{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_known_aptamer = 0, surface_class = \"A2_pm_peripheral\" and tier = \"Tier 1\" sorted by evidence_priority descending", "rows": [["P35555", "FBN1", "Fibrillin-1", "Tier 1", 0.809, 1, "A2_pm_peripheral", 11, null, 0, 0, null, null, 0, 0, null, 1, "Marfan syndrome", 0.8969300970597663], ["P51531", "SMARCA2", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2", "Tier 1", 0.797, 1, "A2_pm_peripheral", 31, 65.06, 0, 0, null, null, 0, 0, null, 1, "intellectual disability-sparse hair-brachydactyly syndrome", 0.85547142397368], ["P62873", "GNB1", "Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1", "Tier 1", 0.794, 1, "A2_pm_peripheral", 100, 97.06, 1, 0, null, null, 0, 0, null, 1, "intellectual disability, autosomal dominant 42", 0.8462216225099116], ["P52333", "JAK3", "Tyrosine-protein kinase JAK3", "Tier 1", 0.794, 1, "A2_pm_peripheral", 42, 85.69, 0, 0, null, null, 0, 0, null, 1, "T-B+ severe combined immunodeficiency due to JAK3 deficiency", 0.8450717197794638], ["O75369", "FLNB", "Filamin-B", "Tier 1", 0.788, 1, "A2_pm_peripheral", 23, 76.25, 0, 0, null, null, 0, 0, null, 1, "Larsen syndrome", 0.826975893141549], ["P06737", "PYGL", "Glycogen phosphorylase, liver form", "Tier 1", 0.787, 1, "A2_pm_peripheral", 19, 92.69, 1, 0, null, null, 0, 0, null, 1, "glycogen storage disease VI", 0.8220063508118274], ["P49770", "EIF2B2", "Translation initiation factor eIF2B subunit beta", "Tier 1", 0.787, 1, "A2_pm_peripheral", 25, 86.56, 1, 0, null, null, 0, 0, null, 1, "CACH syndrome", 0.824634396744653], ["P21333", "FLNA", "Filamin-A", "Tier 1", 0.786, 1, "A2_pm_peripheral", 26, 76.56, 1, 0, null, null, 0, 0, null, 1, "Melnick-Needles syndrome", 0.8200516896124751], ["O43175", "PHGDH", "D-3-phosphoglycerate dehydrogenase", "Tier 1", 0.784, 1, "A2_pm_peripheral", 21, 92.94, 0, 0, null, null, 0, 0, null, 1, "PHGDH deficiency", 0.8128323162948055], ["Q9Y3Z3", "SAMHD1", "Deoxynucleoside triphosphate triphosphohydrolase SAMHD1", "Tier 1", 0.783, 1, "A2_pm_peripheral", 76, 88.19, 0, 0, null, null, 0, 0, null, 1, "Aicardi-Gouti\u00e8res syndrome", 0.8101030032946703], ["Q8TD16", "BICD2", "Protein bicaudal D homolog 2", "Tier 1", 0.782, 1, "A2_pm_peripheral", 2, 78.0, 0, 0, null, null, 0, 0, null, 1, "autosomal dominant childhood-onset proximal spinal muscular atrophy with contractures", 0.8072433385790271], ["Q08499", "PDE4D", "3',5'-cyclic-AMP phosphodiesterase 4D", "Tier 1", 0.782, 1, "A2_pm_peripheral", 100, 67.44, 0, 0, null, null, 0, 0, null, 1, "acrodysostosis 2 with or without hormone resistance", 0.8053064772512085], ["Q01831", "XPC", "DNA repair protein complementing XP-C cells", "Tier 1", 0.782, 1, "A2_pm_peripheral", 14, 66.56, 1, 0, null, null, 0, 0, null, 1, "Xeroderma pigmentosum complementation group C", 0.8056391472748724], ["Q96BN8", "OTULIN", "Ubiquitin thioesterase otulin", "Tier 1", 0.781, 1, "A2_pm_peripheral", 12, 83.81, 0, 0, null, null, 0, 0, null, 1, "autoinflammation, panniculitis, and dermatosis syndrome, autosomal recessive", 0.804614072482804], ["P49773", "HINT1", "Adenosine 5'-monophosphoramidase HINT1", "Tier 1", 0.777, 1, "A2_pm_peripheral", 59, 96.19, 0, 0, null, null, 0, 0, null, 1, "Autosomal recessive axonal neuropathy with neuromyotonia", 0.7895184274923306], ["Q9Y263", "PLAA", "Phospholipase A-2-activating protein", "Tier 1", 0.77, 1, "A2_pm_peripheral", 5, 84.0, 0, 0, null, null, 0, 0, null, 1, "neurodevelopmental disorder with progressive microcephaly, spasticity, and brain anomalies", 0.7656265019633831], ["Q9NWZ3", "IRAK4", "Interleukin-1 receptor-associated kinase 4", "Tier 1", 0.768, 1, "A2_pm_peripheral", 96, 83.94, 0, 0, null, null, 0, 0, null, 1, "immunodeficiency 67", 0.7593923638641371], ["Q9BYI3", "HYCC1", "Hyccin", "Tier 1", 0.766, 1, "A2_pm_peripheral", 5, 67.75, 1, 0, null, null, 0, 0, null, 1, "Hypomyelination - congenital cataract", 0.7528702184568328], ["Q01484", "ANK2", "Ankyrin-2", "Tier 1", 0.762, 1, "A2_pm_peripheral", 11, 61.78, 0, 0, null, null, 0, 0, null, 1, "Romano-Ward syndrome", 0.7390647393986454], ["P13797", "PLS3", "Plastin-3", "Tier 1", 0.757, 