{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_known_aptamer = 0, surface_class = \"B_cargo\" and tier = \"Tier 1.5\" sorted by evidence_priority descending", "rows": [["P15848", "ARSB", "Arylsulfatase B", "Tier 1.5", 0.761, 1, "B_cargo", 1, 93.12, 0, 0, null, null, 0, 0, null, 1, "mucopolysaccharidosis type 6", 0.8708405439406184], ["P54802", "NAGLU", "Alpha-N-acetylglucosaminidase", "Tier 1.5", 0.761, 1, "B_cargo", 1, 96.75, 0, 0, null, null, 0, 0, null, 1, "mucopolysaccharidosis type 3B", 0.8688752515463204], ["P49748", "ACADVL", "Very long-chain acyl-CoA dehydrogenase, mitochondrial", "Tier 1.5", 0.76, 1, "B_cargo", 3, 90.25, 0, 0, null, null, 0, 0, null, 1, "very long chain acyl-CoA dehydrogenase deficiency", 0.8655785842544526], ["Q01968", "OCRL", "Inositol polyphosphate 5-phosphatase OCRL", "Tier 1.5", 0.759, 1, "B_cargo", 5, 82.56, 0, 0, null, null, 0, 0, null, 1, "oculocerebrorenal syndrome", 0.8639646099557533], ["P68133", "ACTA1", "Actin, alpha skeletal muscle", "Tier 1.5", 0.758, 1, "B_cargo", 5, 95.12, 1, 0, null, null, 0, 0, null, 1, "congenital myopathy 2a, typical, autosomal dominant", 0.8588441418736817], ["P30566", "ADSL", "Adenylosuccinate lyase", "Tier 1.5", 0.756, 1, "B_cargo", 4, 96.56, 0, 0, null, null, 0, 0, null, 1, "adenylosuccinate lyase deficiency", 0.8537075354730899], ["P35914", "HMGCL", "Hydroxymethylglutaryl-CoA lyase, mitochondrial", "Tier 1.5", 0.755, 1, "B_cargo", 4, 92.0, 0, 0, null, null, 0, 0, null, 1, "3-hydroxy-3-methylglutaric aciduria", 0.84972741897364], ["P51648", "ALDH3A2", "Aldehyde dehydrogenase family 3 member A2", "Tier 1.5", 0.755, 1, "B_cargo", 1, 96.62, 0, 0, null, null, 0, 0, null, 1, "Sj\u00f6gren-Larsson syndrome", 0.8498976178886021], ["Q14896", "MYBPC3", "Myosin-binding protein C, cardiac-type", "Tier 1.5", 0.755, 1, "B_cargo", 17, 78.81, 1, 0, null, null, 0, 0, null, 1, "hypertrophic cardiomyopathy", 0.8502637105703099], ["P30084", "ECHS1", "Enoyl-CoA hydratase, mitochondrial", "Tier 1.5", 0.755, 1, "B_cargo", 6, 91.69, 1, 0, null, null, 0, 0, null, 1, "mitochondrial short-chain Enoyl-Coa hydratase 1 deficiency", 0.8483381531913922], ["P50336", "PPOX", "Protoporphyrinogen oxidase", "Tier 1.5", 0.755, 1, "B_cargo", 3, 95.31, 0, 0, null, null, 0, 0, null, 1, "variegate porphyria", 0.8511493920751063], ["P36871", "PGM1", "Phosphoglucomutase-1", "Tier 1.5", 0.753, 1, "B_cargo", 16, 97.12, 0, 0, null, null, 0, 0, null, 1, "PGM1-congenital disorder of glycosylation", 0.843931261346685], ["O95571", "ETHE1", "Persulfide dioxygenase ETHE1, mitochondrial", "Tier 1.5", 0.752, 1, "B_cargo", 1, 92.88, 0, 0, null, null, 0, 0, null, 1, "ethylmalonic encephalopathy", 0.8389957647020829], ["P35573", "AGL", "Glycogen debranching enzyme", "Tier 1.5", 0.75, 1, "B_cargo", 1, 92.75, 1, 0, null, null, 0, 0, null, 1, "glycogen storage disease III", 0.8321686508777297], ["Q9Y4W6", "AFG3L2", "Mitochondrial inner membrane m-AAA protease component AFG3L2", "Tier 1.5", 0.75, 1, "B_cargo", 2, 76.75, 1, 0, null, null, 0, 0, null, 1, "spinocerebellar ataxia type 28", 0.8341800061294613], ["P54886", "ALDH18A1", "Delta-1-pyrroline-5-carboxylate synthase", "Tier 1.5", 0.75, 1, "B_cargo", 1, 84.19, 0, 0, null, null, 0, 0, null, 