{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_cryoEM = 1, surface_class = \"B_cargo\" and tier = \"Tier 1.5\" sorted by evidence_priority descending", "rows": [["P68133", "ACTA1", "Actin, alpha skeletal muscle", "Tier 1.5", 0.758, 1, "B_cargo", 5, 95.12, 1, 0, null, null, 0, 0, null, 1, "congenital myopathy 2a, typical, autosomal dominant", 0.8588441418736817], ["P05165", "PCCA", "Propionyl-CoA carboxylase alpha chain, mitochondrial", "Tier 1.5", 0.756, 1, "B_cargo", 25, 87.44, 1, 0, null, null, 1, 1, "36578103", 1, "propionic acidemia", 0.8530542602972598], ["Q14896", "MYBPC3", "Myosin-binding protein C, cardiac-type", "Tier 1.5", 0.755, 1, "B_cargo", 17, 78.81, 1, 0, null, null, 0, 0, null, 1, "hypertrophic cardiomyopathy", 0.8502637105703099], ["P30084", "ECHS1", "Enoyl-CoA hydratase, mitochondrial", "Tier 1.5", 0.755, 1, "B_cargo", 6, 91.69, 1, 0, null, null, 0, 0, null, 1, "mitochondrial short-chain Enoyl-Coa hydratase 1 deficiency", 0.8483381531913922], ["P26440", "IVD", "Isovaleryl-CoA dehydrogenase, mitochondrial", "Tier 1.5", 0.754, 1, "B_cargo", 5, 93.38, 1, 0, null, null, 1, 2, "41230502,26946282", 1, "isovaleric acidemia", 0.8480603595890895], ["P35573", "AGL", "Glycogen debranching enzyme", "Tier 1.5", 0.75, 1, "B_cargo", 1, 92.75, 1, 0, null, null, 0, 0, null, 1, "glycogen storage disease III", 0.8321686508777297], ["Q9Y4W6", "AFG3L2", "Mitochondrial inner membrane m-AAA protease component AFG3L2", "Tier 1.5", 0.75, 1, "B_cargo", 2, 76.75, 1, 0, null, null, 0, 0, null, 1, "spinocerebellar ataxia type 28", 0.8341800061294613], ["P55157", "MTTP", "Microsomal triglyceride transfer protein large subunit", "Tier 1.5", 0.748, 1, "B_cargo", 2, 86.56, 1, 0, null, null, 1, 1, "23770039", 1, "abetalipoproteinemia", 0.8281089516017405], ["Q9Y484", "WDR45", "WD repeat domain phosphoinositide-interacting protein 4", "Tier 1.5", 0.747, 1, "B_cargo", 3, 90.5, 1, 0, null, null, 0, 0, null, 1, "neurodegeneration with brain iron accumulation 5", 0.8230559793277397], ["Q53H12", "AGK", "Acylglycerol kinase, mitochondrial", "Tier 1.5", 0.747, 1, "B_cargo", 1, 87.0, 1, 0, null, null, 1, 1, "35763566", 1, "Sengers syndrome", 0.8231275438888749], ["O75027", "ABCB7", "Iron-sulfur clusters transporter ABCB7, mitochondrial", "Tier 1.5", 0.746, 1, "B_cargo", 1, 78.12, 1, 0, null, null, 0, 0, null, 1, "X-linked sideroblastic anemia with ataxia", 0.821045506234113], ["P63267", "ACTG2", "Actin, gamma-enteric smooth muscle", "Tier 1.5", 0.745, 1, "B_cargo", 4, 95.38, 1, 0, null, null, 0, 0, null, 1, "visceral myopathy 1", 0.8175814609874555], ["P42224", "STAT1", "Signal transducer and activator of transcription 1-alpha/beta", "Tier 1.5", 0.744, 1, "B_cargo", 10, 87.25, 1, 0, null, null, 1, 5, "41290466,38569854,31879964,31702021,21433395", 1, "Chronic mucocutaneous candidosis", 0.8147374964880533], ["P51159", "RAB27A", "Ras-related protein Rab-27A", "Tier 1.5", 0.744, 1, "B_cargo", 11, 83.94, 1, 0, null, null, 0, 0, null, 1, "Griscelli syndrome type 2", 0.8139882966122653], ["Q14839", "CHD4", "ATP-dependent chromatin remodeler CHD4", "Tier 1.5", 0.743, 1, "B_cargo", 12, 64.62, 1, 0, null, null, 0, 0, null, 1, "Sifrim-Hitz-Weiss syndrome", 0.8103430577478806], ["Q8TCS8", "PNPT1", "Polyribonucleotide nucleotidyltransferase 