{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_known_aptamer = 1, in_cev_map = 1 and tier = \"Tier 1\" sorted by priority_score descending", "rows": [["P13747", "HLA-E", "HLA class I histocompatibility antigen, alpha chain E", "Tier 1", 0.865, 34, 87.0, 0, 0, null, null, null, 1, 1, "38473398", 1, "COVID-19", 0.4822929100647597], ["O75581", "LRP6", "Low-density lipoprotein receptor-related protein 6", "Tier 1", 0.865, 27, 79.19, 1, 0, null, null, null, 1, 5, "42031715,37175248,18673242", 1, "tooth agenesis, selective, 7", 0.7022725510765017], ["Q15848", "ADIPOQ", "Adiponectin", "Tier 1", 0.806, 3, 79.88, 0, 0, null, null, null, 1, 10, "41636061,38392020,36508319,35323639,34796696,34117903,33535822,31988066,25105541", 1, "hearing loss", 0.25844907375917336], ["P51679", "CCR4", "C-C chemokine receptor type 4", "Tier 1", 0.804, 7, 80.75, 1, 0, null, null, null, 1, 3, "41518674,39071952,29103909", 1, "mycosis fungoides", 0.5404546856597274], ["P13671", "C6", "Complement component C6", "Tier 1", 0.795, 11, 79.62, 1, 0, null, null, null, 1, 31, "41255414,39736202,39680325,38188151,36290981,36165950,34535250,33034309,32414072,32119944,31819445,30039760,29594379,29408200,28024568,27940247,26588795,26316749,26107993,24512500,24309623,23657986,22973579,22527269,21944470,21788069,21645749,21071077,20008986,19469583,15473710", 1, "Immunodeficiency due to a late component of complements deficiency", 0.75437296887129], ["P04156", "PRNP", "Major prion protein", "Tier 1", 0.785, 70, 64.19, 1, 0, null, null, null, 1, 2, "39556313,34067472", 1, "Gerstmann-Straussler-Scheinker syndrome", 0.8246149684620239], ["P14210", "HGF", "Hepatocyte growth factor", "Tier 1", 0.78, 36, 83.5, 1, 0, null, null, null, 1, 64, "41873087,41601428,41123956,40189053,40041032,39853766,39355222,38963794,38923378,37965838,37075136,36935149,36826373,36477303,36126144,34424707,34165951,31967847,31825565,31595614,30444610,30353654,30312735,28627727,26658271,26592704,25223895,23615526,21546514,20594164,16225393,38925633,38876234,34142433,31381313,30237882,29944203,29416033,27679852,27363484,26131766,11753087", 1, "hearing loss, autosomal recessive", 0.5910507391848663], ["P01019", "AGT", "Angiotensinogen", "Tier 1", 0.779, 22, 86.44, 0, 0, null, null, null, 1, 16, "35983901,34936368,34779902,34248841,32838280,23766021,17673982,11419945,38045440,34619249,29844151,27530235", 1, "renal tubular dysgenesis", 0.7354947364860083], ["P04839", "CYBB", "NADPH oxidase 2", "Tier 1", 0.776, 6, 90.25, 1, 0, null, null, null, 1, 2, "24635113", 1, "chronic granulomatous disease", 0.8633132852459866], ["P61769", "B2M", "Beta-2-microglobulin", "Tier 1", 0.77, 100, 94.06, 0, 0, null, null, null, 1, 15, "41850110,40373155,38904251,40658810,35026285,32631049,29281176,28960840,25100729,20616783,19137104,17878167", 1, "Immunodeficiency by defective expression of HLA class 1", 0.6180318849819645], ["P01189", "POMC", "Pro-opiomelanocortin", "Tier 1", 0.76, 13, 57.66, 1, 0, null, null, null, 1, 1, "30161145", 1, "obesity due to pro-opiomelanocortin deficiency", 0.6958797353500403], ["P05546", "SERPIND1", "Heparin cofactor 2", "Tier 1", 0.752, 9, 79.62, 0, 0, null, null, null, 1, 4, "20062917,20053992,34248840,31247951", 1, "heparin cofactor 2 deficiency", 0.719744572767547], ["P05164", "MPO", "Myeloperoxidase", "Tier 1", 0.745, 49, 89.0, 0, 0, null, null, null, 1, 16, "41629951,41316897,40501769,38127443,33534888,33495506,37991715,37277648,34183667,34117903,33869115,31210423,30431231", 1, "myeloperoxidase deficiency", 0.7742533340195327], ["P15144", "ANPEP", "Aminopeptidase N", "Tier 1", 0.74, 15, 93.06, 1, 0, null, null, null, 1, 1, "33554306", 1, "cholelithiasis", 0.5030146927270738], ["P0C0L4", "C4A", "Complement C4-A", "Tier 1", 0.74, 12, 83.44, 1, 0, null, null, null, 1, 4, "37566081,36619572,34739903,31019918", 1, null, null], ["Q03405", "PLAUR", "Urokinase plasminogen activator