1, "ALDH18A1-related de Barsy syndrome", 0.8337004817329543], ["Q9H0F7", "ARL6", "ADP-ribosylation factor-like protein 6", "Tier 1.5", 0.749, 1, "B_cargo", 1, 94.69, 0, 0, null, null, 0, 0, null, 1, "Bardet-Biedl syndrome", 0.831055560105815], ["P02538", "KRT6A", "Keratin, type II cytoskeletal 6A", "Tier 1.5", 0.748, 1, "B_cargo", 1, 66.31, 0, 0, null, null, 0, 0, null, 1, "pachyonychia congenita", 0.8265917804295808], ["P55809", "OXCT1", "Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial", "Tier 1.5", 0.748, 1, "B_cargo", 1, 91.94, 0, 0, null, null, 0, 0, null, 1, "succinyl-CoA:3-ketoacid CoA transferase deficiency", 0.8271377770408165], ["Q8IWV7", "UBR1", "E3 ubiquitin-protein ligase UBR1", "Tier 1.5", 0.748, 1, "B_cargo", 5, 84.69, 0, 0, null, null, 0, 0, null, 1, "Johanson-Blizzard syndrome", 0.8277473176517505], ["Q9Y484", "WDR45", "WD repeat domain phosphoinositide-interacting protein 4", "Tier 1.5", 0.747, 1, "B_cargo", 3, 90.5, 1, 0, null, null, 0, 0, null, 1, "neurodegeneration with brain iron accumulation 5", 0.8230559793277397], ["P12955", "PEPD", "Xaa-Pro dipeptidase", "Tier 1.5", 0.747, 1, "B_cargo", 21, 97.44, 0, 0, null, null, 0, 0, null, 1, "prolidase deficiency", 0.8227965856258603], ["Q15833", "STXBP2", "Syntaxin-binding protein 2", "Tier 1.5", 0.747, 1, "B_cargo", 1, 90.0, 0, 0, null, null, 0, 0, null, 1, "Familial hemophagocytic lymphohistiocytosis", 0.8239664182555839], ["Q14739", "LBR", "Delta(14)-sterol reductase LBR", "Tier 1.5", 0.746, 1, "B_cargo", 1, 76.62, 0, 0, null, null, 0, 0, null, 1, "Greenberg dysplasia", 0.8198252534620432], ["O75027", "ABCB7", "Iron-sulfur clusters transporter ABCB7, mitochondrial", "Tier 1.5", 0.746, 1, "B_cargo", 1, 78.12, 1, 0, null, null, 0, 0, null, 1, "X-linked sideroblastic anemia with ataxia", 0.821045506234113], ["P08237", "PFKM", "ATP-dependent 6-phosphofructokinase, muscle type", "Tier 1.5", 0.746, 1, "B_cargo", 1, 91.69, 0, 0, null, null, 0, 0, null, 1, "glycogen storage disease VII", 0.8199812991737021], ["P38571", "LIPA", "Lysosomal acid lipase/cholesteryl ester hydrolase", "Tier 1.5", 0.745, 1, "B_cargo", 1, 91.56, 0, 0, null, null, 0, 0, null, 1, "cholesteryl ester storage disease", 0.8176913717992665], ["Q14938", "NFIX", "Nuclear factor 1 X-type", "Tier 1.5", 0.745, 1, "B_cargo", 3, 61.62, 0, 0, null, null, 0, 0, null, 1, "Malan overgrowth syndrome", 0.8156080181042044], ["P02549", "SPTA1", "Spectrin alpha chain, erythrocytic 1", "Tier 1.5", 0.745, 1, "B_cargo", 3, 76.38, 0, 0, null, null, 0, 0, null, 1, "elliptocytosis 2", 0.8153311905916062], ["P63267", "ACTG2", "Actin, gamma-enteric smooth muscle", "Tier 1.5", 0.745, 1, "B_cargo", 4, 95.38, 1, 0, null, null, 0, 0, null, 1, "visceral myopathy 1", 0.8175814609874555], ["P04080", "CSTB", "Cystatin-B", "Tier 1.5", 0.744, 1, "B_cargo", 3, 95.56, 0, 0, null, null, 0, 0, null, 1, "Unverricht-Lundborg disease", 0.8143874694671263], ["Q15738", "NSDHL", "Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating", "Tier 1.5", 0.744, 1, "B_cargo", 2, 88.62, 0, 0, null, null, 0, 0, null, 1, "CHILD syndrome", 0.81209434191833], ["O95822", "MLYCD", "Malonyl-CoA decarboxylase, mitochondrial", "Tier 1.5", 0.744, 1, "B_cargo", 2, 89.94, 0, 0, null, null, 