{"database": "scout", "table": "v_targets", "is_view": true, "human_description_en": "where has_known_aptamer = 1, in_cev_map = 1 and tier = \"Tier 1.5\" sorted by priority_score descending", "rows": [["P25445", "FAS", "Tumor necrosis factor receptor superfamily member 6", "Tier 1.5", 0.914, 7, 77.88, 1, 0, null, null, null, 1, 17, "40784034,39897575,37458448,36908619,35402075,32270033,31436946,30594071,30417194,30339905,26318819,23980164,23511245,18997060,18956014,16729304,16581027", 1, "autoimmune lymphoproliferative syndrome type 1", 0.7377210386590284], ["P15260", "IFNGR1", "Interferon gamma receptor 1", "Tier 1.5", 0.804, 5, 66.0, 0, 0, null, null, null, 1, 2, "33667716", 1, "disseminated atypical mycobacterial infection", 0.5414012388034828], ["P02748", "C9", "Complement component C9", "Tier 1.5", 0.796, 9, 78.75, 1, 0, null, null, null, 1, 10, "41636061,40411682,36428893,36290981,35247355,28794177,27836219,22678933,19261617,15687383", 1, "Immunodeficiency due to a late component of complements deficiency", 0.761965409699055], ["Q13085", "ACACA", "Acetyl-CoA carboxylase 1", "Tier 1.5", 0.79, 10, 82.81, 1, 0, null, null, null, 1, 1, "41854184", 1, null, null], ["P36888", "FLT3", "Receptor-type tyrosine-protein kinase FLT3", "Tier 1.5", 0.788, 11, 75.94, 0, 0, null, null, null, 1, 6, "41733039,34364920,31434881,30237882,29299123,22411871", 1, "acute myeloid leukemia", 0.8313389209288576], ["Q92633", "LPAR1", "Lysophosphatidic acid receptor 1", "Tier 1.5", 0.785, 16, 83.62, 1, 0, null, null, null, 1, 1, "32065590", 1, "Epiretinal membrane", 0.4757255248053499], ["P02776", "PF4", "Platelet factor 4", "Tier 1.5", 0.77, 10, 75.06, 0, 0, null, null, null, 1, 10, "33859620,32366845,31967847,23847186,23673861,34248840,32022468", 1, "systemic scleroderma", 0.11523541376593864], ["P39060", "COL18A1", "Collagen alpha-1(XVIII) chain", "Tier 1.5", 0.769, 9, 50.62, 1, 0, null, null, null, 1, 2, "36707842,23679916", 1, "Knobloch syndrome 1", 0.7867122552672962], ["P43007", "SLC1A4", "Neutral amino acid transporter A", "Tier 1.5", 0.75, 1, 80.56, 1, 0, null, null, null, 1, 6, "36219068,31989939,27571928,26811678,19046328,16139842", 1, "spastic tetraplegia-thin corpus callosum-progressive postnatal microcephaly syndrome", 0.8025684205131692], ["P08648", "ITGA5", "Integrin alpha-5", "Tier 1.5", 0.748, 14, 85.25, 1, 0, null, null, null, 1, 2, "32174798,38258032", 1, "skin disease", 0.28465651599598124], ["O60884", "DNAJA2", "DnaJ homolog subfamily A member 2", "Tier 1.5", 0.73, 1, 83.38, 1, 0, null, null, null, 1, 2, "41935727,33879515", 1, "dengue disease", 0.37068859424875583], ["Q99988", "GDF15", "Growth/differentiation factor 15", "Tier 1.5", 0.718, 4, 75.69, 1, 0, null, null, null, 1, 29, "41924874,41862097,38879214,38477735,37982669,36927042,36638554,36508319,36333824,35762561,33334063,32527800,31988066,29992704,39884764,38497478,38296402,37162508,32739349,30335547", 1, "hyperemesis gravidarum", 0.5821658682742563], ["P41221", "WNT5A", "Protein Wnt-5a", "Tier 1.5", 0.71, 0, 87.69, 0, 0, null, null, null, 1, 4, "40855286,32693649,22363130,18673242", 1, "Robinow syndrome", 0.7220360983378594], ["P07225", "PROS1", "Vitamin K-dependent protein S", "Tier 1.5", 0.7, 3, 82.94, 1, 0, null, null, null, 1, 2, "36859809,33674695", 1, "thrombophilia due to protein S deficiency, autosomal dominant", 0.8240418292042652], ["P19021", "PAM", "Peptidyl-glycine alpha-amidating monooxygenase", "Tier 1.5", 0.695, 0, 71.69, 0, 0, null, null, null, 1, 