1, mitochondrial", "Tier 1.5", 0.743, 1, "B_cargo", 11, 87.44, 1, 0, null, null, 0, 0, null, 1, "combined oxidative phosphorylation defect type 13", 0.8091107966912156], ["O43464", "HTRA2", "Serine protease HTRA2, mitochondrial", "Tier 1.5", 0.742, 1, "B_cargo", 13, 74.44, 1, 0, null, null, 0, 0, null, 1, "3-methylglutaconic aciduria type 8", 0.8079136325441377], ["Q14738", "PPP2R5D", "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform", "Tier 1.5", 0.742, 1, "B_cargo", 2, 79.94, 1, 0, null, null, 0, 0, null, 1, "Hogue-Janssens syndrome 1", 0.8058398703478188], ["Q15125", "EBP", "3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase", "Tier 1.5", 0.742, 1, "B_cargo", 4, 95.56, 1, 0, null, null, 0, 0, null, 1, "MEND syndrome", 0.8082510362309315], ["P43007", "SLC1A4", "Neutral amino acid transporter A", "Tier 1.5", 0.741, 1, "B_cargo", 1, 80.56, 1, 0, null, null, 1, 6, "36219068,31989939,27571928,26811678,19046328,16139842", 1, "spastic tetraplegia-thin corpus callosum-progressive postnatal microcephaly syndrome", 0.8025684205131692], ["Q14669", "TRIP12", "E3 ubiquitin-protein ligase TRIP12", "Tier 1.5", 0.739, 1, "B_cargo", 5, 66.75, 1, 0, null, null, 0, 0, null, 1, "Clark-Baraitser syndrome", 0.795639262535032], ["Q9Y4R8", "TELO2", "Telomere length regulation protein TEL2 homolog", "Tier 1.5", 0.739, 1, "B_cargo", 3, 83.88, 1, 0, null, null, 0, 0, null, 1, "TELO2-related intellectual disability-neurodevelopmental disorder", 0.7971337980726797], ["P10916", "MYL2", "Myosin regulatory light chain 2, ventricular/cardiac muscle isoform", "Tier 1.5", 0.738, 1, "B_cargo", 3, 83.5, 1, 0, null, null, 0, 0, null, 1, "hypertrophic cardiomyopathy", 0.7947577322969279], ["Q14697", "GANAB", "Neutral alpha-glucosidase AB", "Tier 1.5", 0.738, 1, "B_cargo", 2, 92.94, 1, 0, null, null, 0, 0, null, 1, "polycystic kidney disease 3 with or without polycystic liver disease", 0.7928508011740861], ["P98155", "VLDLR", "Very low-density lipoprotein receptor", "Tier 1.5", 0.737, 1, "B_cargo", 27, 75.69, 1, 0, null, null, 1, 1, "19188685", 1, "Dysequilibrium syndrome", 0.790164037509625], ["Q96IJ6", "GMPPA", "Mannose-1-phosphate guanylyltransferase regulatory subunit alpha", "Tier 1.5", 0.737, 1, "B_cargo", 3, 93.06, 1, 0, null, null, 0, 0, null, 1, "Triple A syndrome", 0.7907928491141871], ["O14497", "ARID1A", "AT-rich interactive domain-containing protein 1A", "Tier 1.5", 0.734, 1, "B_cargo", 8, 46.91, 1, 0, null, null, 0, 0, null, 1, "intellectual disability, autosomal dominant 14", 0.7798204163479697], ["P51790", "CLCN3", "H(+)/Cl(-) exchange transporter 3", "Tier 1.5", 0.733, 1, "B_cargo", 5, 80.0, 1, 0, null, null, 0, 0, null, 1, "neurodevelopmental disorder with hypotonia and brain abnormalities", 0.7761855675091979], ["Q15813", "TBCE", "Tubulin-specific chaperone E", "Tier 1.5", 0.732, 1, "B_cargo", 6, 89.19, 1, 0, null, null, 1, 1, "34448574", 1, "hypoparathyroidism-retardation-dysmorphism syndrome", 0.7744447925917005], ["Q2TAL8", "QRICH1", "Transcriptional regulator QRICH1", "Tier 1.5", 0.729, 1, "B_cargo", 2, 57.47, 1, 0, null, null, 0, 0, null, 1, "Ververi-Brady syndrome 1", 0.7633163630733731], ["Q13043", "STK4", "Serine/threonine-protein kinase 4", "Tier 1.5", 0.728, 1, "B_cargo", 16, 75.94, 1, 0, null, null, 1, 1, "31707227", 1, "combined