{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_known_aptamer = 0, in_cev_map = 1 and tier = \"Tier 1.5\" sorted by priority_score descending", "rows": [["Q9NX14", "NDUFB11", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial", "Tier 1.5", 0.86, 0, 77.56, 0, 0, null, null, null, 0, 0, null, 1, "Microphthalmia with linear skin defects syndrome", 0.7364493324598024], ["Q02094", "RHAG", "Ammonium transporter Rh type A", "Tier 1.5", 0.841, 8, 95.62, 1, 0, null, null, null, 0, 0, null, 1, "Rh deficiency syndrome", 0.764209214915708], ["Q14392", "LRRC32", "Transforming growth factor beta activator LRRC32", "Tier 1.5", 0.838, 6, 86.06, 1, 0, null, null, null, 0, 0, null, 1, "cleft palate, proliferative retinopathy, and developmental delay", 0.5770707112957068], ["P12532", "CKMT1A", "Creatine kinase U-type, mitochondrial", "Tier 1.5", 0.83, 9, 89.31, 1, 0, null, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.5385822922582763], ["P54709", "ATP1B3", "Sodium/potassium-transporting ATPase subunit beta-3", "Tier 1.5", 0.81, 7, 89.69, 1, 0, null, null, null, 0, 0, null, 1, "congestive heart failure", 0.5999952111132625], ["Q9UBT7", "CTNNAL1", "Alpha-catulin", "Tier 1.5", 0.795, 0, 84.06, 0, 0, null, null, null, 0, 0, null, 1, "Abnormality of the skeletal system", 0.31316995706583495], ["P27037", "ACVR2A", "Activin receptor type-2A", "Tier 1.5", 0.769, 5, 83.56, 0, 0, null, null, null, 0, 0, null, 1, "hepatocellular carcinoma", 0.4908023126074436], ["O14958", "CASQ2", "Calsequestrin-2", "Tier 1.5", 0.767, 4, 90.5, 0, 0, null, null, null, 0, 0, null, 1, "catecholaminergic polymorphic ventricular tachycardia", 0.7718998507471558], ["Q9H3K6", "BOLA2", "BolA-like protein 2", "Tier 1.5", 0.765, 0, 92.69, 0, 0, null, null, null, 0, 0, null, 1, "hepatocellular carcinoma", 0.08093942543094014], ["O60568", "PLOD3", "Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3", "Tier 1.5", 0.762, 18, 91.38, 1, 0, null, null, null, 0, 0, null, 1, "bone fragility with contractures, arterial rupture, and deafness", 0.7159150369336311], ["P41440", "SLC19A1", "Reduced folate transporter", "Tier 1.5", 0.755, 19, 72.06, 1, 0, null, null, null, 0, 0, null, 1, "Knobloch syndrome", 0.5526223217595396], ["P26022", "PTX3", "Pentraxin-related protein PTX3", "Tier 1.5", 0.75, 9, 76.75, 1, 0, null, null, null, 0, 0, null, 1, "polycystic ovary syndrome", 0.12287624125782433], ["Q92956", "TNFRSF14", "Tumor necrosis factor receptor superfamily member 14", "Tier 1.5", 0.745, 8, 79.94, 0, 0, null, null, null, 0, 0, null, 1, "diffuse large B-cell lymphoma", 0.5983171413833771], ["Q9Y653", "ADGRG1", "Adhesion G-protein coupled receptor G1", "Tier 1.5", 0.743, 1, 77.88, 1, 0, null, null, null, 0, 0, null, 1, "bilateral frontoparietal polymicrogyria", 0.8322298896713178], ["P16389", "KCNA2", "Potassium voltage-gated channel subfamily A member 2", "Tier 1.5", 0.735, 0, 77.38, 0, 0, null, null, null, 0, 0, null, 1, "genetic developmental and epileptic encephalopathy", 0.7513374591580034], ["P98196", "ATP11A", "Phospholipid-transporting ATPase IH", "Tier 1.5", 0.735, 0, 82.94, 0, 0, null, null, null, 0, 0, null, 1, "hearing loss, autosomal dominant 84", 0.5506821963658654], ["P20702", "ITGAX", "Integrin alpha-X", "Tier 1.5", 0.732, 9, 88.0, 0, 0, null, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.41708750879240836], ["P09603", null, null, "Tier 1.5", 0.729, 8, 57.41, 0, 0, null, null, null, 0, 0, null, 1, "type 2 diabetes mellitus", 0.39219340856589974], ["P22732", "SLC2A5", "Solute carrier family 2, facilitated glucose transporter member 5", "Tier 1.5", 0.728, 0, 90.56, 0, 0, null, null, null, 0, 0, null, 1, "Prolonged QT interval", 0.3326218692162316], ["Q9P2B2", "PTGFRN", "Prostaglandin F2 receptor negative regulator", "Tier 1.5", 0.728, 0, 84.12, 0, 0, null, null, null, 0, 