{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_known_aptamer = 0, in_cev_map = 0 and surface_class = \"A_surface\" sorted by evidence_priority descending", "rows": [["Q14654", "KCNJ11", "ATP-sensitive inward rectifier potassium channel 11", "Tier 1", 0.81, 1, "A_surface", 9, 83.81, 1, 0, null, null, 0, 0, null, 0, "type 2 diabetes mellitus", 0.8651421397012851], ["O95255", "ABCC6", "ATP-binding cassette sub-family C member 6", "Tier 1.5", 0.809, 1, "A_surface", 4, 80.94, 0, 0, null, null, 0, 0, null, 0, "Pseudoxanthoma elasticum", 0.864631668818611], ["P21439", "ABCB4", "Phosphatidylcholine translocator ABCB4", "Tier 1.5", 0.806, 1, "A_surface", 4, 83.25, 1, 0, null, null, 0, 0, null, 0, "progressive familial intrahepatic cholestasis type 3", 0.851728159166962], ["P82251", "SLC7A9", "b(0,+)-type amino acid transporter 1", "Tier 1", 0.805, 1, "A_surface", 4, 85.44, 1, 0, null, null, 0, 0, null, 0, "cystinuria", 0.8484952668941285], ["Q695T7", "SLC6A19", "Sodium-dependent neutral amino acid transporter B(0)AT1", "Tier 1", 0.804, 1, "A_surface", 19, 90.0, 1, 0, null, null, 0, 0, null, 0, "Hartnup disease", 0.8464240093600148], ["P41180", "CASR", "Extracellular calcium-sensing receptor", "Tier 1", 0.804, 1, "A_surface", 31, 75.69, 1, 0, null, null, 0, 0, null, 0, "familial hypocalciuric hypercalcemia 1", 0.8460848589627423], ["Q9UM01", "SLC7A7", "Y+L amino acid transporter 1", "Tier 1.5", 0.804, 1, "A_surface", 5, 83.81, 1, 0, null, null, 0, 0, null, 0, "lysinuric protein intolerance", 0.8450026270275782], ["P48029", "SLC6A8", "Sodium- and chloride-dependent creatine transporter 1", "Tier 1.5", 0.804, 1, "A_surface", 6, 84.62, 1, 0, null, null, 0, 0, null, 0, "creatine transporter deficiency", 0.847268393806457], ["Q05586", "GRIN1", "Glutamate receptor ionotropic, NMDA 1", "Tier 1", 0.803, 1, "A_surface", 84, 82.88, 1, 0, null, null, 0, 0, null, 0, "neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant", 0.8446685494288694], ["O43526", "KCNQ2", "Potassium voltage-gated channel subfamily KQT member 2", "Tier 1", 0.803, 1, "A_surface", 24, 58.19, 1, 0, null, null, 0, 0, null, 0, "Benign familial neonatal seizures", 0.8423358217314708], ["Q9UQD0", "SCN8A", "Sodium channel protein type 8 subunit alpha", "Tier 1.5", 0.803, 1, "A_surface", 4, 68.38, 1, 0, null, null, 0, 0, null, 0, "developmental and epileptic encephalopathy, 13", 0.8437707419548253], ["Q9HBA0", "TRPV4", "Transient receptor potential cation channel subfamily V member 4", "Tier 1", 0.801, 1, "A_surface", 19, 71.62, 1, 0, null, null, 0, 0, null, 0, "metatropic dysplasia", 0.8356240344517467], ["P78508", "KCNJ10", "ATP-sensitive inward rectifier potassium channel 10", "Tier 1.5", 0.801, 1, "A_surface", 4, 82.44, 1, 0, null, null, 0, 0, null, 0, "EAST syndrome", 0.8357483559927158], ["P30968", "GNRHR", "Gonadotropin-releasing hormone receptor", "Tier 1.5", 0.799, 1, "A_surface", 1, 84.19, 0, 0, null, null, 0, 0, null, 0, "hypogonadotropic hypogonadism", 0.83100005285263], ["Q16281", "CNGA3", "Cyclic nucleotide-gated channel alpha-3", "Tier 1.5", 0.799, 1, "A_surface", 10, 74.44, 1, 0, null, null, 0, 0, null, 0, "achromatopsia", 0.8315799021867489], ["P13866", "SLC5A1", "Sodium/glucose cotransporter 1", "Tier 1.5", 0.797, 1, "A_surface", 4, 84.38, 1, 0, null, null, 0, 0, null, 0, "glucose-galactose malabsorption", 0.8220991027793896], ["Q04844", "CHRNE", "Acetylcholine receptor subunit epsilon", "Tier 1.5", 0.797, 1, "A_surface", 13, 80.69, 1, 0, null, null, 0, 0, null, 0, "Congenital myasthenic syndromes", 0.8223287249629152], ["Q8IZF0", "NALCN", "Sodium leak channel NALCN", "Tier 1", 0.796, 1, "A_surface", 5, 76.69, 1, 0, null, null, 0, 0, null, 0, "congenital contractures of the limbs and face, hypotonia, and developmental delay", 0.8198033442161259], ["P23942", "PRPH2", "Peripherin-2", "Tier 1.5", 0.796, 1, "A_surface", 1, 87.0, 1, 0, null, null, 0, 0, null, 0, "retinitis pigmentosa", 0.8194208847382956], ["Q9BZV2", "SLC19A3", "Thiamine transporter 2", "Tier 1.5", 0.796, 1, "A_surface", 19, 81.56, 1, 0, null, null, 0, 0, null, 