{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_known_aptamer = 0, in_cev_map = 1 and tier = \"Tier 1\" sorted by priority_score descending", "rows": [["P01911", "HLA-DRB1", "HLA class II histocompatibility antigen, DRB1 beta chain", "Tier 1", 0.84, 100, 88.44, 0, 0, null, null, null, 0, 0, null, 1, "rheumatoid arthritis", 0.40051584219092445], ["P43005", "SLC1A1", "Excitatory amino acid transporter 3", "Tier 1", 0.805, 22, 80.12, 1, 0, null, null, null, 0, 0, null, 1, "dicarboxylic aminoaciduria", 0.6273449709512636], ["P00488", "F13A1", "Coagulation factor XIII A chain", "Tier 1", 0.799, 15, 90.88, 1, 0, null, null, null, 0, 0, null, 1, "Factor XIII subunit A deficiency", 0.7939842013132387], ["P06731", "CEACAM5", "Cell adhesion molecule CEACAM5", "Tier 1", 0.795, 6, 87.12, 1, 0, null, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.45156128674958135], ["P35555", "FBN1", "Fibrillin-1", "Tier 1", 0.78, 11, null, 0, 0, null, null, null, 0, 0, null, 1, "Marfan syndrome", 0.8969300970597663], ["P02671", "FGA", "Fibrinogen alpha chain", "Tier 1", 0.77, 40, 60.34, 0, 0, null, null, null, 0, 0, null, 1, "familial dysfibrinogenemia", 0.7947496460990987], ["P03951", "F11", "Coagulation factor XI", "Tier 1", 0.77, 100, 86.88, 0, 0, null, null, null, 0, 0, null, 1, "factor XI deficiency", 0.841884208404384], ["P02747", "C1QC", "Complement C1q subcomponent subunit C", "Tier 1", 0.762, 11, 80.56, 1, 0, null, null, null, 0, 0, null, 1, "C1Q deficiency", 0.6233532074390745], ["Q02817", "MUC2", "Mucin-2", "Tier 1", 0.76, 12, null, 1, 0, null, null, null, 0, 0, null, 1, null, null], ["P07360", null, null, "Tier 1", 0.755, 15, 89.75, 1, 0, null, null, null, 0, 0, null, 1, "complement deficiency", 0.3695798546847018], ["P55899", "FCGRT", "IgG receptor FcRn large subunit p51", "Tier 1", 0.752, 31, 85.0, 1, 0, null, null, null, 0, 0, null, 1, "Myasthenia gravis", 0.5932721106551206], ["Q9BY67", "CADM1", "Cell adhesion molecule 1", "Tier 1", 0.734, 2, 80.56, 0, 0, null, null, null, 0, 0, null, 1, "Abnormality of the skeletal system", 0.442731358018962], ["Q99497", "PARK7", "Parkinson disease protein 7", "Tier 1", 0.723, 88, 98.44, 0, 0, null, null, null, 0, 0, null, 1, "Young adult-onset Parkinsonism", 0.7264878745993893], ["P11215", "ITGAM", "Integrin alpha-M", "Tier 1", 0.72, 30, 86.25, 1, 0, null, null, null, 0, 0, null, 1, "systemic lupus erythematosus", 0.30502849242596436], ["Q9NV96", "TMEM30A", "Cell cycle control protein 50A", "Tier 1", 0.71, 33, 89.5, 1, 0, null, null, null, 0, 0, null, 1, "atrial fibrillation", 0.31177132249681394], ["P01889", "HLA-B", "HLA class I histocompatibility antigen, B alpha chain", "Tier 1", 0.708, 100, 88.06, 0, 0, null, null, null, 0, 0, null, 1, "COVID-19", 0.48417012135481613], ["O60486", "PLXNC1", "Plexin-C1", "Tier 1", 0.703, 4, 79.06, 1, 0, null, null, null, 0, 0, null, 1, "asthma", 0.532656225351722], ["P08473", "MME", "Neprilysin", "Tier 1", 0.699, 16, 96.19, 0, 0, null, null, null, 0, 0, null, 1, "Charcot-Marie-Tooth disease axonal type 2T", 0.7912653398252156], ["Q92187", "ST8SIA4", "CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase", "Tier 1", 0.69, 3, 86.44, 0, 0, null, null, null, 0, 0, null, 1, "systemic lupus erythematosus", 0.43832763677821385], ["Q8NBJ9", null, null, "Tier 1", 0.688, 7, 80.25, 1, 0, null, null, null, 0, 0, null, 1, "hypothyroidism", 0.32686531914177924], ["O95399", "UTS2", "Urotensin-2", "Tier 1", 0.685, 2, 58.44, 0, 0, null, null, null, 