{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_known_aptamer = 1, in_cev_map = 0 and surface_class = \"A2_pm_peripheral\" sorted by evidence_priority descending", "rows": [["P25054", "APC", "Adenomatous polyposis coli protein", "Tier 1", 0.644, 1, "A2_pm_peripheral", 31, null, 0, 0, null, null, 1, 39, "41471356,40788329,40207978,39796151,39335496,39189513,38710049,38509823,37199793,37185533,36894782,36882463,36827736,36252203,35544380,35490167,34837173,34708097,34240523,34008621,32486960,32429721,32386347,31937772,31295701,31249960,30609568,29886066,29666278,27736370,27427891,26552824,26552816,25059182,24681393,22236082,19389630,19029139,9546673", 0, "familial adenomatous polyposis 1", 0.8462165290909345], ["P15104", "GLUL", "Glutamine synthetase", "Tier 1.5", 0.622, 1, "A2_pm_peripheral", 12, 97.5, 1, 0, null, null, 1, 4, "39533430,30085248,21282981", 0, "congenital brain dysgenesis due to glutamine synthetase deficiency", 0.7733687702812198], ["P10636", "MAPT", "Microtubule-associated protein tau", "Tier 1", 0.618, 1, "A2_pm_peripheral", 100, 49.22, 1, 0, null, null, 1, 9, "40380000,39241336,38585969,38397086,37003060,31900535,30004544,29268187", 0, "Pick disease", 0.7600399335134378], ["P12643", "BMP2", "Bone morphogenetic protein 2", "Tier 1", 0.611, 1, "A2_pm_peripheral", 21, 79.56, 0, 0, null, null, 1, 10, "41144653,38542880,37231465,35591468,35195734,34067593,33997500", 0, "short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 1", 0.7361833785834584], ["O14640", "DVL1", "Segment polarity protein dishevelled homolog DVL-1", "Tier 1.5", 0.611, 1, "A2_pm_peripheral", 3, 59.84, 0, 0, null, null, 1, 1, "37231925", 0, "autosomal dominant Robinow syndrome", 0.7359277384599506], ["P41159", "LEP", "Leptin", "Tier 1", 0.606, 1, "A2_pm_peripheral", 10, 81.12, 1, 0, null, null, 1, 14, "40330320,40008515,39263947,37331044,36508319,36173490,35884340,34016094,33650854,32527800,27530235,26529285,23232067,20594164", 0, "obesity due to congenital leptin deficiency", 0.7197450249224271], ["Q2Q1W2", "TRIM71", "E3 ubiquitin-protein ligase TRIM71", "Tier 1.5", 0.578, 1, "A2_pm_peripheral", 2, 79.12, 0, 0, null, null, 1, 2, "31732746", 0, "hydrocephalus, congenital communicating, 1", 0.6276048232841862], ["P51813", "BMX", "Cytoplasmic tyrosine-protein kinase BMX", "Tier 1", 0.555, 1, "A2_pm_peripheral", 6, 75.75, 0, 0, null, null, 1, 1, "34962102", 0, "alopecia areata", 0.5491699656070116], ["Q96RU8", "TRIB1", "Tribbles homolog 1", "Tier 1", 0.552, 1, "A2_pm_peripheral", 5, 76.56, 0, 0, null, null, 1, 1, "36579647", 0, "neurodegenerative disease", 0.5397808385585621], ["Q5TC82", "RC3H1", "Roquin-1", "Tier 1", 0.545, 1, "A2_pm_peripheral", 6, 61.12, 0, 0, null, null, 1, 2, "27010430", 0, "hemophagocytic lymphohistiocytosis, familial, 6", 0.5161798637096334], ["Q96AT9", "RPE", "Ribulose-phosphate 3-epimerase", "Tier 1", 0.54, 1, "A2_pm_peripheral", 4, 96.56, 0, 0, null, null, 1, 19, "37958909,31080896,26923800,25270019,23539459,22913867,22710369,22281826,21701525,21546514,21448811,21137477,20623466,19197318,18628724,18441313,17891009,17369776,16815269", 0, "neurodegenerative disease", 0.4992627094132485], ["Q96MU7", "YTHDC1", "YTH domain-containing protein 1", "Tier 1", 0.533, 1, "A2_pm_peripheral", 100, 60.34, 0, 0, null, null, 1, 1, "41430607", 0, "neurodegenerative disease", 0.47698771849556626], ["P43351", "RAD52", "DNA repair protein RAD52 homolog", "Tier 1", 0.528, 1, "A2_pm_peripheral", 11, 69.62, 1, 0, null, null, 1, 6, "37288783,32945515,31495919,26784987,24500205,23836560", 0, "Abnormality of the skeletal system", 0.45994164258033876], ["Q9Y2K6", "USP20", "Ubiquitin carboxyl-terminal hydrolase 20", "Tier 1.5", 0.509, 1, "A2_pm_peripheral", 1, 72.31, 0, 0, null, null, 1, 1, "30863411", 0, "connective tissue neoplasm", 0.3981371748391643], ["O75182", "SIN3B", "Paired