{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_known_aptamer = 1, in_cev_map = 0 and tier = \"Tier 1\" sorted by priority_score descending", "rows": [["P23946", "CMA1", "Chymase", "Tier 1", 0.875, 42, 91.31, 0, 0, null, null, null, 1, 1, "30572223", 0, "pernicious anemia", 0.17348905136256007], ["A0A0E3EAY4", "env", "Envelope glycoprotein gp160", "Tier 1", 0.82, 2, null, 1, 0, null, null, null, 1, 12, "36576612,29464116,29217761,22379083,18776229,18569791,16146716,16043495,16013840,12498773,11024283,9713975", 0, null, null], ["P35414", "APLNR", "Apelin receptor", "Tier 1", 0.8, 37, 81.69, 1, 0, null, null, null, 1, 1, "36126144", 0, "essential hypertension", 0.2159614840844307], ["P01236", "PRL", "Prolactin", "Tier 1", 0.795, 12, 85.56, 0, 0, null, null, null, 1, 6, "40327044,30834248,29277631,28263753,27679852,16947086", 0, "AL amyloidosis", 0.4619748183558772], ["O14788", "TNFSF11", "Tumor necrosis factor ligand superfamily member 11", "Tier 1", 0.79, 2, 79.19, 0, 0, null, null, null, 1, 2, "15562003,41226313", 0, "osteoporosis", 0.6957850224892792], ["P07911", "UMOD", "Uromodulin", "Tier 1", 0.774, 10, 82.94, 1, 0, null, null, null, 1, 4, "37533140,35446786", 0, "familial juvenile hyperuricemic nephropathy type 1", 0.8446536377993564], ["P26951", "IL3RA", "Interleukin-3 receptor subunit alpha", "Tier 1", 0.767, 4, 85.25, 0, 0, null, null, null, 1, 3, "40931580,36171541,31323275", 0, "acute myeloid leukemia", 0.46904332714118013], ["P40225", "THPO", "Thrombopoietin", "Tier 1", 0.76, 3, 61.44, 1, 0, null, null, null, 1, 2, "38928037,30312735", 0, "thrombocythemia 1", 0.7027329039559379], ["Q9ULV1", "FZD4", "Frizzled-4", "Tier 1", 0.745, 11, 84.31, 1, 0, null, null, null, 1, 1, "18673242", 0, "Familial exudative vitreoretinopathy", 0.8152111103672746], ["P21730", "C5AR1", "C5a anaphylatoxin chemotactic receptor 1", "Tier 1", 0.741, 19, 85.75, 1, 0, null, null, null, 1, 5, "33495506,29981048,29327939,28288993,25901944", 0, "anti-neutrophil cytoplasmic antibody-associated vasculitis", 0.5076734733894334], ["K7N5M4", "B2M", null, "Tier 1", 0.72, 24, 90.94, 0, 0, null, null, null, 1, 3, "41850110,40373155,38904251", 0, null, null], ["P42262", "GRIA2", "Glutamate receptor 2", "Tier 1", 0.715, 16, 84.94, 0, 0, null, null, null, 1, 4, "28325839,19417060,17929944,17024188", 0, "neurodevelopmental disorder with language impairment and behavioral abnormalities", 0.8328652004757138], ["P20809", "IL11", "Interleukin-11", "Tier 1", 0.712, 8, 82.62, 1, 0, null, null, null, 1, 8, "39408993,39263947,28791655,27878687,25696907,24629635", 0, "osteoarthritis, hip", 0.31754029889853136], ["P14207", "FOLR2", "Folate receptor beta", "Tier 1", 0.701, 5, 89.12, 0, 0, null, null, null, 1, 2, "28686804", 0, "neoplasm", 0.11545394821329319], ["P15248", "IL9", "Interleukin-9", "Tier 1", 0.7, 5, 84.06, 0, 0, null, null, null, 1, 1, "40972397", 0, "neurodegenerative disease", 0.40148548290272756], ["P01374", "LTA", "Lymphotoxin-alpha", "Tier 1", 0.7, 3, 83.44, 0, 0, null, null, null, 1, 3, "41810142,30576605", 0, null, null], ["P15309", "ACP3", "Prostatic acid phosphatase", "Tier 1", 0.695, 17, 92.25, 1, 0, null, null, null, 1, 3, "41890985,25591398", 0, "prostate cancer", 0.5521391557206573], ["Q95460", "MR1", "Major histocompatibility complex class I-related protein 1", "Tier 1", 0.693, 79, 87.5, 0, 0, null, null, null, 1, 2, "41134135,20000526", 0, "Immunodeficiency", 