{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_known_aptamer = 1, in_cev_map = 0 and surface_class = \"B_cargo\" sorted by evidence_priority descending", "rows": [["P00439", "PAH", "Phenylalanine-4-hydroxylase", "Tier 1", 0.618, 1, "B_cargo", 20, 88.69, 0, 0, null, null, 1, 11, "39435559,35394406,35081018,34973551,33386219,32587339,31349094,26043089,24749544,23583275,16914451", 0, "phenylketonuria", 0.892702971437507], ["P40337", "VHL", "von Hippel-Lindau disease tumor suppressor", "Tier 1", 0.616, 1, "B_cargo", 100, 84.44, 0, 0, null, null, 1, 5, "39437434,36250201,34549489,23142634,17290195", 0, "von Hippel-Lindau disease", 0.8883247767048489], ["Q13315", "ATM", "Serine-protein kinase ATM", "Tier 1", 0.613, 1, "B_cargo", 14, null, 1, 0, null, null, 1, 9, "41867498,39253616,37656667,34733968,28838608,28706912,26176230,17386435,15181173", 0, "ataxia telangiectasia", 0.8759719859489208], ["P22304", "IDS", "Iduronate 2-sulfatase", "Tier 1.5", 0.613, 1, "B_cargo", 2, 93.06, 0, 0, null, null, 1, 9, "41791433,41521476,41396069,40394224,37948569,31273548,30529550,28420169,20842131", 0, "mucopolysaccharidosis type 2", 0.8781523206667287], ["P35670", "ATP7B", "Copper-transporting ATPase 2", "Tier 1", 0.61, 1, "B_cargo", 13, 71.69, 1, 0, null, null, 1, 1, "39737993", 0, "Wilson disease", 0.8657500553466239], ["O14746", "TERT", "Telomerase reverse transcriptase", "Tier 1", 0.607, 1, "B_cargo", 23, 80.19, 1, 0, null, null, 1, 13, "41104418,40347637,40062394,39513874,39441744,37427434,36005058,35658460,33476148,28004350,24176970,22013508", 0, "dyskeratosis congenita, autosomal dominant 2", 0.8577919827748599], ["P04629", "NTRK1", "High affinity nerve growth factor receptor", "Tier 1", 0.607, 1, "B_cargo", 65, 78.25, 0, 0, null, null, 1, 1, "38604287", 0, "hereditary sensory and autonomic neuropathy type 4", 0.8579248191890114], ["Q9BZS1", "FOXP3", "Forkhead box protein P3", "Tier 1", 0.606, 1, "B_cargo", 2, 56.72, 0, 0, null, null, 1, 8, "40448637,34457999,32892748,26999456,24460675,22323540,18698484,18319343", 0, "immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome", 0.8516802661294931], ["P19544", "WT1", "Wilms tumor protein", "Tier 1", 0.606, 1, "B_cargo", 28, 50.78, 0, 0, null, null, 1, 3, "27417971,19123921,11329270", 0, "Denys-Drash syndrome", 0.8525486743466777], ["P37231", "PPARG", "Peroxisome proliferator-activated receptor gamma", "Tier 1", 0.605, 1, "B_cargo", 100, 76.12, 0, 0, null, null, 1, 3, "37203464,33671292,28206680", 0, "type 2 diabetes mellitus", 0.8486094742593474], ["Q9Y6K1", "DNMT3A", "DNA (cytosine-5)-methyltransferase 3A", "Tier 1", 0.605, 1, "B_cargo", 43, 72.94, 1, 0, null, null, 1, 3, "39079576,31733056,23179556", 0, "acute myeloid leukemia", 0.8505245588442946], ["P54132", "BLM", "RecQ-like DNA helicase BLM", "Tier 1", 0.605, 1, "B_cargo", 15, 60.53, 0, 0, null, null, 1, 9, "40700985,38959435,34973563,33571410,33050386,31563064,30343567,27332117,19146404", 0, "Bloom syndrome", 0.8491084997646711], ["Q92574", "TSC1", "Hamartin", "Tier 1", 0.604, 1, "B_cargo", 5, 62.06, 1, 0, null, null, 1, 1, "18974095", 0, "tuberous sclerosis", 0.8476796313298992], ["Q92793", "CREBBP", "CREB-binding protein", "Tier 1", 0.603, 1, "B_cargo", 100, 52.53, 0, 0, null, null, 1, 1, "39429683", 0, "Rubinstein-Taybi syndrome due to CREBBP mutations", 0.8442311239876018], ["P58012", "FOXL2", "Forkhead