{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_known_aptamer = 1, in_cev_map = 0 and tier = \"Tier 1.5\" sorted by priority_score descending", "rows": [["P21583", "KITLG", "Kit ligand", "Tier 1.5", 0.848, 6, 71.88, 1, 0, null, null, null, 1, 2, "36579647,23967247", 0, "hyperpigmentation with or without hypopigmentation, familial progressive", 0.6756727302967072], ["Q00975", "CACNA1B", "Voltage-dependent N-type calcium channel subunit alpha-1B", "Tier 1.5", 0.807, 7, 59.91, 1, 0, null, null, null, 1, 2, "31118475,25782368", 0, "Seizure", 0.7217241968702018], ["P03971", "AMH", "Anti-Muellerian hormone", "Tier 1.5", 0.783, 3, 68.62, 1, 0, null, null, null, 1, 2, "41101154,27364573", 0, "persistent Mullerian duct syndrome", 0.7847328444470535], ["P48023", "FASLG", "Tumor necrosis factor ligand superfamily member 6", "Tier 1.5", 0.775, 3, 80.19, 0, 0, null, null, null, 1, 1, "16581027", 0, "autoimmune lymphoproliferative syndrome type 1", 0.6984292519156657], ["Q9GZU2", "PEG3", "Paternally-expressed gene 3 protein", "Tier 1.5", 0.75, 1, 44.53, 0, 0, null, null, null, 1, 1, "16595502", 0, "neurodegenerative disease", 0.34815912577489827], ["P18075", "BMP7", "Bone morphogenetic protein 7", "Tier 1.5", 0.749, 4, 76.19, 0, 0, null, null, null, 1, 1, "30537181", 0, "Inguinal hernia", 0.4420059023371716], ["Q9Y5C1", "ANGPTL3", "Angiopoietin-related protein 3", "Tier 1.5", 0.727, 1, 79.62, 0, 0, null, null, null, 1, 1, "23770039", 0, "familial hypobetalipoproteinemia 2", 0.6739043862507132], ["Q00604", "NDP", "Norrin", "Tier 1.5", 0.716, 11, 83.56, 1, 0, null, null, null, 1, 2, "39057719,11352723", 0, "Norrie disease", 0.8566451682188412], ["P46094", "XCR1", "Chemokine XC receptor 1", "Tier 1.5", 0.715, 1, 84.94, 1, 0, null, null, null, 1, 1, "35212764", 0, "COVID-19", 0.459103766220463], ["P32239", "CCKBR", "Gastrin/cholecystokinin type B receptor", "Tier 1.5", 0.713, 5, 75.75, 1, 0, null, null, null, 1, 2, "33776434,27754762", 0, "gastroesophageal reflux disease", 0.4256110167566802], ["P25106", "ACKR3", "Atypical chemokine receptor 3", "Tier 1.5", 0.71, 14, 82.44, 1, 0, null, null, null, 1, 2, "40401615,28670693", 0, "oculomotor-abducens synkinesis", 0.49893280382434735], ["A0A0C5B5G6", "MT-RNR1", "Mitochondrial-derived peptide MOTS-c", "Tier 1.5", 0.7, 0, 72.06, 0, 0, null, null, null, 1, 1, "35311942", 0, null, null], ["P08620", "FGF4", "Fibroblast growth factor 4", "Tier 1.5", 0.7, 1, 81.5, 0, 0, null, null, null, 1, 3, "35415885,33536494,7547864", 0, "cancer", 0.6026669167438079], ["P21781", "FGF7", "Fibroblast growth factor 7", "Tier 1.5", 0.695, 0, 82.44, 0, 0, null, null, null, 1, 5, "35415885,15719578,7547864,16462265", 0, "cancer", 0.5963369026823151], ["Q96RJ3", "TNFRSF13C", "Tumor necrosis factor receptor superfamily member 13C", "Tier 1.5", 0.681, 8, 63.03, 1, 0, null, null, null, 1, 1, "23470998", 0, "immunodeficiency, common variable, 4", 0.660711678987284], ["P26718", "KLRK1", "NKG2-D type II integral membrane protein", "Tier 1.5", 0.679, 22, 79.19, 0, 0, null, null, null, 1, 1, "24629635", 0, "Behcet's syndrome", 0.18614538678991077], ["O95750", "FGF19", "Fibroblast growth factor 19", "Tier 1.5", 0.668, 4, 79.81, 0, 0, null, null, null, 1, 4, "35415885,31967847,27679852", 0, "cancer", 0.38540691230511315], ["O00744", "WNT10B", "Protein Wnt-10b", "Tier 1.5", 0.668, 0, 80.06, 0, 0, null, null, null, 1, 2, "32810272,18673242", 0, "Split hand-split foot malformation", 0.7755225395358214], ["Q9HCK4", "ROBO2", "Roundabout homolog 2", "Tier 1.5", 0.665, 6, 67.38, 0, 0, null, null, null, 1, 2, "40616090,31640794", 0, "familial vesicoureteral reflux", 0.6460375744556555], ["Q6PCB0", "VWA1", "von Willebrand factor A domain-containing protein 1", "Tier 1.5", 0.664, 0, 78.38, 0, 0, null, null, null, 1, 4, "41906877,41693575,38904251,38299345", 0, "neuronopathy, distal hereditary motor, autosomal recessive 7", 0.7420531156755253], ["A2RU14", "TMEM218", "Transmembrane protein 218", "Tier 1.5", 0.663, 0, 87.62, 0, 0, null, null, null, 1, 6, "41360349,34861273,31349094,29277631,26580576,26248137", 0, "Joubert syndrome 39", 