{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_known_aptamer = 0, surface_class = \"A_assoc\" and tier = \"Tier 1.5\" sorted by evidence_priority descending", "rows": [["P02462", "COL4A1", "Collagen alpha-1(IV) chain", "Tier 1.5", 0.854, 1, "A_assoc", 4, 48.47, 0, 0, null, null, 0, 0, null, 1, "brain small vessel disease 1 with or without ocular anomalies", 0.84655287380359], ["P04180", "LCAT", "Phosphatidylcholine-sterol acyltransferase", "Tier 1.5", 0.848, 1, "A_assoc", 7, 86.75, 1, 0, null, null, 0, 0, null, 1, "Fish-eye disease", 0.8273460309828392], ["Q15582", "TGFBI", "Transforming growth factor-beta-induced protein ig-h3", "Tier 1.5", 0.847, 1, "A_assoc", 10, 90.25, 1, 0, null, null, 0, 0, null, 1, "lattice corneal dystrophy type I", 0.8242841141270143], ["P07942", "LAMB1", "Laminin subunit beta-1", "Tier 1.5", 0.84, 1, "A_assoc", 3, 76.69, 1, 0, null, null, 0, 0, null, 1, "cobblestone lissencephaly without muscular or ocular involvement", 0.8016665947624902], ["P22105", "TNXB", "Tenascin-X", "Tier 1.5", 0.837, 1, "A_assoc", 3, 87.81, 0, 0, null, null, 0, 0, null, 1, "Ehlers-Danlos syndrome due to tenascin-X deficiency", 0.7916412481554758], ["P35858", "IGFALS", "Insulin-like growth factor-binding protein complex acid labile subunit", "Tier 1.5", 0.833, 1, "A_assoc", 1, 90.56, 1, 0, null, null, 0, 0, null, 1, "Reduced insulin like growth factor binding protein acid labile subunit concentration", 0.7760522769257892], ["O15230", "LAMA5", "Laminin subunit alpha-5", "Tier 1.5", 0.828, 1, "A_assoc", 2, 79.12, 1, 0, null, null, 0, 0, null, 1, "nephrotic syndrome, IIa 26", 0.7594872666460903], ["P08572", "COL4A2", "Collagen alpha-2(IV) chain", "Tier 1.5", 0.819, 1, "A_assoc", 4, 47.25, 0, 0, null, null, 0, 0, null, 1, "porencephaly 2", 0.7294975109351518], ["O60568", "PLOD3", "Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3", "Tier 1.5", 0.815, 1, "A_assoc", 18, 91.38, 1, 0, null, null, 0, 0, null, 1, "bone fragility with contractures, arterial rupture, and deafness", 0.7159150369336311], ["Q9Y6C2", "EMILIN1", "EMILIN-1", "Tier 1.5", 0.786, 1, "A_assoc", 2, 62.91, 0, 0, null, null, 0, 0, null, 1, "arterial tortuosity-bone fragility syndrome", 0.6185329512431467], ["P49767", "VEGFC", "Vascular endothelial growth factor C", "Tier 1.5", 0.785, 1, "A_assoc", 4, 73.19, 0, 0, null, null, 0, 0, null, 1, "Milroy disease", 0.6170524106764851], ["O00622", "CCN1", "CCN family member 1", "Tier 1.5", 0.765, 1, "A_assoc", 2, 73.12, 0, 0, null, null, 0, 0, null, 1, "Abnormality of the skeletal system", 0.5505331194769112], ["Q68CZ2", "TNS3", "Tensin-3", "Tier 1.5", 0.762, 1, "A_assoc", 1, 56.81, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.539772721274482], ["Q9Y3B8", "REXO2", "Oligoribonuclease, mitochondrial", "Tier 1.5", 0.754, 1, "A_assoc", 10, 88.19, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.5134178677464454], ["P36980", "CFHR2", "Complement factor H-related protein 2", "Tier 1.5", 0.753, 1, "A_assoc", 4, 90.62, 0, 0, null, null, 0, 0, null, 1, "age-related macular degeneration", 0.5100732932209376], ["Q13177", "PAK2", "Serine/threonine-protein kinase PAK 2", "Tier 1.5", 0.736, 1, "A_assoc", 5, 74.62, 0, 0, null, null, 0, 0, null, 1, "Knobloch syndrome", 0.45371318009439854], ["Q13625", "TP53BP2", "Apoptosis-stimulating of p53 protein 2", "Tier 1.5", 0.735, 1, "A_assoc", 6, 58.97, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.4484066399496438], ["Q9UKU9", "ANGPTL2", "Angiopoietin-related protein 2", "Tier 1.5", 0.727, 1, "A_assoc", 1, 78.19, 0, 0, null, null, 0, 0, null, 1, "Abnormality of the skeletal system", 0.4235882639081519], ["Q96SL4", "GPX7", "Glutathione peroxidase 7", "Tier 1.5", 0.721, 1, "A_assoc", 1, 92.69, 0, 0, null, null, 0, 0, null, 1, "Abnormality of the skeletal system", 0.40349356855524837], ["Q16627", "CCL14", "C-C motif chemokine 14", "Tier 1.5", 0.711, 1, "A_assoc", 2, 85.38, 0, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.37013422446672883], ["O95970", "LGI1", "Leucine-rich glioma-inactivated