0, 0, null, 1, "malonic aciduria", 0.8148554714603661], ["P51159", "RAB27A", "Ras-related protein Rab-27A", "Tier 1.5", 0.744, 1, "B_cargo", 11, 83.94, 1, 0, null, null, 0, 0, null, 1, "Griscelli syndrome type 2", 0.8139882966122653], ["Q01433", "AMPD2", "AMP deaminase 2", "Tier 1.5", 0.744, 1, "B_cargo", 4, 80.69, 0, 0, null, null, 0, 0, null, 1, "pontocerebellar hypoplasia type 9", 0.8149450703818453], ["Q14839", "CHD4", "ATP-dependent chromatin remodeler CHD4", "Tier 1.5", 0.743, 1, "B_cargo", 12, 64.62, 1, 0, null, null, 0, 0, null, 1, "Sifrim-Hitz-Weiss syndrome", 0.8103430577478806], ["Q8TCS8", "PNPT1", "Polyribonucleotide nucleotidyltransferase 1, mitochondrial", "Tier 1.5", 0.743, 1, "B_cargo", 11, 87.44, 1, 0, null, null, 0, 0, null, 1, "combined oxidative phosphorylation defect type 13", 0.8091107966912156], ["Q9UGM6", "WARS2", "Tryptophan--tRNA ligase, mitochondrial", "Tier 1.5", 0.743, 1, "B_cargo", 1, 89.75, 0, 0, null, null, 0, 0, null, 1, "neurodevelopmental disorder, mitochondrial, with abnormal movements and lactic acidosis, with or without seizures", 0.8094386747017313], ["P02533", "KRT14", "Keratin, type I cytoskeletal 14", "Tier 1.5", 0.743, 1, "B_cargo", 2, 73.25, 0, 0, null, null, 0, 0, null, 1, "epidermolysis bullosa simplex 1A, generalized severe", 0.8088593947918921], ["O43464", "HTRA2", "Serine protease HTRA2, mitochondrial", "Tier 1.5", 0.742, 1, "B_cargo", 13, 74.44, 1, 0, null, null, 0, 0, null, 1, "3-methylglutaconic aciduria type 8", 0.8079136325441377], ["Q14738", "PPP2R5D", "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform", "Tier 1.5", 0.742, 1, "B_cargo", 2, 79.94, 1, 0, null, null, 0, 0, null, 1, "Hogue-Janssens syndrome 1", 0.8058398703478188], ["Q15125", "EBP", "3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase", "Tier 1.5", 0.742, 1, "B_cargo", 4, 95.56, 1, 0, null, null, 0, 0, null, 1, "MEND syndrome", 0.8082510362309315], ["Q16836", "HADH", "Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial", "Tier 1.5", 0.742, 1, "B_cargo", 12, 96.81, 0, 0, null, null, 0, 0, null, 1, "Hyperinsulinism due to short chain 3-hydroxylacyl-CoA dehydrogenase deficiency", 0.8054501080547742], ["Q9UJS0", "SLC25A13", "Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial", "Tier 1.5", 0.742, 1, "B_cargo", 1, 82.31, 0, 0, null, null, 0, 0, null, 1, "neonatal intrahepatic cholestasis due to citrin deficiency", 0.8051027586554986], ["O95202", "LETM1", "Mitochondrial proton/calcium exchanger protein", "Tier 1.5", 0.742, 1, "B_cargo", 2, 66.56, 0, 0, null, null, 0, 0, null, 1, "neurodegeneration, childhood-onset, with multisystem involvement due to mitochondrial dysfunction", 0.8053871863850453], ["P51610", "HCFC1", "Host cell factor 1", "Tier 1.5", 0.741, 1, "B_cargo", 11, 46.41, 0, 0, null, null, 0, 0, null, 1, "methylmalonic acidemia with homocystinuria, type cblX", 0.8025576540875302], ["Q16854", "DGUOK", "Deoxyguanosine kinase, mitochondrial", "Tier 1.5", 0.741, 1, "B_cargo", 1, 86.06, 0, 0, null, null, 0, 0, null, 1, "mitochondrial DNA depletion syndrome 3 (hepatocerebral type)", 0.8027927477832228], ["Q14669", "TRIP12", "E3 ubiquitin-protein ligase TRIP12", "Tier 1.5", 0.739, 1, "B_cargo", 5, 66.75, 1, 