{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_cryoEM = 1, surface_class = \"A_surface\" and tier = \"Tier 1.5\" sorted by evidence_priority descending", "rows": [["P21359", "NF1", "Neurofibromin", "Tier 1.5", 0.965, 1, "A_surface", 26, 87.19, 1, 0, null, null, 1, 2, "32980430,22617876", 1, "neurofibromatosis type 1", 0.8844735398780649], ["P36021", "SLC16A2", "Monocarboxylate transporter 8", "Tier 1.5", 0.956, 1, "A_surface", 7, 79.56, 1, 0, null, null, 0, 0, null, 1, "Allan-Herndon-Dudley syndrome", 0.8533069932022032], ["Q14524", "SCN5A", "Sodium channel protein type 5 subunit alpha", "Tier 1.5", 0.953, 1, "A_surface", 16, 67.25, 1, 0, null, null, 0, 0, null, 1, "long QT syndrome 3", 0.8448298602976083], ["Q969N2", "PIGT", "GPI-anchor transamidase component PIGT", "Tier 1.5", 0.953, 1, "A_surface", 3, 87.25, 1, 0, null, null, 0, 0, null, 1, "multiple congenital anomalies-hypotonia-seizures syndrome 3", 0.8439030764005646], ["P13637", "ATP1A3", "Sodium/potassium-transporting ATPase subunit alpha-3", "Tier 1.5", 0.953, 1, "A_surface", 5, 88.81, 1, 0, null, null, 0, 0, null, 1, "alternating hemiplegia of childhood 2", 0.842328126568451], ["Q99250", "SCN2A", "Sodium channel protein type 2 subunit alpha", "Tier 1.5", 0.952, 1, "A_surface", 5, 68.81, 1, 0, null, null, 0, 0, null, 1, "developmental and epileptic encephalopathy, 11", 0.8388748085806758], ["Q9HAB3", "SLC52A2", "Solute carrier family 52, riboflavin transporter, member 2", "Tier 1.5", 0.95, 1, "A_surface", 1, 84.12, 1, 0, null, null, 0, 0, null, 1, "riboflavin transporter deficiency", 0.8333271825486935], ["Q9Y653", "ADGRG1", "Adhesion G-protein coupled receptor G1", "Tier 1.5", 0.95, 1, "A_surface", 1, 77.88, 1, 0, null, null, 0, 0, null, 1, "bilateral frontoparietal polymicrogyria", 0.8322298896713178], ["P14770", "GP9", "Platelet glycoprotein IX", "Tier 1.5", 0.947, 1, "A_surface", 2, 84.69, 1, 0, null, null, 0, 0, null, 1, "Bernard-Soulier syndrome", 0.8233582238860002], ["P16234", "PDGFRA", "Platelet-derived growth factor receptor alpha", "Tier 1.5", 0.945, 1, "A_surface", 14, 72.69, 1, 0, null, null, 1, 4, "33334063,32127469,28010895,30594071", 1, "gastrointestinal stromal tumor", 0.8167494524079806], ["P51798", "CLCN7", "H(+)/Cl(-) exchange transporter 7", "Tier 1.5", 0.942, 1, "A_surface", 9, 80.94, 1, 0, null, null, 0, 0, null, 1, "Autosomal recessive malignant osteopetrosis", 0.8065499095904218], ["Q96JI7", "SPG11", "Spatacsin", "Tier 1.5", 0.937, 1, "A_surface", 3, 66.75, 1, 0, null, null, 0, 0, null, 1, "Autosomal recessive spastic paraplegia type 11", 0.7886006646085494], ["Q8TD43", "TRPM4", "Transient receptor potential cation channel subfamily M member 4", "Tier 1.5", 0.936, 1, "A_surface", 25, 77.44, 1, 0, null, null, 0, 0, null, 1, "Familial progressive cardiac conduction defect", 0.7868180621357534], ["P05023", "ATP1A1", "Sodium/potassium-transporting ATPase subunit alpha-1", "Tier 1.5", 0.936, 1, "A_surface", 10, 88.69, 1, 0, null, null, 0, 0, null, 1, "Charcot-Marie-tooth disease, axonal, type 2DD", 0.7868851290226483], ["P15529", "CD46", "Membrane cofactor protein", "Tier 1.5", 0.934, 1, "A_surface", 7, 82.12, 1, 0, null, null, 1, 9, "35114109,34248841,31761039,31077760,27734375,19915929,17046833,11084032", 1, "atypical hemolytic-uremic syndrome with MCP/CD46 anomaly", 