0.3336382138166145], ["Q9NPF0", "CD320", "CD320 antigen", "Tier 1", 0.69, 6, 63.81, 0, 0, null, null, null, 1, 1, "39493449", 0, "Methylmalonic aciduria due to transcobalamin receptor defect", 0.49918945650121177], ["P48061", "CXCL12", "Stromal cell-derived factor 1", "Tier 1", 0.685, 34, 83.25, 1, 0, null, null, null, 1, 36, "41951573,41931849,41907643,41527798,40401615,40008515,39865939,39263947,38806504,38477735,32784904,31267721,31097627,30465210,30385042,29111236,28963140,28670693,27940247,27924617,27392463,26265085,25560701,25236655,24526776,24277076,23615526,22376154,21147843,41963275", 0, "HIV-1 infection", 0.3675509850165065], ["Q6NW40", "RGMB", "Repulsive guidance molecule B", "Tier 1", 0.683, 11, 79.44, 1, 0, null, null, null, 1, 1, "39263947", 0, "Abnormality of the skeletal system", 0.42535629367019584], ["P39900", "MMP12", "Macrophage metalloelastase", "Tier 1", 0.68, 86, 86.94, 0, 0, null, null, null, 1, 8, "41861669,38477735,38296402,37015819,35120890,34183667,27530235", 0, "atopic eczema", 0.4795677061208266], ["Q9UEF7", "KL", "Klotho", "Tier 1", 0.676, 6, 89.06, 1, 0, null, null, null, 1, 19, "41978019,41851110,41038766,40370992,39975897,39909827,38500260,38233588,37584531,36891771,36535944,35770801,35360393,34375633,33536505,31511614,25325398,18569791,40514411", 0, "type 2 diabetes mellitus", 0.5587488336100863], ["Q86Z14", "KLB", "Beta-klotho", "Tier 1", 0.676, 5, 89.38, 0, 0, null, null, null, 1, 1, "40514411", 0, "congenital hypogonadotropic hypogonadism", 0.462898767992589], ["P51681", "CCR5", "C-C chemokine receptor type 5", "Tier 1", 0.674, 25, 85.38, 1, 0, null, null, null, 1, 23, "36576612,33981364,29678881,29556342,29301363,27807347,27652575,26965267,25794434,25754473,25329893,23629001,22811524,21576818,18799178,16631118,16227301,15813986,14610191,12498773", 0, "HIV infection", 0.7442590579227027], ["P62576", "nanA", "Sialidase A", "Tier 1", 0.67, 5, 81.19, 0, 0, null, null, null, 1, 4, "37350189,34976356,34341854,32034503", 0, null, null], ["Q9GZX9", "TWSG1", "Twisted gastrulation protein homolog 1", "Tier 1", 0.67, 6, 80.38, 0, 0, null, null, null, 1, 1, "39299474", 0, "Abruptio Placentae", 0.29495361755469174], ["P56704", "WNT3A", "Protein Wnt-3a", "Tier 1", 0.665, 4, 88.31, 1, 0, null, null, null, 1, 1, "37231925", 0, "neurodegenerative disease", 0.5271953966006525], ["P05113", "IL5", "Interleukin-5", "Tier 1", 0.664, 5, 86.69, 1, 0, null, null, null, 1, 12, "40972397,35487180,35356877,34831332,32784904,32038731,29881374,28062796,26048585", 0, "asthma", 0.6399821251487101], ["O15169", "AXIN1", "Axin-1", "Tier 1", 0.664, 22, 61.09, 0, 0, null, null, null, 1, 2, "28129128", 0, "hepatocellular carcinoma", 0.7864172882686208], ["P15941", "MUC1", "Mucin-1", "Tier 1", 0.66, 23, 47.41, 0, 0, null, null, null, 1, 686, "42025056,41988862,41954302,41771296,41744704,41744190,41657320,41627316,41621292,41582516,41535857,41471303,41362016,41352919,41346179,41330302,41243570,41205458,41185018,41101154,41047832,41027169,40682599,40665615,40627939,40607530,40590839,40578633,40568899,40556592,40504676,40500890,40499867,40479828,40432219,40422041,40360093,40286646,40274149,40158809,40119836,39978149,39910821,39705316,39679901,39626346,39579679,39566700,39552005,39550818,41997681,41247195,40813258,39454542,39454415,39440615,39421884,39406784,39256285,39243449,39154820,39142532,39136402,39119745,39118454,38923850,38912896", 0, "tubulointerstitial kidney disease, autosomal