{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_cryoEM = 1, surface_class = \"B_cargo\" and tier = \"Tier 1\" sorted by evidence_priority descending", "rows": [["P43246", "MSH2", "DNA mismatch repair protein Msh2", "Tier 1", 0.766, 1, "B_cargo", 30, 85.31, 1, 0, null, null, 0, 0, null, 1, "Lynch syndrome", 0.8882239051809577], ["P35520", "CBS", "Cystathionine beta-synthase", "Tier 1", 0.76, 1, "B_cargo", 19, 90.06, 1, 0, null, null, 1, 6, "41780400,40454747,39984441,39541715,30792407,8650546", 1, "classic homocystinuria", 0.8675045223052872], ["P02545", "LMNA", "Prelamin-A/C", "Tier 1", 0.758, 1, "B_cargo", 27, 76.38, 1, 0, null, null, 1, 1, "37565451", 1, "dilated cardiomyopathy", 0.8593312064339074], ["Q96RQ3", "MCCC1", "Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial", "Tier 1", 0.757, 1, "B_cargo", 14, 87.62, 1, 0, null, null, 0, 0, null, 1, "Isolated 3-methylcrotonyl-CoA carboxylase deficiency", 0.8573370131864518], ["Q16595", "FXN", "Frataxin, mitochondrial", "Tier 1", 0.757, 1, "B_cargo", 20, 75.5, 1, 0, null, null, 0, 0, null, 1, "Friedreich ataxia", 0.8550760415889643], ["P11310", "ACADM", "Medium-chain specific acyl-CoA dehydrogenase, mitochondrial", "Tier 1", 0.756, 1, "B_cargo", 7, 93.38, 1, 0, null, null, 0, 0, null, 1, "medium chain acyl-CoA dehydrogenase deficiency", 0.8542618568274527], ["P11413", "G6PD", "Glucose-6-phosphate 1-dehydrogenase", "Tier 1", 0.755, 1, "B_cargo", 25, 94.38, 1, 0, null, null, 1, 3, "41935727,20811084", 1, "anemia, nonspherocytic hemolytic, due to G6PD deficiency", 0.8516109113701843], ["Q12756", "KIF1A", "Kinesin-like protein KIF1A", "Tier 1", 0.754, 1, "B_cargo", 21, 70.5, 1, 0, null, null, 0, 0, null, 1, "intellectual disability, autosomal dominant 9", 0.8481151412193974], ["Q9HCC0", "MCCC2", "Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial", "Tier 1", 0.753, 1, "B_cargo", 14, 94.69, 1, 0, null, null, 0, 0, null, 1, "3-methylcrotonyl-CoA carboxylase 2 deficiency", 0.8437575319886195], ["Q15465", "SHH", "Sonic hedgehog protein", "Tier 1", 0.753, 1, "B_cargo", 20, 78.38, 1, 0, null, null, 1, 4, "33257185,32867229,18698484,38462144", 1, "holoprosencephaly 3", 0.8433062137163501], ["Q13144", "EIF2B5", "Translation initiation factor eIF2B subunit epsilon", "Tier 1", 0.752, 1, "B_cargo", 25, 78.75, 1, 0, null, null, 0, 0, null, 1, "CACH syndrome", 0.8411470079917355], ["P55265", "ADAR", "Double-stranded RNA-specific adenosine deaminase", "Tier 1", 0.752, 1, "B_cargo", 24, 68.38, 1, 0, null, null, 1, 8, "41910181,41791686,41772759,41497668,41267360,39673485,38583236,17000903", 1, "Aicardi-Goutieres syndrome 6", 0.8388797454328872], ["P46777", "RPL5", "Large ribosomal subunit protein uL18", "Tier 1", 0.751, 1, "B_cargo", 30, 94.5, 1, 0, null, null, 0, 0, null, 1, "Blackfan-Diamond anemia", 0.8352702821155725], ["P16219", "ACADS", "Short-chain specific acyl-CoA dehydrogenase, mitochondrial", "Tier 1", 0.751, 1, "B_cargo", 4, 93.62, 1, 0, null, null, 0, 0, null, 1, "short chain acyl-CoA dehydrogenase deficiency", 0.8352413435265167], ["P00367", "GLUD1", "Glutamate dehydrogenase 1, mitochondrial", "Tier 1", 0.751, 1, "B_cargo", 7, 90.25, 1, 0, null, null, 0, 0, null, 1, "hyperinsulinism-hyperammonemia syndrome", 0.8355052949188112], ["P49768", "PSEN1", "Presenilin-1", "Tier 1", 0.751, 1, "B_cargo", 27, 72.12, 1, 0, null, null, 0, 0, null, 1, "Alzheimer disease 3", 0.8373536811398027], ["P63261", "ACTG1", "Actin, cytoplasmic 2", "Tier 1", 0.75, 1, "B_cargo", 10, 95.38, 1, 0, null, null, 