{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_known_aptamer = 0, surface_class = \"A_surface\" and tier = \"Tier 1\" sorted by evidence_priority descending", "rows": [["P33897", "ABCD1", "ATP-binding cassette sub-family D member 1", "Tier 1", 0.96, 1, "A_surface", 14, 80.62, 1, 0, null, null, 0, 0, null, 1, "adrenoleukodystrophy", 0.8656366512509434], ["Q9NQ11", "ATP13A2", "Polyamine-transporting ATPase 13A2", "Tier 1", 0.953, 1, "A_surface", 25, 79.62, 1, 0, null, null, 0, 0, null, 1, "Kufor-Rakeb syndrome", 0.8439049037191295], ["P35499", "SCN4A", "Sodium channel protein type 4 subunit alpha", "Tier 1", 0.952, 1, "A_surface", 3, 72.44, 1, 0, null, null, 0, 0, null, 1, "paramyotonia congenita of Von Eulenburg", 0.8401628899371881], ["O00571", "DDX3X", "ATP-dependent RNA helicase DDX3X", "Tier 1", 0.951, 1, "A_surface", 17, 72.19, 0, 0, null, null, 0, 0, null, 1, "X-linked non-syndromic intellectual disability", 0.8362533125067105], ["P54760", "EPHB4", "Ephrin type-B receptor 4", "Tier 1", 0.95, 1, "A_surface", 23, 82.0, 0, 0, null, null, 0, 0, null, 1, "Capillary malformation - arteriovenous malformation", 0.8317426466005666], ["P07359", "GP1BA", "Platelet glycoprotein Ib alpha chain", "Tier 1", 0.95, 1, "A_surface", 22, 64.31, 1, 0, null, null, 0, 0, null, 1, "Bernard-Soulier syndrome", 0.8346884735388165], ["Q9NRA2", "SLC17A5", "Sialin", "Tier 1", 0.949, 1, "A_surface", 7, 84.12, 1, 0, null, null, 0, 0, null, 1, "free sialic acid storage disease, infantile form", 0.8292382821211967], ["P63092", "GNAS", "Guanine nucleotide-binding protein G(s) subunit alpha isoforms short", "Tier 1", 0.948, 1, "A_surface", 100, 91.31, 1, 0, null, null, 0, 0, null, 1, "pseudohypoparathyroidism type 1A", 0.826829760867455], ["Q8WZA1", "POMGNT1", "Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1", "Tier 1", 0.948, 1, "A_surface", 10, 89.88, 0, 0, null, null, 0, 0, null, 1, "muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A3", 0.826104223872448], ["Q5JWF2", "GNAS", "Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas", "Tier 1", 0.948, 1, "A_surface", 9, 56.72, 1, 0, null, null, 0, 0, null, 1, "pseudohypoparathyroidism type 1A", 0.826829760867455], ["P16615", "ATP2A2", "Sarcoplasmic/endoplasmic reticulum calcium ATPase 2", "Tier 1", 0.947, 1, "A_surface", 15, 85.44, 1, 0, null, null, 0, 0, null, 1, "Darier disease", 0.8223208039299769], ["Q13936", "CACNA1C", "Voltage-dependent L-type calcium channel subunit alpha-1C", "Tier 1", 0.947, 1, "A_surface", 33, 61.94, 1, 0, null, null, 0, 0, null, 1, "Timothy syndrome", 0.8227725490420764], ["P02730", "SLC4A1", "Band 3 anion transport protein", "Tier 1", 0.946, 1, "A_surface", 54, 82.12, 1, 0, null, null, 0, 0, null, 1, "hereditary spherocytosis type 4", 0.820137113225454], ["Q9H3H5", "DPAGT1", "UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase", "Tier 1", 0.943, 1, "A_surface", 8, 94.69, 1, 0, null, null, 0, 0, null, 1, "DPAGT1-congenital disorder of glycosylation", 0.8101246300555436], ["P49810", "PSEN2", "Presenilin-2", "Tier 1", 0.941, 1, "A_surface", 2, 71.81, 1, 0, null, null, 0, 0, null, 1, "early-onset autosomal dominant Alzheimer disease", 0.8047686386596943], ["O94766", "B3GAT3", "Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3", "Tier 1", 0.94, 1, "A_surface", 3, 92.56, 0, 0, null, null, 0, 0, null, 1, "Larsen-like syndrome, B3GAT3 type", 0.7995331164339264], ["Q9H2M9", "RAB3GAP2", "Rab3 GTPase-activating protein non-catalytic subunit", "Tier 1", 0.939, 1, "A_surface", 1, 79.62, 1, 0, null, null, 0, 0, null, 1, "Cataract - intellectual disability - hypogonadism", 0.7977527040203786], ["Q9Y5Y0", "FLVCR1", "Choline/ethanolamine transporter FLVCR1", "Tier 1", 0.938, 1, "A_surface", 8, 77.56, 1, 0, null, null, 0, 0, null, 1, "Posterior column ataxia - retinitis pigmentosa", 0.7932113640677738], ["Q14118", "DAG1", "Dystroglycan 1", "Tier 1", 0.938, 1, "A_surface", 8, 68.19, 0, 0, null, null, 0, 0, null, 1, "autosomal recessive limb-girdle muscular dystrophy type 2P", 0.7935290060634741], ["Q9UPN3", "MACF1", "Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5", "Tier 1", 0.938, 1, "A_surface", 3, null, 0, 0, null, null, 0, 