{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_known_aptamer = 0, in_cev_map = 0 and tier = \"Tier 1\" sorted by priority_score descending", "rows": [["P12263", null, null, "Tier 1", 0.9, 7, 63.59, 1, 0, null, null, null, 0, 0, null, 0, null, null], ["Q12879", "GRIN2A", "Glutamate receptor ionotropic, NMDA 2A", "Tier 1", 0.88, 37, 60.84, 1, 0, null, null, null, 0, 0, null, 0, "Landau-Kleffner syndrome", 0.8407159711916629], ["Q9UJA9", "ENPP5", "Ectonucleotide pyrophosphatase/phosphodiesterase family member 5", "Tier 1", 0.87, 1, 88.12, 0, 0, null, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.33211724272317855], ["Q5T848", "GPR158", "Metabotropic glycine receptor", "Tier 1", 0.839, 6, 58.03, 1, 0, null, null, null, 0, 0, null, 0, "diverticular disease", 0.4384404783771627], ["P0DSE2", "TRB", "M1-specific T cell receptor beta chain", "Tier 1", 0.83, 5, 90.12, 1, 0, null, null, null, 0, 0, null, 0, null, null], ["Q31135", "H2-Ab1", null, "Tier 1", 0.83, 12, 85.12, 0, 0, null, null, null, 0, 0, null, 0, null, null], ["Q9NS82", "SLC7A10", "Asc-type amino acid transporter 1", "Tier 1", 0.803, 4, 83.38, 1, 0, null, null, null, 0, 0, null, 0, "asthma", 0.5295411410172121], ["O60895", "RAMP2", "Receptor activity-modifying protein 2", "Tier 1", 0.802, 10, 80.94, 1, 0, null, null, null, 0, 0, null, 0, "diabetes mellitus", 0.4219370007650345], ["P01909", "HLA-DQA1", "HLA class II histocompatibility antigen, DQ alpha 1 chain", "Tier 1", 0.792, 27, 87.94, 1, 0, null, null, null, 0, 0, null, 0, "Pleural Mesothelioma", 0.1228600330569846], ["Q13639", null, null, "Tier 1", 0.781, 3, 80.88, 1, 0, null, null, null, 0, 0, null, 0, "schizophrenia", 0.6060830827022777], ["O15393", null, null, "Tier 1", 0.775, 31, 79.38, 1, 0, null, null, null, 0, 0, null, 0, "COVID-19", 0.6157541390484623], ["A6ND01", "IZUMO1R", "Sperm-egg fusion protein Juno", "Tier 1", 0.773, 7, 87.38, 0, 0, null, null, null, 0, 0, null, 0, "placental retention", 0.23306495563589497], ["A0A5H2UYS3", "HLA-A", null, "Tier 1", 0.77, 20, 85.25, 0, 0, null, null, null, 0, 0, null, 0, null, null], ["P29460", "IL12B", "Interleukin-12 subunit beta", "Tier 1", 0.769, 20, 91.12, 1, 0, null, null, null, 0, 0, null, 0, "psoriasis", 0.7914863943708039], ["P98073", null, null, "Tier 1", 0.761, 14, 81.5, 1, 0, null, null, null, 0, 0, null, 0, "congenital enteropathy due to enteropeptidase deficiency", 0.7102613227574134], ["O75762", "TRPA1", "Transient receptor potential cation channel subfamily A member 1", "Tier 1", 0.76, 17, 81.94, 1, 0, null, null, null, 0, 0, null, 0, "familial episodic pain syndrome with predominantly upper body involvement", 0.6615353934604322], ["O43614", null, null, "Tier 1", 0.75, 11, 78.94, 1, 0, null, null, null, 0, 0, null, 0, "insomnia", 0.5988748728311054], ["P16471", "PRLR", "Prolactin receptor", "Tier 1", 0.747, 12, 61.03, 0, 0, null, null, null, 0, 0, null, 0, "familial hyperprolactinemia", 0.5718636087471152], ["P01563", null, null, "Tier 1", 0.744, 13, 85.06, 0, 0, null, null, null, 0, 0, null, 0, "renal cell carcinoma", 0.3938654263610389], ["O15245", "SLC22A1", "Solute carrier family 22 member 1", "Tier 1", 0.744, 16, 84.25, 1, 0, null, null, null, 0, 0, null, 0, "coronary artery disease", 0.5384890077265535], ["Q8N158", "GPC2", "Glypican-2", "Tier 1", 0.744, 2, 79.06, 1, 0, null, null, null, 0, 0, null, 0, "COVID-19", 