0, "biotin-responsive basal ganglia disease", 0.8189646480334981], ["P41181", "AQP2", "Aquaporin-2", "Tier 1", 0.795, 1, "A_surface", 7, 91.75, 1, 0, null, null, 0, 0, null, 0, "diabetes insipidus, nephrogenic, autosomal", 0.817870726313342], ["Q5JUK3", "KCNT1", "Potassium channel subfamily T member 1", "Tier 1.5", 0.795, 1, "A_surface", 6, 73.88, 1, 0, null, null, 0, 0, null, 0, "developmental and epileptic encephalopathy, 14", 0.8165232785825526], ["Q9H222", "ABCG5", "ATP-binding cassette sub-family G member 5", "Tier 1", 0.793, 1, "A_surface", 8, 85.06, 1, 0, null, null, 0, 0, null, 0, "sitosterolemia", 0.810555184820483], ["Q9NQW8", "CNGB3", "Cyclic nucleotide-gated channel beta-3", "Tier 1.5", 0.791, 1, "A_surface", 9, 68.12, 1, 0, null, null, 0, 0, null, 0, "achromatopsia", 0.8033348000666748], ["Q12866", "MERTK", "Tyrosine-protein kinase Mer", "Tier 1", 0.79, 1, "A_surface", 42, 72.25, 0, 0, null, null, 0, 0, null, 0, "retinitis pigmentosa", 0.7985580877708576], ["Q01718", "MC2R", "Adrenocorticotropic hormone receptor", "Tier 1.5", 0.79, 1, "A_surface", 2, 85.38, 1, 0, null, null, 0, 0, null, 0, "familial glucocorticoid deficiency", 0.8001007686411645], ["Q9H1D0", "TRPV6", "Transient receptor potential cation channel subfamily V member 6", "Tier 1", 0.789, 1, "A_surface", 24, 80.56, 1, 0, null, null, 0, 0, null, 0, "hyperparathyroidism, transient neonatal", 0.7964821997780153], ["P16871", "IL7R", "Interleukin-7 receptor subunit alpha", "Tier 1", 0.789, 1, "A_surface", 8, 67.44, 0, 0, null, null, 0, 0, null, 0, "immunodeficiency 104", 0.7983119488718231], ["O43525", "KCNQ3", "Potassium voltage-gated channel subfamily KQT member 3", "Tier 1.5", 0.789, 1, "A_surface", 1, 56.72, 0, 0, null, null, 0, 0, null, 0, "Benign familial neonatal seizures", 0.7961763561533409], ["P37023", "ACVRL1", "Activin receptor type-1-like", "Tier 1.5", 0.789, 1, "A_surface", 7, 82.0, 0, 0, null, null, 0, 0, null, 0, "telangiectasia, hereditary hemorrhagic, type 2", 0.7951167515831324], ["P15509", "CSF2RA", "Granulocyte-macrophage colony-stimulating factor receptor subunit alpha", "Tier 1", 0.788, 1, "A_surface", 2, 82.0, 0, 0, null, null, 0, 0, null, 0, "Congenital pulmonary alveolar proteinosis", 0.7922592394513138], ["Q14028", "CNGB1", "Cyclic nucleotide-gated channel beta-1", "Tier 1", 0.788, 1, "A_surface", 11, 57.66, 1, 0, null, null, 0, 0, null, 0, "retinitis pigmentosa", 0.7931901344765326], ["P24530", "EDNRB", "Endothelin receptor type B", "Tier 1", 0.786, 1, "A_surface", 17, 75.0, 1, 0, null, null, 0, 0, null, 0, "Waardenburg syndrome type 4A", 0.7874601728728147], ["Q03431", "PTH1R", "Parathyroid hormone/parathyroid hormone-related peptide receptor", "Tier 1", 0.786, 1, "A_surface", 52, 70.94, 1, 0, null, null, 0, 0, null, 0, "metaphyseal chondrodysplasia, Jansen type", 0.7859378587442476], ["O60741", "HCN1", "Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1", "Tier 1", 0.786, 1, "A_surface", 12, 68.94, 1, 0, null, null, 0, 0, null, 0, "Generalized epilepsy with febrile seizures-plus", 0.7853938745545654], ["Q13698", "CACNA1S", "Voltage-dependent L-type calcium channel subunit alpha-1S", "Tier 1.5", 0.786, 1, "A_surface", 2, 71.81, 0, 0, null, null, 0, 0, null, 0, "hypokalemic periodic paralysis, type 1", 0.7869997029542154], ["O43909", "EXTL3", "Exostosin-like 3", "Tier 1", 0.785, 1, "A_surface", 4, 83.69, 1, 0, null, null, 0, 0, null, 0, "immunoskeletal dysplasia with neurodevelopmental abnormalities", 0.7837827977649315], ["P22888", "LHCGR", "Lutropin-choriogonadotropic hormone receptor", "Tier 1", 0.785, 1, "A_surface", 4, 80.12, 1, 0, null, null, 0, 0, null, 0, "Leydig cell hypoplasia, type 1", 0.783461117057047], ["O95622", "ADCY5", "Adenylate cyclase type 5", "Tier 1.5", 0.785, 1, "A_surface", 2, 73.19, 1, 0, null, null, 0, 0, null, 0, "dyskinesia with orofacial involvement, autosomal dominant", 0.7830401650561951], ["P23416", "GLRA2", "Glycine receptor subunit alpha-2", "Tier 1", 0.784, 1, "A_surface", 13, 83.81, 1, 0, null, null, 0, 0, null, 0, "intellectual developmental