protein 1", "Tier 1.5", 0.697, 1, "A_assoc", 9, 92.56, 1, 0, null, null, 0, 0, null, 0, "autosomal dominant epilepsy with auditory features", 0.8225657483127345], ["Q8WUP2", "FBLIM1", "Filamin-binding LIM protein 1", "Tier 1.5", 0.687, 1, "A_assoc", 3, 66.44, 0, 0, null, null, 0, 0, null, 1, "COVID-19", 0.28975781420803737], ["P29120", "PCSK1", "Neuroendocrine convertase 1", "Tier 1.5", 0.682, 1, "A_assoc", 3, 82.5, 0, 0, null, null, 0, 0, null, 0, "obesity due to prohormone convertase I deficiency", 0.773875795833803], ["P19876", "CXCL3", "C-X-C motif chemokine 3", "Tier 1.5", 0.679, 1, "A_assoc", 2, 81.88, 1, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.26311734927710556], ["P16112", "ACAN", "Aggrecan core protein", "Tier 1.5", 0.677, 1, "A_assoc", 4, 51.91, 0, 0, null, null, 0, 0, null, 0, "Familial osteochondritis dissecans", 0.7558487616449627], ["P55789", "GFER", "FAD-linked sulfhydryl oxidase ALR", "Tier 1.5", 0.677, 1, "A_assoc", 7, 76.88, 0, 0, null, null, 0, 0, null, 0, "congenital cataract-progressive muscular hypotonia-hearing loss-developmental delay syndrome", 0.7556346526616893], ["P19875", "CXCL2", "C-X-C motif chemokine 2", "Tier 1.5", 0.674, 1, "A_assoc", 4, 81.62, 1, 0, null, null, 0, 0, null, 1, "neurodegenerative disease", 0.24624512698601778], ["Q12794", "HYAL1", "Hyaluronidase-1", "Tier 1.5", 0.672, 1, "A_assoc", 1, 94.0, 0, 0, null, null, 0, 0, null, 0, "Hyaluronidase deficiency", 0.7412407206736383], ["Q92752", "TNR", "Tenascin-R", "Tier 1.5", 0.672, 1, "A_assoc", 2, 78.5, 0, 0, null, null, 0, 0, null, 0, "neurodevelopmental disorder, nonprogressive, with spasticity and transient opisthotonus", 0.7403484347367364], ["P11686", "SFTPC", "Surfactant protein C", "Tier 1.5", 0.663, 1, "A_assoc", 3, 70.06, 0, 0, null, null, 0, 0, null, 0, "Congenital pulmonary alveolar proteinosis", 0.7110128683619542], ["O43897", "TLL1", null, "Tier 1.5", 0.662, 1, "A_assoc", 1, 80.31, 0, 0, null, null, 0, 0, null, 0, "atrial heart septal defect", 0.7050140477090344], ["P27352", "CBLIF", "Cobalamin binding intrinsic factor", "Tier 1.5", 0.655, 1, "A_assoc", 2, 90.5, 0, 0, null, null, 0, 0, null, 0, "hereditary intrinsic factor deficiency", 0.683930100359911], ["O95631", "NTN1", "Netrin-1", "Tier 1.5", 0.648, 1, "A_assoc", 5, 88.5, 1, 0, null, null, 0, 0, null, 0, "mirror movements 4", 0.6611393488240481], ["Q9NWU2", "GID8", "Glucose-induced degradation protein 8 homolog", "Tier 1.5", 0.631, 1, "A_assoc", 1, 91.94, 1, 0, null, null, 0, 0, null, 1, "Abnormality of the skeletal system", 0.10187555420552867], ["Q15818", "NPTX1", "Neuronal pentraxin-1", "Tier 1.5", 0.628, 1, "A_assoc", 1, 75.75, 0, 0, null, null, 0, 0, null, 0, "spinocerebellar ataxia 50", 0.5937598292127286], ["P07098", "LIPF", "Gastric triacylglycerol lipase", "Tier 1.5", 0.626, 1, "A_assoc", 1, 89.75, 0, 0, null, null, 0, 0, null, 0, "obesity", 0.5864662753480862], ["Q6IBW4", "NCAPH2", "Condensin-2 complex subunit H2", "Tier 1.5", 0.62, 1, "A_assoc", 1, 62.41, 1, 0, null, null, 0, 0, null, 0, "cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 1", 0.5674645203025676], ["O00175", "CCL24", "C-C motif chemokine 24", "Tier 1.5", 0.613, 1, "A_assoc", 2, 82.12, 0, 0, null, null, 0, 0, null, 0, "Iron deficiency anemia", 0.5428194908352497], ["P35556", "FBN2", "Fibrillin-2", "Tier 1.5", 0.612, 0, "A_assoc", 0, 68.38, 0, 0, null, null, 0, 0, null, 1, "congenital contractural arachnodactyly", 0.8556257369085999], ["P55268", "LAMB2", "Laminin subunit beta-2", "Tier 1.5", 0.598, 0, "A_assoc", 0, 75.62, 0, 0, null, null, 0, 0, null, 1, "LAMB2-related infantile-onset nephrotic syndrome", 0.8098669226688374], ["Q13751", "LAMB3", "Laminin subunit beta-3", "Tier 1.5", 0.596, 0, "A_assoc", 0, 78.25, 0, 0, null, null, 0, 0, null, 1, "junctional epidermolysis bullosa, non-Herlitz type", 0.8026933429516515], ["Q9UKX2", "MYH2", "Myosin-2", "Tier 1.5", 0.593, 0, "A_assoc", 0, 73.31, 0, 0, null, null, 0, 0, null, 1, "myopathy, proximal, and ophthalmoplegia", 0.7931369221020983], ["Q9ULL8", "SHROOM4", "Protein