25, "41855944,41500123,41384307,41285544,41222440,40607956,39929897,39472107,38867016,38846799,37977804,37977780,37906116,37127012,36905684,35478209,33911033,33516855,32315032,32307868,30399413,30124431,26406332,22954359,14965210", 1, "type 2 diabetes mellitus", 0.5754371880839976], ["P21359", "NF1", "Neurofibromin", "Tier 1.5", 0.695, 26, 87.19, 1, 0, null, null, null, 1, 2, "32980430,22617876", 1, "neurofibromatosis type 1", 0.8844735398780649], ["P10586", "PTPRF", "Receptor-type tyrosine-protein phosphatase F", "Tier 1.5", 0.69, 13, 82.0, 0, 0, null, null, null, 1, 4, "42101929,39087949,36594741", 1, "smoking initiation", 0.4641111755355386], ["O00501", "CLDN5", "Claudin-5", "Tier 1.5", 0.685, 0, 83.75, 0, 0, null, null, null, 1, 1, "18951306", 1, "genetic disorder", 0.40861362787778505], ["P14384", "CPM", "Carboxypeptidase M", "Tier 1.5", 0.68, 1, 90.31, 0, 0, null, null, null, 1, 3, "38876068,38060303,36768220", 1, "hydronephrosis", 0.3163273148871551], ["P09758", "TACSTD2", "Tumor-associated calcium signal transducer 2", "Tier 1.5", 0.673, 7, 82.69, 0, 0, null, null, null, 1, 4, "41384307,41241473,40050871,39250993", 1, "gelatinous drop-like corneal dystrophy", 0.7293087728162646], ["P98066", "TNFAIP6", "Tumor necrosis factor-inducible gene 6 protein", "Tier 1.5", 0.671, 5, 81.12, 0, 0, null, null, null, 1, 1, "39263947", 1, "type 2 diabetes mellitus", 0.30862220597837015], ["P16870", "CPE", "Carboxypeptidase E", "Tier 1.5", 0.66, 0, 90.38, 0, 0, null, null, null, 1, 16, "39863729,39793371,38861005,36832010,36773630,27886773,27219679,25738486,28706644,24768847,23875581,22280349,21419619,20949139,20491465,19174227", 1, "BDV syndrome", 0.7029731914682913], ["P98155", "VLDLR", "Very low-density lipoprotein receptor", "Tier 1.5", 0.66, 27, 75.69, 1, 0, null, null, null, 1, 1, "19188685", 1, "Dysequilibrium syndrome", 0.790164037509625], ["P22692", "IGFBP4", "Insulin-like growth factor-binding protein 4", "Tier 1.5", 0.66, 4, 77.25, 0, 0, null, null, null, 1, 6, "35323639,32515246,31930684", 1, "allergic rhinitis", 0.35214760515440524], ["Q13433", "SLC39A6", "Zinc transporter ZIP6", "Tier 1.5", 0.66, 0, 60.44, 0, 0, null, null, null, 1, 1, "40132409", 1, "breast cancer", 0.11188167100061543], ["Q9Y625", "GPC6", "Glypican-6", "Tier 1.5", 0.655, 0, 82.0, 0, 0, null, null, null, 1, 1, "40093223", 1, "autosomal recessive omodysplasia", 0.7503216726357611], ["P02766", "TTR", "Transthyretin", "Tier 1.5", 0.655, 0, 88.0, 0, 0, null, null, null, 1, 11, "39737993,32616928,23770039,21875107,21314458,39596348,38399458,36881759,33572452", 1, "amyloidosis, hereditary systemic 1", 0.846421986844374], ["Q9H0R3", "TMEM222", "Transmembrane protein 222", "Tier 1.5", 0.654, 0, 84.81, 0, 0, null, null, null, 1, 3, "41643149,36174865,25998051", 1, "neurodevelopmental disorder with motor and speech delay and behavioral abnormalities", 0.6449281600938256], ["P16234", "PDGFRA", "Platelet-derived growth factor receptor alpha", "Tier 1.5", 0.652, 14, 72.69, 1, 0, null, null, null, 1, 4, "33334063,32127469,28010895,30594071", 1, "gastrointestinal stromal tumor", 0.8167494524079806], ["P32942", "ICAM3", "Intercellular adhesion molecule 3", "Tier 1.5", 0.648, 1, 87.12, 0, 0, null, null, null, 1, 3, "40650261,34730968,17660953", 1, "lymphatic system disease", 0.28331776251399693], ["P07237", "P4HB", "Protein disulfide-isomerase", "Tier 1.5", 0.644, 14, 88.5, 1, 0, null, null, null, 1, 2, "31625090,28952381", 1, "Cole-Carpenter syndrome", 0.7447295842045853], ["Q14242", "SELPLG", "P-selectin glycoprotein ligand 1", "Tier 1.5", 0.64, 1, 50.38, 0, 0, null, null, null, 1, 1, "25979951", 1, "glaucoma", 