surface receptor", "Tier 1", 0.738, 13, 81.44, 1, 0, null, null, null, 1, 2, "37533140", 1, "Abdominal Aortic Aneurysm", 0.4819526979346149], ["P05187", "ALPP", "Alkaline phosphatase, placental type", "Tier 1", 0.72, 8, 93.44, 0, 0, null, null, null, 1, 7, "41329468,38238732,37425696,37047289,31687420,25919296,23467613", 1, "male reproductive organ cancer", 0.16284411775950106], ["P29622", "SERPINA4", "Kallistatin", "Tier 1", 0.719, 3, 86.69, 0, 0, null, null, null, 1, 4, "38904251,30297859,37351609,28794177", 1, "optic atrophy", 0.28896631154492924], ["Q96IY4", "CPB2", "Carboxypeptidase B2", "Tier 1", 0.709, 10, 94.12, 0, 0, null, null, null, 1, 4, "37329944,36805075,35861072,30297859", 1, "type 2 diabetes mellitus", 0.19338213943947646], ["P13987", "CD59", "CD59 glycoprotein", "Tier 1", 0.705, 17, 79.31, 1, 0, null, null, null, 1, 1, "19915929", 1, "primary CD59 deficiency", 0.7738276843579196], ["P25311", "AZGP1", "Zinc-alpha-2-glycoprotein", "Tier 1", 0.701, 9, 92.88, 0, 0, null, null, null, 1, 1, "41325160", 1, "neoplasm", 0.10887540652591159], ["Q12884", "FAP", "Prolyl endopeptidase FAP", "Tier 1", 0.7, 4, 95.62, 1, 0, null, null, null, 1, 7, "40046817,39710916,39026723,37192373,36838669,36494579,35879297", 1, "psoriasis", 0.40173767366839236], ["P00746", "CFD", "Complement factor D", "Tier 1", 0.695, 40, 91.0, 0, 0, null, null, null, 1, 4, "38057414,38071633,28972568,25727321", 1, "recurrent Neisseria infections due to factor D deficiency", 0.7726408204424132], ["P00738", "HP", "Haptoglobin", "Tier 1", 0.695, 15, 84.81, 1, 0, null, null, null, 1, 76, "41855944,41638958,40968672,40231802,39880691,39880501,39835381,39804483,39788927,39613489,39435559,38585969,38545293,38218089,38185050,38047083,38039678,37879039,37701520,37696275,37560929,37104434,36863194,36564526,36291832,36201958,35868696,35686646,35439614,35394406,35195734,35081018,34647930,34556234,34520834,34064911,34038999,33896635,33534888,33404555,33395442,33234387,33214769,33131243,31892078,31820139,31665673,31655906,31655383,31494507,38916796,34183667,34117903", 1, "Hypercholesterolemia", 0.5684135700226365], ["O95858", "TSPAN15", "Tetraspanin-15", "Tier 1", 0.692, 3, 87.56, 1, 0, null, null, null, 1, 1, "37047289", 1, "venous thromboembolism", 0.5182425801223098], ["P00451", "F8", "Coagulation factor VIII", "Tier 1", 0.691, 25, 60.75, 1, 0, null, null, null, 1, 13, "40727755,40266188,28791655,21144556,41587892,40009491,38992298,38752747,31493779,29609491,28979328,21389323,20589313", 1, "hemophilia A", 0.9108044347811838], ["P50148", "GNAQ", "Guanine nucleotide-binding protein G(q) subunit alpha", "Tier 1", 0.685, 30, 93.0, 1, 0, null, null, null, 1, 1, "40015005", 1, "Sturge-Weber syndrome", 0.6941111530708174], ["P22303", "ACHE", "Acetylcholinesterase", "Tier 1", 0.685, 78, 92.94, 0, 0, null, null, null, 1, 135, "41985393,41898380,41654945,41639270,41639254,41565777,41276911,41237904,41230502,41086326,41006757,40855286,40500390,40487355,40452137,40444021,40277325,40262341,40215752,40154972,40128122,39834132,39728786,39689579,39665919,39282962,39102642,38996565,38953438,38949022,38722683,38569854,38559166,38544485,38462144,38410271,38168820,38026177,37905115,37759795,37622311,37506391,37117194,36741760,36551106,36368824,36047811,35842727,35770801,35439419,36971430,36375221,36359944,35479481,35402070,35235478,35057959,34509014,33218485,33096123,32143069,31748191,31170561,26003847,25569873,24756130,24299064,12852840", 1, "Alzheimer disease", 0.628678841772617], ["P03950", "ANG", "Angiogenin", "Tier 1", 0.685, 56, 89.81, 0, 0, null, null, null, 1, 99, "41948065,41736700,41688234,41686152,41625383,41551985,41550856,41338305,41194434,40839054,40825091,40233536,40046817,39891801,39871473,39727889,39700796,39226945,39078660,38458987,38282417,37683754,37585601,37556929,37527337,37367006,37284580,37185488,37100807,36520671,36315359,36291000,36087171,35731347,35489276,35408368,35290881,35218097,35084794,34987275,34964948,34902643,34617153,34523638,34500620,34474207,34464491,34439828,34350496,34232998,27841380,25461163,25422408,22018671,21774079,18585145,18533682,17260069,9578572", 