{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_known_aptamer = 1, in_cev_map = 0 and surface_class = \"A_surface\" sorted by evidence_priority descending", "rows": [["P13569", "CFTR", "Cystic fibrosis transmembrane conductance regulator", "Tier 1", 0.824, 1, "A_surface", 58, 75.62, 1, 0, null, null, 1, 10, "41148207,31029337,30595527,22483890,15657417", 0, "cystic fibrosis", 0.9133535862571094], ["P07949", "RET", "Proto-oncogene tyrosine-protein kinase receptor Ret", "Tier 1", 0.809, 1, "A_surface", 34, 78.81, 1, 0, null, null, 1, 83, "41962371,41744190,41636718,41526122,41406741,41171123,41082837,41060784,41027166,40932619,40815127,40711581,40633058,40602121,40410423,40285964,40252505,40222299,39344894,39288589,39190775,38953438,38876068,38852325,38718747,38604287,38354543,38282384,38237282,37851382,37774402,37757695,37437453,37245460,36952259,36315022,35550937,35420408,34342436,34132907,34016094,33513536,33462661,33119785,33011620,32760976,32527800,32212604,32138930,31897454", 0, "medullary thyroid gland carcinoma", 0.8617460262224842], ["Q12809", "KCNH2", "Voltage-gated inwardly rectifying potassium channel KCNH2", "Tier 1", 0.806, 1, "A_surface", 23, 62.75, 1, 0, null, null, 1, 1, "22617876", 0, "Romano-Ward syndrome", 0.8549238933917284], ["P31785", "IL2RG", "Cytokine receptor common subunit gamma", "Tier 1.5", 0.804, 1, "A_surface", 14, 75.5, 1, 0, null, null, 1, 2, "30800133,33869115", 0, "gamma chain deficiency", 0.8469997000418428], ["P08100", "RHO", "Rhodopsin", "Tier 1.5", 0.804, 1, "A_surface", 4, 88.75, 1, 0, null, null, 1, 45, "41963275,41924874,41636061,40808302,40642289,40330320,40045571,39863313,39788632,38070612,37191882,36705086,36696850,36095194,36049339,35622174,34709779,34471566,32696702,32479610,32319623,32119944,31737572,31588238,31535128,29570714,29281176,28648779,27893356,25645980,23757206,23701883,25033804,22689339,22302221,22121695,19766091,19389625,16419035,12123800,8743323,7678562,19188685,18230760", 0, "retinitis pigmentosa", 0.8481942240861982], ["P07911", "UMOD", "Uromodulin", "Tier 1", 0.803, 1, "A_surface", 10, 82.94, 1, 0, null, null, 1, 4, "37533140,35446786", 0, "familial juvenile hyperuricemic nephropathy type 1", 0.8446536377993564], ["P07333", "CSF1R", "Macrophage colony-stimulating factor 1 receptor", "Tier 1", 0.802, 1, "A_surface", 26, 77.81, 0, 0, null, null, 1, 1, "29277631", 0, "leukoencephalopathy, diffuse hereditary, with spheroids 1", 0.8391971566583056], ["O95342", "ABCB11", "Bile salt export pump", "Tier 1.5", 0.801, 1, "A_surface", 8, 83.12, 1, 0, null, null, 1, 1, "36313979", 0, "progressive familial intrahepatic cholestasis type 2", 0.8372060401943777], ["P42262", "GRIA2", "Glutamate receptor 2", "Tier 1", 0.8, 1, "A_surface", 16, 84.94, 0, 0, null, null, 1, 4, "28325839,19417060,17929944,17024188", 0, "neurodevelopmental disorder with language impairment and behavioral abnormalities", 0.8328652004757138], ["P16473", "TSHR", "Thyrotropin receptor", "Tier 1", 0.8, 1, "A_surface", 9, 74.0, 1, 0, null, null, 1, 6, "41054857,40997970,40588369,38650837", 0, "hypothyroidism due to TSH receptor mutations", 0.8327127196409464], ["Q92736", "RYR2", "Ryanodine receptor 2", "Tier 1", 0.8, 1, "A_surface", 26, null, 