disorder, X-linked, syndromic, Pilorge type", 0.7805605973560554], ["P56696", "KCNQ4", "Potassium voltage-gated channel subfamily KQT member 4", "Tier 1", 0.783, 1, "A_surface", 13, 65.25, 1, 0, null, null, 0, 0, null, 0, "autosomal dominant nonsyndromic hearing loss 2A", 0.7765455627642878], ["Q13224", "GRIN2B", "Glutamate receptor ionotropic, NMDA 2B", "Tier 1", 0.783, 1, "A_surface", 36, 60.69, 1, 0, null, null, 0, 0, null, 0, "intellectual disability, autosomal dominant 6", 0.7771650025965382], ["P51168", "SCNN1B", "Epithelial sodium channel subunit beta", "Tier 1.5", 0.783, 1, "A_surface", 5, 82.44, 1, 0, null, null, 0, 0, null, 0, "bronchiectasis with or without elevated sweat chloride 1", 0.775668400727201], ["O43497", "CACNA1G", "Voltage-dependent T-type calcium channel subunit alpha-1G", "Tier 1.5", 0.783, 1, "A_surface", 2, 58.22, 1, 0, null, null, 0, 0, null, 0, "Spinocerebellar ataxia type 42", 0.7770459773037601], ["P43004", "SLC1A2", "Excitatory amino acid transporter 2", "Tier 1.5", 0.783, 1, "A_surface", 7, 77.75, 1, 0, null, null, 0, 0, null, 0, "developmental and epileptic encephalopathy, 41", 0.7772658651722512], ["P30531", "SLC6A1", "Sodium- and chloride-dependent GABA transporter 1", "Tier 1", 0.782, 1, "A_surface", 5, 87.94, 1, 0, null, null, 0, 0, null, 0, "epilepsy with myoclonic atonic seizures", 0.7729414443362785], ["Q9H251", "CDH23", "Cadherin-23", "Tier 1", 0.781, 1, "A_surface", 6, 76.75, 0, 0, null, null, 0, 0, null, 0, "Usher syndrome type 1", 0.7713456285400272], ["Q9NY46", "SCN3A", "Sodium channel protein type 3 subunit alpha", "Tier 1", 0.781, 1, "A_surface", 2, 68.25, 1, 0, null, null, 0, 0, null, 0, "familial focal epilepsy with variable foci", 0.7708874082891223], ["Q8TDI8", "TMC1", "Transmembrane channel-like protein 1", "Tier 1.5", 0.781, 1, "A_surface", 1, 76.88, 0, 0, null, null, 0, 0, null, 0, "autosomal recessive nonsyndromic hearing loss 7", 0.7694318181814068], ["P48547", "KCNC1", "Voltage-gated potassium channel KCNC1", "Tier 1.5", 0.78, 1, "A_surface", 10, 78.56, 1, 0, null, null, 0, 0, null, 0, "Progressive myoclonic epilepsy", 0.7675090944252294]], "truncated": false, "filtered_table_rows_count": 564, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_known_aptamer\" = :p0 and \"in_cev_map\" = :p1 and \"surface_class\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "0", "p1": "0", "p2": "A_surface"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&in_cev_map=0&surface_class=A_surface", "results": [{"value": 1, "label": 1, "count": 347, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=0&surface_class=A_surface&has_structure=1", "selected": false}, {"value": 0, "label": 0, "count": 217, "toggle_url": 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"label": 0, "count": 564, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=0&surface_class=A_surface&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&in_cev_map=0&surface_class=A_surface", "results": [{"value": 0, "label": 0, "count": 564, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=A_surface", "selected": true}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&in_cev_map=0&surface_class=A_surface", "results": [{"value": "A_surface", "label": "A_surface", "count": 564, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=0", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&in_cev_map=0&surface_class=A_surface", "results": [{"value": 0, "label": 0, "count": 564, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=A_surface", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&in_cev_map=0&surface_class=A_surface", "results": [{"value": 0, "label": 0, "count": 348, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=0&surface_class=A_surface&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 216, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=0&surface_class=A_surface&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=0&surface_class=A_surface&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 1511.2001961097121, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}