{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_known_aptamer = 0, in_cev_map = 1 and surface_class = \"A_assoc\" sorted by evidence_priority descending", "rows": [["P12883", "MYH7", "Myosin-7", "Tier 1", 0.871, 1, "A_assoc", 43, 74.25, 1, 0, null, null, 0, 0, null, 1, "hypertrophic cardiomyopathy", 0.9029865147265421], ["P02462", "COL4A1", "Collagen alpha-1(IV) chain", "Tier 1.5", 0.854, 1, "A_assoc", 4, 48.47, 0, 0, null, null, 0, 0, null, 1, "brain small vessel disease 1 with or without ocular anomalies", 0.84655287380359], ["P03951", "F11", "Coagulation factor XI", "Tier 1", 0.853, 1, "A_assoc", 100, 86.88, 0, 0, null, null, 0, 0, null, 1, "factor XI deficiency", 0.841884208404384], ["P04180", "LCAT", "Phosphatidylcholine-sterol acyltransferase", "Tier 1.5", 0.848, 1, "A_assoc", 7, 86.75, 1, 0, null, null, 0, 0, null, 1, "Fish-eye disease", 0.8273460309828392], ["Q15582", "TGFBI", "Transforming growth factor-beta-induced protein ig-h3", "Tier 1.5", 0.847, 1, "A_assoc", 10, 90.25, 1, 0, null, null, 0, 0, null, 1, "lattice corneal dystrophy type I", 0.8242841141270143], ["P07942", "LAMB1", "Laminin subunit beta-1", "Tier 1.5", 0.84, 1, "A_assoc", 3, 76.69, 1, 0, null, null, 0, 0, null, 1, "cobblestone lissencephaly without muscular or ocular involvement", 0.8016665947624902], ["Q9BWP8", "COLEC11", "Collectin-11", "Tier 1", 0.839, 1, "A_assoc", 3, 78.31, 0, 0, null, null, 0, 0, null, 1, "3MC syndrome 2", 0.7977893521540559], ["P20908", "COL5A1", "Collagen alpha-1(V) chain", "Tier 1", 0.839, 1, "A_assoc", 1, 51.25, 0, 0, null, null, 0, 0, null, 1, "Ehlers-Danlos syndrome, classic type, 1", 0.7979601586599098], ["P02671", "FGA", "Fibrinogen alpha chain", "Tier 1", 0.838, 1, "A_assoc", 40, 60.34, 0, 0, null, null, 0, 0, null, 1, "familial dysfibrinogenemia", 0.7947496460990987], ["P00488", "F13A1", "Coagulation factor XIII A chain", "Tier 1", 0.838, 1, "A_assoc", 15, 90.88, 1, 0, null, null, 0, 0, null, 1, "Factor XIII subunit A deficiency", 0.7939842013132387], ["P22105", "TNXB", "Tenascin-X", "Tier 1.5", 0.837, 1, "A_assoc", 3, 87.81, 0, 0, null, null, 0, 0, null, 1, "Ehlers-Danlos syndrome due to tenascin-X deficiency", 0.7916412481554758], ["P13645", "KRT10", "Keratin, type I cytoskeletal 10", "Tier 1", 0.836, 1, "A_assoc", 6, 64.31, 0, 0, null, null, 0, 0, null, 1, "epidermolytic hyperkeratosis 2A, autosomal dominant", 0.7860749239386174], ["Q12904", "AIMP1", "Aminoacyl tRNA synthase complex-interacting multifunctional protein 1", "Tier 1", 0.834, 1, "A_assoc", 6, 81.12, 0, 0, null, null, 0, 0, null, 1, "hypomyelinating leukodystrophy 3", 0.7806847123659254], ["O43707", "ACTN4", "Alpha-actinin-4", "Tier 1", 0.833, 1, "A_assoc", 5, 84.12, 0, 0, null, null, 0, 0, null, 1, "focal segmental glomerulosclerosis 1", 0.7778533437264424], ["P35858", "IGFALS", "Insulin-like growth factor-binding protein complex acid labile subunit", "Tier 1.5", 0.833, 1, "A_assoc", 1, 90.56, 1, 0, null, null, 0, 0, null, 1, "Reduced insulin like growth factor binding protein acid labile subunit concentration", 0.7760522769257892], ["O15230", "LAMA5", "Laminin subunit alpha-5", "Tier 1.5", 0.828, 1, "A_assoc", 2, 79.12, 1, 0, null, null, 0, 0, null, 1, "nephrotic syndrome, IIa 26", 0.7594872666460903], ["P08572", "COL4A2", "Collagen alpha-2(IV) chain", "Tier 1.5", 0.819, 1, "A_assoc", 4, 47.25, 0, 0, null, null, 0, 0, null, 1, "porencephaly 2", 0.7294975109351518], ["O60568", "PLOD3", "Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3", "Tier 1.5", 0.815, 1, "A_assoc", 18, 91.38, 1, 0, null, null, 0, 0, null, 1, "bone fragility with contractures, arterial rupture, and deafness", 0.7159150369336311], ["P48200", "IREB2", "Iron-responsive element-binding protein 2", "Tier 1", 0.799, 1, "A_assoc", 1, 86.75, 1, 0, null, null, 0, 0, null, 1, "neurodegeneration, early-onset, with choreoathetoid movements and microcytic anemia", 0.664403876125082], ["P02745", "C1QA", "Complement C1q subcomponent subunit A", "Tier 1", 0.79, 1, "A_assoc", 11, 82.62, 1, 0, null, null, 