1, 0, null, null, 1, 1, "24130701", 0, "catecholaminergic polymorphic ventricular tachycardia 1", 0.8338648743498255], ["P10912", "GHR", "Growth hormone receptor", "Tier 1.5", 0.799, 1, "A_surface", 9, 58.69, 0, 0, null, null, 1, 5, "38811951,38477735,31603904", 0, "Laron syndrome", 0.8304020079647765], ["Q9ULV1", "FZD4", "Frizzled-4", "Tier 1", 0.795, 1, "A_surface", 11, 84.31, 1, 0, null, null, 1, 1, "18673242", 0, "Familial exudative vitreoretinopathy", 0.8152111103672746], ["Q13651", "IL10RA", "Interleukin-10 receptor subunit alpha", "Tier 1", 0.795, 1, "A_surface", 7, 62.0, 1, 0, null, null, 1, 2, "25870409,25558474", 0, "Autosomal recessive early-onset inflammatory bowel disease", 0.8151052076044897], ["Q01974", "ROR2", "Tyrosine-protein kinase transmembrane receptor ROR2", "Tier 1", 0.794, 1, "A_surface", 6, 68.31, 0, 0, null, null, 1, 2, "41782379,18673242", 0, "autosomal recessive Robinow syndrome", 0.8145559265435566], ["Q9UM73", "ALK", "ALK tyrosine kinase receptor", "Tier 1", 0.791, 1, "A_surface", 79, 68.19, 0, 0, null, null, 1, 6, "40347134,38604287,32218299,29205808,24116381,21281497", 0, "neuroblastoma", 0.8016889264946979], ["Q4KMG0", "CDON", "Cell adhesion molecule-related/down-regulated by oncogenes", "Tier 1", 0.79, 1, "A_surface", 3, 62.03, 0, 0, null, null, 1, 3, "36333824,24629635,18698484", 0, "holoprosencephaly", 0.800378039564866], ["P16410", "CTLA4", "Cytotoxic T-lymphocyte protein 4", "Tier 1.5", 0.787, 1, "A_surface", 22, 80.12, 0, 0, null, null, 1, 26, "41907643,40972397,40870970,40811947,40536609,39417693,38473398,38158454,36966395,36831533,36603108,36015348,33970170,32929022,32840510,32280743,32024070,31405808,28918052,28082399,26030229,25565435,24892807,23460536,23460531,14612549", 0, "autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency", 0.7906408646569979], ["P22223", "CDH3", "Cadherin-3", "Tier 1", 0.786, 1, "A_surface", 19, 76.75, 0, 0, null, null, 1, 1, "41304780", 0, "EEM syndrome", 0.7851776755128059], ["Q96MS0", "ROBO3", "Roundabout homolog 3", "Tier 1.5", 0.784, 1, "A_surface", 3, 63.69, 0, 0, null, null, 1, 2, "32369590", 0, "horizontal gaze palsy with progressive scoliosis", 0.7813306356858872], ["P43220", "GLP1R", "Glucagon-like peptide 1 receptor", "Tier 1", 0.78, 1, "A_surface", 70, 81.5, 1, 0, null, null, 1, 2, "40691365,30957581", 0, "type 2 diabetes mellitus", 0.7667004144705459], ["P51654", "GPC3", "Glypican-3", "Tier 1.5", 0.779, 1, "A_surface", 4, 75.06, 1, 0, null, null, 1, 65, "42083729,41790019,41653459,41045695,40825648,40722645,39998646,39874791,39608318,39427046,38910291,38787447,38621313,38368644,37665421,36903516,36457288,36317566,36072763,35788872,35699181,35477501,35051745,34974867,34306031,33254049,33080969,32356075,30347351,30122918,29675356,29605994,29277631,27601357,28263753", 0, "Simpson-Golabi-Behmel syndrome type 1", 0.762708583613362], ["P20023", "CR2", "Complement receptor type 2", "Tier 1.5", 0.776, 1, "A_surface", 9, 74.94, 1, 0, null, null, 1, 1, "33235290", 0, "immunodeficiency, common variable, 7", 0.7543125403898414], ["P26678", "PLN", "Phospholamban", "Tier 1", 0.775, 1, "A_surface", 7, 81.88, 0, 0, null, null, 1, 9, "39536855,32382487,30777430,25240642,21848510,19158349", 