0.40058604767334977], ["P01732", "CD8A", "T-cell surface glycoprotein CD8 alpha chain", "Tier 1.5", 0.635, 8, 78.19, 0, 0, null, null, null, 1, 2, "38487531,36979667", 1, "progressive supranuclear palsy", 0.2036023725502463], ["P51884", "LUM", "Lumican", "Tier 1.5", 0.625, 0, 90.38, 0, 0, null, null, null, 1, 7, "41744190,36785906,28453726,26230699,24180352,23890607", 1, "lumbar disc herniation", 0.3492311458288365], ["O75976", "CPD", "Carboxypeptidase D", "Tier 1.5", 0.625, 3, 82.5, 1, 0, null, null, null, 1, 1, "36457699", 1, "neurodegenerative disease", 0.34777406871587735], ["P49862", "KLK7", "Kallikrein-7", "Tier 1.5", 0.624, 12, 91.56, 0, 0, null, null, null, 1, 1, "30114962", 1, "neurodegenerative disease", 0.2420324965785189], ["P21926", "CD9", "CD9 antigen", "Tier 1.5", 0.623, 5, 88.56, 0, 0, null, null, null, 1, 17, "41999228,41625383,40618375,39266887,38866706,38057814,37585601,37351166,37019008,36704890,34647460,34505435,33304477,32730952,32207293,28959386", 1, "diphtheria", 0.5261379875719714], ["P16671", "CD36", "Platelet glycoprotein 4", "Tier 1.5", 0.62, 1, 93.94, 0, 0, null, null, null, 1, 6, "41713143,41140242,39762152,33596054,33291667,31904170", 1, "platelet-type bleeding disorder 10", 0.7360571429413174], ["Q9ULC3", "RAB23", "Ras-related protein Rab-23", "Tier 1.5", 0.619, 6, 79.56, 1, 0, null, null, null, 1, 1, "23618401", 1, "RAB23-related Carpenter syndrome", 0.7879955689930709], ["P10451", "SPP1", "Osteopontin", "Tier 1.5", 0.615, 3, 53.41, 0, 0, null, null, null, 1, 62, "41690559,41223977,39422353,38600327,32943056,32042311,31603904,30307407,28916037,28453726,25278703,21147843,42136308,42108056,40845664,40479828,39677448,39340832,38834269,37162508,36508319,36284815,35433114,35190123,34420232,32166466,31987218,31879964,31806966,31301870,30135425,29441346,28988933,28706912,26529285,25949891,25930003,25713073,24902765,24491763,24438228,23889968,23619316,22880609,22241292,21962803,21801960,20967826,19570203,18985031", 1, "osteoporosis", 0.5729473764531288], ["P01876", "IGHA1", "Immunoglobulin heavy constant alpha 1", "Tier 1.5", 0.612, 14, 81.88, 1, 0, null, null, null, 1, 2, "37325361", 1, "IGA glomerulonephritis", 0.12053726815801102], ["O43866", "CD5L", "CD5 antigen-like", "Tier 1.5", 0.61, 4, 85.88, 1, 0, null, null, null, 1, 3, "40215752,37100807", 1, "functional neutrophil defect", 0.3529395470693119], ["O75487", "GPC4", "Glypican-4", "Tier 1.5", 0.61, 0, 83.19, 0, 0, null, null, null, 1, 1, "40766128", 1, "Keipert syndrome", 0.737596102373947], ["P23368", "ME2", "NAD-dependent malic enzyme, mitochondrial", "Tier 1.5", 0.61, 18, 94.38, 1, 0, null, null, null, 1, 2, "39602246,29779113", 1, "diabetes mellitus", 0.277416610655893], ["Q12891", "HYAL2", "Hyaluronidase-2", "Tier 1.5", 0.61, 0, 91.0, 0, 0, null, null, null, 1, 1, "37353120", 1, "Muggenthaler-Chowdhury-Chioza syndrome", 0.6952425210951342], ["P15529", "CD46", "Membrane cofactor protein", "Tier 1.5", 0.608, 7, 82.12, 1, 0, null, null, null, 1, 9, "35114109,34248841,31761039,31077760,27734375,19915929,17046833,11084032", 1, "atypical hemolytic-uremic syndrome with MCP/CD46 anomaly", 0.7798469882597787], ["P55157", "MTTP", "Microsomal triglyceride transfer protein large subunit", "Tier 1.5", 0.608, 2, 86.56, 1, 0, null, null, null, 1, 1, "23770039", 1, "abetalipoproteinemia", 0.8281089516017405], ["O75508", "CLDN11", "Claudin-11", "Tier 1.5", 0.608, 0, 85.75, 0, 0, null, null, null, 1, 1, "35207732", 1, "leukodystrophy, hypomyelinating, 22", 0.6787731842933689], ["P10646", "TFPI", "Tissue factor pathway inhibitor", "Tier 1.5", 0.605, 9, 73.62, 