0, null, 1, "lissencephaly 9 with complex brainstem malformation", 0.7945569032416216], ["P08473", "MME", "Neprilysin", "Tier 1", 0.937, 1, "A_surface", 16, 96.19, 0, 0, null, null, 0, 0, null, 1, "Charcot-Marie-Tooth disease axonal type 2T", 0.7912653398252156], ["Q9NW15", "ANO10", "Anoctamin-10", "Tier 1", 0.937, 1, "A_surface", 5, 86.12, 1, 0, null, null, 0, 0, null, 1, "autosomal recessive spinocerebellar ataxia 10", 0.7915327777093032], ["P35916", "FLT4", "Vascular endothelial growth factor receptor 3", "Tier 1", 0.937, 1, "A_surface", 2, 72.44, 0, 0, null, null, 0, 0, null, 1, "lymphatic malformation 1", 0.7904355931811005], ["Q6PJF5", "RHBDF2", "Inactive rhomboid protein 2", "Tier 1", 0.936, 1, "A_surface", 5, 67.38, 1, 0, null, null, 0, 0, null, 1, "palmoplantar keratoderma-esophageal carcinoma syndrome", 0.7882817956366938], ["O75880", "SCO1", "Cytochrome c oxidase assembly factor SCO1", "Tier 1", 0.935, 1, "A_surface", 10, 77.75, 0, 0, null, null, 0, 0, null, 1, "mitochondrial complex IV deficiency, nuclear type 4", 0.7827872588103603], ["Q9NP58", "ABCB6", "ATP-binding cassette sub-family B member 6", "Tier 1", 0.934, 1, "A_surface", 16, 83.06, 1, 0, null, null, 0, 0, null, 1, "dyschromatosis universalis hereditaria 3", 0.7783407126197405], ["Q8N766", "EMC1", "ER membrane protein complex subunit 1", "Tier 1", 0.931, 1, "A_surface", 10, 87.44, 1, 0, null, null, 0, 0, null, 1, "cerebellar atrophy, visual impairment, and psychomotor retardation;", 0.7687056132401411], ["P78536", "ADAM17", "Disintegrin and metalloproteinase domain-containing protein 17", "Tier 1", 0.929, 1, "A_surface", 33, 72.69, 1, 0, null, null, 0, 0, null, 1, "neonatal inflammatory skin and bowel disease", 0.7624558659108367], ["Q9BVK8", "TMEM147", "BOS complex subunit TMEM147", "Tier 1", 0.928, 1, "A_surface", 3, 92.5, 1, 0, null, null, 0, 0, null, 1, "neurodevelopmental disorder with facial dysmorphism, absent language, and pseudo-pelger-huet anomaly", 0.7615388401822349], ["O95714", "HERC2", "E3 ubiquitin-protein ligase HERC2", "Tier 1", 0.925, 1, "A_surface", 15, null, 0, 0, null, null, 0, 0, null, 1, "developmental delay with autism spectrum disorder and gait instability", 0.74952129063985], ["P20963", "CD247", "T-cell surface glycoprotein CD3 zeta chain", "Tier 1", 0.923, 1, "A_surface", 38, 62.41, 1, 0, null, null, 0, 0, null, 1, "immunodeficiency 25", 0.7436838111879828], ["P55011", "SLC12A2", "Solute carrier family 12 member 2", "Tier 1", 0.92, 1, "A_surface", 14, 73.12, 1, 0, null, null, 0, 0, null, 1, "Delpire-McNeill syndrome", 0.7337659829979022], ["P03891", "MT-ND2", "NADH-ubiquinone oxidoreductase chain 2", "Tier 1", 0.91, 1, "A_surface", 7, 95.12, 1, 0, null, null, 0, 0, null, 1, "Leber hereditary optic neuropathy", 0.6993991624020442], ["Q8N1F7", "NUP93", "Nuclear pore complex protein Nup93", "Tier 1", 0.909, 1, "A_surface", 9, 79.88, 1, 0, null, null, 0, 0, null, 1, "nephrotic syndrome, type 12", 0.6970966479548709], ["O75787", "ATP6AP2", "Renin receptor", "Tier 1", 0.909, 1, "A_surface", 10, 79.19, 1, 0, null, null, 0, 0, null, 1, "syndromic X-linked intellectual disability Hedera type", 0.6955327890748848], ["P54289", "CACNA2D1", "Voltage-dependent calcium channel subunit alpha-2/delta-1", "Tier 1", 0.908, 1, "A_surface", 30, 86.56, 1, 0, null, null, 0, 0, null, 1, "Seizure", 0.6942469435259896], ["Q9NZ42", "PSENEN", "Gamma-secretase subunit PEN-2", "Tier 1", 0.905, 1, "A_surface", 27, 92.62, 1, 0, null, null, 0, 0, null, 1, "hidradenitis suppurativa", 0.6825090820129278], ["P19634", "SLC9A1", "Sodium/hydrogen exchanger 1", "Tier 1", 0.901, 1, "A_surface", 20, 67.56, 1, 0, null, null, 0, 0, null, 1, "Lichtenstein-Knorr syndrome", 0.6714801793153262], ["Q9Y6N7", "ROBO1", "Roundabout homolog 1", "Tier 1", 0.897, 1, "A_surface", 12, 60.0, 0, 0, null, null, 0, 0, null, 1, "neurooculorenal syndrome", 0.6567040910170603], ["P08172", "CHRM2", "Muscarinic acetylcholine receptor M2", "Tier 1", 0.889, 1, "A_surface", 17, 72.06, 1, 0, null, null, 0, 0, null, 1, "asthma", 0.6301982693270526], ["P43005", "SLC1A1", "Excitatory amino acid transporter 3", "Tier 1", 0.888, 1, "A_surface", 22, 80.12, 1, 0, null, null, 0, 