{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_known_aptamer = 1 and in_cev_map = 0 sorted by priority_score descending", "rows": [["P23946", "CMA1", "Chymase", "Tier 1", 0.875, 42, 91.31, 0, 0, null, null, null, 1, 1, "30572223", 0, "pernicious anemia", 0.17348905136256007], ["P21583", "KITLG", "Kit ligand", "Tier 1.5", 0.848, 6, 71.88, 1, 0, null, null, null, 1, 2, "36579647,23967247", 0, "hyperpigmentation with or without hypopigmentation, familial progressive", 0.6756727302967072], ["A0A0E3EAY4", "env", "Envelope glycoprotein gp160", "Tier 1", 0.82, 2, null, 1, 0, null, null, null, 1, 12, "36576612,29464116,29217761,22379083,18776229,18569791,16146716,16043495,16013840,12498773,11024283,9713975", 0, null, null], ["Q00975", "CACNA1B", "Voltage-dependent N-type calcium channel subunit alpha-1B", "Tier 1.5", 0.807, 7, 59.91, 1, 0, null, null, null, 1, 2, "31118475,25782368", 0, "Seizure", 0.7217241968702018], ["P35414", "APLNR", "Apelin receptor", "Tier 1", 0.8, 37, 81.69, 1, 0, null, null, null, 1, 1, "36126144", 0, "essential hypertension", 0.2159614840844307], ["P01236", "PRL", "Prolactin", "Tier 1", 0.795, 12, 85.56, 0, 0, null, null, null, 1, 6, "40327044,30834248,29277631,28263753,27679852,16947086", 0, "AL amyloidosis", 0.4619748183558772], ["O14788", "TNFSF11", "Tumor necrosis factor ligand superfamily member 11", "Tier 1", 0.79, 2, 79.19, 0, 0, null, null, null, 1, 2, "15562003,41226313", 0, "osteoporosis", 0.6957850224892792], ["P03971", "AMH", "Anti-Muellerian hormone", "Tier 1.5", 0.783, 3, 68.62, 1, 0, null, null, null, 1, 2, "41101154,27364573", 0, "persistent Mullerian duct syndrome", 0.7847328444470535], ["P48023", "FASLG", "Tumor necrosis factor ligand superfamily member 6", "Tier 1.5", 0.775, 3, 80.19, 0, 0, null, null, null, 1, 1, "16581027", 0, "autoimmune lymphoproliferative syndrome type 1", 0.6984292519156657], ["P07911", "UMOD", "Uromodulin", "Tier 1", 0.774, 10, 82.94, 1, 0, null, null, null, 1, 4, "37533140,35446786", 0, "familial juvenile hyperuricemic nephropathy type 1", 0.8446536377993564], ["P26951", "IL3RA", "Interleukin-3 receptor subunit alpha", "Tier 1", 0.767, 4, 85.25, 0, 0, null, null, null, 1, 3, "40931580,36171541,31323275", 0, "acute myeloid leukemia", 0.46904332714118013], ["P40225", "THPO", "Thrombopoietin", "Tier 1", 0.76, 3, 61.44, 1, 0, null, null, null, 1, 2, "38928037,30312735", 0, "thrombocythemia 1", 0.7027329039559379], ["Q9GZU2", "PEG3", "Paternally-expressed gene 3 protein", "Tier 1.5", 0.75, 1, 44.53, 0, 0, null, null, null, 1, 1, "16595502", 0, "neurodegenerative disease", 0.34815912577489827], ["P18075", "BMP7", "Bone morphogenetic protein 7", "Tier 1.5", 0.749, 4, 76.19, 0, 0, null, null, null, 1, 1, "30537181", 0, "Inguinal hernia", 0.4420059023371716], ["Q9ULV1", "FZD4", "Frizzled-4", "Tier 1", 0.745, 11, 84.31, 1, 0, null, null, null, 1, 1, "18673242", 0, "Familial exudative vitreoretinopathy", 0.8152111103672746], ["P21730", "C5AR1", "C5a anaphylatoxin chemotactic receptor 1", "Tier 1", 0.741, 19, 85.75, 1, 0, null, null, null, 1, 5, "33495506,29981048,29327939,28288993,25901944", 0, "anti-neutrophil cytoplasmic antibody-associated vasculitis", 0.5076734733894334], ["Q9Y5C1", "ANGPTL3", "Angiopoietin-related protein 3", "Tier 1.5", 0.727, 1, 79.62, 0, 0, null, null, null, 1, 1, "23770039", 0, "familial hypobetalipoproteinemia 2", 0.6739043862507132], ["K7N5M4", "B2M", null, "Tier 1", 0.72, 24, 90.94, 0, 0, null, null, null, 1, 3, "41850110,40373155,38904251", 0, null, null], ["Q00604", "NDP", "Norrin", "Tier 1.5", 0.716, 11, 83.56, 1, 0, null, null, null, 1, 2, "39057719,11352723", 0, "Norrie disease", 0.8566451682188412], ["P42262", "GRIA2", "Glutamate receptor 2", "Tier 1", 0.715, 16, 84.94, 0, 0, null, null, null, 1, 