0.7308441626389979], ["P18510", "IL1RN", "Interleukin-1 receptor antagonist protein", "Tier 1.5", 0.66, 5, 87.06, 0, 0, null, null, null, 1, 1, "38928037", 0, "sterile multifocal osteomyelitis with periostitis and pustulosis", 0.7734282711738736], ["Q86YL7", "PDPN", "Podoplanin", "Tier 1.5", 0.66, 6, 57.97, 0, 0, null, null, null, 1, 4, "41304780,41292412,39451677", 0, "Microscopic hematuria", 0.41183796492083136], ["O15389", "SIGLEC5", "Sialic acid-binding Ig-like lectin 5", "Tier 1.5", 0.656, 3, 77.75, 0, 0, null, null, null, 1, 3, "33584010,27678199,24405684", 0, "dentures", 0.15815607474115415], ["O15263", "DEFB4A", "Defensin beta 4A", "Tier 1.5", 0.65, 6, 78.0, 0, 0, null, null, null, 1, 2, "40362575,32067984", 0, "ulcerative colitis", 0.09865892368546408], ["P84996", "GNAS", "Protein ALEX", "Tier 1.5", 0.65, 0, 43.59, 0, 0, null, null, null, 1, 9, "39154820,37963924,36037714,34488577,31129134,30979095,30682825,29146902,28626560", 0, null, null], ["P01138", "NGF", "Beta-nerve growth factor", "Tier 1.5", 0.648, 8, 73.25, 0, 0, null, null, null, 1, 6, "42015870,38780008,32982626,21216401,7545283,29754498", 0, "hereditary sensory and autonomic neuropathy type 5", 0.7785402119369383], ["Q2I0M5", "RSPO4", "R-spondin-4", "Tier 1.5", 0.646, 0, 78.56, 0, 0, null, null, null, 1, 3, "38238732,37425696", 0, "nonsyndromic congenital nail disorder 4", 0.7604902779349189], ["Q9BQ51", "PDCD1LG2", "Programmed cell death 1 ligand 2", "Tier 1.5", 0.645, 2, 86.38, 0, 0, null, null, null, 1, 1, "38928037", 0, "melanoma", 0.42716921377769757], ["P08100", "RHO", "Rhodopsin", "Tier 1.5", 0.645, 4, 88.75, 1, 0, null, null, null, 1, 45, "41963275,41924874,41636061,40808302,40642289,40330320,40045571,39863313,39788632,38070612,37191882,36705086,36696850,36095194,36049339,35622174,34709779,34471566,32696702,32479610,32319623,32119944,31737572,31588238,31535128,29570714,29281176,28648779,27893356,25645980,23757206,23701883,25033804,22689339,22302221,22121695,19766091,19389625,16419035,12123800,8743323,7678562,19188685,18230760", 0, "retinitis pigmentosa", 0.8481942240861982], ["Q9UKP5", "ADAMTS6", "A disintegrin and metalloproteinase with thrombospondin motifs 6", "Tier 1.5", 0.644, 0, 77.5, 0, 0, null, null, null, 1, 1, "35700850", 0, "Abnormality of the skeletal system", 0.5444162515485208], ["P15391", "CD19", "B-lymphocyte antigen CD19", "Tier 1.5", 0.642, 4, 62.22, 1, 0, null, null, null, 1, 13, "41079126,40652441,38661725,38148412,36095289,35829681,34680368,34364920,32401486,31912987,29928472,21127492", 0, "immunodeficiency, common variable, 3", 0.6821072538733047], ["Q8NEV9", "IL27", "Interleukin-27 subunit alpha", "Tier 1.5", 0.641, 4, 75.62, 1, 0, null, null, null, 1, 2, "35859339,32784904", 0, "Crohn's disease", 0.40963715551754365], ["P07202", "TPO", "Thyroid peroxidase", "Tier 1.5", 0.64, 0, 83.44, 0, 0, null, null, null, 1, 1, "29881374", 0, "familial thyroid dyshormonogenesis", 0.6710562308468054], ["P45844", "ABCG1", "ATP-binding cassette sub-family G member 1", "Tier 1.5", 0.639, 5, 81.12, 1, 0, null, null, null, 1, 1, "41854184", 0, "neurodegenerative disease", 0.3915225348167794], ["P31994", "FCGR2B", "Low affinity immunoglobulin gamma Fc region receptor II-b", "Tier 1.5", 0.636, 5, 78.44, 0, 0, null, null, null, 1, 1, "38928037", 0, "systemic lupus erythematosus", 0.460465747544726], ["P51654", "GPC3", "Glypican-3", "Tier 1.5", 0.636, 4, 75.06, 1, 0, null, null, null, 1, 65, "42083729,41790019,41653459,41045695,40825648,40722645,39998646,39874791,39608318,39427046,38910291,38787447,38621313,38368644,37665421,36903516,36457288,36317566,36072763,35788872,35699181,35477501,35051745,34974867,34306031,33254049,33080969,32356075,30347351,30122918,29675356,29605994,29277631,27601357,28263753", 0, "Simpson-Golabi-Behmel syndrome type 1", 0.762708583613362], ["Q16674", "MIA", "Melanoma-derived growth regulatory protein", "Tier 1.5", 0.636, 4, 86.38, 0, 0, null, null, null, 1, 15, "41768714,40943389,40444021,38899488,37853818,35842727,35593028,35061691,34038704,32957732,31878307,31289496,29499935,28059418,26840019", 0, "neurodegenerative disease", 