{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_known_aptamer = 0, in_cev_map = 0 and surface_class = \"B_cargo\" sorted by evidence_priority descending", "rows": [["O00255", "MEN1", "Menin", "Tier 1", 0.61, 1, "B_cargo", 61, 84.44, 0, 0, null, null, 0, 0, null, 0, "multiple endocrine neoplasia type 1", 0.8653255032429027], ["P35557", "GCK", "Hexokinase-4", "Tier 1", 0.609, 1, "B_cargo", 35, 93.69, 0, 0, null, null, 0, 0, null, 0, "MODY", 0.8633086470947097], ["O43602", "DCX", "Neuronal migration protein doublecortin", "Tier 1", 0.609, 1, "B_cargo", 18, 66.5, 1, 0, null, null, 0, 0, null, 0, "lissencephaly type 1 due to doublecortin gene mutation", 0.864453842605602], ["Q8NCM8", "DYNC2H1", "Cytoplasmic dynein 2 heavy chain 1", "Tier 1.5", 0.608, 1, "B_cargo", 4, 83.44, 1, 0, null, null, 0, 0, null, 0, "asphyxiating thoracic dystrophy 3", 0.8610362911667925], ["P21549", "AGXT", "Alanine--glyoxylate aminotransferase", "Tier 1", 0.607, 1, "B_cargo", 17, 98.31, 0, 0, null, null, 0, 0, null, 0, "primary hyperoxaluria type 1", 0.8572717660798254], ["Q3T906", "GNPTAB", "N-acetylglucosamine-1-phosphotransferase subunits alpha/beta", "Tier 1", 0.605, 1, "B_cargo", 5, 71.62, 1, 0, null, null, 0, 0, null, 0, "mucolipidosis type III, alpha/beta", 0.8490445308315259], ["P23760", "PAX3", "Paired box protein Pax-3", "Tier 1", 0.605, 1, "B_cargo", 1, 63.94, 0, 0, null, null, 0, 0, null, 0, "Waardenburg syndrome type 1", 0.8500072027894306], ["O76039", "CDKL5", "Cyclin-dependent kinase-like 5", "Tier 1.5", 0.605, 1, "B_cargo", 3, 53.12, 0, 0, null, null, 0, 0, null, 0, "developmental and epileptic encephalopathy, 2", 0.8510325653635987], ["Q9UIF7", "MUTYH", "Adenine DNA glycosylase", "Tier 1.5", 0.605, 1, "B_cargo", 3, 78.94, 0, 0, null, null, 0, 0, null, 0, "familial adenomatous polyposis 2", 0.8483469680730393], ["Q96RY7", "IFT140", "Intraflagellar transport protein 140 homolog", "Tier 1", 0.604, 1, "B_cargo", 4, 80.12, 1, 0, null, null, 0, 0, null, 0, "short-rib thoracic dysplasia 9 with or without polydactyly", 0.8464676938353167], ["P54098", "POLG", "DNA polymerase subunit gamma-1", "Tier 1", 0.604, 1, "B_cargo", 36, 78.94, 1, 0, null, null, 0, 0, null, 0, "mitochondrial DNA depletion syndrome 4a", 0.8474167021250057], ["P40692", "MLH1", "DNA mismatch repair protein Mlh1", "Tier 1", 0.604, 1, "B_cargo", 7, 77.31, 0, 0, null, null, 0, 0, null, 0, "Lynch syndrome", 0.8472183133029993], ["O15360", "FANCA", "Fanconi anemia group A protein", "Tier 1", 0.604, 1, "B_cargo", 6, 74.88, 1, 0, null, null, 0, 0, null, 0, "Fanconi anemia complementation group A", 0.8469248580955555], ["Q2NKJ3", "CTC1", "CST complex subunit CTC1", "Tier 1", 0.603, 1, "B_cargo", 7, 77.5, 1, 0, null, null, 0, 0, null, 0, "Coats plus syndrome", 0.8438631461095314], ["Q2M1P5", "KIF7", "Kinesin-like protein KIF7", "Tier 1.5", 0.603, 1, "B_cargo", 5, 67.19, 1, 0, null, null, 0, 0, null, 0, "acrocallosal syndrome", 0.8424257475739304], ["O60931", "CTNS", "Cystinosin", "Tier 1.5", 0.603, 1, "B_cargo", 6, 89.44, 1, 0, null, null, 0, 0, null, 0, "nephropathic cystinosis", 0.841818398377195], ["Q12879", "GRIN2A", "Glutamate receptor ionotropic, NMDA 2A", "Tier 1", 0.602, 1, "B_cargo", 37, 60.84, 1, 0, null, null, 0, 0, null, 0, "Landau-Kleffner syndrome", 0.8407159711916629], ["P38935", "IGHMBP2", "DNA-binding protein SMUBP-2", "Tier 1.5", 0.602, 1, "B_cargo", 4, 77.38, 0, 0, null, null, 0, 0, null, 0, "autosomal recessive distal spinal muscular atrophy 1", 0.8396147647161344], ["Q9HBG6", "IFT122", "Intraflagellar transport protein 122 homolog", "Tier 1.5", 0.602, 1, "B_cargo", 5, 82.88, 1, 0, null, null, 0, 0, null, 0, "cranioectodermal dysplasia", 