box protein L2", "Tier 1.5", 0.603, 1, "B_cargo", 2, 60.12, 0, 0, null, null, 1, 1, "37933840", 0, "blepharophimosis, ptosis, and epicanthus inversus syndrome", 0.841709236718747], ["P38398", "BRCA1", "Breast cancer type 1 susceptibility protein", "Tier 1", 0.602, 1, "B_cargo", 33, 41.59, 1, 0, null, null, 1, 13, "40251554,37288783,36858016,32945515,32245065,29737162,28841982,26784987,24734899,23836560,21800393,16825284", 0, "breast cancer", 0.839035109761358], ["P20823", "HNF1A", "Hepatocyte nuclear factor 1-alpha", "Tier 1.5", 0.602, 1, "B_cargo", 6, 56.97, 0, 0, null, null, 1, 4, "15781225,15629461", 0, "MODY", 0.8405262466243777], ["O43435", "TBX1", "T-box transcription factor TBX1", "Tier 1.5", 0.602, 1, "B_cargo", 1, 68.19, 0, 0, null, null, 1, 1, "24797903", 0, "22q11.2 deletion syndrome", 0.8406035626999856], ["Q02127", "DHODH", "Dihydroorotate dehydrogenase (quinone), mitochondrial", "Tier 1", 0.6, 1, "B_cargo", 100, 96.12, 0, 0, null, null, 1, 1, "29626096", 0, "postaxial acrofacial dysostosis", 0.8330628404263816], ["Q5S007", "LRRK2", "Leucine-rich repeat serine/threonine-protein kinase 2", "Tier 1", 0.6, 1, "B_cargo", 44, 77.5, 1, 0, null, null, 1, 4, "38467937,37586882,37422510,36774388", 0, "Hereditary late-onset Parkinson disease", 0.8349742982582067], ["Q15910", "EZH2", "Histone-lysine N-methyltransferase EZH2", "Tier 1", 0.6, 1, "B_cargo", 38, 76.25, 1, 0, null, null, 1, 8, "41574287,41223251,40931580,39853766,36626902,32884286,30795863,27719642", 0, "Weaver syndrome", 0.8324078192564933], ["P49715", "CEBPA", "CCAAT/enhancer-binding protein alpha", "Tier 1", 0.6, 1, "B_cargo", 2, 61.69, 0, 0, null, null, 1, 7, "38965606,30909853,31546149,30795863,28639199,26983359", 0, "acute myeloid leukemia", 0.8336701187896877], ["Q05066", "SRY", "Sex-determining region Y protein", "Tier 1.5", 0.599, 1, "B_cargo", 10, 67.62, 1, 0, null, null, 1, 1, "40082426", 0, "46,XY sex reversal 1", 0.8290523705747719], ["P41235", "HNF4A", "Hepatocyte nuclear factor 4-alpha", "Tier 1", 0.598, 1, "B_cargo", 8, 73.88, 0, 0, null, null, 1, 1, "37016361", 0, "MODY", 0.8258786338560885], ["Q14191", "WRN", "Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN", "Tier 1", 0.598, 1, "B_cargo", 42, 68.62, 0, 0, null, null, 1, 1, "27332117", 0, "Werner syndrome", 0.8278730962406992], ["O94761", "RECQL4", "ATP-dependent DNA helicase Q4", "Tier 1", 0.598, 1, "B_cargo", 2, 67.38, 0, 0, null, null, 1, 1, "31495919", 0, "Rothmund-Thomson syndrome type 2", 0.8261878622968941], ["Q9H3D4", "TP63", "Tumor protein 63", "Tier 1", 0.598, 1, "B_cargo", 26, 63.19, 0, 0, null, null, 1, 1, "17563751", 0, "ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 3", 0.8281511708882607], ["P48431", "SOX2", "Transcription factor SOX-2", "Tier 1", 0.598, 1, "B_cargo", 13, 59.84, 1, 0, null, null, 1, 13, "41377018,40082426,37891174,37370863,36284815,34405338,31991109,31301870,28988933,26176230,23892456,18490265,15863505", 0, "anophthalmia/microphthalmia-esophageal atresia syndrome", 0.8263477268235936], ["Q13485", "SMAD4", "SMAD family member 4", "Tier 1.5", 0.598, 1, "B_cargo", 12, 73.38, 0, 0, null, null, 1, 10, "39602246,35356877,33124760,32456365,31876518,29632714,27843907,21266541,17132729,16775010", 0, "juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome", 0.8277625447220475], ["P13686", "ACP5", "Tartrate-resistant acid