{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_known_aptamer = 0, surface_class = \"B_cargo\" and tier = \"Tier 1\" sorted by evidence_priority descending", "rows": [["P43246", "MSH2", "DNA mismatch repair protein Msh2", "Tier 1", 0.766, 1, "B_cargo", 30, 85.31, 1, 0, null, null, 0, 0, null, 1, "Lynch syndrome", 0.8882239051809577], ["P01112", "HRAS", "GTPase HRas", "Tier 1", 0.765, 1, "B_cargo", 100, 91.94, 0, 1, "5P21", "4Q21", 0, 0, null, 1, "Costello syndrome", 0.8839339324666988], ["P15289", "ARSA", "Arylsulfatase A", "Tier 1", 0.763, 1, "B_cargo", 10, 96.12, 0, 0, null, null, 0, 0, null, 1, "metachromatic leukodystrophy", 0.8781786404283894], ["O15305", "PMM2", "Phosphomannomutase 2", "Tier 1", 0.761, 1, "B_cargo", 7, 96.44, 0, 0, null, null, 0, 0, null, 1, "PMM2-congenital disorder of glycosylation", 0.8687293837006977], ["P08559", "PDHA1", "Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial", "Tier 1", 0.758, 1, "B_cargo", 9, 94.5, 0, 0, null, null, 0, 0, null, 1, "pyruvate dehydrogenase E1-alpha deficiency", 0.8590861671403908], ["Q96RQ3", "MCCC1", "Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial", "Tier 1", 0.757, 1, "B_cargo", 14, 87.62, 1, 0, null, null, 0, 0, null, 1, "Isolated 3-methylcrotonyl-CoA carboxylase deficiency", 0.8573370131864518], ["P36507", "MAP2K2", "Dual specificity mitogen-activated protein kinase kinase 2", "Tier 1", 0.757, 1, "B_cargo", 3, 81.62, 0, 0, null, null, 0, 0, null, 1, "cardiofaciocutaneous syndrome", 0.8571797350022399], ["Q16595", "FXN", "Frataxin, mitochondrial", "Tier 1", 0.757, 1, "B_cargo", 20, 75.5, 1, 0, null, null, 0, 0, null, 1, "Friedreich ataxia", 0.8550760415889643], ["Q04656", "ATP7A", "Copper-transporting ATPase 1", "Tier 1", 0.757, 1, "B_cargo", 22, 73.38, 0, 0, null, null, 0, 0, null, 1, "Menkes disease", 0.8556218833987248], ["P00966", "ASS1", "Argininosuccinate synthase", "Tier 1", 0.756, 1, "B_cargo", 1, 95.5, 0, 0, null, null, 0, 0, null, 1, "citrullinemia type I", 0.8547319473775126], ["P11310", "ACADM", "Medium-chain specific acyl-CoA dehydrogenase, mitochondrial", "Tier 1", 0.756, 1, "B_cargo", 7, 93.38, 1, 0, null, null, 0, 0, null, 1, "medium chain acyl-CoA dehydrogenase deficiency", 0.8542618568274527], ["P30613", "PKLR", "Pyruvate kinase PKLR", "Tier 1", 0.756, 1, "B_cargo", 58, 90.69, 0, 0, null, null, 0, 0, null, 1, "pyruvate kinase deficiency of red cells", 0.8545857147634045], ["P46100", "ATRX", "Transcriptional regulator ATRX", "Tier 1", 0.755, 1, "B_cargo", 12, 51.81, 0, 0, null, null, 0, 0, null, 1, "alpha thalassemia-X-linked intellectual disability syndrome", 0.8486940552679562], ["P11217", "PYGM", "Glycogen phosphorylase, muscle form", "Tier 1", 0.754, 1, "B_cargo", 1, 94.31, 0, 0, null, null, 0, 0, null, 1, "glycogen storage disease V", 0.8482737151867437], ["Q12756", "KIF1A", "Kinesin-like protein KIF1A", "Tier 1", 0.754, 1, "B_cargo", 21, 70.5, 1, 0, null, null, 0, 0, null, 1, "intellectual disability, autosomal dominant 9", 0.8481151412193974], ["P51570", "GALK1", "Galactokinase", "Tier 1", 0.753, 1, "B_cargo", 20, 97.19, 0, 0, null, null, 0, 0, null, 1, "galactokinase deficiency", 0.8442002323363244], ["Q9HCC0", "MCCC2", "Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial", "Tier 1", 0.753, 1, "B_cargo", 14, 94.69, 1, 0, null, null, 0, 0, null, 1, "3-methylcrotonyl-CoA carboxylase 2 deficiency", 