amphipathic helix protein Sin3b", "Tier 1.5", 0.501, 1, "A2_pm_peripheral", 4, 68.0, 1, 0, null, null, 1, 2, "16914451", 0, "syndromic intellectual disability", 0.37050380432141355], ["P32298", "GRK4", "G protein-coupled receptor kinase 4", "Tier 1.5", 0.49, 1, "A2_pm_peripheral", 1, 88.69, 0, 0, null, null, 1, 2, "31555351", 0, "Nausea and vomiting", 0.33267400228074584], ["Q13569", "TDG", "G/T mismatch-specific thymine DNA glycosylase", "Tier 1", 0.472, 1, "A2_pm_peripheral", 21, 70.19, 0, 0, null, null, 1, 5, "34906054,33568907,33015024,32649855,32280216", 0, "venous thromboembolism", 0.2744822808753576], ["P55089", "UCN", "Urocortin", "Tier 1.5", 0.469, 1, "A2_pm_peripheral", 6, 68.25, 1, 0, null, null, 1, 3, "30221506,26488412,23248006", 0, "neurodegenerative disease", 0.26311734927710556], ["Q9NYZ3", "GTSE1", "G2 and S phase-expressed protein 1", "Tier 1", 0.462, 1, "A2_pm_peripheral", 2, 50.94, 0, 0, null, null, 1, 1, "41902775", 0, "Paroxysmal supraventricular tachycardia", 0.240265138515043], ["P19957", "PI3", "Elafin", "Tier 1.5", 0.446, 1, "A2_pm_peripheral", 3, 72.25, 0, 0, null, null, 1, 3, "37351609,36517803,30087279", 0, "Abruptio Placentae", 0.18626794135552627], ["P01887", "B2m", "Beta-2-microglobulin", "Tier 1", 0.39, 1, "A2_pm_peripheral", 100, 93.81, 0, 0, null, null, 1, 15, "41850110,40373155,38904251,40658810,35026285,32631049,29281176,28960840,25100729,20616783,19137104,17878167", 0, null, null], ["P16213", "B2M", "Beta-2-microglobulin", "Tier 1", 0.39, 1, "A2_pm_peripheral", 9, 94.19, 0, 0, null, null, 1, 15, "41850110,40373155,38904251,40658810,35026285,32631049,29281176,28960840,25100729,20616783,19137104,17878167", 0, null, null], ["K7N5M4", "B2M", null, "Tier 1", 0.39, 1, "A2_pm_peripheral", 24, 90.94, 0, 0, null, null, 1, 3, "41850110,40373155,38904251", 0, null, null], ["K7N5M3", "B2M", null, "Tier 1", 0.39, 1, "A2_pm_peripheral", 22, 87.81, 0, 0, null, null, 1, 3, "41850110,40373155,38904251", 0, null, null], ["P16110", "Lgals3", "Galectin-3", "Tier 1", 0.39, 1, "A2_pm_peripheral", 5, 72.44, 0, 0, null, null, 1, 4, "39681229,31418072", 0, null, null], ["A0A2K6KCS5", "YTHDC1", "YTH domain-containing family protein", "Tier 1", 0.39, 1, "A2_pm_peripheral", 2, 53.59, 0, 0, null, null, 1, 1, "41430607", 0, null, null], ["Q9H4F8", "SMOC1", "SPARC-related modular calcium-binding protein 1", "Tier 1.5", 0.388, 0, "A2_pm_peripheral", 0, 73.31, 0, 0, null, null, 1, 1, "36333824", 0, "microphthalmia with limb anomalies", 0.8103774498041117], ["Q9UHK6", "AMACR", "Alpha-methylacyl-CoA racemase", "Tier 1.5", 0.374, 0, "A2_pm_peripheral", 0, 95.81, 0, 0, null, null, 1, 10, "40271962,35780537,35539643,26547498,24994506", 0, "Alpha-methylacyl-CoA racemase deficiency", 0.762086344446303], ["O14543", "SOCS3", "Suppressor of cytokine signaling 3", "Tier 1.5", 0.287, 0, "A2_pm_peripheral", 0, 71.88, 0, 0, null, null, 1, 2, "39571081", 0, "neurodegenerative disease", 0.47223972419523075], ["Q9P2M7", "CGN", "Cingulin", "Tier 1.5", 0.251, 0, "A2_pm_peripheral", 0, 69.56, 0, 0, null, null, 1, 3, "35297595,33476120,21342520", 0, "Abnormality of the skeletal system", 0.3547927821140923], ["Q8WW22", "DNAJA4", "DnaJ homolog subfamily A member 4", "Tier 1.5", 0.241, 0, "A2_pm_peripheral", 0, 84.44, 0, 0, null, null, 1, 2, "41935727,33879515", 0, "coronary atherosclerosis", 0.3210951574534216], ["Q9Y5Z7", "HCFC2", "Host cell factor 2", "Tier 1.5", 0.235, 0, "A2_pm_peripheral", 0, 72.88, 0, 0, null, null, 1, 24, "41651417,41187655,40586934,40410820,40371468,38829419,38471488,36836536,36517803,36480517,34132569,32981365,32884147,32157871,32101978,31985806,31077760,25534780,23770039,20967861,20445260,19195013,15629041,12177446", 0, "neurodegenerative disease", 0.29928415571034084], ["Q6XZB0", "LIPI", "Lipase member I", "Tier 1.5", 0.215, 