0, 0, null, 1, "C1Q deficiency 1", 0.6319053256658114], ["P02747", "C1QC", "Complement C1q subcomponent subunit C", "Tier 1", 0.787, 1, "A_assoc", 11, 80.56, 1, 0, null, null, 0, 0, null, 1, "C1Q deficiency", 0.6233532074390745], ["Q9Y6C2", "EMILIN1", "EMILIN-1", "Tier 1.5", 0.786, 1, "A_assoc", 2, 62.91, 0, 0, null, null, 0, 0, null, 1, "arterial tortuosity-bone fragility syndrome", 0.6185329512431467], ["P49767", "VEGFC", "Vascular endothelial growth factor C", "Tier 1.5", 0.785, 1, "A_assoc", 4, 73.19, 0, 0, null, null, 0, 0, null, 1, "Milroy disease", 0.6170524106764851], ["P09486", "SPARC", "SPARC", "Tier 1", 0.784, 1, "A_assoc", 4, 84.31, 0, 0, null, null, 0, 0, null, 1, "osteogenesis imperfecta", 0.6138892200186172], ["P04746", "AMY2A", "Pancreatic alpha-amylase", "Tier 1", 0.78, 1, "A_assoc", 51, 96.75, 0, 0, null, null, 0, 0, null, 1, "type 2 diabetes mellitus", 0.5997984923419163], ["O00622", "CCN1", "CCN family member 1", "Tier 1.5", 0.765, 1, "A_assoc", 2, 73.12, 0, 0, null, null, 0, 0, null, 1, "Abnormality of the skeletal system", 0.5505331194769112], ["P02749", "APOH", "Beta-2-glycoprotein 1", "Tier 1", 0.764, 1, "A_assoc", 14, 93.12, 0, 0, null, null, 0, 0, null, 1, "atrial fibrillation", 0.5456247991985232], ["A8K2U0", "A2ML1", "Alpha-2-macroglobulin-like protein 1", "Tier 1", 0.764, 1, "A_assoc", 5, 80.5, 1, 0, null, null, 0, 0, null, 1, "Otitis media", 0.5479914512784171], ["P20061", "TCN1", "Transcobalamin-1", "Tier 1", 0.763, 1, "A_assoc", 2, 89.12, 0, 0, null, null, 0, 0, null, 1, "vitamin B deficiency", 0.5449702229454368], ["Q68CZ2", "TNS3", "Tensin-3", "Tier 1.5", 0.762, 1, "A_assoc", 1, 56.81, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.539772721274482], ["Q14766", "LTBP1", "Latent-transforming growth factor beta-binding protein 1", "Tier 1", 0.754, 1, "A_assoc", 1, 58.88, 0, 0, null, null, 0, 0, null, 1, "Abnormality of the skeletal system", 0.5142669818409414], ["Q9Y3B8", "REXO2", "Oligoribonuclease, mitochondrial", "Tier 1.5", 0.754, 1, "A_assoc", 10, 88.19, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.5134178677464454], ["P36980", "CFHR2", "Complement factor H-related protein 2", "Tier 1.5", 0.753, 1, "A_assoc", 4, 90.62, 0, 0, null, null, 0, 0, null, 1, "age-related macular degeneration", 0.5100732932209376], ["Q08043", "ACTN3", "Alpha-actinin-3", "Tier 1", 0.752, 1, "A_assoc", 3, 84.19, 1, 0, null, null, 0, 0, null, 1, "Abnormality of the skeletal system", 0.5080072819822437], ["Q9H792", "PEAK1", "Inactive tyrosine-protein kinase PEAK1", "Tier 1", 0.752, 1, "A_assoc", 2, 48.03, 0, 0, null, null, 0, 0, null, 1, "type 2 diabetes mellitus", 0.5080681892268507], ["Q04756", "HGFAC", "Hepatocyte growth factor activator serine protease", "Tier 1", 0.747, 1, "A_assoc", 7, 75.31, 0, 0, null, null, 0, 0, null, 1, "metabolic disease", 0.4900675680377984], ["Q9UM22", "EPDR1", "Mammalian ependymin-related protein 1", "Tier 1", 0.746, 1, "A_assoc", 3, 85.88, 0, 0, null, null, 0, 0, null, 1, "Dupuytren Contracture", 0.48568453021554975], ["Q07157", "TJP1", "Tight junction protein 1", "Tier 1", 0.741, 1, "A_assoc", 19, 54.62, 0, 0, null, null, 0, 0, null, 1, "dengue disease", 0.47083190223446686], ["P05161", "ISG15", "Ubiquitin-like protein ISG15", "Tier 1", 0.74, 1, "A_assoc", 22, 85.88, 1, 0, null, null, 0, 0, null, 1, "COVID-19", 0.4668295741563516], ["P0DUB6", "AMY1A", "Alpha-amylase 1A", "Tier 1", 0.738, 1, "A_assoc", 13, 96.69, 0, 0, null, null, 0, 0, null, 1, "dentures", 0.4597705945086364], ["Q9NR12", "PDLIM7", "PDZ and LIM domain protein 7", "Tier 1", 0.738, 1, "A_assoc", 2, 70.25, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.4602637679250804], ["Q13177", "PAK2", "Serine/threonine-protein kinase PAK 2", "Tier 1.5", 0.736, 1, "A_assoc", 5, 74.62, 0, 0, null, null, 0, 0, null, 1, "Knobloch syndrome", 0.45371318009439854], ["Q13625", "TP53BP2", "Apoptosis-stimulating of p53 protein 2", "Tier 1.5", 0.735, 1, "A_assoc", 6, 58.97, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.4484066399496438], ["Q9BVC4", "MLST8", "Target