{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_known_aptamer = 0, surface_class = \"A_assoc\" and tier = \"Tier 1\" sorted by evidence_priority descending", "rows": [["P12883", "MYH7", "Myosin-7", "Tier 1", 0.871, 1, "A_assoc", 43, 74.25, 1, 0, null, null, 0, 0, null, 1, "hypertrophic cardiomyopathy", 0.9029865147265421], ["P03951", "F11", "Coagulation factor XI", "Tier 1", 0.853, 1, "A_assoc", 100, 86.88, 0, 0, null, null, 0, 0, null, 1, "factor XI deficiency", 0.841884208404384], ["Q9BWP8", "COLEC11", "Collectin-11", "Tier 1", 0.839, 1, "A_assoc", 3, 78.31, 0, 0, null, null, 0, 0, null, 1, "3MC syndrome 2", 0.7977893521540559], ["P20908", "COL5A1", "Collagen alpha-1(V) chain", "Tier 1", 0.839, 1, "A_assoc", 1, 51.25, 0, 0, null, null, 0, 0, null, 1, "Ehlers-Danlos syndrome, classic type, 1", 0.7979601586599098], ["P02671", "FGA", "Fibrinogen alpha chain", "Tier 1", 0.838, 1, "A_assoc", 40, 60.34, 0, 0, null, null, 0, 0, null, 1, "familial dysfibrinogenemia", 0.7947496460990987], ["P00488", "F13A1", "Coagulation factor XIII A chain", "Tier 1", 0.838, 1, "A_assoc", 15, 90.88, 1, 0, null, null, 0, 0, null, 1, "Factor XIII subunit A deficiency", 0.7939842013132387], ["P13645", "KRT10", "Keratin, type I cytoskeletal 10", "Tier 1", 0.836, 1, "A_assoc", 6, 64.31, 0, 0, null, null, 0, 0, null, 1, "epidermolytic hyperkeratosis 2A, autosomal dominant", 0.7860749239386174], ["Q12904", "AIMP1", "Aminoacyl tRNA synthase complex-interacting multifunctional protein 1", "Tier 1", 0.834, 1, "A_assoc", 6, 81.12, 0, 0, null, null, 0, 0, null, 1, "hypomyelinating leukodystrophy 3", 0.7806847123659254], ["O43707", "ACTN4", "Alpha-actinin-4", "Tier 1", 0.833, 1, "A_assoc", 5, 84.12, 0, 0, null, null, 0, 0, null, 1, "focal segmental glomerulosclerosis 1", 0.7778533437264424], ["P48200", "IREB2", "Iron-responsive element-binding protein 2", "Tier 1", 0.799, 1, "A_assoc", 1, 86.75, 1, 0, null, null, 0, 0, null, 1, "neurodegeneration, early-onset, with choreoathetoid movements and microcytic anemia", 0.664403876125082], ["P02745", "C1QA", "Complement C1q subcomponent subunit A", "Tier 1", 0.79, 1, "A_assoc", 11, 82.62, 1, 0, null, null, 0, 0, null, 1, "C1Q deficiency 1", 0.6319053256658114], ["P02747", "C1QC", "Complement C1q subcomponent subunit C", "Tier 1", 0.787, 1, "A_assoc", 11, 80.56, 1, 0, null, null, 0, 0, null, 1, "C1Q deficiency", 0.6233532074390745], ["P09486", "SPARC", "SPARC", "Tier 1", 0.784, 1, "A_assoc", 4, 84.31, 0, 0, null, null, 0, 0, null, 1, "osteogenesis imperfecta", 0.6138892200186172], ["P04746", "AMY2A", "Pancreatic alpha-amylase", "Tier 1", 0.78, 1, "A_assoc", 51, 96.75, 0, 0, null, null, 0, 0, null, 1, "type 2 diabetes mellitus", 0.5997984923419163], ["P02749", "APOH", "Beta-2-glycoprotein 1", "Tier 1", 0.764, 1, "A_assoc", 14, 93.12, 0, 0, null, null, 0, 0, null, 1, "atrial fibrillation", 0.5456247991985232], ["A8K2U0", "A2ML1", "Alpha-2-macroglobulin-like protein 1", "Tier 1", 0.764, 1, "A_assoc", 5, 80.5, 1, 0, null, null, 0, 0, null, 1, "Otitis media", 0.5479914512784171], ["P20061", "TCN1", "Transcobalamin-1", "Tier 1", 0.763, 1, "A_assoc", 2, 89.12, 0, 0, null, null, 0, 0, null, 1, "vitamin B deficiency", 0.5449702229454368], ["Q14766", "LTBP1", "Latent-transforming growth factor beta-binding protein 1", "Tier 1", 0.754, 1, "A_assoc", 1, 58.88, 0, 0, null, null, 0, 0, null, 1, "Abnormality of the skeletal system", 0.5142669818409414], ["Q08043", "ACTN3", "Alpha-actinin-3", "Tier 1", 0.752, 1, "A_assoc", 3, 84.19, 1, 0, null, null, 0, 0, null, 1, "Abnormality of the skeletal system", 0.5080072819822437], ["Q9H792", "PEAK1", "Inactive tyrosine-protein kinase PEAK1", "Tier 1", 0.752, 1, "A_assoc", 2, 48.03, 0, 0, null, null, 0, 0, null, 1, "type 2 diabetes mellitus", 0.5080681892268507], ["Q04756", "HGFAC", "Hepatocyte growth factor activator serine protease", "Tier 1", 0.747, 