, 75.62, 1, 0, null, null, 1, 2, "35859339,32784904", 0, "Crohn's disease", 0.40963715551754365], ["P01282", "VIP", "VIP peptides", "Tier 1.5", 0.55, 1, "A_assoc", 5, 67.62, 1, 0, null, null, 1, 24, "41292425,40957130,40403614,40056883,39952883,38763821,37527574,36669289,36129574,35879297,35436736,33990848,33688885,31689596,31403149,30167802,30069577,29708252,28441340,27542489,27334718,27088368,26802746,25782595", 0, "uterine fibroid", 0.3332844575068197], ["O14960", "LECT2", "Leukocyte cell-derived chemotaxin-2", "Tier 1.5", 0.542, 1, "A_assoc", 4, 92.44, 1, 0, null, null, 1, 2, "35045701", 0, "neurodegenerative disease", 0.30565036648724025], ["Q06141", "REG3A", "Regenerating islet-derived protein 3-alpha", "Tier 1.5", 0.539, 1, "A_assoc", 4, 89.0, 1, 0, null, null, 1, 2, "39695715,24771595", 0, "alcohol drinking", 0.29724052454892086], ["M5A8F1", "ERVH48-1", "Suppressyn", "Tier 1.5", 0.519, 1, "A_assoc", 1, 74.94, 1, 0, null, null, 0, 0, null, 0, "hypertension", 0.23115391486595976], ["P01178", "OXT", "Oxytocin-neurophysin 1", "Tier 1.5", 0.514, 1, "A_assoc", 4, 83.81, 1, 0, null, null, 1, 1, "34649198", 0, "neurodegenerative disease", 0.21368454441108417], ["Q5T4W7", "ARTN", "Artemin", "Tier 1.5", 0.512, 1, "A_assoc", 5, 75.0, 1, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.20507822956537197], ["P09683", "SCT", "Secretin", "Tier 1.5", 0.495, 1, "A_assoc", 3, 65.88, 1, 0, null, null, 1, 2, "17495522,7752141", 0, "idiopathic pulmonary fibrosis", 0.14866387905285056], ["Q07325", "CXCL9", "C-X-C motif chemokine 9", "Tier 1.5", 0.486, 1, "A_assoc", 1, 87.44, 1, 0, null, null, 1, 7, "42046114,37395276,35204399,35018777,33742062,27959341,27819142", 0, "neoplasm", 0.1199067650750674], ["Q8IZI9", "IFNL3", "Interferon lambda-3", "Tier 1.5", 0.484, 1, "A_assoc", 3, 84.81, 1, 0, null, null, 0, 0, null, 0, "hepatocellular carcinoma", 0.1145400757875244], ["O00230", "CORT", "Cortistatin", "Tier 1.5", 0.484, 1, "A_assoc", 5, 62.84, 1, 0, null, null, 0, 0, null, 0, "neoplasm", 0.11461560504839655], ["Q9Y5Q6", "INSL5", "Insulin-like peptide INSL5", "Tier 1.5", 0.477, 1, "A_assoc", 3, 64.06, 1, 0, null, null, 0, 0, null, 0, "polycystic ovary syndrome", 0.08868171274230166]], "truncated": false, "filtered_table_rows_count": 39, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_cryoEM\" = :p0 and \"surface_class\" = :p1 and \"tier\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "1", "p1": "A_assoc", "p2": "Tier 1.5"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=A_assoc&tier=Tier+1.5", "results": [{"value": 1, "label": 1, "count": 39, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A_assoc&tier=Tier+1.5&has_structure=1", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=A_assoc&tier=Tier+1.5", "results": [{"value": "Tier 1.5", "label": "Tier 1.5", "count": 39, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A_assoc", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=A_assoc&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 39, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A_assoc&tier=Tier+1.5&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=A_assoc&tier=Tier+1.5", "results": [{"value": 1, "label": 1, "count": 21, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A_assoc&tier=Tier+1.5&has_known_aptamer=1", "selected": false}, {"value": 0, "label": 0, "count": 18, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A_assoc&tier=Tier+1.5&has_known_aptamer=0", "selected": false}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=A_assoc&tier=Tier+1.5", "results": [{"value": "A_assoc", "label": "A_assoc", "count": 39, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&tier=Tier+1.5", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=A_assoc&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 20, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A_assoc&tier=Tier+1.5&in_cev_map=0", "selected": false}, {"value": 1, "label": 1, "count": 19, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A_assoc&tier=Tier+1.5&in_cev_map=1", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=A_assoc&tier=Tier+1.5", "results": [{"value": 1, "label": 1, "count": 39, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_assoc&tier=Tier+1.5", "selected": true}], "truncated": false}}, "suggested_facets": [{"name": "pdb_count_total", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A_assoc&tier=Tier+1.5&_facet=pdb_count_total"}, {"name": "aptamer_count_pubmed", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A_assoc&tier=Tier+1.5&_facet=aptamer_count_pubmed"}], "next": null, "next_url": null, "private": false, "allow_execute_sql": true, "query_ms": 627.9858276247978, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}