0.7798469882597787], ["Q02094", "RHAG", "Ammonium transporter Rh type A", "Tier 1.5", 0.929, 1, "A_surface", 8, 95.62, 1, 0, null, null, 0, 0, null, 1, "Rh deficiency syndrome", 0.764209214915708], ["P00846", "MT-ATP6", "ATP synthase F(0) complex subunit a", "Tier 1.5", 0.928, 1, "A_surface", 10, 88.94, 1, 0, null, null, 0, 0, null, 1, "NARP syndrome", 0.760749518172638], ["P25445", "FAS", "Tumor necrosis factor receptor superfamily member 6", "Tier 1.5", 0.921, 1, "A_surface", 7, 77.88, 1, 0, null, null, 1, 17, "40784034,39897575,37458448,36908619,35402075,32270033,31436946,30594071,30417194,30339905,26318819,23980164,23511245,18997060,18956014,16729304,16581027", 1, "autoimmune lymphoproliferative syndrome type 1", 0.7377210386590284], ["O15554", "KCNN4", "Intermediate conductance calcium-activated potassium channel protein 4", "Tier 1.5", 0.914, 1, "A_surface", 17, 84.19, 1, 0, null, null, 0, 0, null, 1, "dehydrated hereditary stomatocytosis", 0.7145864899974032], ["O75110", "ATP9A", "Probable phospholipid-transporting ATPase IIA", "Tier 1.5", 0.914, 1, "A_surface", 4, 84.19, 1, 0, null, null, 0, 0, null, 1, "neurodevelopmental disorder with poor growth and behavioral abnormalities", 0.7120328673255018], ["Q9NR82", "KCNQ5", "Potassium voltage-gated channel subfamily KQT member 5", "Tier 1.5", 0.913, 1, "A_surface", 5, 56.41, 1, 0, null, null, 0, 0, null, 1, "intellectual disability, autosomal dominant 46", 0.7086662845211597], ["P51797", "CLCN6", "H(+)/Cl(-) exchange transporter 6", "Tier 1.5", 0.897, 1, "A_surface", 3, 77.81, 1, 0, null, null, 0, 0, null, 1, "neurodegeneration, childhood-onset, with hypotonia, respiratory insufficiency, and brain imaging abnormalities", 0.6554030932062199], ["P21731", "TBXA2R", "Thromboxane A2 receptor", "Tier 1.5", 0.892, 1, "A_surface", 6, 86.25, 1, 0, null, null, 0, 0, null, 1, "bleeding diathesis due to thromboxane synthesis deficiency", 0.639967145559869], ["P02786", "TFRC", "Transferrin receptor protein 1", "Tier 1.5", 0.887, 1, "A_surface", 22, 86.69, 1, 0, null, null, 1, 3, "39831311,29046922,32527800", 1, "TFRC-related combined immunodeficiency", 0.623449899069336], ["P54709", "ATP1B3", "Sodium/potassium-transporting ATPase subunit beta-3", "Tier 1.5", 0.88, 1, "A_surface", 7, 89.69, 1, 0, null, null, 0, 0, null, 1, "congestive heart failure", 0.5999952111132625], ["P01825", "IGHV4-59", "Immunoglobulin heavy variable 4-59", "Tier 1.5", 0.876, 1, "A_surface", 3, 91.56, 1, 0, null, null, 0, 0, null, 1, "cutaneous Leishmaniasis", 0.5868213846274001], ["P15954", "COX7C", "Cytochrome c oxidase subunit 7C, mitochondrial", "Tier 1.5", 0.868, 1, "A_surface", 3, 91.38, 1, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.5589133210585959], ["P41440", "SLC19A1", "Reduced folate transporter", "Tier 1.5", 0.866, 1, "A_surface", 19, 72.06, 1, 0, null, null, 0, 0, null, 1, "Knobloch syndrome", 0.5526223217595396], ["Q8TEM1", "NUP210", "Nuclear pore membrane glycoprotein 210", "Tier 1.5", 0.862, 1, "A_surface", 2, 79.56, 1, 0, null, null, 0, 0, null, 1, "HIV infection", 0.5409211817593593], ["Q9Y6M7", "SLC4A7", "Sodium bicarbonate cotransporter 3", "Tier 1.5", 0.856, 1, "A_surface", 1, 67.5, 1, 0, null, null, 0, 0, null, 1, "hypertension", 0.5199335074832467], ["Q92536", "SLC7A6", "Y+L amino acid transporter 2", "Tier 