{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_cryoEM = 1, surface_class = \"A_surface\" and tier = \"Tier 1\" sorted by evidence_priority descending", "rows": [["P33897", "ABCD1", "ATP-binding cassette sub-family D member 1", "Tier 1", 0.96, 1, "A_surface", 14, 80.62, 1, 0, null, null, 0, 0, null, 1, "adrenoleukodystrophy", 0.8656366512509434], ["P04839", "CYBB", "NADPH oxidase 2", "Tier 1", 0.959, 1, "A_surface", 6, 90.25, 1, 0, null, null, 1, 2, "24635113", 1, "chronic granulomatous disease", 0.8633132852459866], ["P29965", "CD40LG", "CD40 ligand", "Tier 1", 0.954, 1, "A_surface", 8, 82.62, 1, 0, null, null, 1, 6, "37331977,36203210,26504624", 1, "hyper-IgM syndrome type 1", 0.8451678829647167], ["Q9NQ11", "ATP13A2", "Polyamine-transporting ATPase 13A2", "Tier 1", 0.953, 1, "A_surface", 25, 79.62, 1, 0, null, null, 0, 0, null, 1, "Kufor-Rakeb syndrome", 0.8439049037191295], ["P37173", "TGFBR2", "TGF-beta receptor type-2", "Tier 1", 0.952, 1, "A_surface", 22, 81.0, 1, 0, null, null, 1, 8, "32452828,30595527,29522674,29375127,26284552,23999222,22899759,11856769", 1, "Loeys-Dietz syndrome", 0.8390072008866913], ["P35499", "SCN4A", "Sodium channel protein type 4 subunit alpha", "Tier 1", 0.952, 1, "A_surface", 3, 72.44, 1, 0, null, null, 0, 0, null, 1, "paramyotonia congenita of Von Eulenburg", 0.8401628899371881], ["P19438", "TNFRSF1A", "Tumor necrosis factor receptor superfamily member 1A", "Tier 1", 0.951, 1, "A_surface", 13, 71.38, 1, 0, null, null, 1, 1, "35197258", 1, "TNF receptor 1-associated periodic fever syndrome", 0.8352778213184682], ["P07359", "GP1BA", "Platelet glycoprotein Ib alpha chain", "Tier 1", 0.95, 1, "A_surface", 22, 64.31, 1, 0, null, null, 0, 0, null, 1, "Bernard-Soulier syndrome", 0.8346884735388165], ["P06744", "GPI", "Glucose-6-phosphate isomerase", "Tier 1", 0.949, 1, "A_surface", 13, 97.94, 1, 0, null, null, 1, 19, "41911185,41329468,41232387,35821507,34953205,32730952,29501157,27419372,25919296,25483705,24334484,23656757,23578283,23018995,22116094,20967861,17574575,27380815", 1, "hemolytic anemia due to glucophosphate isomerase deficiency", 0.8306909118751346], ["Q9NRA2", "SLC17A5", "Sialin", "Tier 1", 0.949, 1, "A_surface", 7, 84.12, 1, 0, null, null, 0, 0, null, 1, "free sialic acid storage disease, infantile form", 0.8292382821211967], ["P63092", "GNAS", "Guanine nucleotide-binding protein G(s) subunit alpha isoforms short", "Tier 1", 0.948, 1, "A_surface", 100, 91.31, 1, 0, null, null, 0, 0, null, 1, "pseudohypoparathyroidism type 1A", 0.826829760867455], ["P36897", "TGFBR1", "TGF-beta receptor type-1", "Tier 1", 0.948, 1, "A_surface", 44, 84.19, 1, 0, null, null, 1, 1, "41089000", 1, "Loeys-Dietz syndrome 1", 0.8275292516338373], ["P22607", "FGFR3", "Fibroblast growth factor receptor 3", "Tier 1", 0.948, 1, "A_surface", 13, 74.19, 1, 0, null, null, 1, 6, "38569854,37704353,34864168,33952673,31357131", 1, "achondroplasia", 0.8270702096931246], ["Q5JWF2", "GNAS", "Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas", "Tier 1", 0.948, 1, "A_surface", 9, 56.72, 1, 0, null, null, 0, 0, null, 1, "pseudohypoparathyroidism type 1A", 0.826829760867455], ["P16615", "ATP2A2", "Sarcoplasmic/endoplasmic reticulum calcium ATPase 2", "Tier 1", 0.947, 1, "A_surface", 15, 85.44, 1, 