0.36367051545295126], ["P31785", "IL2RG", "Cytokine receptor common subunit gamma", "Tier 1.5", 0.635, 14, 75.5, 1, 0, null, null, null, 1, 2, "30800133,33869115", 0, "gamma chain deficiency", 0.8469997000418428], ["Q92563", "SPOCK2", "Testican-2", "Tier 1.5", 0.627, 0, 66.94, 0, 0, null, null, null, 1, 8, "39695715,35474272,32958645,28794177,38656806,36288905", 0, "Back pain", 0.3687304175767662], ["P34810", "CD68", "Macrosialin", "Tier 1.5", 0.627, 0, 73.19, 0, 0, null, null, null, 1, 4, "37422510,33321636,28315675,27940247", 0, "neurodegenerative disease", 0.3710186480081222], ["O95342", "ABCB11", "Bile salt export pump", "Tier 1.5", 0.624, 8, 83.12, 1, 0, null, null, null, 1, 1, "36313979", 0, "progressive familial intrahepatic cholestasis type 2", 0.8372060401943777], ["Q96NZ8", "WFIKKN1", "WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1", "Tier 1.5", 0.621, 2, 78.06, 0, 0, null, null, null, 1, 1, "33591955", 0, "neurodegenerative disease", 0.3060887002952384], ["P49238", "CX3CR1", "CX3C chemokine receptor 1", "Tier 1.5", 0.62, 2, 80.5, 1, 0, null, null, null, 1, 2, "28727998", 0, "age-related macular degeneration", 0.4006854573775187], ["Q06141", "REG3A", "Regenerating islet-derived protein 3-alpha", "Tier 1.5", 0.62, 4, 89.0, 1, 0, null, null, null, 1, 2, "39695715,24771595", 0, "alcohol drinking", 0.29724052454892086], ["Q13508", "ART3", "Ecto-ADP-ribosyltransferase 3", "Tier 1.5", 0.62, 0, 74.0, 0, 0, null, null, null, 1, 5, "41503480,41083485,41020397,40313273,41325160", 0, "type 2 diabetes mellitus", 0.3004670185438895], ["O43435", "TBX1", "T-box transcription factor TBX1", "Tier 1.5", 0.619, 1, 68.19, 0, 0, null, null, null, 1, 1, "24797903", 0, "22q11.2 deletion syndrome", 0.8406035626999856], ["Q96MS0", "ROBO3", "Roundabout homolog 3", "Tier 1.5", 0.618, 3, 63.69, 0, 0, null, null, null, 1, 2, "32369590", 0, "horizontal gaze palsy with progressive scoliosis", 0.7813306356858872], ["Q07325", "CXCL9", "C-X-C motif chemokine 9", "Tier 1.5", 0.617, 1, 87.44, 1, 0, null, null, null, 1, 7, "42046114,37395276,35204399,35018777,33742062,27959341,27819142", 0, "neoplasm", 0.1199067650750674], ["O60938", "KERA", "Keratocan", "Tier 1.5", 0.612, 0, 87.56, 0, 0, null, null, null, 1, 3, "37696275,41280530,38079395", 0, "cornea plana 2", 0.7200491760465073]], "truncated": false, "filtered_table_rows_count": 261, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "priority_score", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "drug_count_approved", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, priority_score, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, drug_count_approved, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_known_aptamer\" = :p0 and \"in_cev_map\" = :p1 and \"tier\" = :p2 order by priority_score desc limit 51", "params": {"p0": "1", "p1": "0", "p2": "Tier 1.5"}}, "facet_results": {"tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&tier=Tier+1.5", "results": [{"value": "Tier 1.5", "label": "Tier 1.5", "count": 261, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 261, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&tier=Tier+1.5&has_activation_state_pdb_pair=0", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&tier=Tier+1.5", "results": [{"value": 1, "label": 1, "count": 261, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=0&tier=Tier+1.5", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 261, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&tier=Tier+1.5", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 211, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&tier=Tier+1.5&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 50, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&tier=Tier+1.5&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [{"name": "pdb_count_total", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&tier=Tier+1.5&_facet=pdb_count_total"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=0&tier=Tier+1.5&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 285.99248899990926, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}