0.8402296001002503], ["P82279", "CRB1", "Protein crumbs homolog 1", "Tier 1.5", 0.602, 1, "B_cargo", 1, 75.06, 0, 0, null, null, 0, 0, null, 0, "Leber congenital amaurosis 8", 0.8398871782775204], ["P20807", "CAPN3", "Calpain-3", "Tier 1", 0.601, 1, "B_cargo", 5, 78.25, 0, 0, null, null, 0, 0, null, 0, "autosomal recessive limb-girdle muscular dystrophy type 2A", 0.8360959201056175], ["O60260", "PRKN", "E3 ubiquitin-protein ligase parkin", "Tier 1", 0.601, 1, "B_cargo", 21, 78.06, 0, 0, null, null, 0, 0, null, 0, "Young adult-onset Parkinsonism", 0.8361755700457273], ["Q8N159", "NAGS", "N-acetylglutamate synthase, mitochondrial", "Tier 1.5", 0.601, 1, "B_cargo", 1, 79.75, 0, 0, null, null, 0, 0, null, 0, "hyperammonemia due to N-acetylglutamate synthase deficiency", 0.8382373711482316], ["Q7Z2E3", "APTX", "Aprataxin", "Tier 1", 0.6, 1, "B_cargo", 11, 80.75, 0, 0, null, null, 0, 0, null, 0, "ataxia, early-onset, with oculomotor apraxia and hypoalbuminemia", 0.832110422501825], ["Q13402", "MYO7A", "Unconventional myosin-VIIa", "Tier 1", 0.6, 1, "B_cargo", 1, 77.25, 0, 0, null, null, 0, 0, null, 0, "Usher syndrome type 1B", 0.8326791560829035], ["Q2TBA0", "KLHL40", "Kelch-like protein 40", "Tier 1.5", 0.6, 1, "B_cargo", 1, 89.44, 0, 0, null, null, 0, 0, null, 0, "nemaline myopathy 8", 0.8348979900805442], ["Q9BXW9", "FANCD2", "Fanconi anemia group D2 protein", "Tier 1.5", 0.6, 1, "B_cargo", 13, 76.75, 1, 0, null, null, 0, 0, null, 0, "Fanconi anemia complementation group D2", 0.8319139646572291], ["Q9BY41", "HDAC8", "Histone deacetylase 8", "Tier 1", 0.599, 1, "B_cargo", 53, 95.31, 0, 0, null, null, 0, 0, null, 0, "Cornelia de Lange syndrome", 0.8312421317616957], ["O14832", "PHYH", "Phytanoyl-CoA dioxygenase, peroxisomal", "Tier 1", 0.598, 1, "B_cargo", 1, 85.44, 0, 0, null, null, 0, 0, null, 0, "Refsum disease", 0.8265474775217052], ["P22557", "ALAS2", "5-aminolevulinate synthase, erythroid-specific, mitochondrial", "Tier 1", 0.598, 1, "B_cargo", 27, 82.19, 0, 0, null, null, 0, 0, null, 0, "X-linked sideroblastic anemia 1", 0.8266521651625864], ["Q96SD1", "DCLRE1C", "Protein artemis", "Tier 1", 0.598, 1, "B_cargo", 14, 69.44, 1, 0, null, null, 0, 0, null, 0, "severe combined immunodeficiency due to DCLRE1C deficiency", 0.826513936982479], ["Q9UMN6", "KMT2B", "Histone-lysine N-methyltransferase 2B", "Tier 1", 0.598, 1, "B_cargo", 4, null, 0, 0, null, null, 0, 0, null, 0, "dystonia 28, childhood-onset", 0.8253090908207902], ["P31271", "HOXA13", "Homeobox protein Hox-A13", "Tier 1.5", 0.598, 1, "B_cargo", 1, 54.28, 0, 0, null, null, 0, 0, null, 0, "hand-foot-genital syndrome", 0.8270145658663097], ["Q99593", "TBX5", "T-box transcription factor TBX5", "Tier 1.5", 0.598, 1, "B_cargo", 4, 62.66, 0, 0, null, null, 0, 0, null, 0, "Holt-Oram syndrome", 0.827317913681364], ["P11473", "VDR", "Vitamin D3 receptor", "Tier 1", 0.597, 1, "B_cargo", 52, 83.56, 0, 0, null, null, 0, 0, null, 0, "Hypocalcemic vitamin D-resistant rickets", 0.8226576498848421], ["Q9Y253", "POLH", "DNA polymerase eta", "Tier 1", 0.597, 1, "B_cargo", 100, 76.88, 1, 0, null, null, 0, 0, null, 0, "xeroderma pigmentosum variant type", 0.8236705244099821], ["Q8IWS0", "PHF6", "PHD finger protein 6", "Tier 1", 0.597, 1, "B_cargo", 2, 73.44, 0, 0, null, null, 0, 0, null, 0, "Borjeson-Forssman-Lehmann syndrome", 0.8219833984621376], ["Q96GM8", "TOE1", "Target of EGR1 protein 1", "Tier 1.5", 0.597, 1, "B_cargo", 1, 77.75, 0, 0, null, null, 0, 0, null, 0, "pontocerebellar hypoplasia type 7", 0.824632140055663], ["Q9UH77", "KLHL3", "Kelch-like protein 3", "Tier 1.5", 0.597, 1, "B_cargo", 3, 90.5, 0, 0, null, null, 0, 0, null, 0, "pseudohypoaldosteronism