0, null, 1, "dicarboxylic aminoaciduria", 0.6273449709512636], ["P01854", "IGHE", "Immunoglobulin heavy constant epsilon", "Tier 1", 0.888, 1, "A_surface", 35, 76.56, 1, 0, null, null, 0, 0, null, 1, "asthma", 0.6278691016373346], ["P31431", "SDC4", "Syndecan-4", "Tier 1", 0.885, 1, "A_surface", 5, 63.28, 0, 0, null, null, 0, 0, null, 1, "non-small cell lung carcinoma", 0.6168120240815278], ["P08913", "ADRA2A", "Alpha-2A adrenergic receptor", "Tier 1", 0.884, 1, "A_surface", 19, 70.19, 1, 0, null, null, 0, 0, null, 1, "asthma", 0.6126234478490361], ["P18577", "RHCE", "Blood group Rh(CE) polypeptide", "Tier 1", 0.883, 1, "A_surface", 8, 84.06, 1, 0, null, null, 0, 0, null, 1, "Rh deficiency syndrome", 0.6093164550623191], ["O95167", "NDUFA3", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3", "Tier 1", 0.882, 1, "A_surface", 7, 96.75, 1, 0, null, null, 0, 0, null, 1, "type 2 diabetes mellitus", 0.6070846413772282], ["P22001", "KCNA3", "Potassium voltage-gated channel subfamily A member 3", "Tier 1", 0.879, 1, "A_surface", 16, 72.0, 1, 0, null, null, 0, 0, null, 1, "multiple sclerosis", 0.5972177355344198], ["P55899", "FCGRT", "IgG receptor FcRn large subunit p51", "Tier 1", 0.878, 1, "A_surface", 31, 85.0, 1, 0, null, null, 0, 0, null, 1, "Myasthenia gravis", 0.5932721106551206], ["P20701", "ITGAL", "Integrin alpha-L", "Tier 1", 0.877, 1, "A_surface", 41, 82.62, 0, 0, null, null, 0, 0, null, 1, "psoriasis", 0.5899795223699872], ["P0DOY3", "IGLC3", "Immunoglobulin lambda constant 3", "Tier 1", 0.876, 1, "A_surface", 4, 96.06, 0, 0, null, null, 0, 0, null, 1, "cutaneous Leishmaniasis", 0.5868213846274001]], "truncated": false, "filtered_table_rows_count": 336, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_known_aptamer\" = :p0 and \"surface_class\" = :p1 and \"tier\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "0", "p1": "A_surface", "p2": "Tier 1"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&surface_class=A_surface&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 329, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=A_surface&tier=Tier+1&has_structure=1", "selected": false}, {"value": 0, "label": 0, "count": 7, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=A_surface&tier=Tier+1&has_structure=0", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&surface_class=A_surface&tier=Tier+1", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 336, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=A_surface", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&surface_class=A_surface&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 336, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=A_surface&tier=Tier+1&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&surface_class=A_surface&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 336, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=A_surface&tier=Tier+1", "selected": true}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&surface_class=A_surface&tier=Tier+1", "results": [{"value": "A_surface", "label": "A_surface", "count": 336, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&tier=Tier+1", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&surface_class=A_surface&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 209, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=A_surface&tier=Tier+1&in_cev_map=0", "selected": false}, {"value": 1, "label": 1, "count": 127, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=A_surface&tier=Tier+1&in_cev_map=1", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&surface_class=A_surface&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 193, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=A_surface&tier=Tier+1&has_cryoEM=1", "selected": false}, {"value": 0, "label": 0, "count": 143, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=A_surface&tier=Tier+1&has_cryoEM=0", "selected": false}], "truncated": false}}, "suggested_facets": [], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=A_surface&tier=Tier+1&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 1432.3810171335936, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}