0, 0, null, 1, "Baraitser-Winter syndrome", 0.834386021888207], ["P19429", "TNNI3", "Troponin I, cardiac muscle", "Tier 1", 0.75, 1, "B_cargo", 39, 78.62, 1, 0, null, null, 1, 1, "26594036", 1, "hypertrophic cardiomyopathy", 0.8340329164680969], ["Q99714", "HSD17B10", "3-hydroxyacyl-CoA dehydrogenase type-2", "Tier 1", 0.749, 1, "B_cargo", 15, 96.88, 1, 0, null, null, 1, 1, "17917077", 1, "HSD10 mitochondrial disease", 0.828877258137219], ["P42345", "MTOR", "Serine/threonine-protein kinase mTOR", "Tier 1", 0.749, 1, "B_cargo", 70, 78.0, 1, 0, null, null, 1, 27, "41951939,41924451,41819327,41563473,40316188,39728786,37574619,35356877,34638443,34362425,33319976,33124760,32521684,32245065,32170897,31840081,33455222,28945233,28471660,25751060,25057446,24292708,24242861,22363130,22239618,19878313,17495522", 1, "Macrocephaly-intellectual disability-neurodevelopmental disorder-small thorax syndrome", 0.8296449565554538], ["Q99707", "MTR", "Methionine synthase", "Tier 1", 0.748, 1, "B_cargo", 9, 87.5, 1, 0, null, null, 1, 1, "25964329", 1, "methylcobalamin deficiency type cblG", 0.8253271986114175], ["P36776", "LONP1", "Lon protease homolog, mitochondrial", "Tier 1", 0.748, 1, "B_cargo", 29, 76.69, 1, 0, null, null, 0, 0, null, 1, "CODAS syndrome", 0.8273562128539942], ["Q9Y3A5", "SBDS", "Ribosome maturation protein SBDS", "Tier 1", 0.748, 1, "B_cargo", 6, 74.06, 1, 0, null, null, 1, 1, "19454024", 1, "Shwachman-Diamond syndrome", 0.8282172244212194], ["Q7Z6Z7", "HUWE1", "E3 ubiquitin-protein ligase HUWE1", "Tier 1", 0.748, 1, "B_cargo", 19, null, 1, 0, null, null, 0, 0, null, 1, "intellectual disability, X-linked syndromic, Turner type", 0.8251574698433977], ["Q71U36", "TUBA1A", "Tubulin alpha-1A chain", "Tier 1", 0.747, 1, "B_cargo", 15, 91.12, 1, 0, null, null, 0, 0, null, 1, "lissencephaly due to TUBA1A mutation", 0.8249848986700001], ["Q9UNE7", "STUB1", "E3 ubiquitin-protein ligase CHIP", "Tier 1", 0.747, 1, "B_cargo", 21, 89.31, 1, 0, null, null, 0, 0, null, 1, "autosomal recessive spinocerebellar ataxia 16", 0.8231010720948859], ["P09493", "TPM1", "Tropomyosin alpha-1 chain", "Tier 1", 0.746, 1, "B_cargo", 14, 91.62, 1, 0, null, null, 0, 0, null, 1, "hypertrophic cardiomyopathy", 0.8201717082603994], ["P11498", "PC", "Pyruvate carboxylase, mitochondrial", "Tier 1", 0.746, 1, "B_cargo", 10, 90.38, 1, 0, null, null, 1, 607, "42025735,42015877,41963040,41956254,41946336,41942404,41940259,41852458,41850902,41813080,41806728,41801682,41791686,41786503,41742365,41713118,41686726,41679186,41671824,41621292,41586771,41570502,41545126,41519040,41453347,41447218,41444487,41422636,41401493,41328792,41294729,41275818,41275550,41268823,41207524,41167900,41155928,41149351,41135241,41103270,41061457,41030495,41002305,40992058,40978513,40974925,40968085,40952515,40942102,40936186", 1, "pyruvate carboxylase deficiency disease", 0.8195584644258792], ["Q8IYB7", "DIS3L2", "DIS3-like exonuclease 2", "Tier 1", 0.746, 1, "B_cargo", 4, 82.69, 1, 0, null, null, 0, 0, null, 1, "Perlman syndrome", 0.8206937660793029], ["Q8TEQ6", "GEMIN5", "Gem-associated protein 5", "Tier 1", 0.746, 1, "B_cargo", 16, 78.94, 1, 0, null, null, 0, 0, null, 1, "neurodevelopmental disorder with cerebellar atrophy and motor dysfunction", 0.8184088962562686], ["Q13148", "TARDBP", "TAR DNA-binding protein 43", "Tier 1", 0.746, 1, "B_cargo", 44, 65.19, 1, 0, null, null, 1, 7, "39548508,34469713,26915990,37671010,35739092,23264567", 1, "amyotrophic lateral sclerosis", 