0.5409211817593593], ["O43526", "KCNQ2", "Potassium voltage-gated channel subfamily KQT member 2", "Tier 1", 0.744, 24, 58.19, 1, 0, null, null, null, 0, 0, null, 0, "Benign familial neonatal seizures", 0.8423358217314708], ["P40879", "SLC26A3", "Chloride anion exchanger", "Tier 1", 0.742, 13, 85.06, 1, 0, null, null, null, 0, 0, null, 0, "congenital secretory chloride diarrhea 1", 0.8189631913308207], ["D7RIG0", "HLA-DRB1", null, "Tier 1", 0.74, 10, 84.94, 1, 0, null, null, null, 0, 0, null, 0, null, null], ["A0A1B0GX56", "TRDV1", "T cell receptor delta variable 1", "Tier 1", 0.737, 7, 90.69, 1, 0, null, null, null, 0, 0, null, 0, "colorectal carcinoma", 0.07391597093694036], ["Q14028", "CNGB1", "Cyclic nucleotide-gated channel beta-1", "Tier 1", 0.734, 11, 57.66, 1, 0, null, null, null, 0, 0, null, 0, "retinitis pigmentosa", 0.7931901344765326], ["P41145", "OPRK1", "Kappa-type opioid receptor", "Tier 1", 0.725, 28, 79.5, 1, 0, null, null, null, 0, 0, null, 0, "alcohol dependence", 0.6106562988740131], ["P23416", "GLRA2", "Glycine receptor subunit alpha-2", "Tier 1", 0.723, 13, 83.81, 1, 0, null, null, null, 0, 0, null, 0, "intellectual developmental disorder, X-linked, syndromic, Pilorge type", 0.7805605973560554], ["Q16878", "CDO1", "Cysteine dioxygenase type 1", "Tier 1", 0.72, 17, 93.62, 0, 0, null, null, null, 0, 0, null, 0, "adolescent idiopathic scoliosis", 0.3105991982786747], ["P29033", "GJB2", "Gap junction beta-2 protein", "Tier 1", 0.72, 24, 86.19, 1, 0, null, null, null, 0, 0, null, 0, "palmoplantar keratoderma-deafness syndrome", 0.8149616697051898], ["B7Z8K6", "TRDC", "T cell receptor delta constant", "Tier 1", 0.72, 12, 81.38, 1, 0, null, null, null, 0, 0, null, 0, null, null], ["Q12918", "KLRB1", "Killer cell lectin-like receptor subfamily B member 1", "Tier 1", 0.719, 3, 81.0, 0, 0, null, null, null, 0, 0, null, 0, "sensory perception of smell", 0.287724180593876], ["A0A0B4J271", "TRAV12-3", "T cell receptor alpha variable 12-3", "Tier 1", 0.715, 12, 92.56, 1, 0, null, null, null, 0, 0, null, 0, "ulcerative colitis", 0.003139210371371825], ["Q695T7", "SLC6A19", "Sodium-dependent neutral amino acid transporter B(0)AT1", "Tier 1", 0.715, 19, 90.0, 1, 0, null, null, null, 0, 0, null, 0, "Hartnup disease", 0.8464240093600148], ["Q99574", "SERPINI1", "Neuroserpin", "Tier 1", 0.712, 3, 88.12, 0, 0, null, null, null, 0, 0, null, 0, "familial encephalopathy with neuroserpin inclusion bodies", 0.7162803151916303], ["A0A583ZB34", null, null, "Tier 1", 0.71, 9, 84.38, 0, 0, null, null, null, 0, 0, null, 0, null, null], ["P49019", "HCAR3", "Hydroxycarboxylic acid receptor 3", "Tier 1", 0.709, 11, 79.19, 1, 0, null, null, null, 0, 0, null, 0, "Oral ulcer", 0.3943093179045574], ["O15342", "ATP6V0E1", "V-type proton ATPase subunit e 1", "Tier 1", 0.708, 9, 92.88, 1, 0, null, null, null, 0, 0, null, 0, "multiple myeloma", 0.18220286553988743], ["Q9BXJ8", "TMEM120A", "Transmembrane protein 120A", "Tier 1", 0.706, 5, 89.25, 1, 0, null, null, null, 0, 0, null, 0, "congenital adrenal hyperplasia due to cytochrome P450 oxidoreductase deficiency", 0.1609725589293368], ["P14555", "PLA2G2A", "Phospholipase A2, membrane associated", "Tier 1", 0.7, 17, 91.0, 0, 0, null, null, null, 0, 0, null, 0, "familial colorectal cancer", 0.3326218692162316], ["Q5Y7D3", "HLA-DQB1", null, "Tier 1", 0.7, 6, 85.31, 0, 0, null, null, null, 