1.5", 0.846, 1, "A_surface", 2, 83.19, 1, 0, null, null, 0, 0, null, 1, "Abnormality of the skeletal system", 0.48544421359843914], ["Q92633", "LPAR1", "Lysophosphatidic acid receptor 1", "Tier 1.5", 0.843, 1, "A_surface", 16, 83.62, 1, 0, null, null, 1, 1, "32065590", 1, "Epiretinal membrane", 0.4757255248053499], ["P14616", "INSRR", "Insulin receptor-related protein", "Tier 1.5", 0.838, 1, "A_surface", 4, 78.0, 1, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.4589515676875687], ["Q3MIR4", "TMEM30B", "Cell cycle control protein 50B", "Tier 1.5", 0.809, 1, "A_surface", 1, 92.19, 1, 0, null, null, 0, 0, null, 1, "androgenetic alopecia", 0.3618940606584721], ["P21439", "ABCB4", "Phosphatidylcholine translocator ABCB4", "Tier 1.5", 0.806, 1, "A_surface", 4, 83.25, 1, 0, null, null, 0, 0, null, 0, "progressive familial intrahepatic cholestasis type 3", 0.851728159166962], ["P31785", "IL2RG", "Cytokine receptor common subunit gamma", "Tier 1.5", 0.804, 1, "A_surface", 14, 75.5, 1, 0, null, null, 1, 2, "30800133,33869115", 0, "gamma chain deficiency", 0.8469997000418428], ["Q5ZPR3", "CD276", "CD276 antigen", "Tier 1.5", 0.804, 1, "A_surface", 3, 83.31, 1, 0, null, null, 1, 1, "38866941", 1, "response to statin", 0.3471917147958521], ["Q92982", "NINJ1", "Ninjurin-1", "Tier 1.5", 0.804, 1, "A_surface", 5, 63.56, 1, 0, null, null, 0, 0, null, 1, "gout", 0.3456637674136287], ["Q9UM01", "SLC7A7", "Y+L amino acid transporter 1", "Tier 1.5", 0.804, 1, "A_surface", 5, 83.81, 1, 0, null, null, 0, 0, null, 0, "lysinuric protein intolerance", 0.8450026270275782], ["P08100", "RHO", "Rhodopsin", "Tier 1.5", 0.804, 1, "A_surface", 4, 88.75, 1, 0, null, null, 1, 45, "41963275,41924874,41636061,40808302,40642289,40330320,40045571,39863313,39788632,38070612,37191882,36705086,36696850,36095194,36049339,35622174,34709779,34471566,32696702,32479610,32319623,32119944,31737572,31588238,31535128,29570714,29281176,28648779,27893356,25645980,23757206,23701883,25033804,22689339,22302221,22121695,19766091,19389625,16419035,12123800,8743323,7678562,19188685,18230760", 0, "retinitis pigmentosa", 0.8481942240861982], ["P48029", "SLC6A8", "Sodium- and chloride-dependent creatine transporter 1", "Tier 1.5", 0.804, 1, "A_surface", 6, 84.62, 1, 0, null, null, 0, 0, null, 0, "creatine transporter deficiency", 0.847268393806457], ["Q9UQD0", "SCN8A", "Sodium channel protein type 8 subunit alpha", "Tier 1.5", 0.803, 1, "A_surface", 4, 68.38, 1, 0, null, null, 0, 0, null, 0, "developmental and epileptic encephalopathy, 13", 0.8437707419548253], ["O95342", "ABCB11", "Bile salt export pump", "Tier 1.5", 0.801, 1, "A_surface", 8, 83.12, 1, 0, null, null, 1, 1, "36313979", 0, "progressive familial intrahepatic cholestasis type 2", 0.8372060401943777], ["P78508", "KCNJ10", "ATP-sensitive inward rectifier potassium channel 10", "Tier 1.5", 0.801, 1, "A_surface", 4, 82.44, 1, 0, null, null, 0, 0, null, 0, "EAST syndrome", 0.8357483559927158], ["Q16281", "CNGA3", "Cyclic nucleotide-gated channel alpha-3", "Tier 1.5", 0.799, 1, "A_surface", 10, 74.44, 1, 0, null, null, 0, 0, null, 0, "achromatopsia", 0.8315799021867489], ["Q9HD23", "MRS2", "Magnesium transporter MRS2 homolog, mitochondrial", "Tier 1.5", 0.799, 1, "A_surface", 9, 71.06, 1, 0, null, null, 0, 0, null, 1, "alcohol drinking", 