4, "28325839,19417060,17929944,17024188", 0, "neurodevelopmental disorder with language impairment and behavioral abnormalities", 0.8328652004757138], ["P46094", "XCR1", "Chemokine XC receptor 1", "Tier 1.5", 0.715, 1, 84.94, 1, 0, null, null, null, 1, 1, "35212764", 0, "COVID-19", 0.459103766220463], ["P32239", "CCKBR", "Gastrin/cholecystokinin type B receptor", "Tier 1.5", 0.713, 5, 75.75, 1, 0, null, null, null, 1, 2, "33776434,27754762", 0, "gastroesophageal reflux disease", 0.4256110167566802], ["P20809", "IL11", "Interleukin-11", "Tier 1", 0.712, 8, 82.62, 1, 0, null, null, null, 1, 8, "39408993,39263947,28791655,27878687,25696907,24629635", 0, "osteoarthritis, hip", 0.31754029889853136], ["P25106", "ACKR3", "Atypical chemokine receptor 3", "Tier 1.5", 0.71, 14, 82.44, 1, 0, null, null, null, 1, 2, "40401615,28670693", 0, "oculomotor-abducens synkinesis", 0.49893280382434735], ["P14207", "FOLR2", "Folate receptor beta", "Tier 1", 0.701, 5, 89.12, 0, 0, null, null, null, 1, 2, "28686804", 0, "neoplasm", 0.11545394821329319], ["P15248", "IL9", "Interleukin-9", "Tier 1", 0.7, 5, 84.06, 0, 0, null, null, null, 1, 1, "40972397", 0, "neurodegenerative disease", 0.40148548290272756], ["P01374", "LTA", "Lymphotoxin-alpha", "Tier 1", 0.7, 3, 83.44, 0, 0, null, null, null, 1, 3, "41810142,30576605", 0, null, null], ["A0A0C5B5G6", "MT-RNR1", "Mitochondrial-derived peptide MOTS-c", "Tier 1.5", 0.7, 0, 72.06, 0, 0, null, null, null, 1, 1, "35311942", 0, null, null], ["P08620", "FGF4", "Fibroblast growth factor 4", "Tier 1.5", 0.7, 1, 81.5, 0, 0, null, null, null, 1, 3, "35415885,33536494,7547864", 0, "cancer", 0.6026669167438079], ["P15309", "ACP3", "Prostatic acid phosphatase", "Tier 1", 0.695, 17, 92.25, 1, 0, null, null, null, 1, 3, "41890985,25591398", 0, "prostate cancer", 0.5521391557206573], ["P21781", "FGF7", "Fibroblast growth factor 7", "Tier 1.5", 0.695, 0, 82.44, 0, 0, null, null, null, 1, 5, "35415885,15719578,7547864,16462265", 0, "cancer", 0.5963369026823151], ["Q95460", "MR1", "Major histocompatibility complex class I-related protein 1", "Tier 1", 0.693, 79, 87.5, 0, 0, null, null, null, 1, 2, "41134135,20000526", 0, "Immunodeficiency", 0.3336382138166145], ["Q9NPF0", "CD320", "CD320 antigen", "Tier 1", 0.69, 6, 63.81, 0, 0, null, null, null, 1, 1, "39493449", 0, "Methylmalonic aciduria due to transcobalamin receptor defect", 0.49918945650121177], ["P48061", "CXCL12", "Stromal cell-derived factor 1", "Tier 1", 0.685, 34, 83.25, 1, 0, null, null, null, 1, 36, "41951573,41931849,41907643,41527798,40401615,40008515,39865939,39263947,38806504,38477735,32784904,31267721,31097627,30465210,30385042,29111236,28963140,28670693,27940247,27924617,27392463,26265085,25560701,25236655,24526776,24277076,23615526,22376154,21147843,41963275", 0, "HIV-1 infection", 0.3675509850165065], ["Q6NW40", "RGMB", "Repulsive guidance molecule B", "Tier 1", 0.683, 11, 79.44, 1, 0, null, null, null, 1, 1, "39263947", 0, "Abnormality of the skeletal system", 0.42535629367019584], ["Q96RJ3", "TNFRSF13C", "Tumor necrosis factor receptor superfamily member 13C", "Tier 1.5", 0.681, 8, 63.03, 1, 0, null, null, null, 1, 1, "23470998", 0, "immunodeficiency, common variable, 4", 0.660711678987284], ["P39900", "MMP12", "Macrophage metalloelastase", "Tier 1", 0.68, 86, 86.94, 0, 0, null, null, null, 1, 8, "41861669,38477735,38296402,37015819,35120890,34183667,27530235", 0, "atopic eczema", 0.4795677061208266], ["P26718", "KLRK1", "NKG2-D type II integral membrane protein", "Tier 1.5", 0.679, 22, 79.19, 0, 0, null, null, null, 1, 1, "24629635", 0, "Behcet's syndrome", 0.18614538678991077], ["Q9UEF7", "KL", "Klotho", "Tier 1", 0.676, 6, 89.06, 1, 0, null, null, null, 1, 