0, null, null, 0, 0, null, 1, "Darier disease", 0.8223208039299769], ["P04156", "PRNP", "Major prion protein", "Tier 1", 0.947, 1, "A_surface", 70, 64.19, 1, 0, null, null, 1, 2, "39556313,34067472", 1, "Gerstmann-Straussler-Scheinker syndrome", 0.8246149684620239], ["Q13936", "CACNA1C", "Voltage-dependent L-type calcium channel subunit alpha-1C", "Tier 1", 0.947, 1, "A_surface", 33, 61.94, 1, 0, null, null, 0, 0, null, 1, "Timothy syndrome", 0.8227725490420764], ["P02730", "SLC4A1", "Band 3 anion transport protein", "Tier 1", 0.946, 1, "A_surface", 54, 82.12, 1, 0, null, null, 0, 0, null, 1, "hereditary spherocytosis type 4", 0.820137113225454], ["P08069", "IGF1R", "Insulin-like growth factor 1 receptor", "Tier 1", 0.945, 1, "A_surface", 46, 78.0, 1, 0, null, null, 1, 10, "40997970,39263947,33410883,30041514,23373648,16019422,15231297", 1, "growth delay due to insulin-like growth factor I resistance", 0.8166352227841136], ["Q9H3H5", "DPAGT1", "UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase", "Tier 1", 0.943, 1, "A_surface", 8, 94.69, 1, 0, null, null, 0, 0, null, 1, "DPAGT1-congenital disorder of glycosylation", 0.8101246300555436], ["Q13563", "PKD2", "Polycystin-2", "Tier 1", 0.943, 1, "A_surface", 31, 70.12, 1, 0, null, null, 1, 3, "41315228,36126144", 1, "polycystic kidney disease 2", 0.810960823768978], ["P49810", "PSEN2", "Presenilin-2", "Tier 1", 0.941, 1, "A_surface", 2, 71.81, 1, 0, null, null, 0, 0, null, 1, "early-onset autosomal dominant Alzheimer disease", 0.8047686386596943], ["P58335", "ANTXR2", "Anthrax toxin receptor 2", "Tier 1", 0.941, 1, "A_surface", 14, 71.81, 1, 0, null, null, 1, 4, "41503480,41083485,41020397,40313273", 1, "hyaline fibromatosis syndrome", 0.8028849863986661], ["P61073", "CXCR4", "C-X-C chemokine receptor type 4", "Tier 1", 0.94, 1, "A_surface", 33, 82.25, 1, 0, null, null, 1, 17, "40671676,40401615,39865939,39778270,37052638,35157940,33739080,31737891,31267721,31097627,28670693,26265085,25329893,22811524,22376154,12498773,41543187", 1, "WHIM syndrome", 0.8009225456235435], ["Q9H2M9", "RAB3GAP2", "Rab3 GTPase-activating protein non-catalytic subunit", "Tier 1", 0.939, 1, "A_surface", 1, 79.62, 1, 0, null, null, 0, 0, null, 1, "Cataract - intellectual disability - hypogonadism", 0.7977527040203786], ["Q9Y5Y0", "FLVCR1", "Choline/ethanolamine transporter FLVCR1", "Tier 1", 0.938, 1, "A_surface", 8, 77.56, 1, 0, null, null, 0, 0, null, 1, "Posterior column ataxia - retinitis pigmentosa", 0.7932113640677738], ["Q9NW15", "ANO10", "Anoctamin-10", "Tier 1", 0.937, 1, "A_surface", 5, 86.12, 1, 0, null, null, 0, 0, null, 1, "autosomal recessive spinocerebellar ataxia 10", 0.7915327777093032], ["Q6PJF5", "RHBDF2", "Inactive rhomboid protein 2", "Tier 1", 0.936, 1, "A_surface", 5, 67.38, 1, 0, null, null, 0, 0, null, 1, "palmoplantar keratoderma-esophageal carcinoma syndrome", 0.7882817956366938], ["Q9NP58", "ABCB6", "ATP-binding cassette sub-family B member 6", "Tier 1", 0.934, 1, "A_surface", 16, 83.06, 1, 0, null, null, 0, 0, null, 1, "dyschromatosis universalis hereditaria 3", 0.7783407126197405], ["P13987", "CD59", "CD59 glycoprotein", "Tier 1", 0.932, 1, "A_surface", 17, 79.31, 1, 0, null, null, 1, 1, "19915929", 1, "primary CD59 deficiency", 0.7738276843579196], ["Q8N766", "EMC1", "ER