phosphatase type 5", "Tier 1.5", 0.597, 1, "B_cargo", 2, 94.62, 0, 0, null, null, 1, 2, "30537181", 0, "Spondyloenchondrodysplasia with immune dysregulation", 0.8234579245679164], ["Q9BYX4", "IFIH1", "Interferon-induced helicase C domain-containing protein 1", "Tier 1.5", 0.597, 1, "B_cargo", 9, 79.44, 1, 0, null, null, 1, 1, "18983163", 0, "Aicardi-Goutieres syndrome 7", 0.8235229759148853], ["Q8NB91", "FANCB", "Fanconi anemia group B protein", "Tier 1", 0.596, 1, "B_cargo", 6, 71.0, 1, 0, null, null, 1, 1, "23836560", 0, "Fanconi anemia", 0.8195998375932156], ["Q9NZJ4", "SACS", "Sacsin", "Tier 1", 0.595, 1, "B_cargo", 7, null, 0, 0, null, null, 1, 5, "41610745,40771130,39719055,33584503", 0, "Autosomal recessive spastic ataxia of Charlevoix-Saguenay", 0.8179172286536236], ["P49638", "TTPA", "Alpha-tocopherol transfer protein", "Tier 1", 0.594, 1, "B_cargo", 6, 94.12, 0, 0, null, null, 1, 20, "41699153,41371773,38963794,36882463,36203210,35563278,33918821,31870256,30197987,30015643,28051346,26876003,25855589,24922319,21142878,20594164,20387790,20050927,19485299,18713263", 0, "Ataxia with vitamin E deficiency", 0.8129089189782969], ["P61244", "MAX", "Protein max", "Tier 1", 0.593, 1, "B_cargo", 12, 81.31, 1, 0, null, null, 1, 288, "41934996,41833970,41619462,41469028,41439640,41422825,41237904,41213249,41083647,41002303,40921876,40905551,40902004,40864593,40850274,40840129,40642767,40491004,40383336,40356230,40164941,40097648,40011207,39923524,39890743,39852074,39828650,39630145,39605530,39566329,39420595,39360861,39225197,39117896,39115976,39103298,39056617,38968658,38920574,38907914,38899396,38846799,38682443,38573322,38542416,38385442,38359718,38348887,38217658,38103284", 0, "pheochromocytoma", 0.8086574254358271], ["P04198", "MYCN", "N-myc proto-oncogene protein", "Tier 1.5", 0.593, 1, "B_cargo", 2, 60.16, 0, 0, null, null, 1, 3, "38074684,34703655,23243020", 0, "Feingold syndrome type 1", 0.8115451687313872], ["Q9NZC2", "TREM2", "Triggering receptor expressed on myeloid cells 2", "Tier 1", 0.592, 1, "B_cargo", 15, 76.75, 0, 0, null, null, 1, 5, "39695715,35147513,35144252", 0, "Nasu-Hakola disease", 0.8076185000216165], ["Q09472", "EP300", "Histone acetyltransferase p300", "Tier 1", 0.591, 1, "B_cargo", 60, 53.25, 1, 0, null, null, 1, 2, "39429683,28539359", 0, "Rubinstein-Taybi syndrome due to EP300 haploinsufficiency", 0.8025866884926094], ["Q03164", "KMT2A", "Histone-lysine N-methyltransferase 2A", "Tier 1", 0.591, 1, "B_cargo", 60, null, 1, 0, null, null, 1, 1, "33606679", 0, "Wiedemann-Steiner syndrome", 0.802084366673722], ["P51530", "DNA2", "DNA replication ATP-dependent helicase/nuclease DNA2", "Tier 1.5", 0.591, 1, "B_cargo", 1, 87.81, 0, 0, null, null, 1, 79, "41919953,40756646,40549055,40280078,40067128,39933341,39701233,39400726,39339485,39263860,39196429,38844882,38240894,38219326,38057050,38015452,37991343,37955623,37604608,37499488,37470836,36958207,36809725,36242904,36178489,36150338,35491044,35384954,35176850,35093773,33676715,33496853,33415103,33217231,32800122,32601890,32475386,32200901,31706177,31561796,31278549,31276907,31159934,30952252,30904620,30862445,30609356,30209628,30172325,29884355", 0, "mitochondrial DNA deletion syndrome with progressive myopathy", 0.8039462281320306], ["P28329", "CHAT", "Choline O-acetyltransferase", "Tier 1", 0.59, 1, "B_cargo", 7, 83.94, 0, 0, null, null, 