dominant, 2", 0.7040398435219726], ["Q92876", "KLK6", "Kallikrein-6", "Tier 1", 0.659, 21, 91.75, 0, 0, null, null, null, 1, 2, "30114962,22505517", 0, "neuroinflammatory disorder", 0.1901077464611955], ["P22894", "MMP8", "Neutrophil collagenase", "Tier 1", 0.655, 25, 90.38, 0, 0, null, null, null, 1, 4, "35821507,34183667,33534888,30197987", 0, "acne", 0.603247809982021], ["Q12809", "KCNH2", "Voltage-gated inwardly rectifying potassium channel KCNH2", "Tier 1", 0.655, 23, 62.75, 1, 0, null, null, null, 1, 1, "22617876", 0, "Romano-Ward syndrome", 0.8549238933917284], ["P45452", "MMP13", "Collagenase 3", "Tier 1", 0.65, 49, 88.62, 0, 0, null, null, null, 1, 4, "41754778,40893365,38471488,38750696", 0, "spondyloepimetaphyseal dysplasia, Missouri type", 0.8032079813035149], ["P10747", "CD28", "T-cell-specific surface glycoprotein CD28", "Tier 1", 0.641, 10, 81.31, 0, 0, null, null, null, 1, 12, "40702285,40479828,36979667,36126113,32584540,32280743,32024070,26999456,26992239,26320067,23756353,10435754", 0, "HIV infection", 0.5105949023227331], ["Q13651", "IL10RA", "Interleukin-10 receptor subunit alpha", "Tier 1", 0.641, 7, 62.0, 1, 0, null, null, null, 1, 2, "25870409,25558474", 0, "Autosomal recessive early-onset inflammatory bowel disease", 0.8151052076044897], ["Q04609", "FOLH1", "Glutamate carboxypeptidase 2", "Tier 1", 0.64, 88, 93.81, 0, 0, null, null, null, 1, 47, "41855944,41683470,41548790,41478044,41126016,40684732,39388218,39187748,38769597,34341883,33794195,33061374,33025277,32721116,32611993,32525981,32208602,29313393,28794625,28746182,27574424,27456457,27228412,27077564,26985893,26472453,26438155,25938427,25620467,25620167,25473281,24954476,24337602,24321253,23590171,21980237,21641946,21555850,21147500,20550178,20407731,19701187,19514954,19488725,18776550,15520166,12124337", 0, "prostate cancer", 0.5500818985644047], ["O00206", "TLR4", "Toll-like receptor 4", "Tier 1", 0.621, 15, 89.19, 1, 0, null, null, null, 1, 32, "41864915,41444487,40521190,39897575,38931862,38742374,38280803,37360693,36916435,36908619,35410404,35402075,35189346,34831332,32784904,29910175,29250957,25483705", 0, "major depressive disorder", 0.5065500149392951], ["P78380", "OLR1", "Oxidized low-density lipoprotein receptor 1", "Tier 1", 0.62, 13, 87.44, 0, 0, null, null, null, 1, 1, "35821507", 0, "head and neck squamous cell carcinoma", 0.10910332327226395], ["O14625", "CXCL11", "C-X-C motif chemokine 11", "Tier 1", 0.62, 2, 79.94, 1, 0, null, null, null, 1, 4, "36649818,32784904,30578658,23935890", 0, "neoplasm", 0.11537901464416651], ["Q9HBE5", "IL21R", "Interleukin-21 receptor", "Tier 1", 0.615, 6, 64.12, 0, 0, null, null, null, 1, 2, "30800133,29244152", 0, "Cryptosporidiosis - chronic cholangitis - liver disease", 0.7501392499286187], ["O60885", "BRD4", "Bromodomain-containing protein 4", "Tier 1", 0.615, 100, 55.31, 0, 0, null, null, null, 1, 6, "41824501,41088826,40957137,35185589,22609015", 0, "Cornelia de Lange syndrome 6", 0.6842985362822729], ["P01887", "B2m", "Beta-2-microglobulin", "Tier 1", 0.61, 100, 93.81, 0, 0, null, null, null, 1, 15, "41850110,40373155,38904251,40658810,35026285,32631049,29281176,28960840,25100729,20616783,19137104,17878167", 0, null, null], ["P12643", "BMP2", "Bone morphogenetic protein 2", "Tier 1", 0.61, 21, 79.56, 0, 0, null, null, null, 1, 10, "41144653,38542880,37231465,35591468,35195734,34067593,33997500", 