19, "41978019,41851110,41038766,40370992,39975897,39909827,38500260,38233588,37584531,36891771,36535944,35770801,35360393,34375633,33536505,31511614,25325398,18569791,40514411", 0, "type 2 diabetes mellitus", 0.5587488336100863], ["Q86Z14", "KLB", "Beta-klotho", "Tier 1", 0.676, 5, 89.38, 0, 0, null, null, null, 1, 1, "40514411", 0, "congenital hypogonadotropic hypogonadism", 0.462898767992589], ["P51681", "CCR5", "C-C chemokine receptor type 5", "Tier 1", 0.674, 25, 85.38, 1, 0, null, null, null, 1, 23, "36576612,33981364,29678881,29556342,29301363,27807347,27652575,26965267,25794434,25754473,25329893,23629001,22811524,21576818,18799178,16631118,16227301,15813986,14610191,12498773", 0, "HIV infection", 0.7442590579227027], ["P62576", "nanA", "Sialidase A", "Tier 1", 0.67, 5, 81.19, 0, 0, null, null, null, 1, 4, "37350189,34976356,34341854,32034503", 0, null, null], ["Q9GZX9", "TWSG1", "Twisted gastrulation protein homolog 1", "Tier 1", 0.67, 6, 80.38, 0, 0, null, null, null, 1, 1, "39299474", 0, "Abruptio Placentae", 0.29495361755469174], ["O95750", "FGF19", "Fibroblast growth factor 19", "Tier 1.5", 0.668, 4, 79.81, 0, 0, null, null, null, 1, 4, "35415885,31967847,27679852", 0, "cancer", 0.38540691230511315], ["O00744", "WNT10B", "Protein Wnt-10b", "Tier 1.5", 0.668, 0, 80.06, 0, 0, null, null, null, 1, 2, "32810272,18673242", 0, "Split hand-split foot malformation", 0.7755225395358214], ["P56704", "WNT3A", "Protein Wnt-3a", "Tier 1", 0.665, 4, 88.31, 1, 0, null, null, null, 1, 1, "37231925", 0, "neurodegenerative disease", 0.5271953966006525], ["Q9HCK4", "ROBO2", "Roundabout homolog 2", "Tier 1.5", 0.665, 6, 67.38, 0, 0, null, null, null, 1, 2, "40616090,31640794", 0, "familial vesicoureteral reflux", 0.6460375744556555], ["P05113", "IL5", "Interleukin-5", "Tier 1", 0.664, 5, 86.69, 1, 0, null, null, null, 1, 12, "40972397,35487180,35356877,34831332,32784904,32038731,29881374,28062796,26048585", 0, "asthma", 0.6399821251487101], ["O15169", "AXIN1", "Axin-1", "Tier 1", 0.664, 22, 61.09, 0, 0, null, null, null, 1, 2, "28129128", 0, "hepatocellular carcinoma", 0.7864172882686208], ["Q6PCB0", "VWA1", "von Willebrand factor A domain-containing protein 1", "Tier 1.5", 0.664, 0, 78.38, 0, 0, null, null, null, 1, 4, "41906877,41693575,38904251,38299345", 0, "neuronopathy, distal hereditary motor, autosomal recessive 7", 0.7420531156755253]], "truncated": false, "filtered_table_rows_count": 629, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "priority_score", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "drug_count_approved", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, priority_score, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, drug_count_approved, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_known_aptamer\" = :p0 and \"in_cev_map\" = :p1 order by priority_score desc limit 51", "params": {"p0": "1", "p1": "0"}}, "facet_results": {"tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 368, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&tier=Tier+1", "selected": false}, {"value": "Tier 1.5", "label": "Tier 1.5", "count": 261, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&tier=Tier+1.5", "selected": false}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0", "results": [{"value": 0, "label": 0, "count": 629, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0", "results": [{"value": 1, "label": 1, "count": 629, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0", "results": [{"value": 0, "label": 0, "count": 629, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0", "results": [{"value": 0, "label": 0, "count": 454, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 175, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 268.4892779943766, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}