1, "A_assoc", 7, 75.31, 0, 0, null, null, 0, 0, null, 1, "metabolic disease", 0.4900675680377984], ["Q9UM22", "EPDR1", "Mammalian ependymin-related protein 1", "Tier 1", 0.746, 1, "A_assoc", 3, 85.88, 0, 0, null, null, 0, 0, null, 1, "Dupuytren Contracture", 0.48568453021554975], ["Q07157", "TJP1", "Tight junction protein 1", "Tier 1", 0.741, 1, "A_assoc", 19, 54.62, 0, 0, null, null, 0, 0, null, 1, "dengue disease", 0.47083190223446686], ["P05161", "ISG15", "Ubiquitin-like protein ISG15", "Tier 1", 0.74, 1, "A_assoc", 22, 85.88, 1, 0, null, null, 0, 0, null, 1, "COVID-19", 0.4668295741563516], ["P0DUB6", "AMY1A", "Alpha-amylase 1A", "Tier 1", 0.738, 1, "A_assoc", 13, 96.69, 0, 0, null, null, 0, 0, null, 1, "dentures", 0.4597705945086364], ["Q9NR12", "PDLIM7", "PDZ and LIM domain protein 7", "Tier 1", 0.738, 1, "A_assoc", 2, 70.25, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.4602637679250804], ["Q9BVC4", "MLST8", "Target of rapamycin complex subunit LST8", "Tier 1", 0.733, 1, "A_assoc", 45, 91.62, 1, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.4440338170862142], ["P19827", "ITIH1", "Inter-alpha-trypsin inhibitor heavy chain H1", "Tier 1", 0.731, 1, "A_assoc", 2, 87.44, 0, 0, null, null, 0, 0, null, 1, "osteoarthritis, hip", 0.4360348893142765], ["Q92187", "ST8SIA4", "CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase", "Tier 1", 0.731, 1, "A_assoc", 3, 86.44, 0, 0, null, null, 0, 0, null, 1, "systemic lupus erythematosus", 0.43832763677821385], ["Q14192", "FHL2", "Four and a half LIM domains protein 2", "Tier 1", 0.711, 1, "A_assoc", 4, 92.06, 0, 0, null, null, 0, 0, null, 1, "familial isolated dilated cardiomyopathy", 0.3714277539581253], ["P26447", "S100A4", "Protein S100-A4", "Tier 1", 0.709, 1, "A_assoc", 17, 86.44, 0, 0, null, null, 0, 0, null, 1, "Alzheimer disease", 0.36416197951415524], ["O95399", "UTS2", "Urotensin-2", "Tier 1", 0.706, 1, "A_assoc", 2, 58.44, 0, 0, null, null, 0, 0, null, 1, "hair color", 0.35316475479030335], ["O00602", "FCN1", "Ficolin-1", "Tier 1", 0.705, 1, "A_assoc", 7, 84.94, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.351581018821974], ["P41222", "PTGDS", "Prostaglandin-H2 D-isomerase", "Tier 1", 0.703, 1, "A_assoc", 17, 87.81, 0, 0, null, null, 0, 0, null, 1, "keratoconus", 0.3422478065390684], ["Q9NZK5", "ADA2", "Adenosine deaminase 2", "Tier 1", 0.699, 1, "A_assoc", 2, 95.81, 0, 0, null, null, 0, 0, null, 0, "deficiency of adenosine deaminase 2", 0.8291292532404531], ["Q99972", "MYOC", "Myocilin", "Tier 1", 0.699, 1, "A_assoc", 24, 78.94, 0, 0, null, null, 0, 0, null, 0, "glaucoma 1, open angle, A", 0.8294483747483756], ["P48059", "LIMS1", "LIM and senescent cell antigen-like-containing domain protein 1", "Tier 1", 0.697, 1, "A_assoc", 14, 88.06, 0, 0, null, null, 0, 0, null, 1, "Abruptio Placentae", 0.3236383460637068], ["O75629", "CREG1", "Protein CREG1", "Tier 1", 0.697, 1, "A_assoc", 1, 87.38, 0, 0, null, null, 0, 0, null, 1, "acquired neutropenia", 0.3238393577317927], ["Q9UK55", "SERPINA10", "Protein Z-dependent protease inhibitor", "Tier 1", 0.697, 1, "A_assoc", 4, 86.75, 0, 0, null, null, 0, 0, null, 1, "macular degeneration", 0.3247169581531489], ["O60711", "LPXN", "Leupaxin", "Tier 1", 0.697, 1, "A_assoc", 4, 76.38, 0, 0, null, null, 0, 0, null, 1, "myopathy", 0.32321299435969897], ["Q9UBH0", "IL36RN", "Interleukin-36 receptor antagonist protein", "Tier 1", 0.695, 1, "A_assoc", 3, 92.44, 0, 0, null, null, 0, 0, null, 0, "psoriasis 14, pustular", 0.8155144873787125], ["P19652", "ORM2", "Alpha-1-acid glycoprotein 2", "Tier 1", 0.695, 1, "A_assoc", 5, 91.19, 0, 0, null, null, 0, 0, null, 1, "complication", 0.3155973286233708], ["Q96MK3", "FAM20A", "Pseudokinase FAM20A", "Tier 1", 0.693, 1, "A_assoc", 4, 85.25, 0, 0, null, null, 0, 0, null, 0, "amelogenesis imperfecta type 1G", 0.8106031517056754], ["P55000", "SLURP1", "Secreted