0, "hypertrophic cardiomyopathy", 0.750557685745381], ["Q9HBE5", "IL21R", "Interleukin-21 receptor", "Tier 1", 0.775, 1, "A_surface", 6, 64.12, 0, 0, null, null, 1, 2, "30800133,29244152", 0, "Cryptosporidiosis - chronic cholangitis - liver disease", 0.7501392499286187], ["Q9Y6Q6", "TNFRSF11A", "Tumor necrosis factor receptor superfamily member 11A", "Tier 1", 0.775, 1, "A_surface", 1, 58.91, 0, 0, null, null, 1, 1, "15562003", 0, "Osteopetrosis - hypogammaglobulinemia", 0.7487328542164448], ["P04035", "HMGCR", "3-hydroxy-3-methylglutaryl-coenzyme A reductase", "Tier 1", 0.774, 1, "A_surface", 24, 75.31, 1, 0, null, null, 1, 1, "36470581", 0, "Hypercholesterolemia", 0.7460937406970991], ["P40126", "DCT", "L-dopachrome tautomerase", "Tier 1.5", 0.774, 1, "A_surface", 1, 89.12, 0, 0, null, null, 1, 1, "27245069", 0, "oculocutaneous albinism type 8", 0.7468868816172217], ["P51681", "CCR5", "C-C chemokine receptor type 5", "Tier 1", 0.773, 1, "A_surface", 25, 85.38, 1, 0, null, null, 1, 23, "36576612,33981364,29678881,29556342,29301363,27807347,27652575,26965267,25794434,25754473,25329893,23629001,22811524,21576818,18799178,16631118,16227301,15813986,14610191,12498773", 0, "HIV infection", 0.7442590579227027], ["Q9NR97", "TLR8", "Toll-like receptor 8", "Tier 1", 0.771, 1, "A_surface", 39, 86.12, 0, 0, null, null, 1, 4, "40085160,39956743", 0, "immunodeficiency 98 with autoinflammation, X-linked", 0.7360623201088097], ["P21860", "ERBB3", "Receptor tyrosine-protein kinase erbB-3", "Tier 1", 0.77, 1, "A_surface", 23, 72.44, 1, 0, null, null, 1, 9, "40851486,33770580,33039492,31846731,31626948,29440899,23990977,22733765,18942860", 0, "visceral neuropathy, familial, 1, autosomal recessive", 0.7335342096528644], ["P08887", "IL6R", "Interleukin-6 receptor subunit alpha", "Tier 1.5", 0.768, 1, "A_surface", 10, 77.88, 1, 0, null, null, 1, 18, "40853309,38152968,37034659,36579647,35890412,33590853,33340765,32515246,29211023,28929152,26552813,26383776,24481022,24440854,23235494,22503683,22258147,22094809", 0, "rheumatoid arthritis", 0.7269057706798291], ["Q00975", "CACNA1B", "Voltage-dependent N-type calcium channel subunit alpha-1B", "Tier 1.5", 0.767, 1, "A_surface", 7, 59.91, 1, 0, null, null, 1, 2, "31118475,25782368", 0, "Seizure", 0.7217241968702018], ["P47871", "GCGR", "Glucagon receptor", "Tier 1", 0.766, 1, "A_surface", 27, 81.88, 1, 0, null, null, 1, 5, "28775305,23770039,23744070", 0, "GCGR-related hyperglucagonemia", 0.7213152740071143], ["P26842", "CD27", "CD27 antigen", "Tier 1", 0.763, 1, "A_surface", 5, 71.69, 0, 0, null, null, 1, 3, "39841045,30609550,26320067", 0, "lymphoproliferative syndrome 2", 0.7084378623696481], ["P40225", "THPO", "Thrombopoietin", "Tier 1", 0.761, 1, "A_surface", 3, 61.44, 1, 0, null, null, 1, 2, "38928037,30312735", 0, "thrombocythemia 1", 0.7027329039559379], ["P15941", "MUC1", "Mucin-1", "Tier 1", 0.761, 1, "A_surface", 23, 47.41, 0, 0, null, null, 1, 