0, 0, null, 1, "hair color", 0.35316475479030335], ["P63092", "GNAS", "Guanine nucleotide-binding protein G(s) subunit alpha isoforms short", "Tier 1", 0.683, 100, 91.31, 1, 0, null, null, null, 0, 0, null, 1, "pseudohypoparathyroidism type 1A", 0.826829760867455], ["Q14213", null, null, "Tier 1", 0.683, 4, 87.62, 1, 0, null, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.42776938116451996], ["Q99584", "S100A13", "Protein S100-A13", "Tier 1", 0.681, 12, 80.81, 0, 0, null, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.41302685279153983], ["Q9UNN8", "PROCR", "Endothelial protein C receptor", "Tier 1", 0.68, 13, 86.44, 1, 0, null, null, null, 0, 0, null, 1, "venous thromboembolism", 0.5497662282245215], ["Q9HBI1", "PARVB", "Beta-parvin", "Tier 1", 0.68, 3, 81.75, 0, 0, null, null, null, 0, 0, null, 1, "thyroiditis", 0.28021156500366357], ["O00602", "FCN1", "Ficolin-1", "Tier 1", 0.675, 7, 84.94, 0, 0, null, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.351581018821974], ["Q9UK55", "SERPINA10", "Protein Z-dependent protease inhibitor", "Tier 1", 0.672, 4, 86.75, 0, 0, null, null, null, 0, 0, null, 1, "macular degeneration", 0.3247169581531489], ["P02749", "APOH", "Beta-2-glycoprotein 1", "Tier 1", 0.67, 14, 93.12, 0, 0, null, null, null, 0, 0, null, 1, "atrial fibrillation", 0.5456247991985232], ["P06703", "S100A6", "Protein S100-A6", "Tier 1", 0.67, 6, 87.19, 0, 0, null, null, null, 0, 0, null, 1, "neoplasm", 0.10449825238323361], ["P78552", "IL13RA1", "Interleukin-13 receptor subunit alpha-1", "Tier 1", 0.67, 4, 81.56, 0, 0, null, null, null, 0, 0, null, 1, "type 2 diabetes mellitus", 0.48627783096767857], ["P54762", "EPHB1", "Ephrin type-B receptor 1", "Tier 1", 0.665, 8, 83.62, 0, 0, null, null, null, 0, 0, null, 1, "medullary thyroid gland carcinoma", 0.5204553830376101], ["Q14344", "GNA13", "Guanine nucleotide-binding protein subunit alpha-13", "Tier 1", 0.66, 17, 91.44, 1, 0, null, null, null, 0, 0, null, 1, "lymphoma", 0.37253457492562664], ["Q7L2H7", "EIF3M", "Eukaryotic translation initiation factor 3 subunit M", "Tier 1", 0.66, 0, 55.28, 0, 0, null, null, null, 0, 0, null, 1, "Hernia", 0.2963310523049043], ["P05543", "SERPINA7", "Thyroxine-binding globulin", "Tier 1", 0.655, 9, 87.06, 0, 0, null, null, null, 0, 0, null, 1, "neoplasm", 0.09631257418600654], ["P20701", "ITGAL", "Integrin alpha-L", "Tier 1", 0.655, 41, 82.62, 0, 0, null, null, null, 0, 0, null, 1, "psoriasis", 0.5899795223699872], ["Q5JWF2", "GNAS", "Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas", "Tier 1", 0.653, 9, 56.72, 1, 0, null, null, null, 0, 0, null, 1, "pseudohypoparathyroidism type 1A", 0.826829760867455], ["P54764", null, null, "Tier 1", 0.652, 17, 83.5, 0, 0, null, null, null, 0, 0, null, 1, "medullary thyroid gland carcinoma", 0.5195314334008982], ["P04746", "AMY2A", "Pancreatic alpha-amylase", "Tier 1", 0.65, 51, 96.75, 0, 0, null, null, null, 0, 0, null, 1, "type 2 diabetes mellitus", 0.5997984923419163], ["Q13936", "CACNA1C", "Voltage-dependent L-type calcium channel subunit alpha-1C", "Tier 1", 0.65, 33, 61.94, 1, 0, null, null, null, 0, 0, null, 1, "Timothy syndrome", 0.8227725490420764], ["P62491", "RAB11A", "Ras-related protein Rab-11A", "Tier 1", 0.64, 30, 87.19, 0, 0, null, null, null, 0, 0, null, 1, "Intellectual disability", 0.4852051194358318], ["P26447", "S100A4", "Protein S100-A4", "Tier 1", 0.636, 17, 86.44, 0, 0, null, null, null, 0, 0, null, 1, "Alzheimer disease", 