Shroom4", "Tier 1.5", 0.593, 1, "A_assoc", 1, 47.09, 0, 0, null, null, 0, 0, null, 0, "X-linked intellectual disability, Stocco dos Santos type", 0.4759334640315342], ["Q6KF10", "GDF6", "Growth/differentiation factor 6", "Tier 1.5", 0.588, 0, "A_assoc", 0, 70.06, 0, 0, null, null, 0, 0, null, 1, "Klippel-Feil syndrome 1, autosomal dominant", 0.7775817215750842], ["P28039", "AOAH", "Acyloxyacyl hydrolase", "Tier 1.5", 0.585, 1, "A_assoc", 2, 90.38, 0, 0, null, null, 0, 0, null, 0, "type 2 diabetes mellitus", 0.4486206035972812], ["P11684", "SCGB1A1", "Uteroglobin", "Tier 1.5", 0.581, 1, "A_assoc", 2, 88.56, 0, 0, null, null, 0, 0, null, 0, "chronic obstructive pulmonary disease", 0.43588476688573263], ["P05997", "COL5A2", "Collagen alpha-2(V) chain", "Tier 1.5", 0.579, 0, "A_assoc", 0, 52.0, 0, 0, null, null, 0, 0, null, 1, "Ehlers-Danlos syndrome, classic type, 2", 0.7460629361318855], ["Q63HQ2", "EGFLAM", "Pikachurin", "Tier 1.5", 0.574, 1, "A_assoc", 3, 80.56, 1, 0, null, null, 0, 0, null, 0, "mathematical ability", 0.41387833248094535], ["Q13007", "IL24", "Interleukin-24", "Tier 1.5", 0.572, 1, "A_assoc", 2, 83.38, 0, 0, null, null, 0, 0, null, 0, "clear cell renal carcinoma", 0.4074364261926763], ["Q96A83", "COL26A1", "Collagen alpha-1(XXVI) chain", "Tier 1.5", 0.568, 1, "A_assoc", 6, 59.66, 0, 0, null, null, 0, 0, null, 0, "Inguinal hernia", 0.39338285604421097]], "truncated": false, "filtered_table_rows_count": 177, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_known_aptamer\" = :p0 and \"surface_class\" = :p1 and \"tier\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "0", "p1": "A_assoc", "p2": "Tier 1.5"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&surface_class=A_assoc&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 103, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=A_assoc&tier=Tier+1.5&has_structure=0", "selected": false}, {"value": 1, "label": 1, "count": 74, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=A_assoc&tier=Tier+1.5&has_structure=1", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&surface_class=A_assoc&tier=Tier+1.5", "results": [{"value": "Tier 1.5", "label": "Tier 1.5", "count": 177, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=A_assoc", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&surface_class=A_assoc&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 177, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=A_assoc&tier=Tier+1.5&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&surface_class=A_assoc&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 177, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_assoc&tier=Tier+1.5", "selected": true}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&surface_class=A_assoc&tier=Tier+1.5", "results": [{"value": "A_assoc", "label": "A_assoc", "count": 177, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&tier=Tier+1.5", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&surface_class=A_assoc&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 124, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=A_assoc&tier=Tier+1.5&in_cev_map=0", "selected": false}, {"value": 1, "label": 1, "count": 53, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=A_assoc&tier=Tier+1.5&in_cev_map=1", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&surface_class=A_assoc&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 159, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=A_assoc&tier=Tier+1.5&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 18, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=A_assoc&tier=Tier+1.5&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [{"name": "pdb_count_total", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=A_assoc&tier=Tier+1.5&_facet=pdb_count_total"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=A_assoc&tier=Tier+1.5&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 633.7942620739341, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}