0.8437575319886195], ["Q9Y223", "GNE", "Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase", "Tier 1", 0.753, 1, "B_cargo", 5, 93.12, 0, 0, null, null, 0, 0, null, 1, "GNE myopathy", 0.8438241196803116], ["P51649", "ALDH5A1", "Succinate-semialdehyde dehydrogenase, mitochondrial", "Tier 1", 0.753, 1, "B_cargo", 5, 91.88, 0, 0, null, null, 0, 0, null, 1, "succinic semialdehyde dehydrogenase deficiency", 0.8435061416819137], ["P12694", "BCKDHA", "2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial", "Tier 1", 0.753, 1, "B_cargo", 24, 91.56, 0, 0, null, null, 0, 0, null, 1, "maple syrup urine disease type 1A", 0.8431584865455812], ["Q13144", "EIF2B5", "Translation initiation factor eIF2B subunit epsilon", "Tier 1", 0.752, 1, "B_cargo", 25, 78.75, 1, 0, null, null, 0, 0, null, 1, "CACH syndrome", 0.8411470079917355], ["P46777", "RPL5", "Large ribosomal subunit protein uL18", "Tier 1", 0.751, 1, "B_cargo", 30, 94.5, 1, 0, null, null, 0, 0, null, 1, "Blackfan-Diamond anemia", 0.8352702821155725], ["P16219", "ACADS", "Short-chain specific acyl-CoA dehydrogenase, mitochondrial", "Tier 1", 0.751, 1, "B_cargo", 4, 93.62, 1, 0, null, null, 0, 0, null, 1, "short chain acyl-CoA dehydrogenase deficiency", 0.8352413435265167], ["P07686", "HEXB", "Beta-hexosaminidase subunit beta", "Tier 1", 0.751, 1, "B_cargo", 8, 92.81, 0, 0, null, null, 0, 0, null, 1, "Sandhoff disease", 0.8358490853539441], ["P00367", "GLUD1", "Glutamate dehydrogenase 1, mitochondrial", "Tier 1", 0.751, 1, "B_cargo", 7, 90.25, 1, 0, null, null, 0, 0, null, 1, "hyperinsulinism-hyperammonemia syndrome", 0.8355052949188112], ["P49768", "PSEN1", "Presenilin-1", "Tier 1", 0.751, 1, "B_cargo", 27, 72.12, 1, 0, null, null, 0, 0, null, 1, "Alzheimer disease 3", 0.8373536811398027], ["Q9BX63", "BRIP1", "Fanconi anemia group J protein", "Tier 1", 0.751, 1, "B_cargo", 3, 63.88, 0, 0, null, null, 0, 0, null, 1, "Fanconi anemia complementation group J", 0.8380329286110476], ["P63261", "ACTG1", "Actin, cytoplasmic 2", "Tier 1", 0.75, 1, "B_cargo", 10, 95.38, 1, 0, null, null, 0, 0, null, 1, "Baraitser-Winter syndrome", 0.834386021888207], ["Q8TB36", "GDAP1", "Ganglioside-induced differentiation-associated protein 1", "Tier 1", 0.75, 1, "B_cargo", 8, 87.31, 0, 0, null, null, 0, 0, null, 1, "Autosomal recessive Charcot-Marie-Tooth disease with hoarseness", 0.8335233921018209], ["P06132", "UROD", "Uroporphyrinogen decarboxylase", "Tier 1", 0.749, 1, "B_cargo", 19, 96.75, 0, 0, null, null, 0, 0, null, 1, "Familial porphyria cutanea tarda", 0.8298171209078576], ["P51659", "HSD17B4", "Peroxisomal multifunctional enzyme type 2", "Tier 1", 0.749, 1, "B_cargo", 7, 89.0, 0, 0, null, null, 0, 0, null, 1, "d-bifunctional protein deficiency", 0.830341815259975], ["Q9UBK8", "MTRR", "Methionine synthase reductase", "Tier 1", 0.749, 1, "B_cargo", 2, 85.31, 0, 0, null, null, 0, 0, null, 1, "methylcobalamin deficiency type cblE", 0.8288259674381309], ["O14936", "CASK", "Peripheral plasma membrane protein CASK", "Tier 1", 0.749, 1, "B_cargo", 22, 78.94, 0, 0, null, null, 0, 0, null, 1, "X-linked intellectual disability, Najm type", 0.8302355593197244], ["P04075", "ALDOA", "Fructose-bisphosphate aldolase A", "Tier 1", 0.748, 1, "B_cargo", 8, 96.44, 0, 0, null, null, 0, 0, null, 1, "glycogen storage disease due to aldolase A deficiency", 0.826807229393595], ["P32322", "PYCR1", "Pyrroline-5-carboxylate