1, "A2_pm_peripheral", 6, 88.75, 1, 0, null, null, 0, 0, null, 1, "X-linked osteoporosis with fractures", 0.721756781312783], ["P07948", "LYN", "Tyrosine-protein kinase Lyn", "Tier 1", 0.754, 1, "A2_pm_peripheral", 6, 83.12, 0, 0, null, null, 0, 0, null, 1, "autoinflammatory disease, systemic, with vasculitis", 0.7119500711989845], ["O15117", "FYB1", "FYN-binding protein 1", "Tier 1", 0.752, 1, "A2_pm_peripheral", 3, 56.59, 0, 0, null, null, 0, 0, null, 1, "thrombocytopenia 3", 0.7067701415491194], ["P07357", "C8A", "Complement component C8 alpha chain", "Tier 1", 0.75, 1, "A2_pm_peripheral", 11, 78.69, 1, 0, null, null, 0, 0, null, 1, "Immunodeficiency due to a late component of complements deficiency", 0.700643416115894], ["Q9Y5K6", "CD2AP", "CD2-associated protein", "Tier 1", 0.749, 1, "A2_pm_peripheral", 12, 62.22, 0, 0, null, null, 0, 0, null, 1, "focal segmental glomerulosclerosis", 0.6952333377860125], ["Q8IZQ1", "WDFY3", "WD repeat and FYVE domain-containing protein 3", "Tier 1", 0.748, 1, "A2_pm_peripheral", 2, null, 0, 0, null, null, 0, 0, null, 1, "Autosomal dominant microcephaly", 0.6934322596452817], ["Q96CW1", "AP2M1", "AP-2 complex subunit mu", "Tier 1", 0.741, 1, "A2_pm_peripheral", 4, 89.19, 0, 0, null, null, 0, 0, null, 1, "intellectual developmental disorder 60 with seizures", 0.6712897942723018], ["P48730", "CSNK1D", "Casein kinase I isoform delta", "Tier 1", 0.732, 1, "A2_pm_peripheral", 46, 81.0, 0, 0, null, null, 0, 0, null, 1, "Familial advanced sleep-phase syndrome", 0.6394614732145313], ["P27815", "PDE4A", "3',5'-cyclic-AMP phosphodiesterase 4A", "Tier 1", 0.732, 1, "A2_pm_peripheral", 5, 64.5, 0, 0, null, null, 0, 0, null, 1, "psoriasis", 0.6394621747004946], ["Q5VST9", "OBSCN", "Obscurin", "Tier 1", 0.73, 1, "A2_pm_peripheral", 25, null, 0, 0, null, null, 0, 0, null, 1, "Abnormality of the skeletal system", 0.6328288822708418], ["P11233", "RALA", "Ras-related protein Ral-A", "Tier 1", 0.723, 1, "A2_pm_peripheral", 16, 89.31, 0, 0, null, null, 0, 0, null, 1, "Hiatt-Neu-Cooper neurodevelopmental syndrome", 0.6092132376035464], ["Q16186", "ADRM1", "Proteasomal ubiquitin receptor ADRM1", "Tier 1", 0.722, 1, "A2_pm_peripheral", 21, 62.28, 0, 0, null, null, 0, 0, null, 1, "multiple myeloma", 0.6073517074927846], ["Q96RT1", "ERBIN", "Erbin", "Tier 1", 0.719, 1, "A2_pm_peripheral", 11, 55.66, 0, 0, null, null, 0, 0, null, 1, "cancer", 0.5976773185991211], ["Q32MZ4", "LRRFIP1", "Leucine-rich repeat flightless-interacting protein 1", "Tier 1", 0.719, 1, "A2_pm_peripheral", 1, 55.0, 0, 0, null, null, 0, 0, null, 1, "cancer", 0.5961939963929208], ["P08631", "HCK", "Tyrosine-protein kinase HCK", "Tier 1", 0.717, 1, "A2_pm_peripheral", 40, 83.12, 0, 0, null, null, 0, 0, null, 1, "chronic myelogenous leukemia", 0.5900239698979759], ["P48736", "PIK3CG", "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform", "Tier 1", 0.713, 1, "A2_pm_peripheral", 100, 87.81, 0, 0, null, null, 0, 0, null, 1, "chronic lymphocytic leukemia", 0.5769181159547517], ["P62987", "UBA52", "Ubiquitin-ribosomal protein eL40 fusion protein", "Tier 1", 0.712, 1, "A2_pm_peripheral", 30, 93.5, 1, 0, null, null, 0, 0, null, 1, "HIV infection", 0.5745684844613109], ["Q14160", "SCRIB", "Protein scribble homolog", "Tier 1", 0.708, 1, "A2_pm_peripheral", 36, 62.53, 0, 0, null, null, 0, 0, null, 1, "spina bifida", 0.5598219103770152], ["Q9NZ08", "ERAP1", "Endoplasmic reticulum aminopeptidase 1", "Tier 1", 0.706, 1, "A2_pm_peripheral", 23, 92.38, 0, 0, null, null, 0, 0, null, 1, "psoriasis", 0.5539585583227815], ["P56945", "BCAR1", "Breast cancer anti-estrogen resistance protein 1", "Tier 1", 0.706, 1, "A2_pm_peripheral", 5, 61.69, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.5525303421948999], ["Q9NZN5", "ARHGEF12", "Rho guanine nucleotide exchange factor 12", "Tier 1", 0.703, 1, "A2_pm_peripheral", 4, 60.22, 0, 0, null, null, 0, 0, null, 1, "glaucoma", 0.5425904569436921], ["P24723", "PRKCH", "Protein kinase C eta type", "Tier 1", 0.702, 1, "A2_pm_peripheral", 4, 81.62, 0, 0, null, null, 0, 0, null, 1, "acute myeloid leukemia", 0.5407196990475681], ["Q8NFH5", "NUP35", "Nucleoporin