0.32910269130630654], ["P13866", "SLC5A1", "Sodium/glucose cotransporter 1", "Tier 1.5", 0.797, 1, "A_surface", 4, 84.38, 1, 0, null, null, 0, 0, null, 0, "glucose-galactose malabsorption", 0.8220991027793896], ["Q04844", "CHRNE", "Acetylcholine receptor subunit epsilon", "Tier 1.5", 0.797, 1, "A_surface", 13, 80.69, 1, 0, null, null, 0, 0, null, 0, "Congenital myasthenic syndromes", 0.8223287249629152], ["O60449", "LY75", "Lymphocyte antigen 75", "Tier 1.5", 0.796, 1, "A_surface", 4, 75.62, 1, 0, null, null, 0, 0, null, 1, "Abruptio Placentae", 0.31953367678705413], ["P23942", "PRPH2", "Peripherin-2", "Tier 1.5", 0.796, 1, "A_surface", 1, 87.0, 1, 0, null, null, 0, 0, null, 0, "retinitis pigmentosa", 0.8194208847382956]], "truncated": false, "filtered_table_rows_count": 160, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_cryoEM\" = :p0 and \"surface_class\" = :p1 and \"tier\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "1", "p1": "A_surface", "p2": "Tier 1.5"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=A_surface&tier=Tier+1.5", "results": [{"value": 1, "label": 1, "count": 160, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A_surface&tier=Tier+1.5&has_structure=1", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=A_surface&tier=Tier+1.5", "results": [{"value": "Tier 1.5", "label": "Tier 1.5", "count": 160, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A_surface", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=A_surface&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 160, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A_surface&tier=Tier+1.5&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=A_surface&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 128, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A_surface&tier=Tier+1.5&has_known_aptamer=0", "selected": false}, {"value": 1, "label": 1, "count": 32, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A_surface&tier=Tier+1.5&has_known_aptamer=1", "selected": false}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=A_surface&tier=Tier+1.5", "results": [{"value": "A_surface", "label": "A_surface", "count": 160, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&tier=Tier+1.5", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=A_surface&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 112, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A_surface&tier=Tier+1.5&in_cev_map=0", "selected": false}, {"value": 1, "label": 1, "count": 48, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A_surface&tier=Tier+1.5&in_cev_map=1", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=A_surface&tier=Tier+1.5", "results": [{"value": 1, "label": 1, "count": 160, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&tier=Tier+1.5", "selected": true}], "truncated": false}}, "suggested_facets": [{"name": "pdb_count_total", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A_surface&tier=Tier+1.5&_facet=pdb_count_total"}, {"name": "aptamer_count_pubmed", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A_surface&tier=Tier+1.5&_facet=aptamer_count_pubmed"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=A_surface&tier=Tier+1.5&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 993.5550088994205, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}