1, 0, null, null, null, 1, 28, "32366845,32224381,30994257,30302740,27563744,27196067,24263002,23528042,22951415,22658294,22632032,22239993,21696535,21389323,8578509,25521966,24319161", 1, "hemophilia A", 0.5591056672248635], ["P10909", "CLU", "Clusterin", "Tier 1.5", 0.605, 2, 77.31, 0, 0, null, null, null, 1, 5, "42041411,37179603,36980195,35383192,26061649", 1, "Alzheimer disease", 0.5545645077431476]], "truncated": false, "filtered_table_rows_count": 238, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "tier", "priority_score", "pdb_count_total", "alphafold_mean_pLDDT", "has_cryoEM", "has_activation_state_pdb_pair", "activation_state_pdb_active", "activation_state_pdb_inactive", "drug_count_approved", "has_known_aptamer", "aptamer_count_pubmed", "aptamer_pmids", "in_cev_map", "opentargets_top_disease_name", "opentargets_top_disease_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, tier, priority_score, pdb_count_total, alphafold_mean_pLDDT, has_cryoEM, has_activation_state_pdb_pair, activation_state_pdb_active, activation_state_pdb_inactive, drug_count_approved, has_known_aptamer, aptamer_count_pubmed, aptamer_pmids, in_cev_map, opentargets_top_disease_name, opentargets_top_disease_score from v_targets where \"has_known_aptamer\" = :p0 and \"in_cev_map\" = :p1 and \"tier\" = :p2 order by priority_score desc limit 51", "params": {"p0": "1", "p1": "1", "p2": "Tier 1.5"}}, "facet_results": {"tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&in_cev_map=1&tier=Tier+1.5", "results": [{"value": "Tier 1.5", "label": "Tier 1.5", "count": 238, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=1", "selected": true}], "truncated": false}, "has_activation_state_pdb_pair": {"name": "has_activation_state_pdb_pair", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&in_cev_map=1&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 237, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=1&tier=Tier+1.5&has_activation_state_pdb_pair=0", "selected": false}, {"value": 1, "label": 1, "count": 1, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=1&tier=Tier+1.5&has_activation_state_pdb_pair=1", "selected": false}], "truncated": false}, "has_known_aptamer": {"name": "has_known_aptamer", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&in_cev_map=1&tier=Tier+1.5", "results": [{"value": 1, "label": 1, "count": 238, "toggle_url": "https://apt-scout.org/scout/v_targets.json?in_cev_map=1&tier=Tier+1.5", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&in_cev_map=1&tier=Tier+1.5", "results": [{"value": 1, "label": 1, "count": 238, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&tier=Tier+1.5", "selected": true}], "truncated": false}, "has_cryoEM": {"name": "has_cryoEM", "type": "column", "hideable": false, "toggle_url": "/scout/v_targets.json?has_known_aptamer=1&in_cev_map=1&tier=Tier+1.5", "results": [{"value": 0, "label": 0, "count": 186, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=1&tier=Tier+1.5&has_cryoEM=0", "selected": false}, {"value": 1, "label": 1, "count": 52, "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=1&tier=Tier+1.5&has_cryoEM=1", "selected": false}], "truncated": false}}, "suggested_facets": [{"name": "pdb_count_total", "toggle_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=1&tier=Tier+1.5&_facet=pdb_count_total"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_targets.json?has_known_aptamer=1&in_cev_map=1&tier=Tier+1.5&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 302.5737770003616, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}