NUP35", "Tier 1", 0.702, 1, "A2_pm_peripheral", 5, 63.19, 1, 0, null, null, 0, 0, null, 1, "influenza", 0.5409211817593593], ["Q07866", "KLC1", "Kinesin light chain 1", "Tier 1", 0.701, 1, "A2_pm_peripheral", 4, 75.0, 0, 0, null, null, 0, 0, null, 1, "mitochondrial complex IV deficiency, nuclear type 17", 0.5354714606179074], ["O94806", "PRKD3", "Serine/threonine-protein kinase D3", "Tier 1", 0.701, 1, "A2_pm_peripheral", 1, 68.56, 0, 0, null, null, 0, 0, null, 1, "acute myeloid leukemia", 0.5352221987091332], ["Q13033", "STRN3", "Striatin-3", "Tier 1", 0.701, 1, "A2_pm_peripheral", 4, 67.5, 1, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.5377902198332467], ["O75143", "ATG13", "Autophagy-related protein 13", "Tier 1", 0.701, 1, "A2_pm_peripheral", 13, 63.84, 1, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.5360512349298453], ["Q6IAA8", "LAMTOR1", "Ragulator complex protein LAMTOR1", "Tier 1", 0.7, 1, "A2_pm_peripheral", 22, 80.12, 1, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.5318107016634962], ["P53582", "METAP1", "Methionine aminopeptidase 1", "Tier 1", 0.698, 1, "A2_pm_peripheral", 41, 94.38, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.5276150237273258], ["O60911", "CTSV", "Cathepsin L2", "Tier 1", 0.698, 1, "A2_pm_peripheral", 25, 92.94, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.525380406990464], ["Q99816", "TSG101", "Tumor susceptibility gene 101 protein", "Tier 1", 0.698, 1, "A2_pm_peripheral", 21, 82.94, 0, 0, null, null, 0, 0, null, 1, "HIV infection", 0.5281860759333491]], "truncated": false, "filtered_table_rows_count": 172, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_known_aptamer\" = :p0 and \"surface_class\" = :p1 and \"tier\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "0", "p1": "A2_pm_peripheral", "p2": "Tier 1"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&surface_class=A2_pm_peripheral&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 162, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=A2_pm_peripheral&tier=Tier+1&has_structure=1", "selected": false}, {"value": 0, "label": 0, "count": 10, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=A2_pm_peripheral&tier=Tier+1&has_structure=0", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&surface_class=A2_pm_peripheral&tier=Tier+1", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 172, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=A2_pm_peripheral", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&surface_class=A2_pm_peripheral&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 172, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=A2_pm_peripheral&tier=Tier+1&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&surface_class=A2_pm_peripheral&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 172, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A2_pm_peripheral&tier=Tier+1", "selected": true}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&surface_class=A2_pm_peripheral&tier=Tier+1", "results": [{"value": "A2_pm_peripheral", "label": "A2_pm_peripheral", "count": 172, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&tier=Tier+1", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&surface_class=A2_pm_peripheral&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 121, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=A2_pm_peripheral&tier=Tier+1&in_cev_map=1", "selected": false}, {"value": 0, "label": 0, "count": 51, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=A2_pm_peripheral&tier=Tier+1&in_cev_map=0", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&surface_class=A2_pm_peripheral&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 134, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=A2_pm_peripheral&tier=Tier+1&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 38, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=A2_pm_peripheral&tier=Tier+1&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=A2_pm_peripheral&tier=Tier+1&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 876.9972641021013, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}