0, null, null, 0, 0, null, 1, "Clark-Baraitser syndrome", 0.795639262535032], ["Q9Y4R8", "TELO2", "Telomere length regulation protein TEL2 homolog", "Tier 1.5", 0.739, 1, "B_cargo", 3, 83.88, 1, 0, null, null, 0, 0, null, 1, "TELO2-related intellectual disability-neurodevelopmental disorder", 0.7971337980726797], ["P10916", "MYL2", "Myosin regulatory light chain 2, ventricular/cardiac muscle isoform", "Tier 1.5", 0.738, 1, "B_cargo", 3, 83.5, 1, 0, null, null, 0, 0, null, 1, "hypertrophic cardiomyopathy", 0.7947577322969279]], "truncated": false, "filtered_table_rows_count": 1824, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_known_aptamer\" = :p0 and \"surface_class\" = :p1 and \"tier\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "0", "p1": "B_cargo", "p2": "Tier 1.5"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&surface_class=B_cargo&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 1055, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=B_cargo&tier=Tier+1.5&has_structure=0", "selected": false}, {"value": 1, "label": 1, "count": 769, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=B_cargo&tier=Tier+1.5&has_structure=1", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&surface_class=B_cargo&tier=Tier+1.5", "results": [{"value": "Tier 1.5", "label": "Tier 1.5", "count": 1824, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=B_cargo", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&surface_class=B_cargo&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 1824, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=B_cargo&tier=Tier+1.5&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&surface_class=B_cargo&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 1824, "toggle_url": "https://apt-scout.org/scout/v_targets.json?surface_class=B_cargo&tier=Tier+1.5", "selected": true}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&surface_class=B_cargo&tier=Tier+1.5", "results": [{"value": "B_cargo", "label": "B_cargo", "count": 1824, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&tier=Tier+1.5", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&surface_class=B_cargo&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 1080, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=B_cargo&tier=Tier+1.5&in_cev_map=0", "selected": false}, {"value": 1, "label": 1, "count": 744, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=B_cargo&tier=Tier+1.5&in_cev_map=1", "selected": false}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=0&surface_class=B_cargo&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 1593, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=B_cargo&tier=Tier+1.5&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 231, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=B_cargo&tier=Tier+1.5&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [{"name": "pdb_count_total", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=B_cargo&tier=Tier+1.5&_facet=pdb_count_total"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=0&surface_class=B_cargo&tier=Tier+1.5&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 1704.1019792668521, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}