0, "A2_pm_peripheral", 0, 89.44, 0, 0, null, null, 1, 2, "32981012,27715478", 0, "metabolic disease", 0.23399905961107478], ["Q8N143", "BCL6B", "B-cell CLL/lymphoma 6 member B protein", "Tier 1.5", 0.199, 0, "A2_pm_peripheral", 0, 54.31, 0, 0, null, null, 1, 1, "41169059", 0, "tympanic membrane perforation", 0.18130132303178323], ["Q16206", "ENOX2", "Ecto-NOX disulfide-thiol exchanger 2", "Tier 1.5", 0.167, 0, "A2_pm_peripheral", 0, 77.06, 0, 0, null, null, 1, 2, "37504074", 0, "chronic myelogenous leukemia", 0.0726224414455439], ["O77932", "DXO", "Decapping and exoribonuclease protein", "Tier 1.5", 0.161, 0, "A2_pm_peripheral", 0, 92.69, 0, 0, null, null, 1, 2, "27432610", 0, "breast cancer", 0.05174117965585824]], "truncated": false, "filtered_table_rows_count": 36, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_known_aptamer\" = :p0 and \"in_cev_map\" = :p1 and \"surface_class\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "1", "p1": "0", "p2": "A2_pm_peripheral"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&surface_class=A2_pm_peripheral", "results": [{"value": 1, "label": 1, "count": 26, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&surface_class=A2_pm_peripheral&has_structure=1", "selected": false}, {"value": 0, "label": 0, "count": 10, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&surface_class=A2_pm_peripheral&has_structure=0", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&surface_class=A2_pm_peripheral", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 18, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&surface_class=A2_pm_peripheral&tier=Tier+1", "selected": false}, {"value": "Tier 1.5", "label": "Tier 1.5", "count": 18, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&surface_class=A2_pm_peripheral&tier=Tier+1.5", "selected": false}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&surface_class=A2_pm_peripheral", "results": [{"value": 0, "label": 0, "count": 36, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&surface_class=A2_pm_peripheral&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&surface_class=A2_pm_peripheral", "results": [{"value": 1, "label": 1, "count": 36, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=A2_pm_peripheral", "selected": true}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&surface_class=A2_pm_peripheral", "results": [{"value": "A2_pm_peripheral", "label": "A2_pm_peripheral", "count": 36, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&surface_class=A2_pm_peripheral", "results": [{"value": 0, "label": 0, "count": 36, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A2_pm_peripheral", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&surface_class=A2_pm_peripheral", "results": [{"value": 0, "label": 0, "count": 30, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&surface_class=A2_pm_peripheral&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 6, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&surface_class=A2_pm_peripheral&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [{"name": "evidence_priority", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&surface_class=A2_pm_peripheral&_facet=evidence_priority"}, {"name": "pdb_count_total", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&surface_class=A2_pm_peripheral&_facet=pdb_count_total"}, {"name": "aptamer_count_pubmed", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&surface_class=A2_pm_peripheral&_facet=aptamer_count_pubmed"}, {"name": "opentargets_top_disease_name", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&surface_class=A2_pm_peripheral&_facet=opentargets_top_disease_name"}], "next": null, "next_url": null, "private": false, "allow_execute_sql": true, "query_ms": 778.1168660148978, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}