0, "short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 1", 0.7361833785834584], ["P20062", "TCN2", "Transcobalamin-2", "Tier 1", 0.605, 11, 91.5, 0, 0, null, null, null, 1, 3, "41935727,39493449", 0, "transcobalamin II deficiency", 0.8116989428679681], ["P15018", "LIF", "Leukemia inhibitory factor", "Tier 1", 0.605, 5, 87.12, 1, 0, null, null, null, 1, 38, "41611413,38359901,37549567,37175248,36838669,33640806,32253765,31791592,31357280,30771937,30037541,29289340,28963578,28763192,27855943,26877178,26764106,26695234,26344338,26113415,25335821,25311485,25035238,24716781,22648816,22471443,27335672,20673578,20151395,19803140,18646283,17315151,16331583,16053313,11791582,9823713,39571081,31461490", 0, "alcohol drinking", 0.24197086949132446], ["P00797", "REN", "Renin", "Tier 1", 0.605, 91, 85.44, 0, 0, null, null, null, 1, 456, "42025056,42000159,41992303,41979049,41942404,41934998,41909751,41904852,41851110,41849890,41794534,41780402,41770936,41718462,41711853,41698160,41671930,41659919,41629318,41545413,41538945,41529264,41519163,41454539,41443106,41386094,41330678,41327249,41249026,41234744,41207040,41205456,41175848,41172349,41171135,41164194,41161441,41148632,41118515,41089000,41067030,41024479,41002305,40994449,40968863,40963922,40893365,40891676,40870790,40801503,41906877,40832436,39923730,39263947,39129649,38811951,36190914,35983901,35907639,35187107,34619249,34248841,32981365,32838280,32527800,31988066,26746799,21147843", 0, "familial juvenile hyperuricemic nephropathy type 2", 0.7657976389758877], ["P10636", "MAPT", "Microtubule-associated protein tau", "Tier 1", 0.605, 100, 49.22, 1, 0, null, null, null, 1, 9, "40380000,39241336,38585969,38397086,37003060,31900535,30004544,29268187", 0, "Pick disease", 0.7600399335134378], ["P46059", "SLC15A1", "Solute carrier family 15 member 1", "Tier 1", 0.603, 3, 87.0, 1, 0, null, null, null, 1, 1, "26811678", 0, "cleft palate", 0.3279926002389253]], "truncated": false, "filtered_table_rows_count": 368, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "priority_score", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "drug_count_approved", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, priority_score, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, drug_count_approved, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_known_aptamer\" = :p0 and \"in_cev_map\" = :p1 and \"tier\" = :p2 order by priority_score desc limit 51", "params": {"p0": "1", "p1": "0", "p2": "Tier 1"}}, "facet_results": {"tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&tier=Tier+1", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 368, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 368, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&tier=Tier+1&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 368, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&tier=Tier+1", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 368, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&tier=Tier+1", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 243, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&tier=Tier+1&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 125, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&tier=Tier+1&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&tier=Tier+1&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 285.97815000102855, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}