immunodeficiency due to STK4 deficiency", 0.7613382040802787], ["O75175", "CNOT3", "CCR4-NOT transcription complex subunit 3", "Tier 1.5", 0.727, 1, "B_cargo", 6, 65.44, 1, 0, null, null, 0, 0, null, 1, "intellectual developmental disorder with speech delay, autism and dysmorphic facies", 0.7557397879122256], ["P14854", "COX6B1", "Cytochrome c oxidase subunit 6B1", "Tier 1.5", 0.724, 1, "B_cargo", 3, 95.0, 1, 0, null, null, 0, 0, null, 1, "mitochondrial complex IV deficiency, nuclear type 7", 0.7478662750768209], ["O00400", "SLC33A1", "Acetyl-coenzyme A transporter 1", "Tier 1.5", 0.723, 1, "B_cargo", 2, 82.38, 1, 0, null, null, 0, 0, null, 1, "Huppke-Brendel syndrome", 0.7421018006689203], ["P07237", "P4HB", "Protein disulfide-isomerase", "Tier 1.5", 0.723, 1, "B_cargo", 14, 88.5, 1, 0, null, null, 1, 2, "31625090,28952381", 1, "Cole-Carpenter syndrome", 0.7447295842045853], ["Q63HN8", "RNF213", "E3 ubiquitin-protein ligase RNF213", "Tier 1.5", 0.723, 1, "B_cargo", 4, 86.25, 1, 0, null, null, 0, 0, null, 1, "Moyamoya disease", 0.7432964420796212], ["Q9Y287", "ITM2B", "Integral membrane protein 2B", "Tier 1.5", 0.72, 1, "B_cargo", 1, 75.44, 1, 0, null, null, 0, 0, null, 1, "ABri amyloidosis", 0.7342528954076827], ["O95479", "H6PD", "GDH/6PGL endoplasmic bifunctional protein", "Tier 1.5", 0.719, 1, "B_cargo", 1, 90.56, 1, 0, null, null, 0, 0, null, 1, "Hyperandrogenism due to cortisone reductase deficiency", 0.7312443728931738], ["P17812", "CTPS1", "CTP synthase 1", "Tier 1.5", 0.718, 1, "B_cargo", 7, 91.38, 1, 0, null, null, 0, 0, null, 1, "combined immunodeficiency due to CTPS1 deficiency", 0.727135118379296], ["Q8TAQ2", "SMARCC2", "SWI/SNF complex subunit SMARCC2", "Tier 1.5", 0.715, 1, "B_cargo", 10, 63.41, 1, 0, null, null, 0, 0, null, 1, "Coffin-Siris syndrome 8", 0.7151553459130683], ["P21281", "ATP6V1B2", "V-type proton ATPase subunit B, brain isoform", "Tier 1.5", 0.715, 1, "B_cargo", 8, 86.0, 1, 0, null, null, 0, 0, null, 1, "Zimmermann-Laband syndrome 2", 0.7173813048839504], ["Q02218", "OGDH", "2-oxoglutarate dehydrogenase complex component E1", "Tier 1.5", 0.715, 1, "B_cargo", 3, 90.44, 1, 0, null, null, 0, 0, null, 1, "oxoglutaricaciduria", 0.7171952130928542], ["Q8ND04", "SMG8", "Nonsense-mediated mRNA decay factor SMG8", "Tier 1.5", 0.712, 1, "B_cargo", 6, 73.88, 1, 0, null, null, 0, 0, null, 1, "Alzahrani-Kuwahara syndrome", 0.705812720697099], ["Q8NI36", "WDR36", "WD repeat-containing protein 36", "Tier 1.5", 0.712, 1, "B_cargo", 3, 87.44, 1, 0, null, null, 0, 0, null, 1, "open-angle glaucoma", 0.7050878586165737], ["Q03519", "TAP2", "Antigen peptide transporter 2", "Tier 1.5", 0.712, 1, "B_cargo", 21, 82.69, 1, 0, null, null, 0, 0, null, 1, "MHC class I deficiency", 0.7053973274491012], ["Q5MNZ6", "WDR45B", "WD repeat domain phosphoinositide-interacting protein 3", "Tier 1.5", 0.709, 1, "B_cargo", 5, 94.81, 1, 0, null, null, 0, 0, null, 1, "neurodevelopmental disorder with spastic quadriplegia and brain abnormalities with or without seizures", 0.6954780252748286], ["Q13158", "FADD", "FAS-associated death domain protein", "Tier 1.5", 0.708, 1, "B_cargo", 18, 72.12, 1, 0, null, null, 1, 3, "36309655,30594071,26318819", 1, "FADD-related immunodeficiency", 0.6932338529214827], ["O14979", "HNRNPDL", "Heterogeneous