1, 1, "38780008", 0, "Congenital myasthenic syndromes", 0.80158576006834], ["Q9NRG9", "AAAS", "Aladin", "Tier 1.5", 0.59, 1, "B_cargo", 2, 75.25, 1, 0, null, null, 1, 2, "39798364,30768874", 0, "triple-A syndrome", 0.8009946434571534], ["P17735", "TAT", "Tyrosine aminotransferase", "Tier 1.5", 0.59, 1, "B_cargo", 1, 91.75, 0, 0, null, null, 1, 116, "42052694,41392711,41107360,41026857,40789888,40681131,40125796,40063097,39876991,39558155,39335496,39318271,39167715,38924638,38501479,38054213,37240414,36879476,36832059,36642821,36576612,36475447,36277654,36209487,36198145,35654302,35364795,33981364,33909408,33155468,33149582,32976590,32250590,32147886,32100315,32061015,32051269,31975549,31881749,31880928,31707021,35345244,31243610,30976173,30540162,30529550,30350592,30285239,30198708,29464116", 0, "tyrosinemia type II", 0.7986496109306669], ["Q9NUX5", "POT1", "Protection of telomeres protein 1", "Tier 1", 0.589, 1, "B_cargo", 14, 87.38, 1, 0, null, null, 1, 3, "41867726,25934589,21772997", 0, "tumor predisposition syndrome 3", 0.7983039512174813], ["Q9UMX1", "SUFU", "Suppressor of fused homolog", "Tier 1", 0.589, 1, "B_cargo", 10, 82.31, 0, 0, null, null, 1, 1, "18698484", 0, "medulloblastoma", 0.7957650276957399], ["O43766", "LIAS", "Lipoyl synthase, mitochondrial", "Tier 1", 0.589, 1, "B_cargo", 5, 81.19, 0, 0, null, null, 1, 1, "32329602", 0, "lipoic acid synthetase deficiency", 0.7951307244152087], ["O14770", "MEIS2", "Homeobox protein Meis2", "Tier 1.5", 0.588, 1, "B_cargo", 4, 61.97, 0, 0, null, null, 1, 2, "41495882", 0, "cardiac malformation, cleft lip/palate, microcephaly, and digital anomalies", 0.7938323593532864], ["P05129", "PRKCG", "Protein kinase C gamma type", "Tier 1", 0.587, 1, "B_cargo", 2, 81.44, 0, 0, null, null, 1, 1, "33334063", 0, "spinocerebellar ataxia type 14", 0.7904034101945372], ["P46527", "CDKN1B", "Cyclin-dependent kinase inhibitor 1B", "Tier 1", 0.587, 1, "B_cargo", 19, 69.25, 1, 0, null, null, 1, 1, "20191379", 0, "multiple endocrine neoplasia type 4", 0.7896116263348134], ["P49711", "CTCF", "Transcriptional repressor CTCF", "Tier 1", 0.587, 1, "B_cargo", 21, 58.81, 1, 0, null, null, 1, 5, "41955940,41430607,35927613,31288216,20435085", 0, "CTCF-related neurodevelopmental disorder", 0.7903743707735115]], "truncated": false, "filtered_table_rows_count": 310, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "evidence_priority", "has_structure", "surface_class", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, evidence_priority, has_structure, surface_class, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_known_aptamer\" = :p0 and \"in_cev_map\" = :p1 and \"surface_class\" = :p2 order by evidence_priority desc limit 51", 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"/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&surface_class=B_cargo", "results": [{"value": 0, "label": 0, "count": 243, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&surface_class=B_cargo&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 67, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&surface_class=B_cargo&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&surface_class=B_cargo&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 1150.9938086383045, "source": "apt-scout automated curation pipeline (E. 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