1, "amyotrophic lateral sclerosis", 0.7865457274017922], ["P01008", "SERPINC1", "Antithrombin-III", "Tier 1", 0.685, 27, 84.69, 0, 0, null, null, null, 1, 11, "32199927,31881749,31747245,25467079,25186782,24359968,23637781,18316185,15741074,10660541,10457984", 1, "hereditary antithrombin deficiency", 0.8494671886642873], ["Q15485", "FCN2", "Ficolin-2", "Tier 1", 0.682, 13, 85.12, 0, 0, null, null, null, 1, 2, "27490795", 1, "hypopituitarism", 0.2753784074131916], ["Q07954", "LRP1", "Prolow-density lipoprotein receptor-related protein 1", "Tier 1", 0.682, 7, 79.19, 0, 0, null, null, null, 1, 3, "41599761,38996211,25855589", 1, "developmental dysplasia of the hip", 0.6197148309275711], ["P00918", "CA2", "Carbonic anhydrase 2", "Tier 1", 0.68, 100, 97.38, 0, 0, null, null, null, 1, 109, "41955789,41543229,41513346,40854266,40783389,40744710,40660917,40411663,40380946,40321028,39978259,39928524,39716707,39536855,39515698,38946763,38693181,38462338,38409486,37997814,37726778,37148800,37103734,36792529,36410157,36140102,36107718,35490167,35344667,35211356,35194086,35022247,35006986,34619285,34607961,34440571,34399193,34362425,34166652,33832411,33479839,33410656,33230701,33080851,32991252,35516485,32700526,32493583,32331372,32304233", 1, "Osteopetrosis with renal tubular acidosis", 0.7929568656592082], ["P13501", "CCL5", "C-C motif chemokine 5", "Tier 1", 0.68, 23, 88.44, 1, 0, null, null, null, 1, 6, "41371773,39422353,32784904,30578658,29111236,27392463", 1, "neoplasm", 0.12028522937584413], ["P09958", "FURIN", "Furin", "Tier 1", 0.68, 48, 84.75, 0, 0, null, null, null, 1, 4, "36291832,24808863", 1, "coronary artery disease", 0.5783535503692275], ["P61073", "CXCR4", "C-X-C chemokine receptor type 4", "Tier 1", 0.68, 33, 82.25, 1, 0, null, null, null, 1, 17, "40671676,40401615,39865939,39778270,37052638,35157940,33739080,31737891,31267721,31097627,28670693,26265085,25329893,22811524,22376154,12498773,41543187", 1, "WHIM syndrome", 0.8009225456235435], ["P12259", "F5", "Coagulation factor V", "Tier 1", 0.68, 17, 61.91, 1, 0, null, null, null, 1, 4, "32696338,15496523,24629635,17878169", 1, "thrombophilia due to activated protein C resistance", 0.7962069693286362], ["P09382", "LGALS1", "Galectin-1", "Tier 1", 0.675, 41, 96.5, 0, 0, null, null, null, 1, 6, "37141264,33006019,31778957", 1, "glaucoma", 0.2854257184852107], ["P49913", "CAMP", "Cathelicidin antimicrobial peptide", "Tier 1", 0.675, 20, 80.0, 1, 0, null, null, null, 1, 30, "41316897,40997974,40501769,39429683,39045230,38471488,37947789,35479481,34957366,33832411,31940088,31099939,26843427,26358810,25659966,25437358,25390494,25048161,25044725,24814025,24325980,23748105,23744070,21673794,18165929,12569622,10913311,10780486,37400771", 1, "prostate carcinoma", 0.11970033909944687], ["P25942", "CD40", "Tumor necrosis factor receptor superfamily member 5", "Tier 1", 0.67, 14, 81.19, 0, 0, null, null, null, 1, 8, "41982466,37331977,36203210,33335251,26504624,26231918,23460531,12828856", 1, "hyper-IgM syndrome type 3", 0.8038021669520221], ["P08581", "MET", "Hepatocyte growth factor receptor", "Tier 1", 0.669, 100, 79.25, 0, 0, null, null, null, 1, 149, "42012469,41992303,41973478,41873087,41861669,41858296,41848278,41601428,41462891,41391726,41234744,41123956,41084363,41065179,41024479,40954195,40938088,40923343,40840349,40740738,40728393,40640119,40388621,40189053,40116812,40041032,39930702,39853766,39852082,39744222,39735310,39674868,39631842,39586988,39527480,39513807,39355222,39348183,39288204,39087949,38925633,38923378,38876234,38829176,38697444,38515622,38298092,38277932,38230289,38225704,30237882,29416033,26131766", 1, "papillary renal cell