0.8196962822149189], ["P46531", "NOTCH1", "Neurogenic locus notch homolog protein 1", "Tier 1", 0.746, 1, "B_cargo", 29, 59.59, 1, 0, null, null, 1, 4, "38559166,34431568,33614227,28685750", 1, "Adams-Oliver syndrome", 0.8199672000988557], ["P18077", "RPL35A", "Large ribosomal subunit protein eL33", "Tier 1", 0.744, 1, "B_cargo", 30, 95.56, 1, 0, null, null, 0, 0, null, 1, "Blackfan-Diamond anemia", 0.8140112443681048], ["P26358", "DNMT1", "DNA (cytosine-5)-methyltransferase 1", "Tier 1", 0.744, 1, "B_cargo", 27, 77.81, 1, 0, null, null, 1, 12, "41635784,39079576,38762976,36609400,31733056,29554483,23179556", 1, "autosomal dominant cerebellar ataxia, deafness and narcolepsy", 0.8134195803175972], ["Q9UI10", "EIF2B4", "Translation initiation factor eIF2B subunit delta", "Tier 1", 0.744, 1, "B_cargo", 25, 76.5, 1, 0, null, null, 0, 0, null, 1, "CACH syndrome", 0.8146710778484454], ["P35637", "FUS", "RNA-binding protein FUS", "Tier 1", 0.744, 1, "B_cargo", 23, 53.59, 1, 0, null, null, 1, 8, "40394046,35592098,28701145,15132764,12927206", 1, "sporadic amyotrophic lateral sclerosis", 0.8117088043931799], ["O95831", "AIFM1", "Apoptosis-inducing factor 1, mitochondrial", "Tier 1", 0.743, 1, "B_cargo", 26, 85.81, 1, 0, null, null, 0, 0, null, 1, "severe X-linked mitochondrial encephalomyopathy", 0.8095652882833212], ["P07602", "PSAP", "Prosaposin", "Tier 1", 0.743, 1, "B_cargo", 20, 73.75, 1, 0, null, null, 1, 1, "41889102", 1, "Gaucher disease due to saposin C deficiency", 0.8100495894070405], ["Q13501", "SQSTM1", "Sequestosome-1", "Tier 1", 0.743, 1, "B_cargo", 26, 67.25, 1, 0, null, null, 1, 4, "40413753,32225060", 1, "amyotrophic lateral sclerosis", 0.809360678421687], ["Q9UHD2", "TBK1", "Serine/threonine-protein kinase TBK1", "Tier 1", 0.742, 1, "B_cargo", 25, 89.69, 1, 0, null, null, 1, 1, "40413753", 1, "frontotemporal dementia and/or amyotrophic lateral sclerosis 4", 0.8079405505675022], ["E7ETK0", "RPS24", "40S ribosomal protein S24", "Tier 1", 0.742, 1, "B_cargo", 2, 89.44, 1, 0, null, null, 0, 0, null, 1, "Blackfan-Diamond anemia", 0.808182918000228], ["O15287", "FANCG", "Fanconi anemia group G protein", "Tier 1", 0.742, 1, "B_cargo", 6, 83.12, 1, 0, null, null, 0, 0, null, 1, "Fanconi anemia complementation group G", 0.8075342855580835], ["P09471", "GNAO1", "Guanine nucleotide-binding protein G(o) subunit alpha", "Tier 1", 0.741, 1, "B_cargo", 83, 94.5, 1, 0, null, null, 0, 0, null, 1, "developmental and epileptic encephalopathy, 17", 0.8046862567587088], ["Q13509", "TUBB3", "Tubulin beta-3 chain", "Tier 1", 0.741, 1, "B_cargo", 28, 91.44, 1, 0, null, null, 0, 0, null, 1, "fibrosis of extraocular muscles, congenital, 3A, with or without extraocular involvement", 0.8033756889440116], ["Q9UL18", "AGO1", "Protein argonaute-1", "Tier 1", 0.741, 1, "B_cargo", 8, 91.0, 1, 0, null, null, 0, 0, null, 1, "neurodevelopmental disorder with language delay and behavioral abnormalities, with or without seizures", 0.803337762735991], ["P55072", "VCP", "Transitional endoplasmic reticulum ATPase", "Tier 1", 0.741, 1, "B_cargo", 100, 82.56, 1, 0, null, null, 1, 1, "40972397", 1, "inclusion body myopathy with Paget disease of bone and frontotemporal dementia type 1", 0.8028131613498347], ["Q9H9Q4", "NHEJ1", "Non-homologous end-joining factor 1", "Tier 1", 0.741, 1, "B_cargo", 26, 81.75, 1, 0, null, null, 0, 0, null, 1, "Cernunnos-XLF deficiency", 0.8044005005389401], ["P05067", "APP", "Amyloid-beta precursor protein", "Tier 1", 0.741, 1, "B_cargo", 100, 67.38, 1, 0, null, null, 