of rapamycin complex subunit LST8", "Tier 1", 0.733, 1, "A_assoc", 45, 91.62, 1, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.4440338170862142], ["P19827", "ITIH1", "Inter-alpha-trypsin inhibitor heavy chain H1", "Tier 1", 0.731, 1, "A_assoc", 2, 87.44, 0, 0, null, null, 0, 0, null, 1, "osteoarthritis, hip", 0.4360348893142765], ["Q92187", "ST8SIA4", "CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase", "Tier 1", 0.731, 1, "A_assoc", 3, 86.44, 0, 0, null, null, 0, 0, null, 1, "systemic lupus erythematosus", 0.43832763677821385], ["Q9UKU9", "ANGPTL2", "Angiopoietin-related protein 2", "Tier 1.5", 0.727, 1, "A_assoc", 1, 78.19, 0, 0, null, null, 0, 0, null, 1, "Abnormality of the skeletal system", 0.4235882639081519], ["Q96SL4", "GPX7", "Glutathione peroxidase 7", "Tier 1.5", 0.721, 1, "A_assoc", 1, 92.69, 0, 0, null, null, 0, 0, null, 1, "Abnormality of the skeletal system", 0.40349356855524837], ["Q14192", "FHL2", "Four and a half LIM domains protein 2", "Tier 1", 0.711, 1, "A_assoc", 4, 92.06, 0, 0, null, null, 0, 0, null, 1, "familial isolated dilated cardiomyopathy", 0.3714277539581253], ["Q16627", "CCL14", "C-C motif chemokine 14", "Tier 1.5", 0.711, 1, "A_assoc", 2, 85.38, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.37013422446672883]], "truncated": false, "filtered_table_rows_count": 98, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_known_aptamer\" = :p0 and \"in_cev_map\" = :p1 and \"surface_class\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "0", "p1": "1", "p2": "A_assoc"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&in_cev_map=1&surface_class=A_assoc", "results": [{"value": 1, "label": 1, "count": 67, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=1&surface_class=A_assoc&has_structure=1", "selected": false}, {"value": 0, "label": 0, "count": 31, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=1&surface_class=A_assoc&has_structure=0", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&in_cev_map=1&surface_class=A_assoc", "results": [{"value": "Tier 1.5", "label": "Tier 1.5", "count": 53, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=1&surface_class=A_assoc&tier=Tier+1.5", "selected": false}, {"value": "Tier 1", "label": "Tier 1", "count": 45, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=1&surface_class=A_assoc&tier=Tier+1", "selected": false}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&in_cev_map=1&surface_class=A_assoc", "results": [{"value": 0, "label": 0, "count": 98, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=1&surface_class=A_assoc&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&in_cev_map=1&surface_class=A_assoc", "results": [{"value": 0, "label": 0, "count": 98, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=1&surface_class=A_assoc", "selected": true}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&in_cev_map=1&surface_class=A_assoc", "results": [{"value": "A_assoc", "label": "A_assoc", "count": 98, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=1", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&in_cev_map=1&surface_class=A_assoc", "results": [{"value": 1, "label": 1, "count": 98, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=A_assoc", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&in_cev_map=1&surface_class=A_assoc", "results": [{"value": 0, "label": 0, "count": 79, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=1&surface_class=A_assoc&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 19, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=1&surface_class=A_assoc&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [{"name": "pdb_count_total", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=1&surface_class=A_assoc&_facet=pdb_count_total"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=1&surface_class=A_assoc&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 885.0189717486501, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}