686, "42025056,41988862,41954302,41771296,41744704,41744190,41657320,41627316,41621292,41582516,41535857,41471303,41362016,41352919,41346179,41330302,41243570,41205458,41185018,41101154,41047832,41027169,40682599,40665615,40627939,40607530,40590839,40578633,40568899,40556592,40504676,40500890,40499867,40479828,40432219,40422041,40360093,40286646,40274149,40158809,40119836,39978149,39910821,39705316,39679901,39626346,39579679,39566700,39552005,39550818,41997681,41247195,40813258,39454542,39454415,39440615,39421884,39406784,39256285,39243449,39154820,39142532,39136402,39119745,39118454,38923850,38912896", 0, "tubulointerstitial kidney disease, autosomal dominant, 2", 0.7040398435219726], ["P48023", "FASLG", "Tumor necrosis factor ligand superfamily member 6", "Tier 1.5", 0.76, 1, "A_surface", 3, 80.19, 0, 0, null, null, 1, 1, "16581027", 0, "autoimmune lymphoproliferative syndrome type 1", 0.6984292519156657], ["O14788", "TNFSF11", "Tumor necrosis factor ligand superfamily member 11", "Tier 1", 0.759, 1, "A_surface", 2, 79.19, 0, 0, null, null, 1, 2, "15562003,41226313", 0, "osteoporosis", 0.6957850224892792], ["Q9BYF1", "ACE2", "Angiotensin-converting enzyme 2", "Tier 1", 0.758, 1, "A_surface", 100, 90.69, 1, 0, null, null, 1, 91, "41716474,41541792,41274248,40642289,40333723,40321580,40227272,39964138,39923730,39281706,38973558,38553521,37932762,37808754,37692001,37666993,37385465,37375202,36950312,36822303,36714461,36683236,36581924,36073793,35972202,35910791,35907639,35542182,34876524,34855379,34847324,34798263,34696413,34619249,34458322,34282416,34248841,34230708,34230707,34166652,34123223,33684258,33683787,33629859,33561300,33389440,32981365,32838280,32551560,36288301,36170362,35748608,34953639", 0, "COVID-19", 0.6925739512122528], ["P15391", "CD19", "B-lymphocyte antigen CD19", "Tier 1.5", 0.755, 1, "A_surface", 4, 62.22, 1, 0, null, null, 1, 13, "41079126,40652441,38661725,38148412,36095289,35829681,34680368,34364920,32401486,31912987,29928472,21127492", 0, "immunodeficiency, common variable, 3", 0.6821072538733047], ["P32970", "CD70", "CD70 antigen", "Tier 1.5", 0.75, 1, "A_surface", 1, 83.19, 0, 0, null, null, 1, 1, "30609550", 0, "severe combined immunodeficiency due to CD70 deficiency", 0.6651491980619259], ["Q96RJ3", "TNFRSF13C", "Tumor necrosis factor receptor superfamily member 13C", "Tier 1.5", 0.748, 1, "A_surface", 8, 63.03, 1, 0, null, null, 1, 1, "23470998", 0, "immunodeficiency, common variable, 4", 0.660711678987284], ["Q9HCK4", "ROBO2", "Roundabout homolog 2", "Tier 1.5", 0.744, 1, "A_surface", 6, 67.38, 0, 0, null, null, 1, 2, "40616090,31640794", 0, "familial vesicoureteral reflux", 0.6460375744556555], ["P48551", "IFNAR2", "Interferon alpha/beta receptor 2", "Tier 1", 0.743, 1, "A_surface", 9, 64.44, 0, 0, null, null, 1, 1, "35212764", 0, "COVID-19", 0.6417504201511338], ["P21554", "CNR1", "Cannabinoid receptor 1", "Tier 1", 0.741, 1, "A_surface", 32, 71.69, 1, 0, null, null, 1, 1, "19231809", 0, "obesity", 0.6357831368051927], ["Q15116", "PDCD1", "Programmed cell death protein 1", "Tier 1", 0.738, 1, "A_surface", 37, 74.12, 0, 0, null, null, 1, 27, "41479885,40811947,40758411,39562585,37424077,34156677,33904236,33896107,33319876,33155587,32574155,32429721,31727249,31434881,28912094,28288993,41907643,41125194,38158454,37944524,36484532,36015348,34861397,34386332", 0, "melanoma", 0.6260691959208758], ["Q8NER1", "TRPV1", "Transient receptor potential cation channel subfamily V member 1", "Tier 1.5", 0.738, 1, "A_surface", 