reductase 1, mitochondrial", "Tier 1", 0.748, 1, "B_cargo", 47, 89.81, 0, 0, null, null, 0, 0, null, 1, "autosomal recessive cutis laxa type 2B", 0.826514119676127], ["P36776", "LONP1", "Lon protease homolog, mitochondrial", "Tier 1", 0.748, 1, "B_cargo", 29, 76.69, 1, 0, null, null, 0, 0, null, 1, "CODAS syndrome", 0.8273562128539942], ["Q7Z6Z7", "HUWE1", "E3 ubiquitin-protein ligase HUWE1", "Tier 1", 0.748, 1, "B_cargo", 19, null, 1, 0, null, null, 0, 0, null, 1, "intellectual disability, X-linked syndromic, Turner type", 0.8251574698433977], ["P00558", "PGK1", "Phosphoglycerate kinase 1", "Tier 1", 0.747, 1, "B_cargo", 30, 96.38, 0, 0, null, null, 0, 0, null, 1, "glycogen storage disease due to phosphoglycerate kinase 1 deficiency", 0.8228898260165487], ["Q71U36", "TUBA1A", "Tubulin alpha-1A chain", "Tier 1", 0.747, 1, "B_cargo", 15, 91.12, 1, 0, null, null, 0, 0, null, 1, "lissencephaly due to TUBA1A mutation", 0.8249848986700001], ["Q9UNE7", "STUB1", "E3 ubiquitin-protein ligase CHIP", "Tier 1", 0.747, 1, "B_cargo", 21, 89.31, 1, 0, null, null, 0, 0, null, 1, "autosomal recessive spinocerebellar ataxia 16", 0.8231010720948859], ["P09493", "TPM1", "Tropomyosin alpha-1 chain", "Tier 1", 0.746, 1, "B_cargo", 14, 91.62, 1, 0, null, null, 0, 0, null, 1, "hypertrophic cardiomyopathy", 0.8201717082603994], ["O43819", "SCO2", "Cytochrome c oxidase assembly factor SCO2", "Tier 1", 0.746, 1, "B_cargo", 1, 83.75, 0, 0, null, null, 0, 0, null, 1, "cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 1", 0.8204831517684852], ["Q8IYB7", "DIS3L2", "DIS3-like exonuclease 2", "Tier 1", 0.746, 1, "B_cargo", 4, 82.69, 1, 0, null, null, 0, 0, null, 1, "Perlman syndrome", 0.8206937660793029], ["Q8TEQ6", "GEMIN5", "Gem-associated protein 5", "Tier 1", 0.746, 1, "B_cargo", 16, 78.94, 1, 0, null, null, 0, 0, null, 1, "neurodevelopmental disorder with cerebellar atrophy and motor dysfunction", 0.8184088962562686], ["P09467", "FBP1", "Fructose-1,6-bisphosphatase 1", "Tier 1", 0.745, 1, "B_cargo", 51, 94.31, 0, 0, null, null, 0, 0, null, 1, "fructose-1,6-bisphosphatase deficiency", 0.8178590536523854], ["P18077", "RPL35A", "Large ribosomal subunit protein eL33", "Tier 1", 0.744, 1, "B_cargo", 30, 95.56, 1, 0, null, null, 0, 0, null, 1, "Blackfan-Diamond anemia", 0.8140112443681048], ["P50440", "GATM", "Glycine amidinotransferase, mitochondrial", "Tier 1", 0.744, 1, "B_cargo", 11, 89.62, 0, 0, null, null, 0, 0, null, 1, "AGAT deficiency", 0.8130880750586561], ["P17900", "GM2A", "Ganglioside GM2 activator", "Tier 1", 0.744, 1, "B_cargo", 8, 88.94, 0, 0, null, null, 0, 0, null, 1, "GM2-gangliosidosis, AB variant", 0.8134379375819221], ["Q13825", "AUH", "Methylglutaconyl-CoA hydratase, mitochondrial", "Tier 1", 0.744, 1, "B_cargo", 3, 85.69, 0, 0, null, null, 0, 0, null, 1, "3-methylglutaconic aciduria type 1", 0.8135711454915439], ["Q9UI10", "EIF2B4", "Translation initiation factor eIF2B subunit delta", "Tier 1", 0.744, 1, "B_cargo", 25, 76.5, 1, 0, null, null, 0, 0, null, 1, "CACH syndrome", 0.8146710778484454]], "truncated": false, "filtered_table_rows_count": 1570, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_known_aptamer\" = :p0 and \"surface_class\" = :p1 and \"tier\" = :p2 order by evidence_priority 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curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}