membrane protein complex subunit 1", "Tier 1", 0.931, 1, "A_surface", 10, 87.44, 1, 0, null, null, 0, 0, null, 1, "cerebellar atrophy, visual impairment, and psychomotor retardation;", 0.7687056132401411], ["P78536", "ADAM17", "Disintegrin and metalloproteinase domain-containing protein 17", "Tier 1", 0.929, 1, "A_surface", 33, 72.69, 1, 0, null, null, 0, 0, null, 1, "neonatal inflammatory skin and bowel disease", 0.7624558659108367], ["Q9BVK8", "TMEM147", "BOS complex subunit TMEM147", "Tier 1", 0.928, 1, "A_surface", 3, 92.5, 1, 0, null, null, 0, 0, null, 1, "neurodevelopmental disorder with facial dysmorphism, absent language, and pseudo-pelger-huet anomaly", 0.7615388401822349], ["P02511", "CRYAB", "Alpha-crystallin B chain", "Tier 1", 0.925, 1, "A_surface", 21, 75.75, 1, 0, null, null, 1, 2, "28720498,23530262", 1, "myofibrillar myopathy 2", 0.7505030087389963], ["Q14432", "PDE3A", "cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A", "Tier 1", 0.924, 1, "A_surface", 9, 60.25, 1, 0, null, null, 1, 1, "34456709", 1, "Brachydactyly - arterial hypertension", 0.7468849549430213], ["P20963", "CD247", "T-cell surface glycoprotein CD3 zeta chain", "Tier 1", 0.923, 1, "A_surface", 38, 62.41, 1, 0, null, null, 0, 0, null, 1, "immunodeficiency 25", 0.7436838111879828], ["P07204", "THBD", "Thrombomodulin", "Tier 1", 0.92, 1, "A_surface", 13, 78.62, 1, 0, null, null, 1, 5, "41988704,34708097,28549218,21526769,7622501", 1, "thrombomodulin-related bleeding disorder", 0.7323266135403641], ["P55011", "SLC12A2", "Solute carrier family 12 member 2", "Tier 1", 0.92, 1, "A_surface", 14, 73.12, 1, 0, null, null, 0, 0, null, 1, "Delpire-McNeill syndrome", 0.7337659829979022], ["Q9H244", "P2RY12", "P2Y purinoceptor 12", "Tier 1", 0.919, 1, "A_surface", 5, 84.44, 1, 0, null, null, 1, 2, "32679592,19509485", 1, "platelet-type bleeding disorder 8", 0.7304079345653686], ["P08575", "PTPRC", "Receptor-type tyrosine-protein phosphatase C", "Tier 1", 0.916, 1, "A_surface", 6, 76.06, 1, 0, null, null, 1, 1, "25251012", 1, "immunodeficiency 104", 0.7200430416648742], ["Q9UNQ0", "ABCG2", "Broad substrate specificity ATP-binding cassette transporter ABCG2", "Tier 1", 0.915, 1, "A_surface", 29, 85.25, 1, 0, null, null, 1, 8, "40873307,36807620,35544739,33833512,31180052,31085078,26176230,24319544", 1, "gout", 0.7158028003520317], ["P13612", "ITGA4", "Integrin alpha-4", "Tier 1", 0.914, 1, "A_surface", 7, 84.44, 1, 0, null, null, 1, 3, "30065768,28670693,26504766", 1, "Crohn's disease", 0.7134551179424343], ["O75581", "LRP6", "Low-density lipoprotein receptor-related protein 6", "Tier 1", 0.911, 1, "A_surface", 27, 79.19, 1, 0, null, null, 1, 5, "42031715,37175248,18673242", 1, "tooth agenesis, selective, 7", 0.7022725510765017], ["P40189", "IL6ST", "Interleukin-6 receptor subunit beta", "Tier 1", 0.911, 1, "A_surface", 20, 74.62, 1, 0, null, null, 1, 2, "39571081,22258147", 1, "Autosomal recessive hyper-IgE syndrome", 0.7027634038262931], ["P03891", "MT-ND2", "NADH-ubiquinone oxidoreductase chain 2", "Tier 1", 0.91, 1, "A_surface", 7, 95.12, 1, 0, null, null, 0, 0, null, 1, "Leber hereditary optic neuropathy", 0.6993991624020442], ["Q8N1F7", "NUP93", "Nuclear pore complex protein Nup93", "Tier 1", 0.909, 1, "A_surface", 9, 79.88, 1, 