nuclear ribonucleoprotein D-like", "Tier 1.5", 0.705, 1, "B_cargo", 1, 62.78, 1, 0, null, null, 0, 0, null, 1, "autosomal dominant limb-girdle muscular dystrophy type 1G", 0.6837247353165932], ["P31483", "TIA1", "Cytotoxic granule associated RNA binding protein TIA1", "Tier 1.5", 0.699, 1, "B_cargo", 10, 73.69, 1, 0, null, null, 0, 0, null, 1, "amyotrophic lateral sclerosis 26 with or without frontotemporal dementia", 0.6625203683612911], ["Q15645", "TRIP13", "Pachytene checkpoint protein 2 homolog", "Tier 1.5", 0.696, 1, "B_cargo", 6, 86.69, 1, 0, null, null, 0, 0, null, 1, "mosaic variegated aneuploidy syndrome 3", 0.6540826184796098]], "truncated": false, "filtered_table_rows_count": 272, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_cryoEM\" = :p0 and \"surface_class\" = :p1 and \"tier\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "1", "p1": "B_cargo", "p2": "Tier 1.5"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=B_cargo&tier=Tier+1.5", "results": [{"value": 1, "label": 1, "count": 272, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=B_cargo&tier=Tier+1.5&has_structure=1", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=B_cargo&tier=Tier+1.5", "results": [{"value": "Tier 1.5", "label": "Tier 1.5", "count": 272, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=B_cargo", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=B_cargo&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 272, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=B_cargo&tier=Tier+1.5&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=B_cargo&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 231, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=B_cargo&tier=Tier+1.5&has_known_aptamer=0", "selected": false}, {"value": 1, "label": 1, "count": 41, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=B_cargo&tier=Tier+1.5&has_known_aptamer=1", "selected": false}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=B_cargo&tier=Tier+1.5", "results": [{"value": "B_cargo", "label": "B_cargo", "count": 272, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&tier=Tier+1.5", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=B_cargo&tier=Tier+1.5", "results": [{"value": 1, "label": 1, "count": 148, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=B_cargo&tier=Tier+1.5&in_cev_map=1", "selected": false}, {"value": 0, "label": 0, "count": 124, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=B_cargo&tier=Tier+1.5&in_cev_map=0", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_cryoEM=1&surface_class=B_cargo&tier=Tier+1.5", "results": [{"value": 1, "label": 1, "count": 272, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=B_cargo&tier=Tier+1.5", "selected": true}], "truncated": false}}, "suggested_facets": [{"name": "pdb_count_total", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=B_cargo&tier=Tier+1.5&_facet=pdb_count_total"}, {"name": "aptamer_count_pubmed", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=B_cargo&tier=Tier+1.5&_facet=aptamer_count_pubmed"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_cryoEM=1&surface_class=B_cargo&tier=Tier+1.5&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 1348.8226127810776, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}