0, 0, null, 0, null, null], ["P22888", "LHCGR", "Lutropin-choriogonadotropic hormone receptor", "Tier 1", 0.698, 4, 80.12, 1, 0, null, null, null, 0, 0, null, 0, "Leydig cell hypoplasia, type 1", 0.783461117057047], ["O43570", "CA12", "Carbonic anhydrase 12", "Tier 1", 0.695, 40, 87.81, 0, 0, null, null, null, 0, 0, null, 0, "isolated hyperchlorhidrosis", 0.6794515382695604], ["Q07699", "SCN1B", "Sodium channel regulatory subunit beta-1", "Tier 1", 0.695, 36, 87.06, 1, 0, null, null, null, 0, 0, null, 0, "Generalized epilepsy with febrile seizures-plus", 0.7638796221342504], ["P30989", "NTSR1", "Neurotensin receptor type 1", "Tier 1", 0.695, 24, 79.62, 1, 0, null, null, null, 0, 0, null, 0, "Cough", 0.31206841983343936], ["Q96QV1", "HHIP", "Hedgehog-interacting protein", "Tier 1", 0.692, 11, 79.75, 0, 0, null, null, null, 0, 0, null, 0, "Abnormality of the skeletal system", 0.5195282784554633], ["P04435", "TRBV7-9", "T cell receptor beta variable 7-9", "Tier 1", 0.691, 2, 90.06, 0, 0, null, null, null, 0, 0, null, 0, "neoplasm", 0.11454334012562349], ["Q02083", "NAAA", "N-acylethanolamine-hydrolyzing acid amidase", "Tier 1", 0.69, 2, 92.25, 0, 0, null, null, null, 0, 0, null, 0, "abscess", 0.2726858643799341], ["Q15788", "NCOA1", "Nuclear receptor coactivator 1", "Tier 1", 0.69, 100, 46.72, 0, 0, null, null, null, 0, 0, null, 0, "neurodegenerative disease", 0.48697450901885614], ["A0A9P1NJI6", null, null, "Tier 1", 0.69, 6, null, 0, 0, null, null, null, 0, 0, null, 0, null, null]], "truncated": false, "filtered_table_rows_count": 1060, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "priority_score", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "drug_count_approved", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, priority_score, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, drug_count_approved, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_known_aptamer\" = :p0 and \"in_cev_map\" = :p1 and \"tier\" = :p2 order by priority_score desc limit 51", "params": {"p0": "0", "p1": "0", "p2": "Tier 1"}}, "facet_results": {"tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&in_cev_map=0&tier=Tier+1", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 1060, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=0", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&in_cev_map=0&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 1060, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=0&tier=Tier+1&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&in_cev_map=0&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 1060, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&tier=Tier+1", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&in_cev_map=0&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 1060, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&tier=Tier+1", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&in_cev_map=0&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 663, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=0&tier=Tier+1&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 397, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=0&tier=Tier+1&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=0&tier=Tier+1&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 583.9925090040197, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}