0, null, null, 0, 0, null, 1, "nephrotic syndrome, type 12", 0.6970966479548709], ["O75787", "ATP6AP2", "Renin receptor", "Tier 1", 0.909, 1, "A_surface", 10, 79.19, 1, 0, null, null, 0, 0, null, 1, "syndromic X-linked intellectual disability Hedera type", 0.6955327890748848], ["P54289", "CACNA2D1", "Voltage-dependent calcium channel subunit alpha-2/delta-1", "Tier 1", 0.908, 1, "A_surface", 30, 86.56, 1, 0, null, null, 0, 0, null, 1, "Seizure", 0.6942469435259896], ["Q9NZ42", "PSENEN", "Gamma-secretase subunit PEN-2", "Tier 1", 0.905, 1, "A_surface", 27, 92.62, 1, 0, null, null, 0, 0, null, 1, "hidradenitis suppurativa", 0.6825090820129278], ["Q15303", "ERBB4", "Receptor tyrosine-protein kinase erbB-4", "Tier 1", 0.903, 1, "A_surface", 14, 73.12, 1, 0, null, null, 1, 3, "32592467,30697465,23990977", 1, "non-small cell lung carcinoma", 0.6754899662390331]], "truncated": false, "filtered_table_rows_count": 280, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_cryoEM\" = :p0 and \"surface_class\" = :p1 and \"tier\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "1", "p1": "A_surface", "p2": "Tier 1"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=A_surface&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 280, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A_surface&tier=Tier+1&has_structure=1", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=A_surface&tier=Tier+1", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 280, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A_surface", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=A_surface&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 280, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A_surface&tier=Tier+1&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=A_surface&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 193, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A_surface&tier=Tier+1&has_known_aptamer=0", "selected": false}, {"value": 1, "label": 1, "count": 87, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A_surface&tier=Tier+1&has_known_aptamer=1", "selected": false}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=A_surface&tier=Tier+1", "results": [{"value": "A_surface", "label": "A_surface", "count": 280, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&tier=Tier+1", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=A_surface&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 164, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A_surface&tier=Tier+1&in_cev_map=0", "selected": false}, {"value": 1, "label": 1, "count": 116, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A_surface&tier=Tier+1&in_cev_map=1", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=A_surface&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 280, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&tier=Tier+1", "selected": true}], "truncated": false}}, "suggested_facets": [{"name": "aptamer_count_pubmed", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A_surface&tier=Tier+1&_facet=aptamer_count_pubmed"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A_surface&tier=Tier+1&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 510.0045050494373, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}