0.36416197951415524], ["P54289", "CACNA2D1", "Voltage-dependent calcium channel subunit alpha-2/delta-1", "Tier 1", 0.635, 30, 86.56, 1, 0, null, null, null, 0, 0, null, 1, "Seizure", 0.6942469435259896], ["P20963", "CD247", "T-cell surface glycoprotein CD3 zeta chain", "Tier 1", 0.635, 38, 62.41, 1, 0, null, null, null, 0, 0, null, 1, "immunodeficiency 25", 0.7436838111879828], ["Q96A54", "ADIPOR1", "Adiponectin receptor protein 1", "Tier 1", 0.632, 3, 83.25, 0, 0, null, null, null, 0, 0, null, 1, "Retinal dystrophy", 0.17324768030468937], ["Q16555", "DPYSL2", "Dihydropyrimidinase-related protein 2", "Tier 1", 0.63, 15, 90.25, 1, 0, null, null, null, 0, 0, null, 1, "hypertension", 0.4377422749119531], ["O14939", "PLD2", "Phospholipase D2", "Tier 1", 0.63, 6, 88.94, 0, 0, null, null, null, 0, 0, null, 1, "systemic lupus erythematosus", 0.22499036596471594], ["Q15113", "PCOLCE", "Procollagen C-endopeptidase enhancer 1", "Tier 1", 0.63, 4, 79.56, 0, 0, null, null, null, 0, 0, null, 1, "hair color", 0.09954732229482598], ["P49790", "NUP153", "Nuclear pore complex protein Nup153", "Tier 1", 0.63, 12, 43.59, 1, 0, null, null, null, 0, 0, null, 1, "HIV infection", 0.5431773609684529], ["O75970", "MPDZ", "Multiple PDZ domain protein", "Tier 1", 0.628, 9, 63.72, 0, 0, null, null, null, 0, 0, null, 1, "Congenital muscular alpha-dystroglycanopathy with brain and eye anomalies", 0.7761660121864681]], "truncated": false, "filtered_table_rows_count": 1278, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "priority_score", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "drug_count_approved", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, priority_score, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, drug_count_approved, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_known_aptamer\" = :p0 and \"in_cev_map\" = :p1 and \"tier\" = :p2 order by priority_score desc limit 51", "params": {"p0": "0", "p1": "1", "p2": "Tier 1"}}, "facet_results": {"tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&in_cev_map=1&tier=Tier+1", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 1278, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=1", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&in_cev_map=1&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 1277, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=1&tier=Tier+1&has_activation_state_pdb_pair=0", "selected": false}, {"value": 1, "label": 1, "count": 1, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=1&tier=Tier+1&has_activation_state_pdb_pair=1", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&in_cev_map=1&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 1278, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=1&tier=Tier+1", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&in_cev_map=1&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 1278, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&tier=Tier+1", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&in_cev_map=1&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 830, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=1&tier=Tier+1&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 448, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=1&tier=Tier+1&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=1&tier=Tier+1&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 603.8030859999708, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}