1, 63, "40845665,40781183,40398131,40392609,40168709,39916963,39815389,39609809,39558155,39462761,39293375,39224911,38895620,38476032,38397086,38256230,38101030,37791572,37770666,37504144,36963325,36709587,36651835,36149663,35910789,35762921,35546375,35215961,34832326,34696413,34282416,33756331,33657486,33334063,33104885,32905362,32339154,31641824,31606675,31560515,31513457,31259533,31192585,30959405,30715838,29193172,28965053,28054670,27834794,26476448", 1, "Alzheimer disease", 0.8042536996738855], ["P37840", "SNCA", "Alpha-synuclein", "Tier 1", 0.74, 1, "B_cargo", 100, 75.19, 1, 0, null, null, 1, 62, "40140103,38917326,38397086,38256230,37586882,36403906,35164441,33079553,31627816,26096948,41212423,40914014,40602043,40489035,40337966,39777233,39377064,38728058,37956285,37821404,37782556,37534999,37506391,37433867,37160866,37037631,36774388,36348612,36339626,35994742,35861142,35581077,35500203,34410317,33934227,33889925,35019576,32349285,32292959,32129373,31900535,31886023,31825201,31437653,31207024,30278340,30051958,29858057,29700982,29104136,23264567", 1, "Hereditary late-onset Parkinson disease", 0.8010568055473846], ["P43694", "GATA4", "Transcription factor GATA-4", "Tier 1", 0.739, 1, "B_cargo", 3, 57.22, 1, 0, null, null, 1, 1, "37762684", 1, "atrial septal defect 2", 0.7972225107836246]], "truncated": false, "filtered_table_rows_count": 695, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_cryoEM\" = :p0 and \"surface_class\" = :p1 and \"tier\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "1", "p1": "B_cargo", "p2": "Tier 1"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": 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"https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=B_cargo&tier=Tier+1&has_activation_state_pdb_pair=0", "selected": false}, {"value": 1, "label": 1, "count": 1, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=B_cargo&tier=Tier+1&has_activation_state_pdb_pair=1", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=B_cargo&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 535, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=B_cargo&tier=Tier+1&has_known_aptamer=0", "selected": false}, {"value": 1, "label": 1, "count": 160, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=B_cargo&tier=Tier+1&has_known_aptamer=1", "selected": false}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=B_cargo&tier=Tier+1", "results": [{"value": "B_cargo", "label": "B_cargo", "count": 695, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&tier=Tier+1", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=B_cargo&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 436, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=B_cargo&tier=Tier+1&in_cev_map=1", "selected": false}, {"value": 0, "label": 0, "count": 259, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=B_cargo&tier=Tier+1&in_cev_map=0", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=B_cargo&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 695, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=B_cargo&tier=Tier+1", "selected": true}], "truncated": false}}, "suggested_facets": [{"name": "aptamer_count_pubmed", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=B_cargo&tier=Tier+1&_facet=aptamer_count_pubmed"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=B_cargo&tier=Tier+1&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 542.3320983536541, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}