{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_known_aptamer = 0, in_cev_map = 0 and surface_class = \"A2_pm_peripheral\" sorted by evidence_priority descending", "rows": [["Q9Y4U1", "MMACHC", "Cyanocobalamin reductase / alkylcobalamin dealkylase", "Tier 1.5", 0.644, 1, "A2_pm_peripheral", 7, 85.62, 0, 0, null, null, 0, 0, null, 0, "Methylmalonic acidemia with homocystinuria, type cblC", 0.8478185420804271], ["Q9Y215", "COLQ", "Acetylcholinesterase collagenic tail peptide", "Tier 1.5", 0.629, 1, "A2_pm_peripheral", 1, 54.47, 0, 0, null, null, 0, 0, null, 0, "Congenital myasthenic syndromes", 0.796199449860989], ["Q4FZB7", "KMT5B", "Histone-lysine N-methyltransferase KMT5B", "Tier 1", 0.628, 1, "A2_pm_peripheral", 10, 54.91, 1, 0, null, null, 0, 0, null, 0, "intellectual disability, autosomal dominant 51", 0.7943209483524042], ["Q68CZ1", "RPGRIP1L", "Protein fantom", "Tier 1.5", 0.628, 1, "A2_pm_peripheral", 1, 70.06, 0, 0, null, null, 0, 0, null, 0, "Joubert syndrome with hepatic defect", 0.7930231953177929], ["Q5JVL4", "EFHC1", "EF-hand domain-containing protein 1", "Tier 1", 0.626, 1, "A2_pm_peripheral", 2, 83.88, 1, 0, null, null, 0, 0, null, 0, "juvenile myoclonic epilepsy", 0.7858434985198706], ["P49459", "UBE2A", "Ubiquitin-conjugating enzyme E2 A", "Tier 1.5", 0.626, 1, "A2_pm_peripheral", 5, 94.12, 1, 0, null, null, 0, 0, null, 0, "syndromic X-linked intellectual disability Nascimento type", 0.7867796040270276], ["O75800", "ZMYND10", "Zinc finger MYND domain-containing protein 10", "Tier 1", 0.625, 1, "A2_pm_peripheral", 2, 88.75, 0, 0, null, null, 0, 0, null, 0, "primary ciliary dyskinesia", 0.7822239837882315], ["Q86SQ9", "DHDDS", "Dehydrodolichyl diphosphate synthase complex subunit DHDDS", "Tier 1", 0.624, 1, "A2_pm_peripheral", 9, 94.75, 0, 0, null, null, 0, 0, null, 0, "retinitis pigmentosa 59", 0.7786578489187141], ["O43586", "PSTPIP1", "Proline-serine-threonine phosphatase-interacting protein 1", "Tier 1", 0.624, 1, "A2_pm_peripheral", 4, 85.75, 0, 0, null, null, 0, 0, null, 0, "pyogenic arthritis-pyoderma gangrenosum-acne syndrome", 0.7793785829807485], ["Q8NFD5", "ARID1B", "AT-rich interactive domain-containing protein 1B", "Tier 1", 0.624, 1, "A2_pm_peripheral", 2, 46.19, 0, 0, null, null, 0, 0, null, 0, "Coffin-Siris syndrome 1", 0.7813407475430133], ["Q9NPP4", "NLRC4", "NLR family CARD domain-containing protein 4", "Tier 1", 0.619, 1, "A2_pm_peripheral", 6, 85.12, 1, 0, null, null, 0, 0, null, 0, "periodic fever-infantile enterocolitis-autoinflammatory syndrome", 0.7635956406357429], ["Q15744", "CEBPE", "CCAAT/enhancer-binding protein epsilon", "Tier 1.5", 0.619, 1, "A2_pm_peripheral", 1, 63.19, 0, 0, null, null, 0, 0, null, 0, "Recurrent infection due to specific granule deficiency", 0.7619369036825959], ["Q96CW9", "NTNG2", "Netrin-G2", "Tier 1.5", 0.616, 1, "A2_pm_peripheral", 3, 84.5, 0, 0, null, null, 0, 0, null, 0, "neurodevelopmental disorder with behavioral abnormalities, absent speech, and hypotonia", 0.7527757254195254], ["P35716", "SOX11", "Transcription factor SOX-11", "Tier 1", 0.614, 1, "A2_pm_peripheral", 4, 56.41, 1, 0, null, null, 0, 0, null, 0, "intellectual developmental disorder with microcephaly and with or without ocular malformations or hypogonadotropic hypogonadism", 0.7470288070793535], ["P48788", "TNNI2", "Troponin I, fast skeletal muscle", "Tier 1.5", 0.613, 1, "A2_pm_peripheral", 2, 80.69, 0, 0, null, null, 0, 0, null, 0, "distal arthrogryposis type 2B1", 0.7424838485252128], ["O15350", "TP73", "Tumor protein p73", "Tier 1", 0.612, 1, "A2_pm_peripheral", 28, 65.19, 0, 0, null, null, 0, 0, null, 0, "ciliary dyskinesia, primary, 47, and lissencephaly", 0.7409037542174439], ["Q6EMB2", "TTLL5", "Tubulin polyglutamylase TTLL5", "Tier 1.5", 0.607, 1, "A2_pm_peripheral", 1, 61.41, 0, 0, null, null, 0, 0, null, 0, "Cone rod dystrophy", 0.72210835127064], ["Q8N136", "DAW1", "Dynein assembly factor with WD repeat domains 1", "Tier 1", 0.596, 1, "A2_pm_peripheral", 1, 96.62, 0, 0, null, null, 0, 0, null, 0, "ciliary dyskinesia, primary, 52", 0.6876653910907874], ["Q9BWF2", "TRAIP", "E3 ubiquitin-protein ligase TRAIP", "Tier 1.5", 0.595, 1, "A2_pm_peripheral", 