Ly-6/uPAR-related protein 1", "Tier 1", 0.692, 1, "A_assoc", 2, 84.19, 0, 0, null, null, 0, 0, null, 0, "mal de Meleda", 0.8064330379723671], ["P29460", "IL12B", "Interleukin-12 subunit beta", "Tier 1", 0.687, 1, "A_assoc", 20, 91.12, 1, 0, null, null, 0, 0, null, 0, "psoriasis", 0.7914863943708039], ["P20849", "COL9A1", "Collagen alpha-1(IX) chain", "Tier 1", 0.678, 1, "A_assoc", 5, 61.5, 0, 0, null, null, 0, 0, null, 0, "Stickler syndrome", 0.7594904923903256], ["Q2MKA7", "RSPO1", "R-spondin-1", "Tier 1", 0.669, 1, "A_assoc", 12, 74.69, 1, 0, null, null, 0, 0, null, 0, "palmoplantar keratoderma-XX sex reversal-predisposition to squamous cell carcinoma syndrome", 0.7285342885472184], ["P12272", "PTHLH", "Parathyroid hormone-related protein", "Tier 1", 0.666, 1, "A_assoc", 11, 62.88, 1, 0, null, null, 0, 0, null, 0, "brachydactyly type E", 0.7203484375635054], ["Q99574", "SERPINI1", "Neuroserpin", "Tier 1", 0.665, 1, "A_assoc", 3, 88.12, 0, 0, null, null, 0, 0, null, 0, "familial encephalopathy with neuroserpin inclusion bodies", 0.7162803151916303], ["Q8N300", "SVBP", "Small vasohibin-binding protein", "Tier 1", 0.649, 1, "A_assoc", 24, 85.06, 1, 0, null, null, 0, 0, null, 0, "neurodevelopmental disorder with ataxia, hypotonia, and microcephaly", 0.6640118055835142]], "truncated": false, "filtered_table_rows_count": 92, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_known_aptamer\" = :p0 and \"surface_class\" = :p1 and \"tier\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "0", "p1": "A_assoc", "p2": "Tier 1"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&surface_class=A_assoc&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 90, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=A_assoc&tier=Tier+1&has_structure=1", "selected": false}, {"value": 0, "label": 0, "count": 2, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=A_assoc&tier=Tier+1&has_structure=0", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&surface_class=A_assoc&tier=Tier+1", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 92, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=A_assoc", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&surface_class=A_assoc&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 92, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=A_assoc&tier=Tier+1&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&surface_class=A_assoc&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 92, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_assoc&tier=Tier+1", "selected": true}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&surface_class=A_assoc&tier=Tier+1", "results": [{"value": "A_assoc", "label": "A_assoc", "count": 92, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&tier=Tier+1", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&surface_class=A_assoc&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 47, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=A_assoc&tier=Tier+1&in_cev_map=0", "selected": false}, {"value": 1, "label": 1, "count": 45, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=A_assoc&tier=Tier+1&in_cev_map=1", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&surface_class=A_assoc&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 66, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=A_assoc&tier=Tier+1&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 26, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=A_assoc&tier=Tier+1&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [{"name": "pdb_count_total", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=A_assoc&tier=Tier+1&_facet=pdb_count_total"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=A_assoc&tier=Tier+1&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 758.9249317534268, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}