type 2D", 0.8246213773832068], ["P40879", "SLC26A3", "Chloride anion exchanger", "Tier 1", 0.596, 1, "B_cargo", 13, 85.06, 1, 0, null, null, 0, 0, null, 0, "congenital secretory chloride diarrhea 1", 0.8189631913308207], ["P28069", "POU1F1", "Pituitary-specific positive transcription factor 1", "Tier 1.5", 0.596, 1, "B_cargo", 1, 67.75, 0, 0, null, null, 0, 0, null, 0, "pituitary hormone deficiency, combined, 1", 0.8206947239178665], ["Q99453", "PHOX2B", "Paired mesoderm homeobox protein 2B", "Tier 1.5", 0.596, 1, "B_cargo", 5, 59.78, 0, 0, null, null, 0, 0, null, 0, "central hypoventilation syndrome, congenital, 1, with or without Hirschsprung disease", 0.8208322275185037], ["Q9H334", "FOXP1", "Forkhead box protein P1", "Tier 1.5", 0.596, 1, "B_cargo", 1, 57.94, 0, 0, null, null, 0, 0, null, 0, "intellectual disability-severe speech delay-mild dysmorphism syndrome", 0.8203183311387787], ["Q7Z4S6", "KIF21A", "Kinesin-like protein KIF21A", "Tier 1", 0.595, 1, "B_cargo", 5, 70.56, 0, 0, null, null, 0, 0, null, 0, "congenital fibrosis of the extraocular muscles", 0.8179974657616618], ["P23769", "GATA2", "Endothelial transcription factor GATA-2", "Tier 1", 0.595, 1, "B_cargo", 2, 56.38, 0, 0, null, null, 0, 0, null, 0, "monocytopenia with susceptibility to infections", 0.8174326010603342], ["Q9UJQ4", "SALL4", "Sal-like protein 4", "Tier 1", 0.595, 1, "B_cargo", 13, 51.06, 1, 0, null, null, 0, 0, null, 0, "Duane-radial ray syndrome", 0.8169322292438749], ["Q86XE5", "HOGA1", "4-hydroxy-2-oxoglutarate aldolase, mitochondrial", "Tier 1", 0.594, 1, "B_cargo", 2, 92.69, 0, 0, null, null, 0, 0, null, 0, "primary hyperoxaluria type 3", 0.8135667789275441], ["P29033", "GJB2", "Gap junction beta-2 protein", "Tier 1", 0.594, 1, "B_cargo", 24, 86.19, 1, 0, null, null, 0, 0, null, 0, "palmoplantar keratoderma-deafness syndrome", 0.8149616697051898], ["Q9BQ52", "ELAC2", "Zinc phosphodiesterase ELAC protein 2", "Tier 1", 0.594, 1, "B_cargo", 10, 82.81, 1, 0, null, null, 0, 0, null, 0, "combined oxidative phosphorylation defect type 17", 0.8142476181884984], ["Q8WWQ0", "PHIP", "PH-interacting protein", "Tier 1", 0.594, 1, "B_cargo", 100, 66.06, 0, 0, null, null, 0, 0, null, 0, "PHIP-related behavioral problems-intellectual disability-obesity-dysmorphic features syndrome", 0.814586276955991]], "truncated": false, "filtered_table_rows_count": 1722, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_known_aptamer\" = :p0 and \"in_cev_map\" = :p1 and \"surface_class\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "0", "p1": "0", "p2": "B_cargo"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": 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"surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&in_cev_map=0&surface_class=B_cargo", "results": [{"value": "B_cargo", "label": "B_cargo", "count": 1722, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=0", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&in_cev_map=0&surface_class=B_cargo", "results": [{"value": 0, "label": 0, "count": 1722, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=B_cargo", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&in_cev_map=0&surface_class=B_cargo", "results": [{"value": 0, "label": 0, "count": 1406, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=0&surface_class=B_cargo&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 316, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=0&surface_class=B_cargo&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=0&surface_class=B_cargo&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 1278.7619708105922, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}