0, null, 1, "type 2 diabetes mellitus", 0.48052208463481294], ["Q92636", "NSMAF", "Protein FAN", "Tier 1.5", 0.725, 0, 88.31, 0, 0, null, null, null, 0, 0, null, 1, "placental retention", 0.36802220150078147], ["P07942", "LAMB1", "Laminin subunit beta-1", "Tier 1.5", 0.72, 3, 76.69, 1, 0, null, null, null, 0, 0, null, 1, "cobblestone lissencephaly without muscular or ocular involvement", 0.8016665947624902], ["Q9NR82", "KCNQ5", "Potassium voltage-gated channel subfamily KQT member 5", "Tier 1.5", 0.711, 5, 56.41, 1, 0, null, null, null, 0, 0, null, 1, "intellectual disability, autosomal dominant 46", 0.7086662845211597], ["O95562", "SFT2D2", "Vesicle transport protein SFT2B", "Tier 1.5", 0.71, 0, 78.5, 0, 0, null, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.38598268164814226], ["P79483", "HLA-DRB3", "HLA class II histocompatibility antigen, DR beta 3 chain", "Tier 1.5", 0.71, 2, 88.38, 0, 0, null, null, null, 0, 0, null, 1, null, null], ["P03905", "MT-ND4", "NADH-ubiquinone oxidoreductase chain 4", "Tier 1.5", 0.705, 0, 93.94, 0, 0, null, null, null, 0, 0, null, 1, "Leber hereditary optic neuropathy", 0.7517935125709835], ["P14770", "GP9", "Platelet glycoprotein IX", "Tier 1.5", 0.702, 2, 84.69, 1, 0, null, null, null, 0, 0, null, 1, "Bernard-Soulier syndrome", 0.8233582238860002], ["P01615", "IGKV2D-28", "Immunoglobulin kappa variable 2D-28", "Tier 1.5", 0.695, 0, 91.0, 0, 0, null, null, null, 0, 0, null, 1, "cutaneous Leishmaniasis", 0.5868213846274001], ["Q30154", "HLA-DRB5", "HLA class II histocompatibility antigen, DR beta 5 chain", "Tier 1.5", 0.694, 4, 86.75, 0, 0, null, null, null, 0, 0, null, 1, "seasonal allergic rhinitis", 0.19424611770933498], ["Q9Y678", "COPG1", "Coatomer subunit gamma-1", "Tier 1.5", 0.692, 1, 87.88, 0, 0, null, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.4905625531390244], ["P36980", "CFHR2", "Complement factor H-related protein 2", "Tier 1.5", 0.691, 4, 90.62, 0, 0, null, null, null, 0, 0, null, 1, "age-related macular degeneration", 0.5100732932209376], ["P01825", "IGHV4-59", "Immunoglobulin heavy variable 4-59", "Tier 1.5", 0.69, 3, 91.56, 1, 0, null, null, null, 0, 0, null, 1, "cutaneous Leishmaniasis", 0.5868213846274001], ["Q8IUH8", "SPPL2C", "Signal peptide peptidase-like 2C", "Tier 1.5", 0.69, 0, 67.06, 0, 0, null, null, null, 0, 0, null, 1, "osteoarthritis, hip", 0.35379836590273994], ["Q6NT16", "SLC18B1", "MFS-type transporter SLC18B1", "Tier 1.5", 0.688, 4, 84.62, 1, 0, null, null, null, 0, 0, null, 1, "Parkinson disease", 0.276931649354752], ["Q14520", "HABP2", "Factor VII-activating protease", "Tier 1.5", 0.686, 0, 77.62, 0, 0, null, null, null, 0, 0, null, 1, "follicular thyroid carcinoma", 0.46213907606907034], ["Q96MP8", "KCTD7", "BTB/POZ domain-containing protein KCTD7", "Tier 1.5", 0.685, 0, 81.12, 0, 0, null, null, null, 0, 0, null, 1, "progressive myoclonic epilepsy type 3", 0.8021556079083692], ["Q99250", "SCN2A", "Sodium channel protein type 2 subunit alpha", "Tier 1.5", 0.685, 5, 68.81, 1, 0, null, null, null, 0, 0, null, 1, "developmental and epileptic encephalopathy, 11", 0.8388748085806758], ["Q15582", "TGFBI", "Transforming growth factor-beta-induced protein ig-h3", "Tier 1.5", 0.682, 10, 90.25, 1, 0, null, null, null, 0, 0, null, 1, "lattice corneal dystrophy type I", 0.8242841141270143], ["O75935", "DCTN3", "Dynactin subunit 3", "Tier 1.5", 0.68, 1, 88.38, 1, 0, null, null, null, 0, 0, null, 1, "viral disease", 0.03700998752471888], ["Q8TD43", "TRPM4", "Transient receptor potential cation channel subfamily M member 4", "Tier 1.5", 0.68, 25, 77.44, 1, 0, null, null, null, 0, 0, null, 1, "Familial progressive cardiac conduction defect", 0.7868180621357534], ["O94842", "TOX4", "TOX high mobility group box family member 4", "Tier 1.5", 0.68, 1, 54.72, 0, 