1, 74.94, 0, 0, null, null, 0, 0, null, 0, "Seckel syndrome 9", 0.683878095944948], ["Q4KMQ1", "TPRN", "Taperin", "Tier 1.5", 0.595, 1, "A2_pm_peripheral", 1, 54.44, 0, 0, null, null, 0, 0, null, 0, "hearing loss, autosomal recessive", 0.6844134134291492], ["Q9H6P5", "TASP1", "Threonine aspartase 1", "Tier 1", 0.594, 1, "A2_pm_peripheral", 10, 86.81, 0, 0, null, null, 0, 0, null, 0, "Suleiman-El-Hattab syndrome", 0.6801464403674466], ["Q8IUC6", "TICAM1", "TIR domain-containing adapter molecule 1", "Tier 1.5", 0.581, 1, "A2_pm_peripheral", 8, 62.78, 1, 0, null, null, 0, 0, null, 0, "Herpetic encephalitis", 0.6364986386236531], ["P50607", "TUB", "Tubby protein homolog", "Tier 1.5", 0.579, 1, "A2_pm_peripheral", 1, 69.12, 0, 0, null, null, 0, 0, null, 0, "retinitis pigmentosa", 0.631297844631827], ["Q9UQC2", "GAB2", "GRB2-associated-binding protein 2", "Tier 1", 0.572, 1, "A2_pm_peripheral", 10, 51.91, 0, 0, null, null, 0, 0, null, 0, "cancer", 0.6072358553557748], ["Q8IWB6", "TEX14", "Inactive serine/threonine-protein kinase TEX14", "Tier 1", 0.571, 1, "A2_pm_peripheral", 2, 50.47, 0, 0, null, null, 0, 0, null, 0, "spermatogenic failure 23", 0.603775324929283], ["P56597", "NME5", "Nucleoside diphosphate kinase 5", "Tier 1.5", 0.563, 1, "A2_pm_peripheral", 1, 90.06, 1, 0, null, null, 0, 0, null, 0, "ciliary dyskinesia, primary, 48, without situs inversus", 0.5766985649142533], ["Q13882", "PTK6", "Protein-tyrosine kinase 6", "Tier 1", 0.56, 1, "A2_pm_peripheral", 9, 88.81, 0, 0, null, null, 0, 0, null, 0, "medullary thyroid gland carcinoma", 0.5657289152364859], ["O76083", "PDE9A", "High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A", "Tier 1", 0.553, 1, "A2_pm_peripheral", 25, 81.0, 0, 0, null, null, 0, 0, null, 0, "coronary artery disease", 0.5429744031742744], ["Q9BVS4", "RIOK2", "Serine/threonine-protein kinase RIO2", "Tier 1", 0.552, 1, "A2_pm_peripheral", 10, 67.38, 1, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.539818754658029], ["Q86T24", "ZBTB33", "Transcriptional regulator Kaiso", "Tier 1", 0.551, 1, "A2_pm_peripheral", 19, 54.78, 0, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.5355170277816887], ["Q9NXF7", "DCAF16", "DDB1- and CUL4-associated factor 16", "Tier 1", 0.548, 1, "A2_pm_peripheral", 2, 38.19, 1, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.5251061120759617], ["Q8WWN9", "IPCEF1", "Interactor protein for cytohesin exchange factors 1", "Tier 1.5", 0.547, 1, "A2_pm_peripheral", 1, 64.06, 0, 0, null, null, 0, 0, null, 0, "response to tramadol", 0.5225136314922196], ["Q14678", "KANK1", "KN motif and ankyrin repeat domain-containing protein 1", "Tier 1", 0.546, 1, "A2_pm_peripheral", 5, 53.97, 0, 0, null, null, 0, 0, null, 0, "basal cell carcinoma", 0.5204468359739138], ["Q8N8R7", "ARL14EP", "ARL14 effector protein", "Tier 1.5", 0.546, 1, "A2_pm_peripheral", 1, 80.69, 0, 0, null, null, 0, 0, null, 0, "endometriosis", 0.5215169504121038], ["O43663", "PRC1", "Protein regulator of cytokinesis 1", "Tier 1", 0.544, 1, "A2_pm_peripheral", 6, 78.94, 1, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.5139662839321523], ["P49789", "FHIT", "Bis(5'-adenosyl)-triphosphatase", "Tier 1", 0.542, 1, "A2_pm_peripheral", 9, 95.25, 0, 0, null, null, 0, 0, null, 0, "Abnormality of the skeletal system", 0.505651828927915], ["P48775", "TDO2", "Tryptophan 2,3-dioxygenase", "Tier 1", 0.541, 1, "A2_pm_peripheral", 22, 90.06, 0, 0, null, null, 0, 0, null, 0, "Hypertryptophanemia", 0.5037265368575525], ["Q5UIP0", "RIF1", "Telomere-associated protein RIF1", "Tier 1.5", 0.541, 1, "A2_pm_peripheral", 1, 53.78, 0, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.5038900373620092], ["P11712", "CYP2C9", "Cytochrome P450 2C9", "Tier 1", 0.536, 1, "A2_pm_peripheral", 15, 92.94, 0, 0, null, null, 0, 0, null, 0, "cholesterol embolism", 0.4868290635834234], ["Q15788", "NCOA1", "Nuclear receptor coactivator 1", "Tier 1", 0.536, 1, "A2_pm_peripheral", 100, 46.72, 0, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.48697450901885614], ["Q9GZN1", "ACTR6", "Actin-related protein 6", "Tier 1.5", 0.533, 1, "A2_pm_peripheral", 9, 94.31, 1, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.4758409073452339], ["O14733", "MAP2K7", "Dual specificity mitogen-activated protein kinase kinase 7", "Tier 1", 0.529, 1, "A2_pm_peripheral", 37, 77.25, 0, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.4624505042962164], ["Q9BX66", "SORBS1", "Sorbin and SH3 domain-containing protein 1", "Tier 1", 0.527, 1, "A2_pm_peripheral", 11, 46.94, 0, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.45582260952481995], ["Q9UK80", "USP21", "Ubiquitin carboxyl-terminal hydrolase 21", "Tier 1", 0.524, 1, "A2_pm_peripheral", 4, 69.75, 1, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.44616960950164986], ["O00757", "FBP2", "Fructose-1,6-bisphosphatase isozyme 2", "Tier 1", 0.523, 1, "A2_pm_peripheral", 14, 93.75, 0, 0, null, null, 0, 0, null, 0, "leukodystrophy, childhood-onset, remitting", 0.44205857063120163], ["O15519", "CFLAR", "CASP8 and FADD-like apoptosis regulator", "Tier 1", 0.523, 1, "A2_pm_peripheral", 17, 78.31, 1, 0, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.4419421569940659], ["Q9UKI9", "POU2F3", "POU domain, class 2, transcription factor 3", "Tier 1.5", 0.523, 1, "A2_pm_peripheral", 3, 59.34, 0, 0, null, null, 0, 0, null, 0, "erythematosquamous dermatosis", 0.44361239146188985], ["O75747", "PIK3C2G", "Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma", "Tier 1.5", 0.523, 1, "A2_pm_peripheral", 1, 73.62, 0, 0, null, null, 0, 0, null, 0, "mathematical ability", 0.4448369190532247], ["Q9Y2I2", "NTNG1", "Netrin-G1", "Tier 1.5", 0.522, 1, "A2_pm_peripheral", 1, 83.62, 0, 0, null, null, 0, 0, null, 0, "obesity", 0.438954995963001], ["Q12923", "PTPN13", "Tyrosine-protein phosphatase non-receptor type 13", "Tier 1", 0.519, 1, "A2_pm_peripheral", 12, 60.03, 0, 0, null, null, 0, 0, null, 0, "Abnormality of the skeletal system", 0.43005634671382553]], "truncated": false, "filtered_table_rows_count": 137, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_known_aptamer\" = :p0 and \"in_cev_map\" = :p1 and \"surface_class\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "0", "p1": "0", "p2": "A2_pm_peripheral"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&in_cev_map=0&surface_class=A2_pm_peripheral", "results": [{"value": 1, "label": 1, "count": 84, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=0&surface_class=A2_pm_peripheral&has_structure=1", "selected": false}, {"value": 0, "label": 0, "count": 53, "toggle_url": 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"/scout/v_targets.json?has_known_aptamer=0&in_cev_map=0&surface_class=A2_pm_peripheral", "results": [{"value": 0, "label": 0, "count": 137, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=0&surface_class=A2_pm_peripheral&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&in_cev_map=0&surface_class=A2_pm_peripheral", "results": [{"value": 0, "label": 0, "count": 137, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=A2_pm_peripheral", "selected": true}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&in_cev_map=0&surface_class=A2_pm_peripheral", "results": [{"value": "A2_pm_peripheral", "label": "A2_pm_peripheral", "count": 137, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=0", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&in_cev_map=0&surface_class=A2_pm_peripheral", "results": [{"value": 0, "label": 0, "count": 137, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=A2_pm_peripheral", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&in_cev_map=0&surface_class=A2_pm_peripheral", "results": [{"value": 0, "label": 0, "count": 120, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=0&surface_class=A2_pm_peripheral&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 17, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=0&surface_class=A2_pm_peripheral&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [{"name": "pdb_count_total", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=0&surface_class=A2_pm_peripheral&_facet=pdb_count_total"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=0&surface_class=A2_pm_peripheral&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 1204.470416996628, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}