8, 71.94, 1, 0, null, null, 1, 2, "40855286,28604222", 0, "migraine disorder", 0.6269329225883602], ["P04233", "CD74", "HLA class II histocompatibility antigen gamma chain", "Tier 1", 0.737, 1, "A_surface", 24, 69.94, 1, 0, null, null, 1, 1, "30899255", 0, "non-small cell lung carcinoma", 0.6217636836935354], ["P42658", "DPP6", "A-type potassium channel modulatory protein DPP6", "Tier 1.5", 0.737, 1, "A_surface", 8, 86.69, 1, 0, null, null, 1, 1, "41313574", 0, "Autosomal dominant microcephaly", 0.6225938492787458]], "truncated": false, "filtered_table_rows_count": 144, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_known_aptamer\" = :p0 and \"in_cev_map\" = :p1 and \"surface_class\" = :p2 order by evidence_priority desc limit 51", "params": {"p0": "1", "p1": "0", "p2": "A_surface"}}, "facet_results": {"has_structure": {"name": "has_structure", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&surface_class=A_surface", "results": [{"value": 1, "label": 1, "count": 127, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&surface_class=A_surface&has_structure=1", "selected": false}, {"value": 0, "label": 0, "count": 17, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&surface_class=A_surface&has_structure=0", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&surface_class=A_surface", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 82, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&surface_class=A_surface&tier=Tier+1", "selected": false}, {"value": "Tier 1.5", "label": "Tier 1.5", "count": 62, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&surface_class=A_surface&tier=Tier+1.5", "selected": false}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&surface_class=A_surface", "results": [{"value": 0, "label": 0, "count": 144, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&surface_class=A_surface&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&surface_class=A_surface", "results": [{"value": 1, "label": 1, "count": 144, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&surface_class=A_surface", "selected": true}], "truncated": false}, "surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&surface_class=A_surface", "results": [{"value": "A_surface", "label": "A_surface", "count": 144, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&surface_class=A_surface", "results": [{"value": 0, "label": 0, "count": 144, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&surface_class=A_surface", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&surface_class=A_surface", "results": [{"value": 0, "label": 0, "count": 84, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&surface_class=A_surface&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 60, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&surface_class=A_surface&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [{"name": "aptamer_count_pubmed", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&surface_class=A_surface&_facet=aptamer_count_pubmed"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&surface_class=A_surface&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 1415.5606380663812, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}