0, null, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.43085410155338943], ["P05023", "ATP1A1", "Sodium/potassium-transporting ATPase subunit alpha-1", "Tier 1.5", 0.679, 10, 88.69, 1, 0, null, null, null, 0, 0, null, 1, "Charcot-Marie-tooth disease, axonal, type 2DD", 0.7868851290226483], ["Q92536", "SLC7A6", "Y+L amino acid transporter 2", "Tier 1.5", 0.678, 2, 83.19, 1, 0, null, null, null, 0, 0, null, 1, "Abnormality of the skeletal system", 0.48544421359843914], ["Q96DA2", "RAB39B", "Ras-related protein Rab-39B", "Tier 1.5", 0.678, 1, 88.38, 0, 0, null, null, null, 0, 0, null, 1, "early-onset parkinsonism-intellectual disability syndrome", 0.7782306319395635], ["P36021", "SLC16A2", "Monocarboxylate transporter 8", "Tier 1.5", 0.675, 7, 79.56, 1, 0, null, null, null, 0, 0, null, 1, "Allan-Herndon-Dudley syndrome", 0.8533069932022032], ["P18564", "ITGB6", "Integrin beta-6", "Tier 1.5", 0.675, 14, 82.88, 1, 0, null, null, null, 0, 0, null, 1, "Hypoplastic amelogenesis imperfecta", 0.6045342804405103], ["Q9UI42", "CPA4", "Carboxypeptidase A4", "Tier 1.5", 0.674, 5, 93.69, 0, 0, null, null, null, 0, 0, null, 1, "rheumatoid arthritis", 0.19026118958920038], ["P08572", "COL4A2", "Collagen alpha-2(IV) chain", "Tier 1.5", 0.673, 4, 47.25, 0, 0, null, null, null, 0, 0, null, 1, "porencephaly 2", 0.7294975109351518], ["P78357", "CNTNAP1", "Contactin-associated protein 1", "Tier 1.5", 0.673, 0, 81.12, 0, 0, null, null, null, 0, 0, null, 1, "Hypomyelination neuropathy - arthrogryposis", 0.8286745612673082], ["Q14C86", "GAPVD1", "GTPase-activating protein and VPS9 domain-containing protein 1", "Tier 1.5", 0.67, 0, 62.19, 0, 0, null, null, null, 0, 0, null, 1, "Abnormality of the skeletal system", 0.46694942126454214]], "truncated": false, "filtered_table_rows_count": 1299, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "priority_score", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "drug_count_approved", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, priority_score, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, drug_count_approved, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_known_aptamer\" = :p0 and \"in_cev_map\" = :p1 and \"tier\" = :p2 order by priority_score desc limit 51", "params": {"p0": "0", "p1": "1", "p2": "Tier 1.5"}}, "facet_results": {"tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&in_cev_map=1&tier=Tier+1.5", "results": [{"value": "Tier 1.5", "label": "Tier 1.5", "count": 1299, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=1", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&in_cev_map=1&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 1299, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=1&tier=Tier+1.5&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&in_cev_map=1&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 1299, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=1&tier=Tier+1.5", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&in_cev_map=1&tier=Tier+1.5", "results": [{"value": 1, "label": 1, "count": 1299, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&tier=Tier+1.5", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&in_cev_map=1&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 1112, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=1&tier=Tier+1.5&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 187, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=1&tier=Tier+1.5&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [{"name": "pdb_count_total", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=1&tier=Tier+1.5&_facet=pdb_count_total"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&in_cev_map=1&tier=Tier+1.5&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 603.2601970000542, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}