carcinoma", 0.84195976263742], ["P56817", "BACE1", "Beta-secretase 1", "Tier 1", 0.668, 100, 87.5, 0, 0, null, null, null, 1, 9, "39241336,36149663,35402070,31513457,30959405,29327496,26473367,23832586,16888322", 1, "metabolic disease", 0.42482013576989197], ["P08311", "CTSG", "Cathepsin G", "Tier 1", 0.667, 16, 91.38, 0, 0, null, null, null, 1, 6, "41316897,40501769,9062133,23598134,19325843", 1, "tuberculosis", 0.37188972877648113], ["P01137", "TGFB1", "Transforming growth factor beta-1 proprotein", "Tier 1", 0.665, 20, 79.56, 1, 0, null, null, null, 1, 4, "38132522,32370304,16775010,11856769", 1, "Camurati-Engelmann disease", 0.7995305374459716], ["Q9Y251", "HPSE", "Heparanase", "Tier 1", 0.66, 58, 94.69, 0, 0, null, null, null, 1, 7, "41363219,31252265,30086306,28150826,25295847,23968994,22719856", 1, "Vitiligo", 0.3120033501413742], ["Q13093", "PLA2G7", "Platelet-activating factor acetylhydrolase", "Tier 1", 0.66, 33, 87.81, 0, 0, null, null, null, 1, 1, "35187107", 1, "Platelet-activating factor acetylhydrolase deficiency", 0.6405981442654826], ["P15151", "PVR", "Poliovirus receptor", "Tier 1", 0.66, 13, 84.88, 1, 0, null, null, null, 1, 3, "37958909,36598052,16419035", 1, "Alzheimer disease", 0.3596586826147091], ["P03952", "KLKB1", "Plasma kallikrein", "Tier 1", 0.656, 22, 87.88, 1, 0, null, null, null, 1, 6, "40008515,36859809,33674695,28959386,28632925,23692437", 1, "inherited prekallikrein deficiency", 0.7077440022291496], ["P02461", "COL3A1", "Collagen alpha-1(III) chain", "Tier 1", 0.656, 11, 53.25, 0, 0, null, null, null, 1, 1, "28453726", 1, "Ehlers-Danlos syndrome, vascular type", 0.8608667500207768], ["P15907", "ST6GAL1", "Beta-galactoside alpha-2,6-sialyltransferase 1", "Tier 1", 0.655, 4, 88.12, 0, 0, null, null, null, 1, 1, "41889102", 1, "COVID-19", 0.5471103766359176]], "truncated": false, "filtered_table_rows_count": 603, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "priority_score", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "drug_count_approved", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, priority_score, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, drug_count_approved, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_known_aptamer\" = :p0 and \"in_cev_map\" = :p1 and \"tier\" = :p2 order by priority_score desc limit 51", "params": {"p0": "1", "p1": "1", "p2": "Tier 1"}}, "facet_results": {"tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&in_cev_map=1&tier=Tier+1", "results": [{"value": "Tier 1", "label": "Tier 1", "count": 603, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=1", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&in_cev_map=1&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 596, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=1&tier=Tier+1&has_activation_state_pdb_pair=0", "selected": false}, {"value": 1, "label": 1, "count": 7, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=1&tier=Tier+1&has_activation_state_pdb_pair=1", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&in_cev_map=1&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 603, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=1&tier=Tier+1", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&in_cev_map=1&tier=Tier+1", "results": [{"value": 1, "label": 1, "count": 603, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&tier=Tier+1", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&in_cev_map=1&tier=Tier+1", "results": [{"value": 0, "label": 0, "count": 404, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=1&tier=Tier+1&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 199, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=1&tier=Tier+1&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=1&tier=Tier+1&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 261.08156699774554, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}